Effects of Different Intensities of Bilateral-transcranial Direct Current Stimulation in Healthy Individuals

NCT05929014 | Completed

• 1 other identifier: MU-CIRB 2023/016.1601
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the effects of 1 mA, 1.5 mA, and 2 mA of bilateral- tDCS on cortical activity and motor learning in healthy individuals

Conditions

Healthy

Keywords

tDCS; Cortical activity; Healthy; Motor learning; Brain symmetry index

Outcome Measures

Primary Outcomes (2)

• Cortical activity

  Acquired by electroencephalography (EEG)

  5 minutes

• The reaction time

  Measured the reaction time from serial reaction time task

  30 minutes

Study Arms (2)

Active bilateral-tDCS

ACTIVE COMPARATOR

Participants will be received different intensities which are 1 mA, 1.5 mA and 2 mA for 20 minutes during performed serial reaction time task. The tDCS will be set with bilateral montage which applied anodal electrode over left hemisphere and cathodal electrode over right hemisphere.

Device: Bilateral-Transcranial direct current stimulation (bilateral-tDCS)

Sham bilateral-tDCS

SHAM COMPARATOR

Participants will be received sham of bilateral tDCS during performed serial reaction time task.

Device: Sham bilateral-tDCS

Interventions

Bilateral-Transcranial direct current stimulation (bilateral-tDCS) DEVICE

The tDCS is non-invasive brain stimulation technique applied over the participant's scalp using a reference to the International 10-20 electrode Placement System for EEG electrode placement. The cathodal and anodal electrodes will be applied over the right and left primary motor areas, respectively.

Also known as: MINDD STIM; Ybrain Inc., Korea

Active bilateral-tDCS

Sham bilateral-tDCS DEVICE

Sham bilateral-tDCS

Sham bilateral-tDCS

Eligibility Criteria

• Age: 18 Years - 29 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \. Age 18-29 years old
• \. Righ-hand dominant according to the Edinburgh handedness inventory
• \. No injury to both upper and lower limb for the past 6 months

You may not qualify if:

• \. Presence of any neurological disorders
• \. Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers
• \. Presence of opened wound or infectious wound around scalp
• \. History of epilepsy or any neurological antecedent or unstable condition which can lead to seizure
• \. Body mass index (BMI) \> 30 kg/m2
• \. Received hormonal treatment and/or drugs that increase sleepiness and affect movement control
• \. Ischemic heart disease and peripheral vascular ischemia
• \. Last stage of kidney disease and liver disease

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of Physical Therapy, Mahidol University

Salaya, Nakonpathom, 73170, Thailand

Location

Study Officials

• Wanalee Klomjai, PhD

  Mahidol University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The participants who will participate in the study will be randomly received 1 mA or 1.5 mA or 2 mA or sham with the washout period for at least 2 weeks.

Study Record Dates

• First Submitted: June 25, 2023
• First Posted: July 3, 2023
• Study Start: June 24, 2023
• Primary Completion: November 30, 2023
• Study Completion: February 28, 2025
• Last Updated: June 3, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)