NCT05443321

Brief Summary

Sub-optimal transfer of clinical information during inter-hospital transfer (IHT, the transfer of patients between acute care hospitals) is common and can lead to patient harm. To address this problem, the investigators will use key stakeholder input to refine and implement an interoperable health information exchange platform that integrates with the electronic health record and improves the reliability of and access to necessary clinical information in three use cases involving transfer of patients between sending and receiving hospitals with varying levels of affiliation and health record integration. The investigators will assess the effect of this intervention on frequency of medical errors, evaluate the use and usability of this platform from the perspective of those that interact with it, and use these results to develop a dissemination plan to spread implementation and use of this platform across other similar institutions.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,006

participants targeted

Target at P75+ for not_applicable

Timeline
15mo left

Started Nov 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress74%
Nov 2022Jun 2027

First Submitted

Initial submission to the registry

June 23, 2022

Completed
12 days until next milestone

First Posted

Study publicly available on registry

July 5, 2022

Completed
4 months until next milestone

Study Start

First participant enrolled

November 1, 2022

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 22, 2025

Completed
1.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2027

Expected
Last Updated

January 23, 2026

Status Verified

January 1, 2026

Enrollment Period

3.1 years

First QC Date

June 23, 2022

Last Update Submit

January 21, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Total clinician-reported medical errors

    Collected via a survey of admitting clinicians 48-72 hours after patient transfer.

    Up to 72 hours after transfer

Secondary Outcomes (9)

  • Clinician-reported medical errors attributable to poor information exchange

    Up to 72 hours after transfer

  • Total clinician-reported adverse events

    Up to 72 hours after transfer

  • Preventable clinician-reported adverse events

    Up to 72 hours after transfer

  • Ameliorable clinician-reported adverse events

    Up to 72 hours after transfer

  • Clinician-reported quality of clinical information available

    Up to 72 hours after transfer

  • +4 more secondary outcomes

Study Arms (2)

Baseline

NO INTERVENTION

The baseline arm will include all included patient transfers from the 3 participating transfer hospitals to the 1 accepting hospital during the 1-year pre-intervention phase. They will not receive any intervention, but rather usual care

Intervention

EXPERIMENTAL

The intervention arm will include all included patient transfers from the 3 participating transfer hospitals to the 1 accepting hospital during the 1-year intervention phase. They will receive the intervention, which will include utilization of the developed health information exchange platform to transfer clinical information between transferring and accepting hospital. The intervention will not interact directly with the patient, but rather their clinical data.

Other: Health Information Exchange (HIE) platform

Interventions

An improved health information exchange (HIE) platform will be developed at the start of the study with key stakeholder input. This platform will be implemented for use after baseline data collection, and will allow for improved data exchange between transferring and accepting hospital. We will allow for a 6-month wash-in period prior to intervention data collection.

Intervention

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age greater than or equal to 18 years old
  • Transferred from one of the 3 included transferring hospitals (Brigham and Women's Faulkner Hospital, South Shore Hospital, Milford Regional Medical Center)
  • Admitted to the general medical, cardiology, oncology, and/or ICU services at Brigham and Women's Hospital

You may not qualify if:

  • Age \< 18 years old
  • Transferred from a different acute care hospital than the 3 included hospitals
  • Admitted through the ER
  • Direct admission from home/clinic
  • Admitted to a service other than general medicine, cardiology, oncology or ICU at Brigham and Women's Hospital

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States

Location

MeSH Terms

Conditions

InfectionsHeart FailureAsthmaGastrointestinal DiseasesCardiovascular DiseasesArrhythmias, CardiacRenal InsufficiencyKidney DiseasesRheumatic DiseasesUrologic DiseasesNervous System DiseasesHematologic DiseasesShockCritical Illness

Interventions

Health Information Exchange

Condition Hierarchy (Ancestors)

Heart DiseasesBronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System DiseasesDigestive System DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesMusculoskeletal DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesHemic and Lymphatic DiseasesDisease Attributes

Intervention Hierarchy (Ancestors)

Electronic Health RecordsMedical Records Systems, ComputerizedMedical RecordsRecordsData CollectionEpidemiologic MethodsInvestigative Techniques

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
SEQUENTIAL
Model Details: pre-post interrupted time series analysis
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Physician

Study Record Dates

First Submitted

June 23, 2022

First Posted

July 5, 2022

Study Start

November 1, 2022

Primary Completion

December 22, 2025

Study Completion (Estimated)

June 30, 2027

Last Updated

January 23, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Individual Participant data will not be shared with any researchers outside of this study. All data will only be shared in aggregate to any member outside the study team.

Locations