NCT05348577

Brief Summary

This study will assess the efficacy and safety of capivasertib plus docetaxel versus placebo plus docetaxel in participants with metastatic castration resistant prostate cancer (mCRPC), all participants will receive the docetaxel with steroid therapy and receive androgen deprivation therapy. The intention of the study is to demonstrate that the combination of capivasertib plus docetaxel is superior to placebo plus docetaxel with respect to the overall survival and/or the radiographic progression free survival of study participants.

Trial Health

67
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Strong global presence with extensive site network
Enrollment
1,035

participants targeted

Target at P75+ for phase_3 prostate-cancer

Timeline
Completed

Started Mar 2022

Geographic Reach
22 countries

217 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 18, 2022

Completed
7 days until next milestone

Study Start

First participant enrolled

March 25, 2022

Completed
1 month until next milestone

First Posted

Study publicly available on registry

April 27, 2022

Completed
3.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 4, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 4, 2026

Completed
Last Updated

January 27, 2025

Status Verified

January 1, 2025

Enrollment Period

3.9 years

First QC Date

March 18, 2022

Last Update Submit

January 23, 2025

Conditions

Keywords

prostate cancer,metastaticcastration resistantcapivasertib,AKT inhibitor,docetaxel

Outcome Measures

Primary Outcomes (2)

  • Overall Survival (OS) in the overall population

    Overall survival is defined as time from randomisation until the date of death due to any cause.

    up to approximately 46 months

  • Radiographic Progression-free Survival (rPFS) in the overall population

    Radiographic Progression-free Survival (rPFS) is defined as time from randomization to radiographic progression as assessed by the investigator per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) for soft tissue and/or Prostate Cancer Working Group 3 (PCWG3) for bone or death due to any cause

    up to approximately 37 months

Secondary Outcomes (10)

  • Overall Survival (OS) in patients with mCRPC and PTEN-proficient tumours (IHC)

    up to approximately 46 months

  • Overall Survival (OS) in patients with mCRPC and PTEN-deficient tumours (IHC).

    up to approximately 46 months

  • Radiographic Progression-free Survival (rPFS) in patients with mCRPC and PTEN-proficient tumours (IHC)

    up to approximately 37 months

  • Radiographic Progression-free Survival (rPFS) in patients with mCRPC and PTEN-deficient tumours (IHC)

    up to approximately 37 months

  • Time to pain progression (TTPP) in the overall population

    up to approximately 37 months

  • +5 more secondary outcomes

Other Outcomes (5)

  • The number of participants with adverse events in the overall population

    Up to approximately 46 months

  • Systolic and diastolic blood pressure

    Up to approximately 46 months

  • Pulse rate (heart rate)

    Up to approximately 46 months

  • +2 more other outcomes

Study Arms (2)

capivasertib + docetaxel

EXPERIMENTAL

Participants receive capivasertib in combination with docetaxel and steroids on a background of ADT.

Drug: capivasertibDrug: docetaxel

placebo + docetaxel

PLACEBO COMPARATOR

Participants receive placebo in combination with docetaxel and steroids on a background of ADT.

Drug: docetaxelOther: placebo

Interventions

320 mg (2 tablets) BD given on an intermittent weekly dosing schedule. Patients will be dosed on Days 2 to 5, 9 to 12, and 16 to 19 in each week of a 21-day treatment cycle. Number of Cycles: until disease progression or unacceptable toxicity develops, death, or if the patient requests to stop the study treatment.

capivasertib + docetaxel

Patients will receive docetaxel in intravenous infusion, 75 mg/m2 BSA, on Day 1 of the 21-day cycles for up to 6 to 10 cycles, according to standard of care practices.

capivasertib + docetaxelplacebo + docetaxel
placeboOTHER

matched to capivasertib appearance (2 tablets) BD given orally on an intermittent weekly dosing schedule. Patients will be dosed on Days 2 to 5, 9 to 12, and 16 to 19 in each week of a 21-day treatment cycle. Number of Cycles: until disease progression or unacceptable toxicity develops, death, or if the patient requests to stop the study treatment.

placebo + docetaxel

Eligibility Criteria

Age18 Years - 130 Years
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Histologically-confirmed prostate adenocarcinoma without predominant neuroendocrine or small cell cancers
  • Metastatic disease documented prior to randomisation by clear evidence of ≥ 1 bone lesion (defined as 1 lesion with positive uptake on bone scan) and/or ≥ 1 soft tissue lesion (measurable or non-measurable)
  • Patient must have been previously treated with a next generation hormonal agent (NHA), ie, abiraterone, enzalutamide, apalutamide or darolutamide, for prostate cancer for at least 3 months and shown evidence of disease progression (radiological or via PSA assessment) while receiving the NHA
  • Evidence of mCRPC with progression of disease despite androgen deprivation therapy (ADT)
  • Serum testosterone level ≤ 50 ng/dL
  • Candidate for docetaxel and steroid therapy
  • Ongoing ADT with LHRH agonist, LHRH antagonist, or bilateral orchiectomy
  • Eastern Cooperative Oncology Group (ECOG)/World Health Organisation (WHO) performance status 0 to 1 and anticipated minimum life expectancy of 12 weeks
  • Confirmation that archival formalin-fixed paraffin-embedded (FFPE) tumour tissue sample which meets the minimum pathology and sample requirements is available to send to the central laboratory
  • Able and willing to swallow and retain oral medication
  • Agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm

You may not qualify if:

  • Radiotherapy with a wide field of radiation within 4 weeks before start of study treatment
  • Major surgery (excl. placement of vascular access, transurethral resection of prostate, bilateral orchiectomy, internal stents) within 4 weeks of start of study treatment
  • Brain metastases,or spinal cord compression (unless spinal cord compression is asymptomatic and stable and not requiring steroids for at least 4 weeks prior to start of study treatment)
  • Any of the following cardiac criteria:
  • i. Mean resting corrected QT interval (QTc) \>470 msec from 3 consecutive ECGs ii. Any clinically important abnormalities in rhythm, conduction or morphology of resting ECG iii. Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, potential for torsades de pointes, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age,or any concomitant medication known to prolong the QT interval iv. Experience of any of the following procedures or conditions in the preceding 3 months: coronary artery bypass graft, vascular stent, myocardial infarction, unstable angina pectoris, congestive heart failure NYHA Grade ≥2 v. Symptomatic hypotension - systolic blood pressure \<90 mmHg and/or diastolic blood pressure \<50 mmHg vi. haemodinamic instability
  • Clinically significant abnormalities of glucose metabolism as defined by any of the following:
  • i. Patients with diabetes mellitus (DM) type 1 or DM type 2 requiring insulin treatment ii. HbA1c ≥8.0% (63.9 mmol/mol)
  • Inadequate bone marrow reserve or organ function as demonstrated by any of the following laboratory values:
  • As judged by the investigator, any evidence of diseases (including severe or uncontrolled systemic diseases, uncontrolled hypertension, history of interstitial pneumonia / pneumonitis or interstitial lung disease, renal transplant and active bleeding diseases), which, in the investigator's opinion, makes it undesirable for the patient to participate in the study or that would jeopardise compliance with the protocol.
  • Refractory nausea and vomiting, malabsorption syndrome, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection, or other condition that would preclude adequate absorption of capivasertib
  • Any other disease, physical examination finding, or clinical laboratory finding that, in the investigator's opinion, gives reasonable suspicion of a disease or condition that contra-indicates the use of an investigational drug, may affect the interpretation of the results, render the patient at high risk from treatment complications or interferes with obtaining informed consent. Evidence of dementia, altered mental status, or any psychiatric condition that would prohibit understanding or rendering of informed consent.
  • Previous allogeneic bone marrow transplant or solid organ transplant
  • History of another primary malignancy except for malignancy treated with curative intent with no known active disease ≥2 years before the first dose of study intervention and of low potential risk for recurrence. Exceptions include adequately resected non-melanoma skin cancer and curatively treated in situ disease.
  • Persistent toxicities (CTCAE Grade ≥2) caused by previous anticancer therapy, excluding alopecia. Patients with irreversible toxicity that is not reasonably expected to be exacerbated by study intervention in the opinion of the investigator may be included (eg, hearing loss)
  • Known to have active hepatitis infection.
  • +8 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (217)

Research Site

Yuma, Arizona, 85364, United States

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Beverly Hills, California, 90211, United States

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Cerritos, California, 90703, United States

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Fresno, California, 93701, United States

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Los Angeles, California, 90095, United States

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Sacramento, California, 95817, United States

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San Francisco, California, 94115, United States

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Santa Barbara, California, 93105, United States

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Santa Monica, California, 90404, United States

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Santa Rosa, California, 95403, United States

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Aurora, Colorado, 80045, United States

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Lakewood, Colorado, 80228, United States

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Littleton, Colorado, 80120, United States

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Baltimore, Maryland, 21201, United States

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Baltimore, Maryland, 21287, United States

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Minneapolis, Minnesota, 55404, United States

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Minneapolis, Minnesota, 55416, United States

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Hackensack, New Jersey, 07601, United States

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Albany, New York, 12208, United States

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The Bronx, New York, 10461, United States

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White Plains, New York, 10601, United States

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Toledo, Ohio, 43623, United States

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Portland, Oregon, 97223, United States

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Bala-Cynwyd, Pennsylvania, 19004-1017, United States

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Philadelphia, Pennsylvania, 19107, United States

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Philadelphia, Pennsylvania, 19111, United States

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Greenville, South Carolina, 29605, United States

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Watertown, South Dakota, 57201, United States

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Chattanooga, Tennessee, 37404, United States

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Nashville, Tennessee, 37203, United States

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Austin, Texas, 78731, United States

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Dallas, Texas, 75235, United States

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Houston, Texas, 77096, United States

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Kingwood, Texas, 77339, United States

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San Antonio, Texas, 78217, United States

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Chesapeake, Virginia, 23320, United States

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Seattle, Washington, 98109, United States

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Birtinya, 4575, Australia

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Greenslopes, 4120, Australia

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Kogarah, 2217, Australia

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North Adelaide, 5000, Australia

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Orange, 2800, Australia

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Redcliffe, 4020, Australia

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Wahroonga, 2076, Australia

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Brasschaat, 2930, Belgium

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Ghent, 9000, Belgium

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Liège, 4000, Belgium

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Cachoeiro de Itapemirim, 29308-014, Brazil

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Ijuí, 98700-000, Brazil

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Itajaí, 88301-220, Brazil

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Joinville, 89201-470, Brazil

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Porto Alegre, 90020-090, Brazil

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Porto Alegre, 90035-903, Brazil

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Porto Alegre, 90110-270, Brazil

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Porto Alegre, 90160-093, Brazil

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Recife, 50040-000, Brazil

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Rio de Janeiro, 22281-100, Brazil

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Rio de Janeiro, 22793-080, Brazil

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Salvador, 41253-190, Brazil

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Salvador, 41820-021, Brazil

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Santa Maria, 97015-450, Brazil

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São José Do Rio Preto - SP, 15090-000, Brazil

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São Paulo, 01221-020, Brazil

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São Paulo, 01509-900, Brazil

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São Paulo, 04014-002, Brazil

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Três Lagoas, 79601-001, Brazil

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Halifax, Nova Scotia, B3H 2Y9, Canada

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Oshawa, Ontario, L1G 2B9, Canada

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Toronto, Ontario, M5G 2M9, Canada

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Montreal, Quebec, H3T 1E2, Canada

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Sherbrooke, Quebec, J1H 5N4, Canada

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Toronto, M4N 3M5, Canada

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Santiago, 7500713, Chile

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Santiago, 7500918, Chile

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Santiago, 7650568, Chile

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Viña del Mar, 2520000, Chile

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Beijing, 100021, China

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Beijing, 100034, China

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Beijing, 100050, China

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Changsha, 410008, China

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Changsha, 410013, China

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Chengdu, 610041, China

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Chengdu, 610072, China

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Chongqing, 400038, China

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Guangzhou, 510180, China

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Hangzhou, 310000, China

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Hangzhou, 310003, China

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Harbin, 150040, China

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Jiaxing, 314001, China

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Nanchang, 330019, China

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Nanjing, 210008, China

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Nantong, 226361, China

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Ningbo, 315010, China

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Shanghai, 200032, China

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Shanghai, 200040, China

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Shenyang, 110042, China

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Tianjin, 300052, China

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Wuhan, 430030, China

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Wuhan, 430079, China

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Yantai, 264000, China

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Zhengzhou, 450008, China

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Hořovice, 268 01, Czechia

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Hradec Králové, 500 05, Czechia

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Pardubice, 532 03, Czechia

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Prague, 10034, Czechia

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Prague, 14059, Czechia

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Prague, 150 06, Czechia

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Bordeaux, 33076, France

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Brest, 29609, France

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Clermont-Ferrand, 63011, France

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Créteil, 94010, France

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Montpellier, 34298, France

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Paris, 75014, France

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Paris, 75020, France

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Rouen, 76031, France

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Saint-Herblain, 44805, France

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Saint-Mandé, 94160, France

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Strasbourg, 67000, France

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Strasbourg, 67033, France

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Vandœuvre-lès-Nancy, 54000, France

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Villejuif, 94805, France

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Athens, 115 22, Greece

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Athens, 155 62, Greece

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Chaïdári, 124 62, Greece

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Marousi, 151 23, Greece

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Pátrai, 26504, Greece

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Piraeus, 185 47, Greece

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Budapest, 1097, Hungary

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Budapest, 1122, Hungary

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Budapest, 1125, Hungary

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Budapest, 1145, Hungary

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Kecskemét, 6000, Hungary

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Nyíregyháza, 4400, Hungary

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Szeged, 6725, Hungary

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Szolnok, 5000, Hungary

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Bikaner, 334003, India

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Meerut, 250001, India

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Mohali, 160055, India

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New Delhi, 110085, India

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Be’er Ya‘aqov, 70300, Israel

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Haifa, 3109601, Israel

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Jerusalem, 91120, Israel

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Kfar Saba, 44281, Israel

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Petah Tikva, 4941492, Israel

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Ramat Gan, 52621, Israel

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Tel Aviv, 6423906, Israel

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Chiba, 260-8717, Japan

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Hirakata-shi, 573-1191, Japan

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Hirosaki-shi, 036-8563, Japan

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Kanazawa, 920-8641, Japan

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Kashihara-shi, 634-8522, Japan

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Kita-gun, 761-0793, Japan

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Kobe, 650-0047, Japan

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Kumamoto, 860-0008, Japan

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Miyazaki, 889-1692, Japan

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Nagano, 381-8551, Japan

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Nagoya, 466-8560, Japan

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Nakano, 164-0001, Japan

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Osaka, 541-8567, Japan

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Osakasayama-shi, 589-8511, Japan

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Sagamihara-shi, 252-0375, Japan

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Sapporo, 003-0804, Japan

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Tsu, 514-8507, Japan

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Wakayama, 641-8510, Japan

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Yokohama, 232-0024, Japan

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Aguascalientes, 20116, Mexico

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Culiacán, 80230, Mexico

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Guadalajara, 44260, Mexico

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Guadalajara, 44680, Mexico

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Mexico City, 03840, Mexico

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México, 04700, Mexico

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Oaxaca City, 68000, Mexico

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Zapopan, 45116, Mexico

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Hoofddorp, 2134 TM, Netherlands

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The Hague, 2545 CH, Netherlands

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Nowa Sól, 67-106, Poland

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Opole, 45-061, Poland

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Wieliszew, 05-135, Poland

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Bukgu, 41404, South Korea

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Busan, 602-739, South Korea

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Goyang-si, 10408, South Korea

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Seoul, 03080, South Korea

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Seoul, 03722, South Korea

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Seoul, 05505, South Korea

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Seoul, 06591, South Korea

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Seoul, 6273, South Korea

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Barcelona, 08003, Spain

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Barcelona, 08035, Spain

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Barcelona, 08036, Spain

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Barcelona, ?08041, Spain

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Córdoba, 14004, Spain

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Lugo, 27003, Spain

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Madrid, 28034, Spain

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Madrid, 28040, Spain

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Málaga, 29010, Spain

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Sabadell, 08208, Spain

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Seville, 41013, Spain

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Kaohsiung City, 81362, Taiwan

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Taichung, 40447, Taiwan

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Tainan, 704, Taiwan

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Tainan, 710, Taiwan

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Taipei, 10002, Taiwan

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Taipei, 11259, Taiwan

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Adana, 01060, Turkey (Türkiye)

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Edirne, 22030, Turkey (Türkiye)

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Izmir, 35575, Turkey (Türkiye)

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Şahinbey, 27310, Turkey (Türkiye)

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Yüreğir, 01240, Turkey (Türkiye)

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Edinburgh, EH4 2XU, United Kingdom

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Glasgow, G12 0YN, United Kingdom

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Guildford, United Kingdom

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Hackensack, 07601-1963, United Kingdom

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London, SE1 9RT, United Kingdom

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London, SW7 3RP, United Kingdom

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Manchester, M20 4BX, United Kingdom

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Southampton, SO16 6YD, United Kingdom

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Sutton, SM2 5PT, United Kingdom

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MeSH Terms

Conditions

Prostatic NeoplasmsNeoplasm Metastasis

Interventions

capivasertibDocetaxel

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital DiseasesNeoplastic ProcessesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

TaxoidsCyclodecanesCycloparaffinsHydrocarbons, AlicyclicHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsDiterpenesTerpenes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
The study is double-blinded, neither the patients nor the investigator will know what study intervention was assigned. Capivasertib and placebo film-coated tablets will be identical in appearance and presented in the same packaging to ensure blinding of the capivasertib. All personnel involved with the statistical analysis of the study will remain blinded until database lock and CSP deviations have been identified.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Approximately 1350 participants will be enrolled and screened to achieve a total of approximately 1000 assigned in a 1:1 ratio to one of the two parallel groups to receive either capivasertib or placebo, in combination with docetaxel on a background of ADT for the duration of the study.
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 18, 2022

First Posted

April 27, 2022

Study Start

March 25, 2022

Primary Completion

March 4, 2026

Study Completion

March 4, 2026

Last Updated

January 27, 2025

Record last verified: 2025-01

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Access Criteria
When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
More information

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