Muscle Typology and Strength Training Adaptations

NCT05108181 | Completed

• 1 other identifier: BC-10253
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers. Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).

Conditions

Muscle Fiber Type; Exercise; Training Frequency

Keywords

Strength training; Muscle typology

Outcome Measures

Primary Outcomes (6)

• Change from baseline muscle volume at 9 weeks

  Muscle volume of the legs and the upper arms - MRI

  Pre and post the 9 weeks training period

• Change from baseline dynamic muscle strength at 3 weeks

  Upper legs and upper arms - strength training devices

  Pre, mid and post 9 weeks training period

• Change from baseline dynamic muscle strength at 6 weeks

  Upper legs and upper arms - strength training devices

  Pre, mid and post 9 weeks training period

• Change from baseline dynamic muscle strength at 9 weeks

  Upper legs and upper arms - strength training devices

  Pre, mid and post 9 weeks training period

• Change from baseline isometric muscle strength at 9 weeks

  Upper legs and upper arms - Biodex

  Pre and post 9 weeks training period

• Change in muscle fiber type specific hypertrophy at 9 weeks

  Legs - Biopsy (vastus lateralis)

  Pre and post 9 weeks training period

Secondary Outcomes (5)

• Change of baseline antropometry at 9 weeks

  Pre and post 9 weeks training period

• Change of baseline skeletal muscle protein content at 9 weeks

  Pre and post 9 weeks training period

• Change of baseline histochemistry at 9 weeks

  Pre and post 9 weeks training period

• Change from basline fatigue feeling over 9 weeks training period

  Assessed every training during the 9 weeks training period

• Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks

  Pre and post 9 weeks training period

Study Arms (2)

Slow muscle typology group

ACTIVE COMPARATOR

The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.

Other: Muscle typology + exercise training; Other: Muscle typology + training frequency

Fast muscle typology group

ACTIVE COMPARATOR

The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.

Other: Muscle typology + exercise training; Other: Muscle typology + training frequency

Interventions

Muscle typology + exercise training OTHER

Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.

Fast muscle typology group; Slow muscle typology group

Muscle typology + training frequency OTHER

Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.

Fast muscle typology group; Slow muscle typology group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Fast or slow muscle typology
• years old
• no strength training experience

You may not qualify if:

• Vegan/vegeterian diet
• Supplement intake
• chronic diseases
• Hypertension,
• Smoking
• Medication use
• Coagulation disorder, infectious diseases

Sponsors & Collaborators

• University Ghent: lead

Study Sites (1)

Department of Movement and Sports Sciences, Ghent University

Ghent, Oost-Vlaanderen, 9000, Belgium

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Wim Derave

  University Ghent

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: The participants don't know their muscle typology during the study. All participants do the same training intervention, no drugs are taken.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All participants will receive the same training intervention but the subjects are divided into two groups based on an inherent physiological characteristic: the muscle typology. A slow typology group (people with a lot of slow muscle fibers) and a fast typology group (people with a lot of fast muscle fibers). Each participant will train their legs and arms unilateral and one arm and one leg will train two times per week, while the other arm and leg will train three times per week for 9 weeks. The assignment of the limbs to the 3x/week condition and the 2x/week condition is randomized. The training outcomes of the two groups will be compared as well as the within subject differences between training two times per week or training 3 times per week.

Study Record Dates

• First Submitted: October 12, 2021
• First Posted: November 4, 2021
• Study Start: September 9, 2021
• Primary Completion: December 8, 2023
• Study Completion: December 8, 2023
• Last Updated: April 12, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)