NCT06952803

Brief Summary

The purpose of the study is to demonstrate superiority of Saruparib (AZD5305) relative to placebo added to a standard radiation therapy (RT) + androgen deprivation therapy (ADT) regimen by assessment of metastases-free survival in participants with high-risk and very high-risk localised/locally advanced prostate cancer with a breast cancer gene mutation (BRCAm).

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
700

participants targeted

Target at P50-P75 for phase_3 prostate-cancer

Timeline
122mo left

Started Aug 2025

Longer than P75 for phase_3 prostate-cancer

Geographic Reach
27 countries

324 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress7%
Aug 2025Apr 2036

First Submitted

Initial submission to the registry

April 30, 2025

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 1, 2025

Completed
3 months until next milestone

Study Start

First participant enrolled

August 6, 2025

Completed
7.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2033

Expected
3.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2036

Last Updated

April 21, 2026

Status Verified

April 1, 2026

Enrollment Period

7.7 years

First QC Date

April 30, 2025

Last Update Submit

April 20, 2026

Conditions

Keywords

Localised/locally advanced prostate cancerHigh-risk biochemical recurrence (BCR)Poly (ADP-ribose) polymeraseRadiation therapy or radiotherapyBreast cancer gene (BRCA) mutation

Outcome Measures

Primary Outcomes (1)

  • Metastasis-free survival (MFS)

    MFS is defined as the time from randomisation until the date of first appearance of distant metastases, confirmed by standard clinical imaging \[computed tomography (CT)/ magnetic resonance imaging (MRI) and bone scan, or prostate-specific membrane antigen-positron emission tomography (PSMA-PET)\], as assessed by blinded independent central review (BICR) or death due to any cause.

    Up to approximately 93 months

Secondary Outcomes (14)

  • Overall Survival (OS)

    Up to approximately 11 years

  • MFS (CT/MRI and bone scan)

    Up to approximately 93 months

  • MFS (PSMA-PET)

    Up to approximately 93 months

  • MFS (standard clinical imaging)

    Up to approximately 93 months

  • Time from randomisation to Progression Free Survival 2 (PFS2)

    Up to approximately 93 months

  • +9 more secondary outcomes

Study Arms (4)

Cohort A: Saruparib (AZD5305) + Physician's Choice ADT

EXPERIMENTAL

Participants will receive saruparib along with ADT.

Drug: SaruparibDrug: Androgen Deprivation Therapy (ADT)

Cohort A: Placebo + Physician's Choice ADT

PLACEBO COMPARATOR

Participants will receive matching placebo to saruparib along with ADT.

Drug: PlaceboDrug: Androgen Deprivation Therapy (ADT)

Cohort B: Saruparib (AZD5305) + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)

EXPERIMENTAL

Participants will receive saruparib, abiraterone and prednisolone/prednisone along with ADT.

Drug: SaruparibDrug: Abiraterone + Prednisolone/PrednisoneDrug: Androgen Deprivation Therapy (ADT)

Cohort B: Placebo + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)

PLACEBO COMPARATOR

Participants will receive matching placebo to saruparib, abiraterone and prednisolone/prednisone along with ADT.

Drug: PlaceboDrug: Abiraterone + Prednisolone/PrednisoneDrug: Androgen Deprivation Therapy (ADT)

Interventions

Standard of care ADT will be administered.

Cohort A: Placebo + Physician's Choice ADTCohort A: Saruparib (AZD5305) + Physician's Choice ADTCohort B: Placebo + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)Cohort B: Saruparib (AZD5305) + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)

Saruparib will be administered orally.

Also known as: AZD5305
Cohort A: Saruparib (AZD5305) + Physician's Choice ADTCohort B: Saruparib (AZD5305) + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)

Matching placebo to saruparib will be administered orally.

Cohort A: Placebo + Physician's Choice ADTCohort B: Placebo + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)

Abiraterone will be administered orally in combination with prednisone/prednisolone.

Cohort B: Placebo + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)Cohort B: Saruparib (AZD5305) + Physician's Choice ADT + Abiraterone (and prednisone/prednisolone)

Eligibility Criteria

Age18 Years+
Sexmale(Gender-based eligibility)
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male participants with a histologically documented diagnosis of prostate adenocarcinoma.
  • Newly diagnosed high-risk and very high-risk (localised/locally advanced) prostate cancer or a high-risk biochemical recurrence (BCR) following radical prostatectomy.
  • Provision of a formalin fixed and paraffin embedded (FFPE) tumour tissue sample.
  • Confirmed BRCA1 or BRCA2 mutation status by central tumour tissue is required for enrolment.
  • Participants required to have a computed tomography (CT) or magnetic resonance imaging (MRI) and a bone scan following the completion of their planned RT. This screening scan must confirm no evidence of disease or evidence of disease confined to the pelvis (M0).
  • Participants required to have a prostate-specific membrane antigen-positron emission tomography (PSMA-PET) following the completion of their planned RT. This screening scan must confirm no evidence of disease or evidence of disease confined to the pelvis (M0).
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 with no deterioration over the 2 weeks prior to randomization.
  • Minimum life expectancy of 12 months.
  • Adequate organ and bone marrow function as described in study protocol.
  • All participants will have received either primary or salvage RT. Participants must be eligible for randomisation within 10 months of initial diagnosis (de novo or BCR). Radiotherapy administered to the prostate (± pelvis) either in the primary or salvage setting must be delivered with curative intent. Use of metastases-directed therapy, as part of the RT radiation plan, is permitted as localised RT treatment for a metastatic lesion(s) outside the pelvis.
  • All participants will have received a planned regimen of ADT with a gonadotropin releasing hormone (GnRH) analogue.
  • Participants must not father children or donate sperm from signing informed consent form (ICF), during the study intervention and for 6 months after the last dose of study intervention.
  • Participants must use a condom (with spermicide - where permitted) from signing ICF, during study intervention, and for 6 months after the last dose of study drug, with all sexual partners.

You may not qualify if:

  • Participants with a history of myelodysplastic syndrome (MDS)/ acute myeloid leukemia (AML) or with features suggestive of MDS/AML.
  • Participants with any known predisposition to bleeding \[e.g., active peptic ulceration, recent (within 6 months) hemorrhagic stroke, proliferative diabetic retinopathy\].
  • Any history of persisting (\> 2 weeks) severe cytopenia due to any cause.
  • Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of saruparib and/or abiraterone.
  • History of another primary malignancy, with exceptions.
  • Persistent toxicities \[Common Terminology Criteria for Adverse Events (CTCAE) Grade ≥ 2\] caused by previous anticancer therapy.
  • Cardiac criteria, including history of arrhythmia and cardiovascular disease.
  • Evidence of active and uncontrolled hepatitis B and/or hepatitis C.
  • Evidence of active and uncontrolled human immunodeficiency virus (HIV) infection.
  • Active tuberculosis infection.
  • Any prior chemotherapy (i.e., docetaxel) or immunotherapy; any prior treatment with a poly (ADP-ribose) polymerase (PARP) inhibitor.
  • Prior treatment within 14 days with blood product support or growth factor support.
  • Concomitant use of strong inducers and inhibitors of CYP3A4 (applies to saruparib and abiraterone) or herbal supplements within 21 days or at least 5 half-lives (whichever is longer), of randomization.
  • Concomitant use of drugs that are known to prolong QT and have a known risk of Torsades de Pointes (TdP).
  • Participants with a known hypersensitivity to saruparib or any excipients of these products.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (329)

Research Site

Phoenix, Arizona, 85054, United States

RECRUITING

Research Site

Tucson, Arizona, 85741, United States

NOT YET RECRUITING

Research Site

La Jolla, California, 92037, United States

RECRUITING

Research Site

La Jolla, California, 92093, United States

RECRUITING

Research Site

Los Angeles, California, 90048, United States

RECRUITING

Research Site

San Diego, California, 92123, United States

RECRUITING

Research Site

San Luis Obispo, California, 93401, United States

RECRUITING

Research Site

Lakewood, Colorado, 80215, United States

RECRUITING

Research Site

Hialeah, Florida, 33016, United States

RECRUITING

Research Site

Jacksonville, Florida, 32224, United States

RECRUITING

Research Site

Tampa, Florida, 33612, United States

RECRUITING

Research Site

Newnan, Georgia, 30265, United States

RECRUITING

Research Site

Chicago, Illinois, 60611, United States

NOT YET RECRUITING

Research Site

Chicago Ridge, Illinois, 60415, United States

RECRUITING

Research Site

Greenwood, Indiana, 46143, United States

RECRUITING

Research Site

Jeffersonville, Indiana, 47130, United States

NOT YET RECRUITING

Research Site

Bethesda, Maryland, 20817, United States

RECRUITING

Research Site

Towson, Maryland, 21204, United States

RECRUITING

Research Site

Plymouth, Massachusetts, 02360, United States

RECRUITING

Research Site

Rochester, Minnesota, 55905, United States

RECRUITING

Research Site

Hackensack, New Jersey, 07601, United States

RECRUITING

Research Site

Voorhees Township, New Jersey, 08043, United States

RECRUITING

Research Site

New York, New York, 10065, United States

RECRUITING

Research Site

Syracuse, New York, 13210, United States

RECRUITING

Research Site

Columbus, Ohio, 43230, United States

RECRUITING

Research Site

Springfield, Oregon, 97477, United States

RECRUITING

Research Site

Hershey, Pennsylvania, 17033, United States

RECRUITING

Research Site

Lancaster, Pennsylvania, 17601, United States

RECRUITING

Research Site

Pittsburgh, Pennsylvania, 15212, United States

RECRUITING

Research Site

Providence, Rhode Island, 02903, United States

RECRUITING

Research Site

Myrtle Beach, South Carolina, 29572, United States

RECRUITING

Research Site

Nashville, Tennessee, 37209, United States

RECRUITING

Research Site

Austin, Texas, 78705, United States

RECRUITING

Research Site

Austin, Texas, 78745, United States

RECRUITING

Research Site

Houston, Texas, 77074, United States

RECRUITING

Research Site

San Antonio, Texas, 78229, United States

RECRUITING

Research Site

Spring, Texas, 77380, United States

RECRUITING

Research Site

Salt Lake City, Utah, 84112, United States

NOT YET RECRUITING

Research Site

Norfolk, Virginia, 23502, United States

RECRUITING

Research Site

Roanoke, Virginia, 24014, United States

RECRUITING

Research Site

Virginia Beach, Virginia, 23462, United States

RECRUITING

Research Site

Seattle, Washington, 98109, United States

NOT YET RECRUITING

Research Site

CABA, 1426, Argentina

NOT YET RECRUITING

Research Site

CABA, C1113AAE, Argentina

NOT YET RECRUITING

Research Site

Ciudad de Buenos Aires, 1181, Argentina

NOT YET RECRUITING

Research Site

Ciudad de Buenos Aires, 1426, Argentina

NOT YET RECRUITING

Research Site

Ciudad de Buenos Aires, C1419AHL, Argentina

NOT YET RECRUITING

Research Site

Córdoba, 5000, Argentina

NOT YET RECRUITING

Research Site

Córdoba, X5008HHW, Argentina

NOT YET RECRUITING

Research Site

Cuidad Autónoma de Buenos Aire, C1426ANZ, Argentina

NOT YET RECRUITING

Research Site

La Plata, 1900, Argentina

NOT YET RECRUITING

Research Site

Pergamino, B2700CPM, Argentina

NOT YET RECRUITING

Research Site

Rosario, S2000KZE, Argentina

NOT YET RECRUITING

Research Site

San Miguel de Tucumán, 4000, Argentina

NOT YET RECRUITING

Research Site

Viedma, R8500ACE, Argentina

NOT YET RECRUITING

Research Site

Kingswood, 2747, Australia

WITHDRAWN

Research Site

Murdoch, 6150, Australia

RECRUITING

Research Site

Orange, 2800, Australia

RECRUITING

Research Site

South Brisbane, 4101, Australia

RECRUITING

Research Site

St Leonards, 2065, Australia

RECRUITING

Research Site

Waratah, 2298, Australia

RECRUITING

Research Site

Woolloongabba, 4102, Australia

RECRUITING

Research Site

Graz, 8036, Austria

NOT YET RECRUITING

Research Site

Innsbruck, 6020, Austria

NOT YET RECRUITING

Research Site

Linz, 4020, Austria

NOT YET RECRUITING

Research Site

Vienna, 1020, Austria

NOT YET RECRUITING

Research Site

Vienna, 1090, Austria

NOT YET RECRUITING

Research Site

Brussels, 1070, Belgium

NOT YET RECRUITING

Research Site

Brussels, 1200, Belgium

RECRUITING

Research Site

Jette, 1090, Belgium

RECRUITING

Research Site

Kortrijk, 8500, Belgium

RECRUITING

Research Site

Libramont-Chevigny, 6800, Belgium

NOT YET RECRUITING

Research Site

Roeselare, 8800, Belgium

RECRUITING

Research Site

Wilrijk, 2610, Belgium

RECRUITING

Research Site

Cachoeiro de Itapemirim, 29308-014, Brazil

RECRUITING

Research Site

Curitiba, 80810-050, Brazil

RECRUITING

Research Site

Curitiba, Brazil

RECRUITING

Research Site

Jaú, 17210-120, Brazil

RECRUITING

Research Site

Londrina, 86015-520, Brazil

RECRUITING

Research Site

Pelotas, 96020-080, Brazil

RECRUITING

Research Site

Porto Alegre, 90035-000, Brazil

NOT YET RECRUITING

Research Site

Porto Alegre, 91350200, Brazil

RECRUITING

Research Site

Rio de Janeiro, 22.250-905, Brazil

RECRUITING

Research Site

Rio de Janeiro, 22775-001, Brazil

RECRUITING

Research Site

Salvador, 41950640, Brazil

RECRUITING

Research Site

São Paulo, 01246-000, Brazil

RECRUITING

Research Site

São Paulo, 01327-001, Brazil

RECRUITING

Research Site

Calgary, Alberta, T2V 1P9, Canada

WITHDRAWN

Research Site

Abbotsford British Columbia, British Columbia, V2S 0C2, Canada

WITHDRAWN

Research Site

Vancouver, British Columbia, V5Z 4E6, Canada

WITHDRAWN

Research Site

Barrie, Ontario, L4M 6M2, Canada

WITHDRAWN

Research Site

Brampton, Ontario, L6R 3J7, Canada

WITHDRAWN

Research Site

London, Ontario, N6A 5A5, Canada

WITHDRAWN

Research Site

Chicoutimi, Quebec, G7H 7K9, Canada

WITHDRAWN

Research Site

Toronto, M4N 3M5, Canada

WITHDRAWN

Research Site

Concepción, 4070196, Chile

WITHDRAWN

Research Site

Temuco, 4781156, Chile

WITHDRAWN

Research Site

Beijing, 100020, China

RECRUITING

Research Site

Beijing, 100021, China

NOT YET RECRUITING

Research Site

Beijing, 100176, China

RECRUITING

Research Site

Changchun, 130012, China

NOT YET RECRUITING

Research Site

Changsha, 410013, China

NOT YET RECRUITING

Research Site

Chongqing, 400016, China

RECRUITING

Research Site

Guangzhou, 510060, China

NOT YET RECRUITING

Research Site

Guangzhou, 510080, China

RECRUITING

Research Site

Guangzhou, 510180, China

NOT YET RECRUITING

Research Site

Guangzhou, 510280, China

RECRUITING

Research Site

Hangzhou, 31000, China

NOT YET RECRUITING

Research Site

Hangzhou, 310022, China

RECRUITING

Research Site

Jinan, 250021, China

NOT YET RECRUITING

Research Site

Jinhua, 322100, China

NOT YET RECRUITING

Research Site

Lanzhou, 730030, China

NOT YET RECRUITING

Research Site

Nanchang, 330006, China

RECRUITING

Research Site

Ningbo, 315010, China

RECRUITING

Research Site

Shanghai, 200025, China

NOT YET RECRUITING

Research Site

Shanghai, 20032, China

NOT YET RECRUITING

Research Site

Shenyang, 110001, China

RECRUITING

Research Site

Shenyang, 110042, China

NOT YET RECRUITING

Research Site

Sichuan, 610041, China

RECRUITING

Research Site

Suining, 629018, China

RECRUITING

Research Site

Tianjin, 300201, China

NOT YET RECRUITING

Research Site

Wuhan, 430022, China

RECRUITING

Research Site

Wuhan, 430060, China

RECRUITING

Research Site

Wuhu, 241000, China

NOT YET RECRUITING

Research Site

Xiamen, 361003, China

RECRUITING

Research Site

Yangzhou, 225001, China

NOT YET RECRUITING

Research Site

Zhuhai, 519099, China

NOT YET RECRUITING

Research Site

Helsinki, 00290, Finland

RECRUITING

Research Site

Helsinki, FI-00180, Finland

RECRUITING

Research Site

Kuopio, 70210, Finland

RECRUITING

Research Site

Oulu, 90029, Finland

NOT YET RECRUITING

Research Site

Tampere, FI-33521, Finland

RECRUITING

Research Site

Turku, 20520, Finland

RECRUITING

Research Site

Angers, 49100, France

RECRUITING

Research Site

Bordeaux, 33000, France

RECRUITING

Research Site

Caen, 14076, France

RECRUITING

Research Site

Clermont-Ferrand, 63011, France

RECRUITING

Research Site

Le Mans, 72000, France

RECRUITING

Research Site

Marseille, 13273, France

NOT YET RECRUITING

Research Site

Montpellier, 34070, France

RECRUITING

Research Site

Montpellier, 34298, France

RECRUITING

Research Site

Nice, 06100, France

RECRUITING

Research Site

Nîmes, 30029, France

RECRUITING

Research Site

Paris, 75020, France

NOT YET RECRUITING

Research Site

Paris, 75674, France

RECRUITING

Research Site

Paris, 75970, France

RECRUITING

Research Site

Pierre-Bénite, 69310, France

RECRUITING

Research Site

Rennes, 35000, France

NOT YET RECRUITING

Research Site

Saint-Herblain, 44805, France

RECRUITING

Research Site

Saint-Priest-en-Jarez, 42270, France

RECRUITING

Research Site

Strasbourg, 67200, France

RECRUITING

Research Site

Suresnes, 92151, France

RECRUITING

Research Site

Tours, 37044, France

RECRUITING

Research Site

Vandœuvre-lès-Nancy, 54511, France

RECRUITING

Research Site

Villejuif, 94805, France

RECRUITING

Research Site

Augsburg, 86156, Germany

RECRUITING

Research Site

Berlin, 10117, Germany

NOT YET RECRUITING

Research Site

Braunschweig, 38126, Germany

RECRUITING

Research Site

Cologne, 50937, Germany

NOT YET RECRUITING

Research Site

Dresden, 1307, Germany

RECRUITING

Research Site

Duisburg, 47169, Germany

RECRUITING

Research Site

Düsseldorf, 40226, Germany

RECRUITING

Research Site

Essen, 45147, Germany

RECRUITING

Research Site

Giessen, 35392, Germany

RECRUITING

Research Site

Göttingen, 37075, Germany

RECRUITING

Research Site

Hamburg, 20246, Germany

NOT YET RECRUITING

Research Site

Herne, 44625, Germany

RECRUITING

Research Site

Kiel, 24105, Germany

NOT YET RECRUITING

Research Site

Lübeck, 23538, Germany

NOT YET RECRUITING

Research Site

Marburg, 35043, Germany

RECRUITING

Research Site

Münster, 48149, Germany

NOT YET RECRUITING

Research Site

Nuremberg, 90419, Germany

RECRUITING

Research Site

Nürtingen, 72622, Germany

NOT YET RECRUITING

Research Site

Regensburg, 93053, Germany

NOT YET RECRUITING

Research Site

Schwerin, 19049, Germany

RECRUITING

Research Site

Trier, 54292, Germany

RECRUITING

Research Site

Ulm, 89081, Germany

NOT YET RECRUITING

Research Site

Würzburg, 97080, Germany

RECRUITING

Research Site

Budapest, 1082, Hungary

RECRUITING

Research Site

Budapest, 1122, Hungary

RECRUITING

Research Site

Budapest, H-1145, Hungary

WITHDRAWN

Research Site

Debrecen, 4032, Hungary

RECRUITING

Research Site

Győr, 9024, Hungary

RECRUITING

Research Site

Gyula, 5700, Hungary

RECRUITING

Research Site

Zalaegerszeg, 8900, Hungary

NOT YET RECRUITING

Research Site

Ansārinagar, 110 029, India

RECRUITING

Research Site

Babgalore, 560069, India

RECRUITING

Research Site

Delhi, 110085, India

WITHDRAWN

Research Site

Hyderabad, 500019, India

RECRUITING

Research Site

Kannur, 670103, India

RECRUITING

Research Site

Kanpur, 208005, India

NOT YET RECRUITING

Research Site

Mumbai, 400012, India

NOT YET RECRUITING

Research Site

Nagpur, 440001, India

RECRUITING

Research Site

Varanasi, 221005, India

NOT YET RECRUITING

Research Site

Afula, 18101, Israel

NOT YET RECRUITING

Research Site

Beersheba, 8410101, Israel

RECRUITING

Research Site

Haifa, 31096, Israel

RECRUITING

Research Site

Jerusalem, 91031, Israel

NOT YET RECRUITING

Research Site

Jerusalem, 9112001, Israel

RECRUITING

Research Site

Kfar Saba, 4428164, Israel

RECRUITING

Research Site

Petah Tikva, 49100, Israel

RECRUITING

Research Site

Ramat Gan, 52621, Israel

RECRUITING

Research Site

Tel Aviv, 6423906, Israel

RECRUITING

Research Site

Arezzo, 52100, Italy

RECRUITING

Research Site

Bari, 70124, Italy

RECRUITING

Research Site

Bergamo, 24125, Italy

NOT YET RECRUITING

Research Site

Bergamo, 24127, Italy

RECRUITING

Research Site

Chieti, 66100, Italy

NOT YET RECRUITING

Research Site

Genoa, 16132, Italy

RECRUITING

Research Site

Milan, 20132, Italy

RECRUITING

Research Site

Milan, 20133, Italy

RECRUITING

Research Site

Milan, 20141, Italy

RECRUITING

Research Site

Naples, 80131, Italy

RECRUITING

Research Site

Palermo, 90127, Italy

RECRUITING

Research Site

Pisa, 56126, Italy

RECRUITING

Research Site

Roma, 00144, Italy

RECRUITING

Research Site

Roma, 00168, Italy

RECRUITING

Research Site

Rozzano, 20089, Italy

RECRUITING

Research Site

Torino, 10126, Italy

RECRUITING

Research Site

Varese, 21100, Italy

RECRUITING

Research Site

Verona, 37134, Italy

RECRUITING

Research Site

Bunkyō City, 113-8431, Japan

RECRUITING

Research Site

Fukuoka, 812-8582, Japan

RECRUITING

Research Site

Kamakura-shi, 247-8533, Japan

RECRUITING

Research Site

Kawagoe-shi, 350-8550, Japan

RECRUITING

Research Site

Kawasaki-shi, 216-8511, Japan

NOT YET RECRUITING

Research Site

Kisarazu-shi, 292-8535, Japan

RECRUITING

Research Site

Kumamoto, 860-8556, Japan

NOT YET RECRUITING

Research Site

Kyoto, 606-8507, Japan

NOT YET RECRUITING

Research Site

Maebashi, 371-8511, Japan

RECRUITING

Research Site

Miyazaki, 889-1692, Japan

NOT YET RECRUITING

Research Site

Ōta-ku, 373-8550, Japan

RECRUITING

Research Site

Sagamihara-shi, 252-0375, Japan

RECRUITING

Research Site

Shimotsuke-shi, 329-0498, Japan

RECRUITING

Research Site

Yokohama, 232-0024, Japan

RECRUITING

Research Site

Yokohama, 241-8515, Japan

RECRUITING

Research Site

Batu Caves, 68100, Malaysia

WITHDRAWN

Research Site

Kuala Lumpur, 59100, Malaysia

WITHDRAWN

Research Site

Kuala Selangor, 62250, Malaysia

WITHDRAWN

Research Site

Pulau Pinang, 10450, Malaysia

WITHDRAWN

Research Site

Hilversum, 1213 XZ, Netherlands

RECRUITING

Research Site

Hoofddorp, 2134 TM, Netherlands

NOT YET RECRUITING

Research Site

Maastricht, 6202 AZ, Netherlands

RECRUITING

Research Site

Nijmegen, 6532 SZ, Netherlands

RECRUITING

Research Site

Roosendaal, 4708 AE, Netherlands

RECRUITING

Research Site

Lima, 15036, Peru

WITHDRAWN

Research Site

Lima, LIMA 29, Peru

WITHDRAWN

Research Site

Lima, Lima 34, Peru

WITHDRAWN

Research Site

Trujillo, 13008, Peru

WITHDRAWN

Research Site

Gdynia, 81-519, Poland

NOT YET RECRUITING

Research Site

Gliwice, 44-101, Poland

NOT YET RECRUITING

Research Site

Koszalin, 75-581, Poland

NOT YET RECRUITING

Research Site

Krakow, 30-727, Poland

NOT YET RECRUITING

Research Site

Piotrkow Trybunalski, 97-300, Poland

NOT YET RECRUITING

Research Site

Poznan, 61-731, Poland

NOT YET RECRUITING

Research Site

Rzeszów, 35-001, Poland

NOT YET RECRUITING

Research Site

Warsaw, 04-073, Poland

NOT YET RECRUITING

Research Site

Busan, 49241, South Korea

RECRUITING

Research Site

Daegu, 41404, South Korea

RECRUITING

Research Site

Goyang-si, 10408, South Korea

RECRUITING

Research Site

Seoul, 03080, South Korea

RECRUITING

Research Site

Seoul, 06273, South Korea

RECRUITING

Research Site

Seoul, 06351, South Korea

RECRUITING

Research Site

Seoul, 06591, South Korea

RECRUITING

Research Site

Seoul, 3722, South Korea

RECRUITING

Research Site

Seoul, 5505, South Korea

RECRUITING

Research Site

Barcelona, 08041, Spain

RECRUITING

Research Site

Barcelona, 8035, Spain

RECRUITING

Research Site

Girona, 17007, Spain

RECRUITING

Research Site

Madrid, 28040, Spain

RECRUITING

Research Site

Madrid, 28041, Spain

RECRUITING

Research Site

Madrid, 28046, Spain

RECRUITING

Research Site

Majadahonda, 28222, Spain

RECRUITING

Research Site

Málaga, 29009, Spain

RECRUITING

Research Site

Málaga, 29010, Spain

RECRUITING

Research Site

Oviedo, 33011, Spain

RECRUITING

Research Site

Sabadell, 08208, Spain

RECRUITING

Research Site

Santander, 39008, Spain

RECRUITING

Research Site

Valencia, 46009, Spain

RECRUITING

Research Site

Valencia, 46014, Spain

RECRUITING

Research Site

Gothenburg, 413 45, Sweden

RECRUITING

Research Site

Malmo, 205 02, Sweden

RECRUITING

Research Site

Stockholm, 112 81, Sweden

NOT YET RECRUITING

Research Site

Stockholm, 141 86, Sweden

RECRUITING

Research Site

Umeå, 901 85, Sweden

RECRUITING

Research Site

Uppsala, 75185, Sweden

NOT YET RECRUITING

Research Site

Kaohsiung City, 83301, Taiwan

RECRUITING

Research Site

Taichung, 40705, Taiwan

RECRUITING

Research Site

Taichung, 43503, Taiwan

RECRUITING

Research Site

Tainan, 704, Taiwan

RECRUITING

Research Site

Taipei, 10055, Taiwan

RECRUITING

Research Site

Taipei, 110, Taiwan

RECRUITING

Research Site

Taipei, Taiwan

RECRUITING

Research Site

Taoyuan District, 333, Taiwan

RECRUITING

Research Site

Bangkok, 10210, Thailand

RECRUITING

Research Site

Bangkok, 10400, Thailand

RECRUITING

Research Site

Bangkok, 10700, Thailand

RECRUITING

Research Site

Khon Kaen, 40002, Thailand

RECRUITING

Research Site

Muang, 50200, Thailand

RECRUITING

Research Site

Pathum Thani, 12120, Thailand

RECRUITING

Research Site

Songkhla, 90110, Thailand

RECRUITING

Research Site

Ankara, 06010, Turkey (Türkiye)

RECRUITING

Research Site

Ankara, 06520, Turkey (Türkiye)

RECRUITING

Research Site

Ankara, 06620, Turkey (Türkiye)

RECRUITING

Research Site

Ankara, 06800, Turkey (Türkiye)

NOT YET RECRUITING

Research Site

Cordaleo, 35575, Turkey (Türkiye)

RECRUITING

Research Site

Diyarbakır, 21280, Turkey (Türkiye)

RECRUITING

Research Site

Istanbul, 34010, Turkey (Türkiye)

RECRUITING

Research Site

Istanbul, 34098, Turkey (Türkiye)

RECRUITING

Research Site

Istanbul, 34722, Turkey (Türkiye)

NOT YET RECRUITING

Research Site

Izmir, 35040, Turkey (Türkiye)

RECRUITING

Research Site

Sakarya, 54290, Turkey (Türkiye)

NOT YET RECRUITING

Research Site

Şahinbey, 27310, Turkey (Türkiye)

RECRUITING

Research Site

Aberdeen, AB25 2ZN, United Kingdom

RECRUITING

Research Site

Bristol, BS2 8ED, United Kingdom

RECRUITING

Research Site

Cambridge, CB2 0QQ, United Kingdom

RECRUITING

Research Site

Edinburgh, EH4 2XU, United Kingdom

NOT YET RECRUITING

Research Site

Exeter, EX2 5DW, United Kingdom

NOT YET RECRUITING

Research Site

Glasgow, G12 0YN, United Kingdom

NOT YET RECRUITING

Research Site

Greater London, SW3 6JJ, United Kingdom

RECRUITING

Research Site

Guildford, GU2 7XX, United Kingdom

NOT YET RECRUITING

Research Site

London, EC1M6BQ, United Kingdom

NOT YET RECRUITING

Research Site

London, NW3 2QG, United Kingdom

RECRUITING

Research Site

London, WC1N 3BG, United Kingdom

RECRUITING

Research Site

Manchester, M20 4BX, United Kingdom

RECRUITING

Research Site

Newcastle, NE7 7DN, United Kingdom

WITHDRAWN

Research Site

Plymouth, PL6 8DH, United Kingdom

RECRUITING

Research Site

Preston, PR2 9HT, United Kingdom

NOT YET RECRUITING

Research Site

Romford, RM7 0AG, United Kingdom

RECRUITING

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

AZD5305abirateronePrednisolonePrednisoneAndrogen Antagonists

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital Diseases

Intervention Hierarchy (Ancestors)

PregnadienetriolsPregnadienesPregnanesSteroidsFused-Ring CompoundsPolycyclic CompoundsPregnadienediolsHormone AntagonistsHormones, Hormone Substitutes, and Hormone AntagonistsPhysiological Effects of DrugsPharmacologic ActionsChemical Actions and Uses

Central Study Contacts

AstraZeneca Clinical Study Information Center

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 30, 2025

First Posted

May 1, 2025

Study Start

August 6, 2025

Primary Completion (Estimated)

March 31, 2033

Study Completion (Estimated)

April 30, 2036

Last Updated

April 21, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Access Criteria
When a request has been approved AstraZeneca will provide access to the anonymized individual patient-level data via secure research environment Vivli.org. Signed Data Usage Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information.
More information

Locations