Cognitive Stimulation Study

NCT02067689 | Completed

• 1 other identifier: IRB201300836
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the influence of non-invasive brain stimulation on different elements of cognitive function in healthy persons between the ages of 18-90 years. It will specifically use transcranial direct current stimulation (tDCS) to evaluate the relationship between certain brain structures and cognitive abilities, like attention, working memory, visual search, etc.

Conditions

Healthy

Keywords

Normal cognition in healthy adults; Cognitive function; Transcranial direct current stimulation; Structural Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (2)

• NIH Toolbox Scores

  Baseline

• NIH Toolbox Scores

  1 hour after baseline

Study Arms (6)

Hemisphere Stimulation

EXPERIMENTAL

Participants will receive 1mA vs. 2mA transcranial direct current stimulation of a) right and b) left brain structures (1x1 stimulation), and sham/placebo stimulation. A subset of participants will undergo right and left brain stimulation, but all will undergo sham stimulation.

Device: Transcranial Direct Current Stimulation

Temporal Lobe Stimulation

EXPERIMENTAL

A group of participants will undergo 1x1 transcranial direct current stimulation of the temporal lobes at 1 mA vs. 2 mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left structures using 4x1 stimulation (e.g., 1mA left temporal, 1mA right temporal, sham; 2mA left temporal, 2mA right temporal, sham).

Device: Transcranial Direct Current Stimulation

Frontal Lobe Stimulation

EXPERIMENTAL

A group of participants will undergo 1x1 transcranial direct current stimulation of the frontal lobes at 1 mA vs. 2 mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left frontal structures using 4x1 stimulation (e.g., 1mA left frontal, 1mA right frontal, sham; 2mA left frontal, 2mA right frontal, sham).

Device: Transcranial Direct Current Stimulation

Parietal Lobe Stimulation

EXPERIMENTAL

A group of participants will undergo 1x1 transcranial direct current stimulation of the parietal lobes at 1 mA vs. 2 mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left parietal lobes using 4x1 stimulation (e.g., 1mA left parietal lobes, 1mA right parietal lobes, sham; 2mA parietal lobes, 2mA right parietal lobes, sham).

Device: Transcranial Direct Current Stimulation

Supplementary Motor Stimulation

EXPERIMENTAL

A group of participants will undergo 1x1 transcranial direct current stimulation of the Supplementary Motor Area at 1mA vs. 2mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left Supplementary Motor Area using 4x1 stimulation (e.g., 1mA left Supplementary Motor Area, 1mA right Supplementary Motor Area, sham; 2mA left Supplementary Motor Area, 2mA right Supplementary Motor Area, sham).

Device: Transcranial Direct Current Stimulation

Brain Structure Interactions Group

EXPERIMENTAL

This cohort will evaluate the interaction between frontal, parietal, temporal, and SMA regions in cognitive function. To accomplish this goal will require evaluation of change in cognitive and neurocognitive performance following transcranial direct current stimulation of different brain regions within the same subjects. For example, we will evaluate the contribution of frontal, SMA, and parietal regions by asking participants to undergo stimulation sessions at each of these sites, in addition to a sham session.

Device: Transcranial Direct Current Stimulation

Interventions

Transcranial Direct Current Stimulation DEVICE

Application of a weak electrical current to the scalp

Also known as: Soterix DC Stimulator, Neuroconn DC Stimulator MR

Brain Structure Interactions Group; Frontal Lobe Stimulation; Hemisphere Stimulation; Parietal Lobe Stimulation; Supplementary Motor Stimulation; Temporal Lobe Stimulation

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy adult
• Eligible to undergo an MRI

You may not qualify if:

• History of neurologic disease or dementia
• History of psychiatric disease which required hospitalization, or
• Current depression
• History of head trauma with unconsciousness
• Developmental learning disability (e.g., dyslexia, dyscalculia)
• History of vital organ failure (e.g., heart, lungs, kidneys, liver)
• Currently taking any psycho-active medications
• Pregnancy

Sponsors & Collaborators

• University of Florida: lead

Study Sites (1)

University of Florida

Gainesville, Florida, 32610, United States

Location

MeSH Terms

Interventions

Transcranial Direct Current Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Officials

• Adam J Woods, PhD

  University of Florida

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 7, 2014
• First Posted: February 20, 2014
• Study Start: January 1, 2016
• Primary Completion: May 10, 2019
• Study Completion: May 10, 2019
• Last Updated: January 28, 2020

Record last verified: 2019-05

Locations

US (1)