Does Biological Sex Influence the Cardiac Output Response to Sprint Interval Exercise Training in Humans?

NCT05205538 | Completed

• 1 other identifier: 14279
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Sprint interval exercise training refers to brief repeated bouts of vigorous effort that are separated by short periods of recovery. Cardiac output refers to the amount of blood that is pumped out of the heart each minute. Research has shown that sprint interval exercise training can increase peak cardiac output - or the highest cardiac output that is achieved during strenuous exercise - but this response may be influenced by biological sex. The primary goal of this study is to determine whether the peak cardiac output response to 12 weeks of sprint interval exercise training differs between males and females. Cardiac output will be estimated using a non-invasive technique that involves breathing in a mixture of standardized gases. This research will help to determine whether biological sex influences the response of the heart to brief vigorous cycle exercise training.

Conditions

Exercise

Keywords

Cardiac output

Outcome Measures

Primary Outcomes (1)

• Peak cardiac output

  Peak cardiac output measured during exercise

  Change from baseline after 12 weeks of sprint interval exercise training

Secondary Outcomes (3)

• Peak oxygen uptake

  Change from baseline after 12 weeks of sprint interval exercise training

• Flow mediated dilation

  Change from baseline after 4 and 12 weeks of sprint interval exercise training

• Pulse wave velocity

  Change from baseline after 4 and 12 weeks of sprint interval exercise training

Study Arms (2)

Females

EXPERIMENTAL

Female participant group

Other: Sprint interval exercise training

Males

EXPERIMENTAL

Male participant group

Other: Sprint interval exercise training

Interventions

Sprint interval exercise training OTHER

A 10-minute sprint interval exercise training protocol that is performed three times per week for a total of 12 weeks.

Females; Males

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being untrained based on a self-report of engaging in \< 1 h of weekly moderate to vigorous physical activity based on the Canadian Society for Exercise Physiology Get Active Questionnaire.
• Having an estimated cardiorespiratory fitness in the lower 50% of adults in the specified age range based on the online fitness calculator available at: www.worldfitnesslevel.org.
• Females who are naturally cycling (i.e., not using any form of hormonal contraceptive) or are using a 2nd generation oral contraceptive.

You may not qualify if:

• Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.
• Females with a positive pregnancy test.

Sponsors & Collaborators

• McMaster University: lead

Study Sites (1)

McMaster University

Hamilton, Ontario, L8S4K1, Canada

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Martin Gibala, PhD

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 23, 2021
• First Posted: January 25, 2022
• Study Start: January 25, 2022
• Primary Completion: February 28, 2023
• Study Completion: February 28, 2023
• Last Updated: April 6, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)