NCT04381390

Brief Summary

Eggs may be a viable alternative to various types of supplemental proteins given its similar ratings on various measures of dietary protein quality. The investigators hypothesis is that whole eggs would create a greater improvement in skeletal regulatory markers, hormonal responses and body composition than egg white ingestion in resistance-trained men.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 10, 2018

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 2, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 2, 2019

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

May 1, 2020

Completed
7 days until next milestone

First Posted

Study publicly available on registry

May 8, 2020

Completed
Last Updated

May 8, 2020

Status Verified

May 1, 2020

Enrollment Period

1.1 years

First QC Date

May 1, 2020

Last Update Submit

May 5, 2020

Conditions

Hypertrophy

Outcome Measures

Primary Outcomes (4)

  • Circulatory Myokines levels

    Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentration of myostatin, follistatin, FGF-2, TGF-β1 and ACVA.

    12 weeks

  • Circulatory hormone levels

    Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentrations of testosterone, IGF-1, insulin and cortisol

    12 weeks

  • Muscle mass

    Skeletal muscle mass will be evaluated using computed tomography

    12 weeks

  • Body fatness

    Body fat will be evaluated using bioelectrical impedance

    12 weeks

Secondary Outcomes (1)

  • Muscular Strength

    12 weeks

Study Arms (2)

Whole egg consumption

EXPERIMENTAL

This arm involved whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training.

Dietary Supplement: Whole egg and resistance training

Egg whites consumption

EXPERIMENTAL

This arm involved egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training.

Dietary Supplement: Egg whites and resistance training

Interventions

Whole egg and resistance trainingDIETARY_SUPPLEMENT

This intervention consisted of whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training.

Whole egg consumption
Egg whites and resistance trainingDIETARY_SUPPLEMENT

This intervention consisted of egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training.

Egg whites consumption

Eligibility Criteria

Age18 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • performing resistance training at least three times a week for 1 year prior to the start of the study
  • not taking any dietary supplements or medications for at least 1 year prior to the start of the study
  • no known medical issues
  • no alcohol consumption or smoking for at least 1 year prior to the start of the study
  • no egg allergy/sensitivity.

You may not qualify if:

  • non-willingness to continue nutritional or exercise protocols
  • participation in exercise other than the prescribed resistance training program
  • consumption of dietary supplement (other than egg) during the study period
  • Missing more than one resistance training session or post-exercise egg consumption throughout the study period

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Marymount University

Arlington, Virginia, 22207, United States

Location

Related Publications (1)

  • Bagheri R, Hooshmand Moghadam B, Ashtary-Larky D, Forbes SC, Candow DG, Galpin AJ, Eskandari M, Kreider RB, Wong A. Whole Egg Vs. Egg White Ingestion During 12 weeks of Resistance Training in Trained Young Males: A Randomized Controlled Trial. J Strength Cond Res. 2021 Feb 1;35(2):411-419. doi: 10.1519/JSC.0000000000003922.

    PMID: 33306586DERIVED

MeSH Terms

Conditions

Hypertrophy

Interventions

Resistance TrainingEgg White

Condition Hierarchy (Ancestors)

Pathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological PhenomenaEggsFoodDiet, Food, and NutritionPhysiological PhenomenaFood and Beverages

Study Officials

  • Alexei Wong

    Marymount University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

May 1, 2020

First Posted

May 8, 2020

Study Start

September 10, 2018

Primary Completion

October 2, 2019

Study Completion

October 2, 2019

Last Updated

May 8, 2020

Record last verified: 2020-05

Data Sharing

IPD Sharing
Will not share

Locations

US(1)