NCT04873804

Brief Summary

Background: Transcranial direct current stimulation(tDCS) has been used to improve cognitive functions in healthy young adults. Purpose: To investigate the effect of TDCS application on different cortex regions on cognitive function. Methods: Sixty individuals aged 18-30 were included in the study. The participants were randomly divided into the left dorsolateral prefrontal cortex (Left DLPFC Group)(n=20), the right posterior parietal cortex (Right PPC Group)(n=20), and the sham group (Sham Group)(n=20). tDCS was applied for 20 minutes on weekdays for 2 weeks. The participants were evaluated in terms of cognitive functions with Neuropsychometric Test Battery before and after treatment.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
57

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Oct 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 10, 2019

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 10, 2020

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 10, 2020

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

April 14, 2021

Completed
21 days until next milestone

First Posted

Study publicly available on registry

May 5, 2021

Completed
Last Updated

May 5, 2021

Status Verified

May 1, 2021

Enrollment Period

7 months

First QC Date

April 14, 2021

Last Update Submit

May 4, 2021

Conditions

Cognitive SymptomHealthy

Keywords

tDCSDorsolateral Prefrontal CortexPosterior Parietal CortexCognitive Function

Outcome Measures

Primary Outcomes (2)

  • Neuropsychiatric Test Battery

    It is a test battery for getting detailed information about general cognitive status.

    3 weeks

  • Beck Depression Scale

    It measures the symptoms seen in depression such as emotional, cognitive and motivational. It includes 21 items determine a behavioral feature related to depression. Items are numbered from 0 to 3. The goal is to objectively break down the degree of symptoms. The total score of all answers is calculated as follows: 0 to 9 points: Minimally depressive symptoms 10 to 16 points: Mild depressive symptoms Between 17 and 29 points: Moderate depressive symptoms Between 30 and 63 points: Severe depressive symptoms

    3 weeks

Study Arms (3)

LEFT DLPFC

ACTIVE COMPARATOR

The anode electrode of tDCS was applied to the left DLPFC and the cathode electrode was connected to the contralateral shoulder.

Other: Transcranial Direct Current Stimulation

RİGHT PPC

ACTIVE COMPARATOR

The anode electrode of tDCS was applied to the right PPC and the cathode electrode was connected to the contralateral shoulder.

Other: Transcranial Direct Current Stimulation

Sham

SHAM COMPARATOR

Placebo was applied by placing the electrodes in the right PPC and left DLPFC without applying current.

Other: Transcranial Direct Current Stimulation

Interventions

Transcranial Direct Current StimulationOTHER

The intervention protocols were applied using tDCS (Teknofil TESsaNova). All individuals received 2 mA of anodal tDCS for 2 weeks on weekdays. All applications were done in the form of 20-minute sessions.

LEFT DLPFCRİGHT PPCSham

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • being 18-30 years old

You may not qualify if:

  • alcohol and substance addiction
  • previous mental illness
  • having mental and cognitive problems
  • a history of head trauma
  • having cardiovascular disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Damla Ören

Istanbul, 34000, Turkey (Türkiye)

Location

Medipol Mega Hospital

Istanbul, 34000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Neurobehavioral Manifestations

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Neurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Electric Stimulation TherapyTherapeuticsConvulsive TherapyPsychiatric Somatic TherapiesBehavioral Disciplines and ActivitiesElectroshockPsychological Techniques

Study Officials

  • Miray Budak, PhD

    Medipol University

    PRINCIPAL INVESTIGATOR

  • Lutfu Hanoglu, PhD

    Medipol University

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Physiotherapist MSc

Study Record Dates

First Submitted

April 14, 2021

First Posted

May 5, 2021

Study Start

October 10, 2019

Primary Completion

May 10, 2020

Study Completion

June 10, 2020

Last Updated

May 5, 2021

Record last verified: 2021-05

Locations

TU(2)