Normal Brain Imaging Database for Brain Disorder Studies
Normal_tDCS
1 other identifier
interventional
40
1 country
1
Brief Summary
Healthy volunteers will be recruited. All subjects will be tested a battery of neuropsychological tests, then undergo fluorodeoxyglucose-positron emission tomography (PET) and magnetic resonance imaging (MRI). During the PET and MRI, they will be stimulated with transcranial direct current stimulation (tDCS) for 15 minutes. A third of subjects will receive real tDCS on the left prefrontal cortex, a third on the right prefrontal cortex, and the other third will receive sham tDCS.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable healthy
Started Jun 2017
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 16, 2017
CompletedFirst Posted
Study publicly available on registry
January 23, 2017
CompletedStudy Start
First participant enrolled
June 28, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 11, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2025
CompletedApril 3, 2025
March 1, 2025
2.7 years
January 16, 2017
March 28, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
functional connectivity
The functional connectivity of the right caudate nucleus will be estimated using graph theory analysis technique of resting-state fMRI.
immediate (less than 30 minutes)
Secondary Outcomes (1)
Stroop task performance
immediate (less than 60 minutes)
Study Arms (3)
Real Left DLPFC tDCS
ACTIVE COMPARATORReal tDCS on the left dorsolateral prefrontal cortex
Sham tDCS
SHAM COMPARATOR30sec ramp-up and 30sec ramp-down
Real Right DLPFC tDCS
ACTIVE COMPARATORReal tDCS on the right dorsolateral prefrontal cortex
Interventions
15 minute anodal stimulation 1.5mA
Eligibility Criteria
You may qualify if:
- N/A
You may not qualify if:
- History of any neurological or psychiatric diseases;
- Abnormal MRI;
- metal implants or a cardiac pacemaker;
- Pregnant or breastfeeding women (female subjects of child bearing potential will be screened for pregnancy before MRI imaging).
- severe hypertension.
- cardiovascular disease.
- Family history of epilepsy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Manitoba
Winnipeg, Manitoba, R3E 0J9, Canada
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
January 16, 2017
First Posted
January 23, 2017
Study Start
June 28, 2017
Primary Completion
March 11, 2020
Study Completion
December 31, 2025
Last Updated
April 3, 2025
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share