Vaper to Vaper: A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping

NCT05140915 | Completed Results DMC

• 2 other identifiers: H00021082R34DA050992
• Study Type: interventional
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

The dramatic increase in the use of e-cigarettes among U.S. adolescents has been called a national epidemic, with more adolescents now using e-cigarettes than traditional cigarettes. The high amounts of nicotine in e-cigarettes harm adolescents and put them at greater risk of becoming traditional cigarette smokers. The investigators propose to develop Vaper-to-Vaper (V2V), a suite of mobile peer driven tools including peer texting and coaching based on lessons learned in the investigators' prior tobacco intervention work, to engage and help adolescents use strategies to manage cravings and successfully quit.

Conditions

E-cigarette Use; Vaping

Keywords

Vaping; Adolescents

Outcome Measures

Primary Outcomes (1)

• Participant Recruitment and Retention

  Investigators will assess the number of those screened, eligible, and consented who remain active in the program at 3 months.

  3 months

Secondary Outcomes (8)

• Acceptability of and Satisfaction With the Intervention

  3 months

• Number of Participants With Abstinence From Vaping as Measured by Saliva Samples [Cotinine-validated 7-day Point Prevalence]

  3 months

• Number of Peer Coaching Interactions

  3 months

• Number of Peer Videos Viewed

  3 months

• Number of Games Engaged In

  3 months

Study Arms (2)

Intervention

EXPERIMENTAL

Students in schools randomized to the intervention will receive: (1) peer messages, written by current and former adolescent e-cigarette users and tailored by age and readiness-to-quit; (2) peer coaching, facilitated by texting; and (3) gamification, designed to motivate participation.

Behavioral: Peer Messaging; Behavioral: Peer Coaching via Text; Behavioral: Gamification

Control

ACTIVE COMPARATOR

Students in schools randomized to the control condition will be provided e-cigarette cessation materials by the Research Coordinator at the time of study enrollment.

Other: E-Cigarette Cessation Materials

Interventions

Peer Messaging BEHAVIORAL

Peer messages, written by current and former adolescent e-cigarette users and tailored by age and readiness-to-quit.

Intervention

Peer Coaching via Text BEHAVIORAL

Peer coaching, facilitated by texting

Intervention

Gamification BEHAVIORAL

Gamification, designed to motivate participation

Intervention

E-Cigarette Cessation Materials OTHER

E-cigarette cessation materials by the Research Coordinator at the time of study enrollment.

Control

Eligibility Criteria

• Age: 13 Years - 19 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Enrolled in grade 9-12 at participating high school
• Current e-cigarette user, as defined as a response greater than "0 days" to the question: "During the past 7 days, on how many days did you use e-cigarettes?" This eligibility criterion is modeled on a question in the 2018 National Youth Tobacco Survey (NYTS), a survey of U.S. middle and high school students which used a 30-day timeframe.
• Have a smartphone.
• English- or Spanish-speaking

Sponsors & Collaborators

• University of Massachusetts, Worcester: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

UMass Chan Medical School

Worcester, Massachusetts, 01605, United States

Location

Related Publications (2)

• Pbert L, Dube CE, Nagawa CS, Simone DP, Wijesundara JG, Sadasivam RS. Vaping cessation support recommendations from adolescents who vape: a qualitative study. BMC Public Health. 2024 Jun 17;24(1):1615. doi: 10.1186/s12889-024-19036-1.

  PMID: 38886719 DERIVED

• Pbert L, Dube CE, Nagawa CS, Simone DP, Wijesundara J, Sadasivam R. Vaping Cessation Support Recommendations from Adolescents Who Vape: A Qualitative Study. Res Sq [Preprint]. 2024 Mar 20:rs.3.rs-4077848. doi: 10.21203/rs.3.rs-4077848/v1.

  PMID: 38562810 DERIVED

MeSH Terms

Conditions

Vaping

Condition Hierarchy (Ancestors)

Smoking; Behavior

Results Point of Contact

• Title: Dr. Rajani Sadasivam
• Organization: University of Massachusetts Chan Medical School

rajani.sadasivam@umassmed.edu

(508) 856-8923

Study Officials

• Rajani Sadasivam, PhD

  University of Massachusetts Chan Medical School

  PRINCIPAL INVESTIGATOR

• Lori Pbert, PhD

  University of Massachusetts Chan Medical School

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 18, 2021
• First Posted: December 2, 2021
• Study Start: December 19, 2022
• Primary Completion: June 9, 2023
• Study Completion: August 30, 2024
• Last Updated: September 4, 2025
• Results First Posted: April 23, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)