Effect of Aerobic Exercise Training in Obese Adults

NCT05202535 | Completed DMC

• 1 other identifier: REC/01092 Khowla shah
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

To determine the effect of aerobic exercise training on arterial stiffness and hemodynamics in obese adults. Proper evidence on the effect of aerobic exercise training on both arterial stiffness and hemodynamics are sparsely present in obese adults whereas separate studies were done in mainly hypertensive and cardiovascular disease populations.

Conditions

Obesity

Keywords

Aerobic exercise, arterial stiffness, hemodynamics, obesity

Outcome Measures

Primary Outcomes (2)

• Arterial Stiffness

  Gradual fragmentation and loss of elastin fibers and accumulation of stiffer collagen fibers in the arterial wall. Calculated through Arterial stiffness index.

  6 weeks

• Hemodynamics

  Factors that govern blood flow calculated through Rate Pressure Product.

  6 weeks

Study Arms (2)

Aerobic exercise training

EXPERIMENTAL

hospital-based aerobic exercise training on treadmill/cycle ergometer with the intensity of 40-70% of HR max, for 15-30 mints for 8 weeks

Other: Aerobic exercise training

Conventional therapy

ACTIVE COMPARATOR

Patient education and counseling with diet plan.Walking 3 days15min/day for 8 weeks

Other: Conventional therapy

Interventions

Aerobic exercise training OTHER

Hospital-based aerobic exercise training for 15-30 minutes including pre and post-vitals assessment. 3x/week on alternate days for 8 weeks at 40-70% of HR Max

Aerobic exercise training

Conventional therapy OTHER

Patient education and counseling with diet plan.Walking 3 days15min/day for 8 weeks

Conventional therapy

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index ≥28 kg/m²
• Able to do exercise

You may not qualify if:

• Involved in structured physical activity in last 6 months
• History of chronic systemic disease (cardiovascular, pulmonary, and metabolic disease)
• Continuous medication use.
• MSK or Neurological problems
• Pregnant females

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Polyclinic Hospital

Islamabad, Punjab Province, 04404, Pakistan

Location

Related Publications (2)

• Hvidt KN. Blood pressure and arterial stiffness in obese children and adolescents. Dan Med J. 2015 Mar;62(3):B5043.

  PMID: 25748874 BACKGROUND

• Cote AT, Phillips AA, Harris KC, Sandor GG, Panagiotopoulos C, Devlin AM. Obesity and arterial stiffness in children: systematic review and meta-analysis. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):1038-44. doi: 10.1161/ATVBAHA.114.305062. Epub 2015 Jan 29.

  PMID: 25633314 BACKGROUND

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mehwish Waseem, MSPT(CPPT)

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2022
• First Posted: January 21, 2022
• Study Start: November 15, 2021
• Primary Completion: March 15, 2022
• Study Completion: March 15, 2022
• Last Updated: September 16, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)