Efficacy of Computerized Cognitive Training in the Elderly With Mild Cognitive Impairment

NCT03577717 | Terminated

• 1 other identifier: 201804
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

Mild cognitive impairment (MCI) is the prodrome of the cognitive function declining before Alzheimer's disease or other dementia showed up, the impairments of language, visuospatial relationship, attention, and memory included and instrumental activities of daily living (IADL) influenced. MCI is considered as a transitional stage between normal aging and mild dementia, and the patients with MCI has differently fluctuated cognitive functions in a period of time, such as from normal cognition to MCI or developing to dementia. The annual conversion rate (ACR) of older adults with normal cognition developed to MCI is 30%, and 5% in clinical setting, and community, respectively. Not all of patients with MCI develop to Alzheimer's disease, the reversion of patients with MCI to normal cognition exists. However, MCI is a significant risk factor. The ACR of older adults with normal cognition or MCI developed to dementia is 1-2%, and 5-15%, respectively; moreover, about half of patients with MCI developed to dementia in 5 years. Cognitive training (CT) improves cognitive functions with repetitive practicing standardized cognitive tasks of specific cognitive functions, such as memory, attention, or problem solving. CT has widely defined including strategy training, in which contained cognitive exercise, strategy indicating and practicing to reducing cognitive impairments and improving performances. CT is more effective for MCI. Recently, computer-based CT (CCT) with many advantages gradually replaced the traditional paper-pencil form. Brief systematic review showed that the computer-based intervention had positive effects on behavioral symptoms, such as depression and anxiety, in patients with MCI and/or dementia. Previous studies demonstrated that computer-based intervention exhibited moderate treatment effects on overall cognitive functions in patients with MCI, and also had positive effects on learning, short-term memory, and behavioral symptoms. Older people with cognitive impairments is expected to increase by global aging. It is important for improving or maintaining cognitive functions of older adults with MCI. The efficacy of the CCT on cognitive functions, neuropsychiatric symptoms, daily functions, and brain activated imaging of the magnetoencephalography (MEG) of in older adults with MCI is worth to explore for busy clinical practice.

Conditions

Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (2)

• Change scores of Quick Mild Cognitive Impairment screen

  The Quick Mild Cognitive Impairment (Qmci) screen , a performance test, contains 6 subtests: Orientation, Registration, Clock Drawing, Delayed Recall, Verbal Fluency, and Logical Memory. The Qmci can be administered and scored in less than 5 min. The Qmci was validated with sound reliability and validity. The Qmci screen scores ranged from 0 to 100, with a higher score indicating greater cognitive function.

  Baseline, 1 month, 2 months

• Change scores of Montreal Cognitive Assessment

  The Montreal Cognitive Assessment (MoCA), a performance test, is a standardized and validated tool designed to measure cognitive functions in visuospatial/executive, naming, memory, attention, language, abstraction, delayed recall, and orientation. The MoCA adds 1 score for those whose educational level ≤ 12 and scores ranged from 0 to 30, with a higher score indicating greater cognitive function.

  Baseline, 1 month, 2 months

Secondary Outcomes (9)

• Change scores of Contextual Memory Test

  Baseline, 1 month, 2 months

• Change scores of Color Trail Test

  Baseline, 1 month, 2 months

• Change scores of Digits Span Tasks-forward and backward

  Baseline, 1 month, 2 months

• Change scores of Cancellation Test

  Baseline, 1 month, 2 months

• Change scores of Pattern Comparison

  Baseline, 1 month, 2 months

Other Outcomes (1)

• Imaging change of the MEG

  Baseline, 1 month, 2 months

Study Arms (2)

computerized cognitive training

EXPERIMENTAL

participants will be trained by the "Cookies for the brainy day", including memory, attention, calculation, executive functions, and language training.

Other: computerized cognitive training

occupational therapy

ACTIVE COMPARATOR

participants will receive craft activities of occupational therapy, such as weaving, origami etc.

Other: occupational therapy

Interventions

computerized cognitive training OTHER

participants will be trained 30 minutes/day, 3 days/week for 4 consecutive weeks.

computerized cognitive training

occupational therapy OTHER

participants will receive craft activities of occupational therapy for 30 minutes/day, 3 days/week for 4 consecutive weeks.

occupational therapy

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• (1) were aged ≥65 years
• (2) amnestic type MCI was made using National Institute on Aging-Alzheimer's Association workgroups diagnostic guidelines for Alzheimer's disease with the clinical dementia rating scale (CDR) global scores of 0.5
• (3) could follow command, understand the content of the assessments, and cooperate with treatment interventions through verbal communication

You may not qualify if:

• (1) had the score of Geriatric Depression Scale-Short Form (GDS-SF) \> 7, indicating depression status
• (2) had the score of Barthel Index (BI)≠100, indicating dependent basic daily living of activities
• (3) were diagnosed with other MCI subtypes, including frontotemporal dementia or Lewy Body those present typically different MCI syndromes
• (4) had other neuropsychotic diseases
• (5) could not administrate with MEG
• (6) could not participate due to severe health problem

Sponsors & Collaborators

• Taipei Hospital, Taiwan: lead

Study Sites (1)

Taipei Hospital, Ministry of Health and Welfare

New Taipei City, 24213, Taiwan

Location

Related Publications (56)

• Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):270-9. doi: 10.1016/j.jalz.2011.03.008. Epub 2011 Apr 21.

  PMID: 21514249 BACKGROUND

• Bahar-Fuchs A, Clare L, Woods B. Cognitive training and cognitive rehabilitation for persons with mild to moderate dementia of the Alzheimer's or vascular type: a review. Alzheimers Res Ther. 2013 Aug 7;5(4):35. doi: 10.1186/alzrt189. eCollection 2013.

  PMID: 23924584 BACKGROUND

• Barnes DE, Yaffe K, Belfor N, Jagust WJ, DeCarli C, Reed BR, Kramer JH. Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):205-10. doi: 10.1097/WAD.0b013e31819c6137.

  PMID: 19812460 BACKGROUND

• Bruscoli M, Lovestone S. Is MCI really just early dementia? A systematic review of conversion studies. Int Psychogeriatr. 2004 Jun;16(2):129-40. doi: 10.1017/s1041610204000092.

  PMID: 15318760 BACKGROUND

• Caviness JN, Driver-Dunckley E, Connor DJ, Sabbagh MN, Hentz JG, Noble B, Evidente VG, Shill HA, Adler CH. Defining mild cognitive impairment in Parkinson's disease. Mov Disord. 2007 Jul 15;22(9):1272-7. doi: 10.1002/mds.21453.

  PMID: 17415797 BACKGROUND

• Chen Y, Denny KG, Harvey D, Farias ST, Mungas D, DeCarli C, Beckett L. Progression from normal cognition to mild cognitive impairment in a diverse clinic-based and community-based elderly cohort. Alzheimers Dement. 2017 Apr;13(4):399-405. doi: 10.1016/j.jalz.2016.07.151. Epub 2016 Aug 30.

  PMID: 27590706 BACKGROUND

• Cheng CH, Baillet S, Hsiao FJ, Lin YY. Effects of aging on neuromagnetic mismatch responses to pitch changes. Neurosci Lett. 2013 Jun 7;544:20-4. doi: 10.1016/j.neulet.2013.02.063. Epub 2013 Apr 2.

  PMID: 23562510 BACKGROUND

• Cheng CH, Baillet S, Hsiao FJ, Lin YY. Effects of aging on the neuromagnetic mismatch detection to speech sounds. Biol Psychol. 2015 Jan;104:48-55. doi: 10.1016/j.biopsycho.2014.11.003. Epub 2014 Nov 15.

  PMID: 25451380 BACKGROUND

• Cheng CH, Baillet S, Lin YY. Region-specific reduction of auditory sensory gating in older adults. Brain Cogn. 2015 Dec;101:64-72. doi: 10.1016/j.bandc.2015.10.004. Epub 2015 Oct 24.

  PMID: 26507900 BACKGROUND

• Davis RN, Massman PJ, Doody RS. Cognitive intervention in Alzheimer disease: a randomized placebo-controlled study. Alzheimer Dis Assoc Disord. 2001 Jan-Mar;15(1):1-9. doi: 10.1097/00002093-200101000-00001.

  PMID: 11236819 BACKGROUND

• De Vreese LP, Neri M, Fioravanti M, Belloi L, Zanetti O. Memory rehabilitation in Alzheimer's disease: a review of progress. Int J Geriatr Psychiatry. 2001 Aug;16(8):794-809. doi: 10.1002/gps.428.

  PMID: 11536347 BACKGROUND

• Gaitan A, Garolera M, Cerulla N, Chico G, Rodriguez-Querol M, Canela-Soler J. Efficacy of an adjunctive computer-based cognitive training program in amnestic mild cognitive impairment and Alzheimer's disease: a single-blind, randomized clinical trial. Int J Geriatr Psychiatry. 2013 Jan;28(1):91-9. doi: 10.1002/gps.3794. Epub 2012 Apr 3.

  PMID: 22473855 BACKGROUND

• Galante E, Venturini G, Fiaccadori C. Computer-based cognitive intervention for dementia: preliminary results of a randomized clinical trial. G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl B):B26-32.

  PMID: 18575355 BACKGROUND

• Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B; International Psychogeriatric Association Expert Conference on mild cognitive impairment. Mild cognitive impairment. Lancet. 2006 Apr 15;367(9518):1262-70. doi: 10.1016/S0140-6736(06)68542-5.

  PMID: 16631882 BACKGROUND

• Garcia-Casal JA, Loizeau A, Csipke E, Franco-Martin M, Perea-Bartolome MV, Orrell M. Computer-based cognitive interventions for people living with dementia: a systematic literature review and meta-analysis. Aging Ment Health. 2017 May;21(5):454-467. doi: 10.1080/13607863.2015.1132677. Epub 2016 Jan 25.

  PMID: 26806365 BACKGROUND

• Gelinas I, Gauthier L, McIntyre M, Gauthier S. Development of a functional measure for persons with Alzheimer's disease: the disability assessment for dementia. Am J Occup Ther. 1999 Sep-Oct;53(5):471-81. doi: 10.5014/ajot.53.5.471.

  PMID: 10500855 BACKGROUND

• Gomar JJ, Harvey PD, Bobes-Bascaran MT, Davies P, Goldberg TE. Development and cross-validation of the UPSA short form for the performance-based functional assessment of patients with mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry. 2011 Nov;19(11):915-22. doi: 10.1097/JGP.0b013e3182011846.

  PMID: 22024615 BACKGROUND

• Herrera C, Chambon C, Michel BF, Paban V, Alescio-Lautier B. Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia. 2012 Jul;50(8):1871-81. doi: 10.1016/j.neuropsychologia.2012.04.012. Epub 2012 Apr 21.

  PMID: 22525705 BACKGROUND

• Hill NT, Mowszowski L, Naismith SL, Chadwick VL, Valenzuela M, Lampit A. Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis. Am J Psychiatry. 2017 Apr 1;174(4):329-340. doi: 10.1176/appi.ajp.2016.16030360. Epub 2016 Nov 14.

  PMID: 27838936 BACKGROUND

• Hughes TF, Flatt JD, Fu B, Butters MA, Chang CC, Ganguli M. Interactive video gaming compared with health education in older adults with mild cognitive impairment: a feasibility study. Int J Geriatr Psychiatry. 2014 Sep;29(9):890-8. doi: 10.1002/gps.4075. Epub 2014 Jan 22.

  PMID: 24452845 BACKGROUND

• Huntley JD, Gould RL, Liu K, Smith M, Howard RJ. Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression. BMJ Open. 2015 Apr 2;5(4):e005247. doi: 10.1136/bmjopen-2014-005247.

  PMID: 25838501 BACKGROUND

• Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, Lopez OL, DeKosky ST. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000 Spring;12(2):233-9. doi: 10.1176/jnp.12.2.233.

  PMID: 11001602 BACKGROUND

• Klimova B, Maresova P. Computer-Based Training Programs for Older People with Mild Cognitive Impairment and/or Dementia. Front Hum Neurosci. 2017 May 16;11:262. doi: 10.3389/fnhum.2017.00262. eCollection 2017.

  PMID: 28559806 BACKGROUND

• Koepsell TD, Monsell SE. Reversion from mild cognitive impairment to normal or near-normal cognition: risk factors and prognosis. Neurology. 2012 Oct 9;79(15):1591-8. doi: 10.1212/WNL.0b013e31826e26b7. Epub 2012 Sep 26.

  PMID: 23019264 BACKGROUND

• Lee GY, Yip CC, Yu EC, Man DW. Evaluation of a computer-assisted errorless learning-based memory training program for patients with early Alzheimer's disease in Hong Kong: a pilot study. Clin Interv Aging. 2013;8:623-33. doi: 10.2147/CIA.S45726. Epub 2013 Jun 7.

  PMID: 23766638 BACKGROUND

• Lin F, Heffner KL, Ren P, Tivarus ME, Brasch J, Chen DG, Mapstone M, Porsteinsson AP, Tadin D. Cognitive and Neural Effects of Vision-Based Speed-of-Processing Training in Older Adults with Amnestic Mild Cognitive Impairment: A Pilot Study. J Am Geriatr Soc. 2016 Jun;64(6):1293-8. doi: 10.1111/jgs.14132.

  PMID: 27321608 BACKGROUND

• Liu CY, Lu CH, Yu S, Yang YY. Correlations between scores on Chinese versions of long and short forms of the Geriatric Depression Scale among elderly Chinese. Psychol Rep. 1998 Feb;82(1):211-4. doi: 10.2466/pr0.1998.82.1.211.

  PMID: 9520556 BACKGROUND

• Loewenstein DA, Acevedo A, Czaja SJ, Duara R. Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors. Am J Geriatr Psychiatry. 2004 Jul-Aug;12(4):395-402. doi: 10.1176/appi.ajgp.12.4.395.

  PMID: 15249277 BACKGROUND

• Manly JJ, Tang MX, Schupf N, Stern Y, Vonsattel JP, Mayeux R. Frequency and course of mild cognitive impairment in a multiethnic community. Ann Neurol. 2008 Apr;63(4):494-506. doi: 10.1002/ana.21326.

  PMID: 18300306 BACKGROUND

• Mao HF, Kuo CA, Huang WN, Cummings JL, Hwang TJ. Values of the Minimal Clinically Important Difference for the Neuropsychiatric Inventory Questionnaire in Individuals with Dementia. J Am Geriatr Soc. 2015 Jul;63(7):1448-52. doi: 10.1111/jgs.13473. Epub 2015 Jun 5.

  PMID: 26046666 BACKGROUND

• Mitchell AJ, Shiri-Feshki M. Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand. 2009 Apr;119(4):252-65. doi: 10.1111/j.1600-0447.2008.01326.x. Epub 2008 Feb 18.

  PMID: 19236314 BACKGROUND

• Mok CC, Siu AM, Chan WC, Yeung KM, Pan PC, Li SW. Functional disabilities profile of chinese elderly people with Alzheimer's disease - a validation study on the chinese version of the disability assessment for dementia. Dement Geriatr Cogn Disord. 2005;20(2-3):112-9. doi: 10.1159/000086612. Epub 2005 Jun 30.

  PMID: 15990425 BACKGROUND

• Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993 Nov;43(11):2412-4. doi: 10.1212/wnl.43.11.2412-a. No abstract available.

  PMID: 8232972 BACKGROUND

• Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9. doi: 10.1111/j.1532-5415.2005.53221.x.

  PMID: 15817019 BACKGROUND

• Neely AS, Vikstrom S, Josephsson S. Collaborative memory intervention in dementia: caregiver participation matters. Neuropsychol Rehabil. 2009 Oct;19(5):696-715. doi: 10.1080/09602010902719105. Epub 2009 Aug 21.

  PMID: 19294562 BACKGROUND

• O'Caoimh R, Gao Y, McGlade C, Healy L, Gallagher P, Timmons S, Molloy DW. Comparison of the quick mild cognitive impairment (Qmci) screen and the SMMSE in screening for mild cognitive impairment. Age Ageing. 2012 Sep;41(5):624-9. doi: 10.1093/ageing/afs059. Epub 2012 May 18.

  PMID: 22610464 BACKGROUND

• Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, Ivnik RJ, Smith GE, Jack CR Jr. Mild cognitive impairment: ten years later. Arch Neurol. 2009 Dec;66(12):1447-55. doi: 10.1001/archneurol.2009.266.

  PMID: 20008648 BACKGROUND

• Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999 Mar;56(3):303-8. doi: 10.1001/archneur.56.3.303.

  PMID: 10190820 BACKGROUND

• Quayhagen MP, Quayhagen M, Corbeil RR, Roth PA, Rodgers JA. A dyadic remediation program for care recipients with dementia. Nurs Res. 1995 May-Jun;44(3):153-9.

  PMID: 7761291 BACKGROUND

• Rabipour S, Raz A. Training the brain: fact and fad in cognitive and behavioral remediation. Brain Cogn. 2012 Jul;79(2):159-79. doi: 10.1016/j.bandc.2012.02.006. Epub 2012 Mar 30.

  PMID: 22463872 BACKGROUND

• Schafer KA, Tractenberg RE, Sano M, Mackell JA, Thomas RG, Gamst A, Thal LJ, Morris JC; Alzheimer's Disease Cooperative Study. Reliability of monitoring the clinical dementia rating in multicenter clinical trials. Alzheimer Dis Assoc Disord. 2004 Oct-Dec;18(4):219-22.

  PMID: 15592134 BACKGROUND

• Spector A, Davies S, Woods B, Orrell M. Reality orientation for dementia: a systematic review of the evidence of effectiveness from randomized controlled trials. Gerontologist. 2000 Apr;40(2):206-12. doi: 10.1093/geront/40.2.206.

  PMID: 10820923 BACKGROUND

• Spector A, Orrell M, Woods B. Cognitive Stimulation Therapy (CST): effects on different areas of cognitive function for people with dementia. Int J Geriatr Psychiatry. 2010 Dec;25(12):1253-8. doi: 10.1002/gps.2464.

  PMID: 20069533 BACKGROUND

• Spector A, Thorgrimsen L, Woods B, Royan L, Davies S, Butterworth M, Orrell M. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. Br J Psychiatry. 2003 Sep;183:248-54. doi: 10.1192/bjp.183.3.248.

  PMID: 12948999 BACKGROUND

• Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ. A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan. PLoS One. 2014 Jun 18;9(6):e100303. doi: 10.1371/journal.pone.0100303. eCollection 2014.

  PMID: 24940604 BACKGROUND

• Royle J, Lincoln NB. The Everyday Memory Questionnaire-revised: development of a 13-item scale. Disabil Rehabil. 2008;30(2):114-21. doi: 10.1080/09638280701223876.

  PMID: 17852284 BACKGROUND

• Tarraga L, Boada M, Modinos G, Espinosa A, Diego S, Morera A, Guitart M, Balcells J, Lopez OL, Becker JT. A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1116-21. doi: 10.1136/jnnp.2005.086074. Epub 2006 Jul 4.

  PMID: 16820420 BACKGROUND

• Tierney MC, Szalai JP, Snow WG, Fisher RH, Nores A, Nadon G, Dunn E, St George-Hyslop PH. Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study. Neurology. 1996 Mar;46(3):661-5. doi: 10.1212/wnl.46.3.661.

  PMID: 8618663 BACKGROUND

• Tsai CF, Lee WJ, Wang SJ, Shia BC, Nasreddine Z, Fuh JL. Psychometrics of the Montreal Cognitive Assessment (MoCA) and its subscales: validation of the Taiwanese version of the MoCA and an item response theory analysis. Int Psychogeriatr. 2012 Apr;24(4):651-8. doi: 10.1017/S1041610211002298. Epub 2011 Dec 12.

  PMID: 22152127 BACKGROUND

• Tsai JC, Chen CW, Chu H, Yang HL, Chung MH, Liao YM, Chou KR. Comparing the Sensitivity, Specificity, and Predictive Values of the Montreal Cognitive Assessment and Mini-Mental State Examination When Screening People for Mild Cognitive Impairment and Dementia in Chinese Population. Arch Psychiatr Nurs. 2016 Aug;30(4):486-91. doi: 10.1016/j.apnu.2016.01.015. Epub 2016 Jan 21.

  PMID: 27455923 BACKGROUND

• Valenzuela M, Sachdev PS. Harnessing brain and cognitive reserve for the prevention of dementia. Indian J Psychiatry. 2009 Jan;51 Suppl 1(Suppl1):S16-21.

  PMID: 21416010 BACKGROUND

• Woods B, Aguirre E, Spector AE, Orrell M. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD005562. doi: 10.1002/14651858.CD005562.pub2.

  PMID: 22336813 BACKGROUND

• Yoon JH, Lee JE, Yong SW, Moon SY, Lee PH. The mild cognitive impairment stage of dementia with Lewy bodies and Parkinson disease: a comparison of cognitive profiles. Alzheimer Dis Assoc Disord. 2014 Apr-Jun;28(2):151-5. doi: 10.1097/WAD.0000000000000007.

  PMID: 24126215 BACKGROUND

• Yuill N, Hollis V. A systematic review of cognitive stimulation therapy for older adults with mild to moderate dementia: an occupational therapy perspective. Occup Ther Int. 2011 Dec;18(4):163-86. doi: 10.1002/oti.315. Epub 2011 Mar 21.

  PMID: 21425381 BACKGROUND

• Gershon RC, Cella D, Fox NA, Havlik RJ, Hendrie HC, Wagster MV. Assessment of neurological and behavioural function: the NIH Toolbox. Lancet Neurol. 2010 Feb;9(2):138-9. doi: 10.1016/S1474-4422(09)70335-7. No abstract available.

  PMID: 20129161 BACKGROUND

• Gershon RC, Wagster MV, Hendrie HC, Fox NA, Cook KF, Nowinski CJ. NIH toolbox for assessment of neurological and behavioral function. Neurology. 2013 Mar 12;80(11 Suppl 3):S2-6. doi: 10.1212/WNL.0b013e3182872e5f.

  PMID: 23479538 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Occupational Therapy

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics

Study Officials

• Wan-ying Chang, MS

  Division of Occupational Therapy,Taipei Hospital, Ministry of Health and Welfare

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: occupational therapist

Study Record Dates

• First Submitted: June 4, 2018
• First Posted: July 5, 2018
• Study Start: July 13, 2018
• Primary Completion: February 13, 2019
• Study Completion: March 11, 2019
• Last Updated: February 17, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)