Responses to Message Source and Presentation Using Psychophysiology

NCT06269003 | Completed Results

• 2 other identifiers: STUDY000012231K99CA281094-01A1
• Study Type: interventional
• Target: 112
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to use psychophysiological methods to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who vape and do not vape.

Conditions

Vaping

Outcome Measures

Primary Outcomes (3)

• Visual Attention

  Visual attention was assessed by measuring dwell time, which is the length of time participants spent on looking at the specific areas of interest (AOIs) collected in miliseconds. Dwell time values were collected for 18 messages, and aggregated to provide the average dwell time scores for each arm. This was done for each vaping status (current vapers and susceptible non-vapers). Higher dwell time scores indicate higher visual attention, indicating better message outcomes.

  The entire duration of message from beginning of its delivery to the completion of viewing, up to 45 minutes.

• Allocation of Cognitive Resources

  Heart rate values were collected in beats per minute (BPM) on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in the BPM values during the message exposure period by comparing the BPM values collected during each message second to the BPM values collected during the immediately preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean BPM value per condition, and this was done for each vaping status (current vapers and susceptible non-vapers). Lower BPM values reflect greater cognitive response, therefore indicate better message outcomes.

  Baseline and immediately after viewing all the messages (approximately 45 minutes).

• Arousal

  Galvanic Skin Response (GSR) values were recorded in microsiemens on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in GSR values by comparing each message response to its preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean GSR score per condition, and this was done for each vaping status group (current vapers and susceptible non-vapers). Higher GSR values reflect greater physiological arousal, and indicate better message outcomes.

  Baseline and immediately after viewing all the messages (approximately 45 minutes).

Secondary Outcomes (2)

• Attitudes

  After exposure to all messages, approximately up to 45 minutes.

• Behavioral Intentions

  After exposure to all messages, approximately up to 45 minutes.

Study Arms (4)

Expert, one-sided

EXPERIMENTAL

Participants assigned to the expert, one-sidedness condition will receive one-sided e-cigarette messages from an expert source.

Other: Expert, one-sided

Expert, two-sided

EXPERIMENTAL

Participants assigned to the expert, two-sidedness condition will receive two-sided e-cigarette messages from an expert source.

Other: Expert, two-sided

Peer, one-sided

EXPERIMENTAL

Participants assigned to the peer, one-sidedness condition will receive one-sided e-cigarette messages from a peer source.

Other: Peer, one-sided

Peer, two-sided

EXPERIMENTAL

Participants assigned to the peer, two-sidedness condition will receive two-sided e-cigarette messages from a peer source.

Other: Peer, two-sided

Interventions

Expert, one-sided OTHER

Participants will view a brief description of an expert source and see one-sided e-cigarette education messages.

Expert, one-sided

Expert, two-sided OTHER

Participants will view a brief description of an expert source and see two-sided e-cigarette education messages.

Expert, two-sided

Peer, one-sided OTHER

Participants will view a brief description of a peer source and see one-sided e-cigarette education messages.

Peer, one-sided

Peer, two-sided OTHER

Participants will view a brief description of a peer source and see two-sided e-cigarette education messages.

Peer, two-sided

Eligibility Criteria

• Age: 18 Years - 24 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Ages 18-24
• Fluent in English
• Either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping
• Self-reported abstinence of combusted tobacco or marijuana at time of visit

You may not qualify if:

• Ages below 18 or above 24
• Not fluent in English
• Not confirmed self-reported abstinence of combusted tobacco or marijuana at time of visit

Sponsors & Collaborators

• University of Massachusetts, Worcester: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

UMass Chan Medical School Shaw Building

Worcester, Massachusetts, 01605, United States

Location

MeSH Terms

Conditions

Vaping

Condition Hierarchy (Ancestors)

Smoking; Behavior

Results Point of Contact

• Title: Donghee Nicole Lee, Assistant Professor
• Organization: University of Hawaii Cancer Center

nlee@cc.hawaii.edu

8084418184

Study Officials

• Donghee N Lee, PhD

  University of Massachusetts, Worcester

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 17, 2024
• First Posted: February 21, 2024
• Study Start: February 18, 2024
• Primary Completion: June 10, 2024
• Study Completion: June 10, 2024
• Last Updated: August 1, 2025
• Results First Posted: August 1, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)