Effects of Collagen Peptide Supplementation on Muscle and Tendon Damage and Function

NCT05425407 | Completed

• 1 other identifier: S64402
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).

Conditions

Exercise; Healthy Male Subjects

Keywords

Whey protein; Collagen peptide; Muscle and tendon overload training

Outcome Measures

Primary Outcomes (4)

• Change in countermovement jump performance

  Change in jump height when performing a countermovement jump, measured via a force platform

  Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

• Change in maximal isometric knee-extension force of the right leg

  Change in maximal isometric knee-extension force (angle = 45°) of the right leg

  Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

• Change in anteroposterior thickness of the right patellar tendon

  Change in anteroposterior thickness of the right patellar tendon

  Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

• Change in neovascularization of the right patellar tendon

  Neovascularization of the right patellar tendon scored with the Modified Ohberg Score (range 0 - 4; the higher the score, the higher the degree of neovascularization).

  Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

Secondary Outcomes (5)

• Change in pain perception at the muscular level (VAS scale)

  Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention)

• Change in pain perception of the patellar tendon of the right leg (VISA-P)

  Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention)

• Change in the blood concentration of creatine kinase

  Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

• Change in the blood concentration of Interleukin 6 (IL-6)

  Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

• Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP)

  Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

Study Arms (2)

Placebo

PLACEBO COMPARATOR

Only whey protein will be provided

Dietary Supplement: whey protein

Collagen

EXPERIMENTAL

A mix of whey protein and collagen peptides will be provided

Dietary Supplement: whey protein + collagen peptide

Interventions

whey protein DIETARY_SUPPLEMENT

Daily 45g of whey protein supplementation during a three week eccentric training period

Placebo

whey protein + collagen peptide DIETARY_SUPPLEMENT

Daily 15g of whey protein and 20g collagen peptide supplementation during a three week eccentric training period

Collagen

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Sports participation, including general fitness training, between 2 and 5 hours max per week
• Body mass index between 18.5 and 25

You may not qualify if:

• Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study
• Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study
• Blood donation within 3 months prior to the start of the study
• Smoking
• Current participation in another research trial
• Any other argument to believe that the subject is unlikely to successfully complete the full study

Sponsors & Collaborators

• KU Leuven: lead
• Rousselot BVBA: collaborator

Study Sites (1)

Exercise Physiology Research Group

Leuven, Vlaams-Brabant, 3001, Belgium

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Whey Proteins

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Milk Proteins; Animal Proteins, Dietary; Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Whey; Milk; Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 3, 2021
• First Posted: June 21, 2022
• Study Start: April 12, 2021
• Primary Completion: May 30, 2021
• Study Completion: June 30, 2021
• Last Updated: June 21, 2022

Record last verified: 2022-06

Locations

BE (1)