Effect of High Intensity Aerobic & Resistance Interval Training on Body Composition, Visceral Adiposity and Myocardial Function in Overweight and Obese Adults
1 other identifier
interventional
52
1 country
1
Brief Summary
The obesity epidemic, predisposing to cardio-metabolic diseases, has increased two-folds over the last decade with a global alarming cost of obesity-associated illnesses, thus representing a grave peril for the survival of public health care systems. It is need of the time to develop evidence-based, time-efficient and cost-effective strategies to prevent and manage obesity. This study would compare the effects of 2 types of exercise regimes providing data on their beneficial effects on body composition and myocardial function along with reducing the central adiposity. This study may also be used as a novel intervention strategy for primary prevention of cardiovascular and metabolic diseases by modification of a major risk factor i.e. obesity in Pakistani population, consequently reducing the burden of morbidity and mortality from cardiometabolic diseases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable obesity
Started Nov 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 25, 2020
CompletedFirst Submitted
Initial submission to the registry
January 1, 2021
CompletedFirst Posted
Study publicly available on registry
January 14, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2021
CompletedJanuary 14, 2021
January 1, 2021
1.1 years
January 1, 2021
January 12, 2021
Conditions
Outcome Measures
Primary Outcomes (2)
Percentage Body Fat
Percentage body fat will be measured using Bioelectrical Impedance Analyzer (Inbody 770) and expressed in forms of percentage (%).
10 weeks
Visceral fat area
Visceral fat area will be measured using Bioelectrical Impedance Analyzer (Inbody 770) and expressed in form of centimeter square.
10 weeks
Secondary Outcomes (4)
Left Ventricular Mass
10 weeks
Left Ventricular Ejection Fraction
10 weeks
Cholesterol/HDL ratio
10 weeks
Fat free mass
10 weeks
Study Arms (2)
High Intensity Interval Training Group
EXPERIMENTALParticipants in this group will initially undergo continuous aerobic training to achieve a baseline fitness level, after which HIIT and resistance training will be employed. Warm-up period will be followed by 4 bouts of 4-minute interval treadmill running and stationary bike cycling at 80-95% of the measured HR reserve, interspersed with active recovery phase at 55-70% HRR. After this resistance exercises will be performed in a circuit fashion for strengthening the upper limbs, lower limbs and trunk. The session will be ended with a 5-7 minute cool-down period
Moderate Intensity Continuous Training Group
ACTIVE COMPARATORParticipants in this group will also initially undergo continuous aerobic training to achieve a baseline fitness level, after which the intensity will be increased to moderate continuous training achieving 55-70% of HRR. Every session will be preceded by appropriate warm-up and end with cool down.
Interventions
4x4 min intervals of high intensity treadmill running (80-95% of HRR, RPE 7-10 on Borg's category ratio scale of perceived exertion) interspersed with active recovery (slow jogging or fast walking at 50-70% HRR). HIIT-Resistance exercises 2 sessions per week, RPE 5 (hard) 6-8 RM, 1-3 sets of as many repetitions as possible in 60 seconds, active recovery 20-60 seconds b/w exercises,
Moderate intensity continuous Aerobic exercises (Stationary cycling for 15-20 min followed by treadmill walking for 15-20 min) at 55-70% 55-70% of HRR, RPE 3-4 on Borg's category ratio scale of perceived exertion. The session will be preceded by 5-7 minute warm-up \& 7-10 min cool-down.
Eligibility Criteria
You may qualify if:
- Individuals categorized as Overweight (BMI 23.0 to 24.9) and Obese-Class I (BMI 25.0 to 29.9).
- Both males \& females willing to participate in the study.
- Otherwise healthy young adults aged 18-35 and middle-aged adults (36-55 years).
- No participation in an exercise or PA program during the last 6 months prior to the study.
- Participants able to complete 6-minute walk test as sub-maximal evaluation test without provoking sign and symptoms.
You may not qualify if:
- Any diagnosed neuromuscular, cardiac, renal, lung, liver disease.
- Individuals with implantable electrical devices such as pacemakers.
- Any physical or psychological dysfunction that hinders participation in the study.
- Individuals already participating in any structured program for weight loss including dietary interventions or usage of nutritional supplements.
- Individuals unable to complete 6 minute walk test due to any reason (dyspnea, fatigue, chest pain etc).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Foundation University Institute of Rehabilitation Sciences.
Islamabad, Federal, 46000, Pakistan
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Masking Details
- It will be a single blinded study. Only the participants will be masked.
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 1, 2021
First Posted
January 14, 2021
Study Start
November 25, 2020
Primary Completion
December 30, 2021
Study Completion
December 30, 2021
Last Updated
January 14, 2021
Record last verified: 2021-01
Data Sharing
- IPD Sharing
- Will not share