Effects of Tai Chi Chuan With Different Doses on Cognitive Function in Elderly Patients With Mild Cognitive Impairment
Dose-Response Effects of Tai Chi Chuan Interventions on Cognitive Function in Mild Cognitive Impairment
1 other identifier
interventional
540
0 countries
N/A
Brief Summary
To determine the impact of Tai Chi Chuan with different exercise volume on cognitive function in elderly patients with mild cognitive impairment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2024
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 18, 2024
CompletedFirst Posted
Study publicly available on registry
April 18, 2024
CompletedStudy Start
First participant enrolled
May 1, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 15, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2025
CompletedApril 18, 2024
April 1, 2024
1.1 years
March 18, 2024
April 17, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Montreal Cognitive Assessment
Global cognition
8 weeks, 16 weeks, 24 weeks
Secondary Outcomes (8)
Montreal Cognitive Assessment
52 weeks
Wechsler Memory Scale
8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks
Digital Symbol test
8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks
Trial Making Test part B
8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks
Stroop color word test
8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks
- +3 more secondary outcomes
Other Outcomes (8)
Blood glucose metabolism index
8 weeks or 16 weeks or 24 weeks [post-intervention] and 52weeks
Blood lipid metabolism index
8 weeks or 16 weeks or 24 weeks [post-intervention] and 52weeks
Functional Magnetic Resonance Imaging
8 weeks or 16 weeks or 24 weeks [post-intervention]
- +5 more other outcomes
Study Arms (9)
Tai Chi Chuan Group1
EXPERIMENTALTai Chi Chuan 0.5 hour/session, 5 sessions/week for 8 weeks.
Tai Chi Chuan Group2
EXPERIMENTALTai Chi Chuan 0.5 hour/session, 5 sessions/week for 16 weeks.
Tai Chi Chuan Group3
EXPERIMENTALTai Chi Chuan 0.5 hour/session, 5 sessions/week for 24 weeks.
Tai Chi Chuan Group4
EXPERIMENTALTai Chi Chuan 1 hour/session, 5 sessions/week for 8 weeks.
Tai Chi Chuan Group5
EXPERIMENTALTai Chi Chuan 1 hour/session, 5 sessions/week for 16 weeks.
Tai Chi Chuan Group6
EXPERIMENTALTai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks.
Tai Chi Chuan Group7
EXPERIMENTALTai Chi Chuan 1.5 hour/session, 5 sessions/week for 8 weeks.
Tai Chi Chuan Group8
EXPERIMENTALTai Chi Chuan 1.5 hour/session, 5 sessions/week for 16 weeks.
Tai Chi Chuan Group9
EXPERIMENTALTai Chi Chuan 1.5 hour/session, 5 sessions/week for 24 weeks.
Interventions
Participants would take 24-form simplified Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 8 weeks. There were 10 minutes warm-up, 30 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 16 weeks. There were 10 minutes warm-up, 30 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 30 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 8 weeks. There were 10 minutes warm-up, 60 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 16 weeks. There were 10 minutes warm-up, 60 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 60 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 8 weeks. There were 10 minutes warm-up, 90 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 16 weeks. There were 10 minutes warm-up, 90 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Participants would take 24-form simplified Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 90 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training.
Eligibility Criteria
You may qualify if:
- Presence of mild cognitive impairment, not demented;
- Age ≥ 60 years old;
- Informed consent and voluntary participation.
You may not qualify if:
- Geriatric Depression Scale score ≥ 9 points
- Cognitive impairment caused by other reasons, taking drugs, poisoning, etc;
- Suffer from severe musculoskeletal system diseases and other contraindications to exercise and are not suitable for Tai Chi training, such as those who suffer from stroke, Parkinson's disease, and have a history of lower limb arthritis, hip and knee joint replacement, etc;
- Patients with severe heart, liver, kidney failure, malignant tumors, and other major diseases;
- Individuals with visual/auditory impairments, writing/reading impairments, illiteracy, etc. that affect training and evaluation;
- Individuals with uncontrolled hypertension (systolic blood pressure greater than 160mmHg or diastolic blood pressure greater than 100mmHg after medication);
- Participating in other experiments that influence this study;
- Engaged in regular exercise in the last three months (at least 3 times a week, at least 20 minutes of regular exercise each time.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Lidian Chenlead
- Peking University Third Hospitalcollaborator
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- PhD
Study Record Dates
First Submitted
March 18, 2024
First Posted
April 18, 2024
Study Start
May 1, 2024
Primary Completion
June 15, 2025
Study Completion
September 30, 2025
Last Updated
April 18, 2024
Record last verified: 2024-04