The Effects of Different Montages of tDCS on Muscle Strength in Healthy Adults

NCT04672109 | Completed

• 1 other identifier: MU2020
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the effects of different montages of tDCS on muscle strength in healthy adults

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Change from baseline muscle strength after tDCS

  Muscle strength will be measured in Newton by using a hand-held dynamometer.

  Baseline (Pretest) and 40 minutes ( posttest)

Study Arms (4)

Anodal-tDCS

EXPERIMENTAL

Anodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the supraorbital area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.

Device: Transcranial direct current stimulation

Cathodal-tDCS

EXPERIMENTAL

Cathodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) of non-dominant hemisphere and Anode on the supraorbital area of dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.

Device: Transcranial direct current stimulation

Dual-tDCS

EXPERIMENTAL

Dual transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the primary motor area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.

Device: Transcranial direct current stimulation

Sham-tDCS

SHAM COMPARATOR

Dual transcranial direct current stimulation (tDCS) will be applied over C3-C4 or the motor area (M1) for 20 mins. Anode on dominant hemisphere, Cathode on non-dominant hemisphere. The scope of intervention is to investigate effect of tDCS on muscle strength.

Device: Transcranial direct current stimulation

Interventions

Transcranial direct current stimulation DEVICE

Dual/Cathodal/Anodal/Sham tDCS will be applied in 2 mA, 20 mins. All experiments will be performed in random order for each subject.

Anodal-tDCS; Cathodal-tDCS; Dual-tDCS; Sham-tDCS

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults
• Age range between 18 - 60 years old
• Right-handed dominant identified by the Edinburg Handedness Inventory
• No recent muscle injuries of both limbs for a past 6-months

You may not qualify if:

• Consumed caffeine within 24 hours prior the experiment
• History of neurological symptoms i.e. seizures, weakness, loss of sensation or unclear history of pass illness
• Present of metal implantation, intracranial shunt, cochlear implantation or cardiac pacemakers
• Present of opened wound or infectious wound around scalp

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of Physical Therapy, Mahidol University

Salaya, Changwat Nakhon Pathom, 73170, Thailand

Location

MeSH Terms

Interventions

Transcranial Direct Current Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Officials

• Wanalee Klomjai, PhD

  MU

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2020
• First Posted: December 17, 2020
• Study Start: November 16, 2020
• Primary Completion: May 31, 2022
• Study Completion: May 31, 2022
• Last Updated: June 22, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)