Responses to E-cigarette Message Source and Presentation

NCT06274723 | Completed Results

• 2 other identifiers: STUDY000012201K99CA281094-01A1
• Study Type: interventional
• Target: 848
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who vape and do not vape.

Conditions

Vaping

Outcome Measures

Primary Outcomes (2)

• Message Acceptance

  Participants' self-reported message acceptance were measured by using a five-point Likert scale using five items assessing whether participants thought the message was worth remembering, grabbed their attention, powerful, convincing, and meaningful on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more more message acceptance, therefore better outcomes.

  After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

• Harm Perceptions

  Harm perceptions was measured by a single item e-cigarette harm perceptions question assessing participants' perceived absolute harm of e-cigarette use on a scale from 1 (Not at all harmful) to 10 (Very harmful). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping harm perceptions, therefore indicating better outcome.

  After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Secondary Outcomes (6)

• Negative Cognition

  After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

• Message Anger

  After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

• Message Liking

  After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

• Source Trust

  After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

• Attitudes

  After exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.

Study Arms (4)

Expert, one-sided

EXPERIMENTAL

Participants assigned to the expert, one-sidedness condition will receive one-sided e-cigarette messages from an expert source.

Other: Expert, one-sided

Expert, two-sided

EXPERIMENTAL

Participants assigned to the expert, two-sidedness condition will receive two-sided e-cigarette messages from an expert source.

Other: Expert, two-sided

Peer, one-sided

EXPERIMENTAL

Participants assigned to the peer, one-sidedness condition will receive one-sided e-cigarette messages from a peer source.

Other: Peer, one-sided

Peer, two-sided

EXPERIMENTAL

Participants assigned to the peer, two-sidedness condition will receive two-sided e-cigarette messages from a peer source.

Other: Peer, two-sided

Interventions

Expert, one-sided OTHER

Participants will view a brief description of an expert source and see one-sided e-cigarette education messages.

Expert, one-sided

Expert, two-sided OTHER

Participants will view a brief description of an expert source and see two-sided e-cigarette education messages.

Expert, two-sided

Peer, one-sided OTHER

Participants will view a brief description of a peer source and see one-sided e-cigarette education messages.

Peer, one-sided

Peer, two-sided OTHER

Participants will view a brief description of a peer source and see two-sided e-cigarette education messages.

Peer, two-sided

Eligibility Criteria

• Age: 18 Years - 24 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• US residents ages 18-24
• Fluent in English
• Reporting either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping

You may not qualify if:

• Age less than 18 or above 24
• Not fluent in English
• Not a member of partnering crowdsourcing behavioral research platform conducting the study

Sponsors & Collaborators

• University of Massachusetts, Worcester: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

UMass Chan Medical School

Worcester, Massachusetts, 01605, United States

Location

MeSH Terms

Conditions

Vaping

Condition Hierarchy (Ancestors)

Smoking; Behavior

Results Point of Contact

• Title: Donghee Nicole Lee, Assistant Professor
• Organization: University of Hawaii Cancer Center

nlee@cc.hawaii.edu

8084418184

Study Officials

• Donghee N Lee, PhD

  UMass Chan Medical School

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postdoctoral Fellow

Study Record Dates

• First Submitted: January 17, 2024
• First Posted: February 23, 2024
• Study Start: November 5, 2024
• Primary Completion: December 5, 2024
• Study Completion: December 17, 2024
• Last Updated: January 14, 2026
• Results First Posted: January 14, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)