Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
ASCENT-04
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer, Whose Tumors Express PD-L1
6 other identifiers
interventional
443
27 countries
499
Brief Summary
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3
Started Jul 2022
Longer than P75 for phase_3
499 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 16, 2022
CompletedFirst Posted
Study publicly available on registry
May 19, 2022
CompletedStudy Start
First participant enrolled
July 25, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
February 1, 2027
September 18, 2025
September 1, 2025
4.5 years
May 16, 2022
September 16, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Progression-free Survival (PFS) as Assessed by Blinded Independent Central Review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1
PFS is defined as the time from the date of randomization until the date of objective progressive disease (PD) or death (whichever comes first).
Randomization up to approximately 33 months
Secondary Outcomes (11)
Overall Survival (OS)
Randomization up to approximately 53 months
Objective Response Rate (ORR) as Assessed by BICR per RECIST Version 1.1
Randomization up to approximately 53 months
Duration of Response (DOR) as Assessed by BICR per RECIST Version 1.1
Randomization up to approximately 53 months
Time to Response (TTR) as Assessed by BICR per RECIST Version 1.1
Randomization up to approximately 53 months
Percentage of Participants Experiencing Treatment-emergent Adverse Events (TEAEs)
First dose date up to 53 months plus 30 days
- +6 more secondary outcomes
Study Arms (2)
Sacituzumab Govitecan-hziy (SG) + Pembrolizumab
EXPERIMENTALParticipants will receive SG 10 mg/kg on Days 1 and 8 of 21-day cycles and pembrolizumab 200 mg on Day 1 of 21-day cycles Pembrolizumab will be administered for a maximum of 35 cycles.
Pembrolizumab + Treatment of Physician's Choice (TPC)
ACTIVE COMPARATORParticipants will receive pembrolizumab 200 mg on Day 1 of each 21-day cycle (maximum 35 cycles) plus TPC determined prior to randomization from 1 of the 3 allowed regimens: * Paclitaxel 90 mg/m\^2 on Days 1, 8, and 15 of 28-day cycles * nab-Paclitaxel 100 mg/m\^2 on Days 1, 8, and 15 of 28-day cycles * Gemcitabine 1000 mg/m\^2 + carboplatin area under the curve (AUC) 2 on Days 1 and 8 of 21-day cycles
Interventions
Administered intravenously
Administered intravenously
Administered intravenously
Administered intravenously
Administered intravenously
Eligibility Criteria
You may qualify if:
- Individuals with locally advanced, inoperable, or metastatic triple-negative breast cancer (TNBC) who have not received previous systemic therapy for advanced disease and whose tumors are programmed cell death ligand 1 (PD-L1) positive at screening.
- Individuals must have completed treatment for Stage I to III breast cancer, if indicated, and ≥ 6 months must have elapsed between completion of treatment with curative intent and first documented local or distant disease recurrence.
- Individuals presenting with de novo metastatic TNBC are eligible for this study.
- TNBC status and tumor PD-L1 combined positive score (CPS) will be confirmed centrally on a recent or archival tumor specimen.
- Individuals must have measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) as per Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1 criteria as evaluated locally.
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.
- Demonstrates adequate organ function
- Male and female individuals of childbearing potential who engage in heterosexual intercourse must agree to use protocol-specified method(s) of contraception.
- Individuals with HIV must be on antiretroviral therapy (ART) and have a well-controlled HIV infection/disease.
You may not qualify if:
- Positive serum pregnancy test or women who are lactating.
- Received prior therapy with an agent directed to another stimulatory or coinhibitory T-cell receptor.
- Individuals may not have received systemic anticancer treatment (with the exception of endocrine therapy) within the previous 6 months or radiation therapy within 2 weeks prior to enrollment.
- Individuals may not be participating in a study with an investigational agent or investigational device within 4 weeks prior to randomization. Individuals participating in observational studies are eligible.
- Have previously received topoisomerase 1 inhibitors or antibody drug conjugates containing a topoisomerase inhibitor.
- Have an active second malignancy.
- Have active serious infection requiring antibiotics.
- Individuals positive for HIV-1 or 2 with a history of Kaposi sarcoma and/or Multicentric Castleman Disease.
- Have active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
- Has an active autoimmune disease that has required systemic treatment in the past 2 years.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Gilead Scienceslead
- Merck Sharp & Dohme LLCcollaborator
Study Sites (504)
Alaska Oncology and Hematology
Anchorage, Alaska, 99508, United States
Arizona Oncology Associates, PC-Hope,1845 W Orange Grove Rd
Tucson, Arizona, 85704, United States
Arizona Oncology Associates, PC-Hope,2070 W. Rudasill Rd.
Tucson, Arizona, 85704, United States
Arizona Oncology Associates, PC-Hope
Tucson, Arizona, 85711, United States
Arizona Oncology Associates, PC-Hope,1620 West St. Mary's Road
Tucson, Arizona, 85745, United States
Genesis Cancer and Blood Institute
Hot Springs, Arkansas, 71913, United States
Genesis Cancer and Blood Institute,1456 Higdon Ferry Road Suite B.
Hot Springs, Arkansas, 71914, United States
Saint Bernards Medical Center
Jonesboro, Arkansas, 72401, United States
Saint Bernards Medical Center,4000 Linwood Drive
Paragould, Arkansas, 72450, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center,201 S. Buena Vista Street, Suite 200
Burbank, California, 91505, United States
University of California Irvine Health Chao Family,1640 Newport Blvd
Costa Mesa, California, 92627, United States
City of Hope
Duarte, California, 91010, United States
University of California San Diego Moores Cancer
La Jolla, California, 92093, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center,24302 Paseo de Valencia, Suite 200
Laguna Hills, California, 91505, United States
Cancer and Blood Specialty Clinic
Los Alamitos, California, 90720, United States
City of Hope,1601 Avocado Ave
Newport, California, 92660, United States
University of California Irvine Health Chao Family
Orange, California, 92868, United States
City of Hope,209 Fair Oaks Ave
Pasadena, California, 91030, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center,892 Aerovista Place, Suite 240
San Luis Obispo, California, 93401, United States
Sansum Clinic
Santa Barbara, California, 93105, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center,2020 Santa Monica Blvd, Suite 600
Santa Monica, California, 90404, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center,2336 Santa Monica, Suites 302 and 304
Santa Monica, California, 90404, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center
Santa Monica, California, 90404, United States
St. Jude Hospital Yorba dba St. Joseph Heritage Healthcare
Santa Rosa, California, 95403, United States
Sansum Clinic,2040 Viborg Road
Solvang, California, 93463, United States
City of Hope,5215 Torrance Blvd
Torrance, California, 90503, United States
Torrance Memorial Physician Network - Cancer Care
Torrance, California, 90505, United States
City of Hope,1100 San Bernardino Rd
Upland, California, 91786, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center,1250 La Venta Dr, Suite 100
Westlake Village, California, 91361, United States
Rocky Mountain Cancer Centers,1700 South Potomac Street
Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers
Boulder, Colorado, 80303, United States
Rocky Mountain Cancer Centers,2312 N. Nevada Avenue
Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers,6031 E. Woodman Rd.
Colorado Springs, Colorado, 80923, United States
Rocky Mountain Cancer Centers,4700 E. Hale Parkway
Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers,11750 West 2nd Place
Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers,22 West Dry Creek Circle
Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers,10107 Ridge Gate Parkway
Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers,2030 Mountain View Ave Ste 210
Longmont, Colorado, 80124, United States
Rocky Mountain Cancer Centers,3676 Parker Blvd
Pueblo, Colorado, 81008, United States
Rocky Mountain Cancer Centers,525 W. 15th Street
Pueblo, Colorado, 81008, United States
Rocky Mountain Cancer Centers,8820 Huron Street
Thornton, Colorado, 80260, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, 06360, United States
Advent Health Medical Group
Altamonte Springs, Florida, 32701, United States
SCRI - Florida Cancer Specialists - North Region R,750 Orienta Ave
Altamonte Springs, Florida, 32701, United States
University of Miami - Sylvester Comprehensive Cancer Center,2801 NE 213th St
Aventura, Florida, 33180, United States
Florida Cancer Specialists,9776 Bonita Beach Road Southeast Suite 201 A
Bonita Springs, Florida, 34135, United States
Florida Cancer Specialists,3630 Manatee Avenue West
Bradenton, Florida, 34205, United States
Florida Cancer Specialists,5985 Silver Falls Run
Bradenton, Florida, 34211, United States
SCRI - Florida Cancer Specialists - North Region R,403 S. Kings Ave.
Brandon, Florida, 33511, United States
Florida Cancer Specialists,1030 Commerce Creek Blvd
Cape Coral, Florida, 33909, United States
SCRI - Florida Cancer Specialists - North Region R,3280 McMullen Booth Road
Clearwater, Florida, 33761, United States
University of Miami - Sylvester Comprehensive Cancer Center,5555 Ponce De Leon Blvd
Coral Gables, Florida, 33146, United States
SCRI - Florida Cancer Specialists - West Palm Beach,224 Memorial Medical Parkway, Suite 300
Daytona Beach, Florida, 32117, United States
University of Miami - Sylvester Comprehensive Cancer Center,1192 East Newport Center Drive
Deerfield Beach, Florida, 33442, United States
Florida Cancer Specialists
Fort Myers, Florida, 33901, United States
Florida Cancer Specialists,8981 Colonial Center Drive
Fort Myers, Florida, 33905, United States
Florida Cancer Specialists,8260 Gladiolus Dr
Fort Myers, Florida, 33908, United States
SCRI - Florida Cancer Specialists - North Region R,6420 W. Newberry Road
Gainesville, Florida, 32605, United States
University of Miami - Sylvester Comprehensive Cancer Center,3850 Hollywood Blvd
Hollywood, Florida, 33021, United States
SCRI - Florida Cancer Specialists - North Region R,100 Highland Avenue
Largo, Florida, 33770, United States
SCRI - Florida Cancer Specialists - North Region R,521 North Lecanto Highway
Lecanto, Florida, 34461, United States
University of Miami - Sylvester Comprehensive Cancer Center,1400 NW 12th Ave
Miami, Florida, 33136, United States
University of Miami - Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
University of Miami - Sylvester Comprehensive Cancer Center,8932 S.W. 97 Ave
Miami, Florida, 33176, United States
Florida Cancer Specialists,1100 Goodlette Road
Naples, Florida, 34102, United States
SCRI - Florida Cancer Specialists - North Region R,4945 SW 49th Place
Ocala, Florida, 34474, United States
SCRI - Florida Cancer Specialists - North Region R,2824 Enterprise Rd
Orange City, Florida, 32763, United States
Advent Health Medical Group,2501 North Orange Ave
Orlando, Florida, 32804, United States
SCRI - Florida Cancer Specialists - North Region R,70 W. Gore Street
Orlando, Florida, 32806, United States
University of Miami - Sylvester Comprehensive Cancer Center,8100 SW 10 Street
Plantation, Florida, 33324, United States
Florida Cancer Specialists,22395 Edgewater Drive
Port Charlotte, Florida, 33980, United States
Florida Cancer Specialists,600 North Cattlemen Road
Sarasota, Florida, 34232, United States
Florida Cancer Specialists,1970 Golf Street
Sarasota, Florida, 34236, United States
SCRI - Florida Cancer Specialists - North Region R,7154 Medical Center Drive
Spring Hill, Florida, 34608, United States
SCRI - Florida Cancer Specialists - North Region R,1201 Fifth Avenue North
St. Petersburg, Florida, 33705, United States
SCRI - Florida Cancer Specialists - North Region R
St. Petersburg, Florida, 33705, United States
SCRI - Florida Cancer Specialists - West Palm Beach,301 SE Ocean Blvd, Suite 102
Stuart, Florida, 34994, United States
SCRI - Florida Cancer Specialists - North Region R,3402 West Dr. Martin Luther King Jr. Boulevard
Tampa, Florida, 33607, United States
SCRI - Florida Cancer Specialists - North Region R,4100 Waterman Way
Tavares, Florida, 32778, United States
SCRI - Florida Cancer Specialists - North Region R,1400 US Highway 441 N
The Villages, Florida, 32159, United States
SCRI - Florida Cancer Specialists - North Region R,9320 State Road 54
Trinity, Florida, 34655, United States
Florida Cancer Specialists,836 Sunset Lake Blvd
Venice, Florida, 34292, United States
SCRI - Florida Cancer Specialists - West Palm Beach,3730 7th Terrace, Suite 101
Vero Beach, Florida, 32960, United States
SCRI - Florida Cancer Specialists - West Palm Beach,1037 S. State Road 7, Bldg B, Suite 303
Wellington, Florida, 33414, United States
SCRI - Florida Cancer Specialists - West Palm Beach
West Palm Beach, Florida, 33401, United States
SCRI - Florida Cancer Specialists - North Region R,460 N Orlando Ave
Winter Park, Florida, 32789, United States
Northside Hospital,125 King Avenue
Athens, Georgia, 30606, United States
Piedmont Cancer Institute - Atlanta,1267 Hwy 54W
Atlanta, Georgia, 30214, United States
Winship Cancer Institute of Emory University,550 Peachtree St NE
Atlanta, Georgia, 30308, United States
Piedmont Cancer Institute - Atlanta
Atlanta, Georgia, 30318, United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, 30322, United States
Northside Hospital,5670 Peachtree Dunwoody Rd.
Atlanta, Georgia, 30342, United States
Northside Hospital
Atlanta, Georgia, 30342, United States
Winship Cancer Institute of Emory University,5665 Peachtree Dunwoody Road
Atlanta, Georgia, 30342, United States
Northside Hospital,308 Deep South Farm Rd, Suite 200
Blairsville, Georgia, 30512, United States
Northside Hospital,228 Riverstone Dr.
Canton, Georgia, 30114, United States
Northside Hospital,1505 Northside Blvd, Suite 4600
Cumming, Georgia, 30041, United States
Northside Hospital,3855 Pleasant Hill Rd., Suite 480
Duluth, Georgia, 30096, United States
Northside Hospital,308 Coliseum Dr.
Macon, Georgia, 31217, United States
Piedmont Cancer Institute - Atlanta,775 Poplar Road
Newnan, Georgia, 30265, United States
Piedmont Cancer Institute - Atlanta,1240 Eagles Landing Pkwy
Stockbridge, Georgia, 30281, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Chicago, Illinois, 60611, United States
University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center)
Chicago, Illinois, 60612, United States
Orchard Healthcare Research Inc,2845 North Sheridan Road, 1st Floor
Chicago, Illinois, 60657, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1 Kish Hospital Drive
DeKalb, Illinois, 60115, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,10 Health Services Drive
DeKalb, Illinois, 60115, United States
Orchard Healthcare Research Inc,800 Austin Street, Suite 360, East Tower
Evanston, Illinois, 60202, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,300 Randall Road
Geneva, Illinois, 60134, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,304 Randall Road
Geneva, Illinois, 60134, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1000 N. Westmoreland Road
Lake Forest, Illinois, 60045, United States
Orchard Healthcare Research Inc
Skokie, Illinois, 60077, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4405 Weaver Parkway
Warrenville, Illinois, 25731, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4455 Weaver Parkway
Warrenville, Illinois, 60555, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,25 N Winfield Road
Winfield, Illinois, 60190, United States
Regulatory Management Only: TRIO-US Central Administration
Fort Wayne, Indiana, 46845, United States
The University of Kansas Cancer Center,2000 Olathe Blvd
Kansas City, Kansas, 66160, United States
The University of Kansas Cancer Center,12200 W. 110th Street
Overland Park, Kansas, 66210, United States
The University of Kansas Cancer Center,10710 Nall Avenue
Overland Park, Kansas, 66211, United States
The University of Kansas Cancer Center,10730 Nall Avenue
Overland Park, Kansas, 66211, United States
The University of Kansas Cancer Center
Westwood, Kansas, 66205, United States
Norton Cancer Institute - Saint Matthews,234 E. Gray Strret
Louisville, Kentucky, 40202, United States
Norton Cancer Institute - Saint Matthews,676 S. Floyd Street
Louisville, Kentucky, 40202, United States
Norton Cancer Institute - Saint Matthews
Louisville, Kentucky, 40207, United States
Norton Cancer Institute - Saint Matthews,4955 Norton Healthcare Blvd
Louisville, Kentucky, 40241, United States
Hematology Oncology Clinic - Baton Rouge
Baton Rouge, Louisiana, 70809, United States
Hematology Oncology Clinic - Baton Rouge,1673 E Mount Please Drive
Zachary, Louisiana, 70791, United States
Cancer Institute Ascension Saint Agnes
Baltimore, Maryland, 21229, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
Massachusetts General Hospital
Boston, Massachusetts, 02215, United States
Massachusetts General Hospital,102 Endicott Street
Danvers, Massachusetts, 01923, United States
Massachusetts General Hospital,2014 Washington St
Newton, Massachusetts, 02462, United States
University of Michigan
Ann Arbor, Michigan, 48109, United States
Ascension St. John Hospital
Grosse Pointe Woods, Michigan, 48236, United States
Ascension Providence Hospital Southfield Cancer Center
Southfield, Michigan, 48075, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
The West Clinic, PLLC dba West Cancer Center,7668 Airways Blvd
Southaven, Mississippi, 38671, United States
The University of Kansas Cancer Center,2750 Clay Edwards Drive
Kansas City, Missouri, 64116, United States
The University of Kansas Cancer Center,8700 North Green Hills Road
Kansas City, Missouri, 64154, United States
The University of Kansas Cancer Center,4881 N.E. Goodview Circle
Lee's Summit, Missouri, 64064, United States
Nebraska Cancer Specialists,2730 W. Faidley Ave
Grand Island, Nebraska, 68803, United States
Nebraska Cancer Specialists,8303 Dodge Street
Omaha, Nebraska, 68114, United States
Nebraska Cancer Specialists
Omaha, Nebraska, 68130, United States
Nebraska Cancer Specialists,611 Fenwick Dr
Papillion, Nebraska, 68046, United States
Comprehensive Cancer Centers of Nevada - Central V,10001 S. Eastern Avenue, Suite 108
Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Central V,2460 W. Horizon Ridge Parkway
Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Central V,1501 Wigwam Parkway, Suite 1300
Henderson, Nevada, 89074, United States
Comprehensive Cancer Centers of Nevada - Central V,653 North Town Center Drive, Suite 402
Las Vegas, Nevada, 89144, United States
Comprehensive Cancer Centers of Nevada - Central V,9280 W. Sunset Road Suite 100
Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada - Central V,7445 Peak Drive
Las Vegas, Nevada, 89169, United States
Comprehensive Cancer Centers of Nevada - Central V
Las Vegas, Nevada, 89169, United States
Summit Medical Group,1 Diamond Hill Road
Berkeley Heights, New Jersey, 07922, United States
Regional Cancer Care Associates - East Brunswick
East Brunswick, New Jersey, 08816, United States
Summit Medical Group
Florham Park, New Jersey, 07932, United States
John Theurer Cancer Center
Hackensack, New Jersey, 07601, United States
Rutgers Cancer Institute of New Jersey,2575 Klockner Road
Hamilton, New Jersey, 08690, United States
Rutgers Cancer Institute of New Jersey,414 Grand Street
Jersey City, New Jersey, 07302, United States
Rutgers Cancer Institute of New Jersey,600 River Avenue
Lakewood, New Jersey, 08701, United States
Rutgers Cancer Institute of New Jersey,94 Old Short Hills Road
Livingston, New Jersey, 07039, United States
Rutgers Cancer Institute of New Jersey,300 Second Ave
Long Branch, New Jersey, 07740, United States
Regional Cancer Care Associates - East Brunswick,9 Centre Drive
Monroe, New Jersey, 08831, United States
Regional Cancer Care Associates - East Brunswick,34-36 Progress Street
New Brunswick, New Jersey, 08820, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
Rutgers Cancer Institute of New Jersey,150 Bergen St.
Newark, New Jersey, 07103, United States
Rutgers Cancer Institute of New Jersey,201 Lyons Avenue
Newark, New Jersey, 07112, United States
Regional Cancer Care Associates - East Brunswick,75 Veronica Avenue
Somerset, New Jersey, 08873, United States
Rutgers Cancer Institute of New Jersey,110 Rehill Ave
Somerville, New Jersey, 08876, United States
Rutgers Cancer Institute of New Jersey,99 Highway 37 West
Toms River, New Jersey, 08755, United States
Rutgers Cancer Institute of New Jersey,100 State Route 36
West Long Branch, New Jersey, 07764, United States
New York Cancer & Blood Specialists - Port Jeffers,72 East Main St.
Babylon, New York, 11702, United States
Perlmutter Cancer Center - Manhattan - 34th Street,259 First Street
Mineola, New York, 11501, United States
New York Cancer & Blood Specialists - Port Jeffers,1 Delaware Dr.
New Hyde Park, New York, 11042, United States
Perlmutter Cancer Center - Manhattan - 34th Street
New York, New York, 10016, United States
NYP/Columbia Univeresity Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
New York Cancer & Blood Specialists - Port Jeffers,365 East Main St.
Patchogue, New York, 11772, United States
New York Cancer & Blood Specialists - Port Jeffers,1500 Rte, 112, Building 4
Port Jefferson, New York, 11776, United States
New York Cancer & Blood Specialists - Port Jeffers,49 Rte. 347, Newconset Hwy
Port Jefferson Station, New York, 11776, United States
New York Cancer & Blood Specialists - Port Jeffers
Port Jefferson Station, New York, 11776, United States
New York Cancer & Blood Specialists - Port Jeffers,750 Old County Rd. Suite 4
Riverhead, New York, 11901, United States
New York Cancer & Blood Specialists - Port Jeffers,12 East 86th St, Suite 4
The Bronx, New York, 10028, United States
Montefiore Medical Center - Montefiore Medical Park
The Bronx, New York, 10467, United States
New York Cancer & Blood Specialists - Port Jeffers,2330 Eastchester Road, Suite 360
The Bronx, New York, 10469, United States
The Ohio State University Wexner Medical Center Clinical Laboratories
Columbus, Ohio, 43212, United States
Zangmeister Cancer Center
Columbus, Ohio, 43219, United States
Northwest Cancer Specialists, PC,5050 NE Hoyt St.
Portland, Oregon, 97213, United States
Northwest Cancer Specialists, PC,265 N. Broadway
Portland, Oregon, 97227, United States
Northwest Cancer Specialists, PC
Tigard, Oregon, 97223, United States
Magee-Womens Hospital of UPMC,200 Oxford Drive
Bethel Park, Pennsylvania, 15102, United States
Magee-Womens Hospital of UPMC,3 St. Francis Way
Cranberry Township, Pennsylvania, 16066, United States
Magee-Womens Hospital of UPMC,2500 West 12th Street
Erie, Pennsylvania, 16505, United States
Magee-Womens Hospital of UPMC,201 State Street, 6 Main
Erie, Pennsylvania, 16550, United States
Magee-Womens Hospital of UPMC,200 Village Drive
Greensburg, Pennsylvania, 15601, United States
Magee-Womens Hospital of UPMC,400 Oxford Drive
Monroeville, Pennsylvania, 15146, United States
University of Pennsylvania Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
Magee-Womens Hospital of UPMC,300 Halket Street
Pittsburgh, Pennsylvania, 15213, United States
Magee-Womens Hospital of UPMC
Pittsburgh, Pennsylvania, 15213, United States
Magee-Womens Hospital of UPMC,5115 Centre Avenue
Pittsburgh, Pennsylvania, 15232, United States
Magee-Womens Hospital of UPMC,9100 Babcock Boulevard
Pittsburgh, Pennsylvania, 15237, United States
Magee-Womens Hospital of UPMC,100 Fairfield Dr
Seneca, Pennsylvania, 16346, United States
Magee-Womens Hospital of UPMC,470 Johnson Road
Washington, Pennsylvania, 15301, United States
Magee-Womens Hospital of UPMC,1703 Innovation Drive
York, Pennsylvania, 17408, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
Rhode Island Hospital,164 Summit Ave, Fain 275A
Providence, Rhode Island, 02906, United States
Tennessee Oncology, PLLC,103 Natchez Park Drive
Dickson, Tennessee, 37055, United States
Tennessee Oncology, PLLC,4488 Carothers Parkway
Franklin, Tennessee, 37067, United States
Tennessee Oncology, PLLC,225 Big Station Camp Blvd
Gallatin, Tennessee, 37066, United States
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, 38138, United States
Tennessee Oncology, PLLC,353 New Shackle Island Road
Hendersonville, Tennessee, 37075, United States
Tennessee Oncology, PLLC,5653 First Blvd.
Hermitage, Tennessee, 37076, United States
Tennessee Oncology, PLLC,103 Physicians Way
Lebanon, Tennessee, 37090, United States
Tennessee Oncology, PLLC,1840 Medical Center Parkway
Murfreesboro, Tennessee, 37129, United States
Tennessee Oncology, PLLC,2004 Hayes Street
Nashville, Tennessee, 37203, United States
Tennessee Oncology, PLLC,SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
Tennessee Oncology, PLLC
Nashville, Tennessee, 37203, United States
Tennessee Oncology, PLLC,4220 Harding Rd
Nashville, Tennessee, 37205, United States
Tennessee Oncology, PLLC,3443 Dickerson Road
Nashville, Tennessee, 37207, United States
Tennessee Oncology, PLLC,397 Wallace Road
Nashville, Tennessee, 37211, United States
Tennessee Oncology, PLLC,120 Frank Martin Road
Shelbyville, Tennessee, 37160, United States
Tennessee Oncology, PLLC,300 Stonecrest Blvd
Smyrna, Tennessee, 37167, United States
The Center for Cancer and Blood Disorders - Magnolia,515 W. Mayfield Rd.
Arlington, Texas, 76104, United States
Texas Oncology-Austin,901 West 38th Street
Austin, Texas, 78705, United States
Texas Oncology-Austin
Austin, Texas, 78731, United States
Texas Oncology-Austin,4101 James Casey, Suite 100
Austin, Texas, 78745, United States
The Center for Cancer and Blood Disorders - Magnolia,11805 South Freeway
Burleson, Texas, 76028, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
Texas Oncology-Denison
Denison, Texas, 75020, United States
The Center for Cancer and Blood Disorders - Magnolia
Fort Worth, Texas, 76104, United States
Oncology Consultants,1631 North Loop West
Houston, Texas, 77008, United States
Oncology Consultants,925 Gessner
Houston, Texas, 77024, United States
Oncology Consultants
Houston, Texas, 77030, United States
University of Texas MD Anderson Cancer Center,1155 Pressler St
Houston, Texas, 77030, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
Mays Cancer Center
San Antonio, Texas, 78229, United States
The Center for Cancer and Blood Disorders - Magnolia,920 Santa Fe Drive
Weatherford, Texas, 76086, United States
Huntsman Cancer Institute, University of Utah,165 North University Avenue
Farmington, Utah, 84025, United States
Huntsman Cancer Institute, University of Utah,1280 E. Stringham Avenue
Salt Lake City, Utah, 84106, United States
Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah, 84112, United States
Huntsman Cancer Institute, University of Utah,5126 West Daybreak Parkway
South Jordan, Utah, 84009, United States
Virginia Oncology Associates,744 N. Battlefield Blvd
Chesapeake, Virginia, 23320, United States
Virginia Cancer Institute,7501 Right Flank Road
Mechanicsville, Virginia, 23116, United States
Virginia Oncology Associates,1051 Loftis Blvd Suite 100
Newport News, Virginia, 23606, United States
Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
Virginia Cancer Institute,210 Medical Park Boulevard
Petersburg, Virginia, 23805, United States
Virginia Cancer Institute,1401 Johnston-Willis Drive
Richmond, Virginia, 23235, United States
Virginia Cancer Institute
Richmond, Virginia, 23298, United States
Virginia Oncology Associates,1950 Glenn Mitchell Drive
Virginia Beach, Virginia, 23456, United States
Northwest Cancer Specialists, PC,210 SE 136th Avenue
Vancouver, Washington, 98684, United States
Hospital Británico de Buenos Aires
Buenos Aires, 1426, Argentina
Instituto de Oncología Ángel H. Roffo
CABA, 1417, Argentina
Fundacion CORI para la Investigacioy y Prevención del Cancer
Capital, F5300COE, Argentina
Instituto de Oncologia de Rosario
Rosario, 2000, Argentina
CAIPO Centro Para La Atención Integral Del Pacient
San Miguel de Tucumán, 4000, Argentina
Clinica Viedma
Viedma, 8500, Argentina
Border Medical Oncology
Albury, New South Wales, 2640, Australia
Saint George Hospital - Australia
Kogarah, New South Wales, 2217, Australia
Mater Hospital - North Sydney
North Sydney, New South Wales, 2060, Australia
GenesisCare - North Shore
St Leonards, New South Wales, 2065, Australia
Mater Misericordiae Limited and Mater Research Limited
South Brisbane, Queensland, 4101, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
Cancer Research SA (CRSA)
Adelaide, South Australia, 5000, Australia
Icon Cancer Centre Hobart
Hobart, Tasmania, 7000, Australia
Monash Medical Centre
Clayton, Victoria, 3168, Australia
Austin Hospital
Melbourne, Victoria, 3084, Australia
Peter MacCallum Cancer Centre
Parkville, Victoria, 3050, Australia
Breast Cancer Research Center - Western Australia
Nedlands, Western Australia, 6009, Australia
Medizinische Universität Innsbruck
Innsbruck, 06020, Austria
Ordensklinikum Linz GmbH Barmherzige Schwestern
Linz, 4010, Austria
Landeskrankenhaus Salzburg
Salzburg, A-5020, Austria
Universitätsklinikum Sankt Pölten
Sankt Pölten, 3100, Austria
Medizinische Universität Wien
Vienna, 1090, Austria
Institut Jules Bordet
Anderlecht, 1070, Belgium
Algemeen Ziekenhuis Klina
Brasschaat, 2930, Belgium
Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
Universitair Ziekenhuis Brussel
Brussels, Belgium
Grand Hopital de Charleroi - Notre Dame
Charleroi, 6000, Belgium
Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
UZ Leuven
Leuven, 3000, Belgium
Centre Hospitalier Universitaire Université Cathol
Namur, 5000, Belgium
Hospital Araújo Jorge - Associacao de Combate ao Cancer em Goias - ACCG
Goiânia, 74605-070, Brazil
Centro de Pesquisa Clinica Em Oncologia - ONCOSITE
Ijuí, 98700-000, Brazil
Hospital de Clinicas de Porto Alegre - HCPA
Itajaí, 88301-220, Brazil
Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho - Hospital Amarval Carvalho
Jaú, 17210080, Brazil
Associacao Hosptialar Moinos de Vento - Hospital Moinhos de Vento
Porto Alegre, 90035-00, Brazil
Hospital de Clínicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
Hospital Sao Lucas da PUCRS
Porto Alegre, 90610001, Brazil
Instituto Nacional de Câncer - Brazil
Rio de Janeiro, Brazil
Núcleo de Oncologia da Bahia
Salvador, 40170170, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Centro Universitário FMABC
Santo André, 09060-650, Brazil
Real e Benemerita Associacao Portuguesa de Beneficencia - Hospital Beneficencia Portuguesa (BP) - Unidade Paulista
São Paulo, 01323-001, Brazil
Clinica de Pesquisas e Centro de Estudos em Oncolo
São Paulo, 1317000, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
São Paulo, 14784400, Brazil
Nucleo de Pesquisa Clinica da Rede Sao Camilo
São Paulo, 4014002, Brazil
Tom Baker Cancer Centre
Calgary, T2N 5G2, Canada
Cross Cancer Institute
Edmonton, T6G 1Z2, Canada
QEII Health Sciences Centre
Halifax, B3H 1V7, Canada
Grand River Regional Cancer Centre at Grand River Hospital
Kitchener, N2G 1G3, Canada
London Health Sciences Centre
London, N6A 5W9, Canada
Jewish General Hospital
Montreal, H3T 1E2, Canada
McGill University Health Centre
Montreal, H4A 3J1, Canada
Princess Margaret Cancer Centre - University Health Network
Ontario, M5G 2M9, Canada
Ottawa Hospital - General Campus
Ottawa, K1H 8L6, Canada
Sunnybrook Research Institute
Toronto, M4N 3M5, Canada
Mount Sinai Hospital
Toronto, M5G 1X5, Canada
British Columbia Cancer - Vancouver
Vancouver, V5Z 4E6, Canada
Oncovida - Santiago
Providencia, 7510035, Chile
Clínica Alemana
Santiago, 7630000, Chile
Clínica IRAM
Santiago, Chile
Centro de Cancer Pontificia Universidad Catolica
Santiago Region, 8330032, Chile
James Lind Centro de Investigacion del Cancer
Temuco, Chile
Masarykuv Onkologicky Ustav, Klinika Komplexni Onkologicke Pece
Brno, 65653, Czechia
Fakultní Nemocnice Hradec Králové
Hradec Králové, 500 05, Czechia
Fakultní Thomayerova nemocnice
Hradec Králové, 50005, Czechia
Fakultni nemocnice Olomouc, Onkologicka klinika
Olomouc, 77520, Czechia
Fakultní Nemocnice Královské Vinohrady, Radioterapeuticka a onkologicka klinika
Prague, 100 34, Czechia
Vseobecna Fakultni Nemocnice v Praze, Onkologicka klinika
Prague, 12808, Czechia
Sainte Catherine Institut du Cancer Avignon Provence
Avignon, 84918, France
Centre Hospitalier Régional et Universitaire de Be
Besançon, 25030, France
Polyclinique Bordeaux Nord Aquitaine
Bordeaux, 33000, France
Hôpital Morvan, Institut de cancérologie
Brest, 29200, France
Centre de Lutte contre le Cancer - François Bacles
Caen, 14000, France
Centre Jean Perrin
Clermont-Ferrand, 63011, France
Centre Leon Berard
Lyon, 69373, France
Institut Paoli-Calmettes
Marseille, 13273, France
Centre de Cancérologie du Grand Montpellier
Montpellier, 34070, France
Institut Régional du Cancer de Montpellier
Montpellier, 34298, France
Hôpital Privé du Confluent
Nantes, 44202, France
Hospices Civils de Lyon, Hôpital Lyon Sud
Pierre-Bénite, 69495, France
Centre Armoricain de Radiothérapie, dImagerie Méd
Plérin, 22190, France
Centre Eugène Marquis
Rennes, 35042, France
Institut Claudius Regaud - IUCT-O
Toulouse, France
Institut Gustave Roussy
Villejuif, 94800, France
Helios Klinikum Berlin-Buch
Berlin, 13125, Germany
: Gynakologisches Zentrum Bonn, Schwerpunkt Gyn. Onkologie,
Bonn, 53111, Germany
Marienhospital Bottrop
Bottrop, 46236, Germany
Klinik Frauenheilkunde, Uniklinik ClO, Studienzentrale
Cologne, 50937, Germany
Universitätsklinikum Erlangen, Frauen klinik
Erlangen, 91054, Germany
Kliniken Essen-Mitte - Evangelische Huyssens-Stift
Essen, 45136, Germany
Praxis für interdisziplinäre Onkologie & Hämatolog
Freiburg im Breisgau, 79110, Germany
: Universitätsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
Facharztzentrum Eppendorf
Hamburg, 20249, Germany
Nationales Centrum für Tumorerkrankungen
Heidelberg, 69120, Germany
Universitätsklinikum Schleswig-Holstein Institut fur Klinische Chermie
Lübeck, 23538, Germany
Universitatsklinikum Mannheim GmBH, Frauenklinik
Mannheim, 68167, Germany
EV. Krankenhaus Bethesda - Johanniter GmbH, Station 1 Brustzentrum Niederrhein
Mönchengladbach, 41061, Germany
Rotkreuzklinikum Munchen Frauenklinik
München, 80637, Germany
Klinik und Poliklinik für Frauenheilkunde
München, 81675, Germany
Universitätsklinikum Münster, Bereich Senologie an der klinik fur Frauenheilkunde und Gerburtschilfe
Münster, 48149, Germany
Universitatsklinikum Tubingen
Tübingen, 72076, Germany
St. Josefs-Hospital Wiesbaden GmbH, Gynakologie und Geburtshilfe
Wiesbaden, 65189, Germany
Department of Medicine, Queen Mary Hospital
Hong Kong, 999077, Hong Kong
Hong Kong Sanatorium and Hospital
Hong Kong, Hong Kong
Tuen Mun Hospital
Hong Kong, Hong Kong
Prince of Wales Hospital - Hong Kong
New Territories, 999077, Hong Kong
Orszagos Onkologiai Intezet
Budapest, 1122, Hungary
Uzsoki Utcai Kórház
Budapest, 1145, Hungary
Debreceni Egyetem Klinikai Központ
Debrecen, 4032, Hungary
Petz Aladár Egyetemi Oktató Kórház - Gy?r
Győr, 9024, Hungary
Soroka Medical Center
Beersheba, 8410101, Israel
Rambam Health Care Campus
Haifa, 3109601, Israel
Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
Hadassah - Hebrew University Medical Center
Jerusalem, Israel
Meir Medical Center
Kfar Saba, 4428164, Israel
Rabin Medical Center
Petah Tikva, 4941492, Israel
Kaplan Medical Center
Rehovot, 7661041, Israel
Sheba Medical Center Hospital - Tel Hashomer
Tel Aviv, 52621, Israel
Tel Aviv Sourasky Medical Center
Tel Aviv, 64239, Israel
IRCCS Istituto Tumori "Giovanni Paolo II"
Bari, 70124, Italy
SSD Oncologia Medica Addarii-Zamagni, IRCSS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola
Bologna, Italy
UO Oncologia, ASST degli Spedali Civili di Brescia
Brescia, 25123, Italy
IRCCS Ospedale Policlinico San Martino
Genova GE, 16132, Italy
S.C. Oncologia medica, ASST di Lecco
Lecco, 23900, Italy
Presidio Ospedaliero di Lucca
Lucca, 55100, Italy
Ospedale Generale Provinciale - Macerata
Macerata, 62100, Italy
Istituto Europeo di Oncologia
Milan, 20141, Italy
Ospedale San Raffaele
Milan, 20132, Italy
Fondazione IRCCS - Istituto Nazionale dei Tumori
Milan, 20133, Italy
Centro Ricerca Fase I, Fondazione IRCSS San Gerado dei Tintori
Monza, 20090, Italy
AOU "Luigi Vanvitelli"
Napoli, 80131, Italy
Oncologia Medica Senologica Sperimentale - Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
Napoli, 80131, Italy
AOU Maggiore della Carita
Novara, 28100, Italy
Istituto Oncologico Veneto - IRCCS
Padua, 35128, Italy
S.O.C Oncologia Medica, Nuovo Ospedale di Prato Santo Stefano
Prato, 59100, Italy
Policlinico di Roma
Roma, 00161, Italy
Fondazione Policlinico Universitario Agostino Geme
Rome, 00168, Italy
Azienda Ospedaliera Universitaria Senese - Losped
Siena, 53100, Italy
Aichi Cancer Center Hospital
Aichi, 464-8681, Japan
Tohoku University Hospital
Aoba-ku, 980-8574, Japan
Juntendo University Hospital
Bunkyō City, 113-8431, Japan
Chiba Cancer Center
Chūōku, 260-8717, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute
Chūōku, 541-8567, Japan
NHO Shikoku Cancer Center
Ehime, 791-0280, Japan
Fukushima Medical University Hospital
Fukushima, Japan
Saitama Cancer Center
Inamachi, 362-0806, Japan
Hakuaikai Sagara Hospital
Kagoshima, 892-0833, Japan
Tokai University Hospital
Kanagawa, 259-1193, Japan
National Cancer Center Hospital East
Kashiwa, 277-8577, Japan
The Cancer Institute Hospital of JFCR
Kōtoku, 135-8550, Japan
Kumamoto University Hospital
Kumamoto, 860-8556, Japan
Kure Medical Center And Chugoku Cancer Center
Kure, 737-0023, Japan
Mie University Hospital
Mie, 514-8507, Japan
Nagoya University Hospital
Nagoya, 466-8560, Japan
Nagoya City University Hospital
Nagoya, 467-8602, Japan
Hiroshima City Hiroshima Citizens Hospital
Nakaku, 730-8518, Japan
NIigata Cancer Center Hospital
Niigata, 951-8566, Japan
Okayama University Hospital
Okayama, 700-8558, Japan
Gunma Prefectural Cancer Center
Ōta-ku, 373-8550, Japan
Kyoto University Hospital
Sakyo-ku, 606-8507, Japan
Hokkaido Cancer Center
Sapporo, 003-0804, Japan
Shizuoka Cancer Center
Shizuoka, 411-8777, Japan
Shizuoka General Hospital
Shizuoka, 420-8527, Japan
Osaka University Hospital
Suita, 565-0871, Japan
Showa University Hospital
Tokyo, 142-8555, Japan
Kanagawa Cancer Center
Yokohama, 241-8515, Japan
Hospital Pulau Pinang
George Town, 10450, Malaysia
Hospital Sultan Ismail
Johor Bahru, 81100, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, 47500, Malaysia
Pantai Hospital Kuala Lumpur
Kuala Lumpur, 59100, Malaysia
University Malaya Medical Centre (UMMC)
Kuala Lumpur, 59100, Malaysia
Institut Kanser Negara
Putrajaya, 62250, Malaysia
Hospital Wanita dan Kanak-Kanak Sabah
Sabak Bernam, 88996, Malaysia
Sarawak General Hospital
Sarawak, 93586, Malaysia
Icaro Investigaciones en Medicina S.A. de C.V.
Chihuahua City, 31000, Mexico
Centro para el Desarrollo de la Medicina
Culiacán, 80230, Mexico
Panamerican Clinical Research Mexico - Guadalajara
Guadalajara, 44670, Mexico
Cryptex Investigación Clínica
Mexico City, 06100, Mexico
Medical Care and Research S.A. de C.V
Mérida, 97070, Mexico
Fucam A.C.
México, 4980, Mexico
Avix Investigacion Clinica S.C.
Monterrey, 64710, Mexico
Oncológico Potosino
San Luis Potosí City, 78209, Mexico
FAICIC Clínical Research
Veracruz, 91900, Mexico
iBiomed - Investigacion Biomedica para el Desarrol
Zapopan, 45070, Mexico
Amphia Ziekenhuis - Breda Langendijk
Breda, 4818 CK, Netherlands
Universitair Medisch Centrum Groningen
Groningen, 9700 RB, Netherlands
Medisch Centrum Leeuwarden
Leeuwarden, 8934 AD, Netherlands
Erasmus Medisch Centrum
Rotterdam, Netherlands
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii
Gdansk, 80-952, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej
Gliwice, 44-102, Poland
SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego
Opole, 45-061, Poland
Wielkopolskie Centrum Onkologii im. Marii Sklodowskiej-Curie
Poznan, 61- 866, Poland
Mazowiecki Szpital Wojewódzki im. w. Jana Pawa II w
Siedlce, 08-110, Poland
Narodowy Instytut Onkologii im.Marii Marii Sklodowskiejs
Warsaw, 02-781, Poland
Wojskowy Instytut Medyczny
Warsaw, 04-141, Poland
Ponce Medical School Foundation Inc.
Ponce, PR, 00716, Puerto Rico
Hopelands Cancer Centre
Hilton, 3245, South Africa
The Medical Oncology Centre of Rosebank
Johannesburg, 2196, South Africa
University of Pretoria
Pretoria, 0002, South Africa
National Cancer Center - Korea
Goyang-si Gyeonggi-do, 10408, South Korea
Seoul National University Bundang Hospital
Seongnam-si, 13620, South Korea
Severance Hospital
Seoul, 03722, South Korea
Asan Medical Center
Seoul, 05505, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
Korea University Anam Hospital
Seoul, 2841, South Korea
Seoul National University Hospital
Seoul, 3080, South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 6591, South Korea
Hospital Teresa Herrera - Materno Infantil
A Coruña, 15006, Spain
Hospital Universitari Dexeus
Barcelona, 08028, Spain
Hospital Clinic Barcelona
Barcelona, 08036, Spain
Hospital Clínic de Barcelona
Barcelona, 08036, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 8023, Spain
Hospital Universitari Vall d'Hebrón
Barcelona, 8035, Spain
Hospital Universitario de Basurto
Bilbao, 48013, Spain
Hospital Universitari Arnau de Vilanova
Lleida, 25198, Spain
Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
MD Anderson Cancer Centre Madrid
Madrid, 28033, Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, 28040, Spain
Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
Hospital General Universitario Morales Meseguer
Murcia, 30008, Spain
Hospital Universitario de Canarias
Santa Cruz de Tenerife, 38320, Spain
Hospital Unviersitario Virgen del Rocio
Seville, 41013, Spain
Hospital Universitario Virgen Macarena
Seville, 41071, Spain
Hospital Clínico Universitario de Valencia
Valencia, 46010, Spain
Kantonsspital Baden
Baden, 5404, Switzerland
Kantonsspital Baselland - Standort Liestal
Liestal, 4410, Switzerland
Kantonsspital Sankt Gallen
Sankt Gallen, 9007, Switzerland
Kantonsspital Winterthur
Winterthur, 8401, Switzerland
Brust-Zentrum Zurich
Zurich, 8008, Switzerland
Changhua Christian Hospital
Changhua, 50006, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Taipei Medical University-Shuang Ho Hospital
New Taipei City, 235, Taiwan
National Cheng Kung University Hospital
Tainan, 704, Taiwan
Chi Mei Hospital, Liouying
Tainan, 73657, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Linkou Chang Gung Memorial Hospital
Taoyuan District, 333, Taiwan
Baskent Uni. Dr Turgut Noyan Uyg. ve Aras. Merkezi
Adana, 1120, Turkey (Türkiye)
Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve A
Ankara, 6010, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Ankara, 6200, Turkey (Türkiye)
Memorial Ankara Hastanesi
Ankara, 6520, Turkey (Türkiye)
Hacettepe Üniversitesi Hastanesi
Ankara, Turkey (Türkiye)
Trakya Universitesi Tip Fakultesi Hastanesi
Edirne, 22030, Turkey (Türkiye)
Istanbul Il Saglik Mudurlugu Goztepe Prof. Dr. Sul
Istanbul, 34000, Turkey (Türkiye)
Medipol Mega Universite Hastanesi
Istanbul, 34214, Turkey (Türkiye)
Ege Universitesi Hastanesi
Izmir, 35100, Turkey (Türkiye)
Medicana International Izmir Hastanesi
Izmir, 35575, Turkey (Türkiye)
Acibadem Maslak Hastanesi
Sarıyer, Turkey (Türkiye)
VKV Amerikan Hastanesi
Şişli, 34365, Turkey (Türkiye)
NHS Lothian
Edinburgh, EH4 2XU, United Kingdom
Clinical Trials Unit Lvl 0 Cancer Research UK Beatson Institute
Glasgow, G12 0YN, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, LS9 7TF, United Kingdom
: Barts Health NHS Trust, St Hospital
London, EC1M 6BQ, United Kingdom
Royal Free London NHS Foundation Trust
London, NW2 2QG, United Kingdom
Guy's and Saint Thomas' NHS Foundation Trust
London, SE1 9RT, United Kingdom
University College London Hospitals
London, WC1E 6BT, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, NG5 1PB, United Kingdom
Related Publications (1)
Tolaney SM, de Azambuja E, Kalinsky K, Loi S, Kim SB, Yam C, Rapoport B, Im SA, Pistilli B, Mchayleh W, Cescon DW, Watanabe J, Banuelas MAL, Freitas-Junior R, Salvador Bofill J, Afshari M, Gary D, Wang L, Lai C, Schmid P; ASCENT-04/KEYNOTE-D19 Clinical Trial Investigators. Sacituzumab Govitecan plus Pembrolizumab for Advanced Triple-Negative Breast Cancer. N Engl J Med. 2026 Jan 22;394(4):354-366. doi: 10.1056/NEJMoa2508959.
PMID: 41564397DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Gilead Study Director
Gilead Sciences
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 16, 2022
First Posted
May 19, 2022
Study Start
July 25, 2022
Primary Completion (Estimated)
February 1, 2027
Study Completion (Estimated)
February 1, 2027
Last Updated
September 18, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will not share