NCT04672122

Brief Summary

To investigate the effects of different intensity of cathodal tDCS on muscle strength in healthy adults.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 16, 2020

Completed
23 days until next milestone

First Submitted

Initial submission to the registry

December 9, 2020

Completed
8 days until next milestone

First Posted

Study publicly available on registry

December 17, 2020

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2022

Completed
Last Updated

June 22, 2022

Status Verified

June 1, 2022

Enrollment Period

1.4 years

First QC Date

December 9, 2020

Last Update Submit

June 19, 2022

Conditions

Healthy Participants

Outcome Measures

Primary Outcomes (1)

  • Change from baseline muscle strength after tDCS

    Muscle strength will be measured in Newton by using a hand-held dynamometer.

    Baseline (Pretest) and 40 minutes ( posttest)

Study Arms (4)

Sham tDCS

SHAM COMPARATOR

Sham transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) and Anode on the supraorbital area of contralateral side. Current intensity will be at 2 mA (sham mode). The scope of intervention is to investigate effect of sham tDCS on muscle strength.

Device: Transcranial direct current stimulation

Cathodal-tDCS 1 mA

EXPERIMENTAL

Cathodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) and Anode on the supraorbital area of contralateral side. Current intensity is fixed at 1 mA and current will flow continuously. The scope of intervention is to investigate effect of cathodal tDCS on muscle strength.

Device: Transcranial direct current stimulation

Cathodal-tDCS 1.5 mA

EXPERIMENTAL

Cathodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) and Anode on the supraorbital area of contralateral side. Current intensity is fixed at 1.5 mA and current will flow continuously. The scope of intervention is to investigate effect of cathodal tDCS on muscle strength.

Device: Transcranial direct current stimulation

Cathodal-tDCS 2 mA

EXPERIMENTAL

Cathodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) and Anode on the supraorbital area of contralateral side. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of cathodal tDCS on muscle strength.

Device: Transcranial direct current stimulation

Interventions

Transcranial direct current stimulationDEVICE

Cathodal tDCS will be applied for 20 mins.

Cathodal-tDCS 1 mACathodal-tDCS 1.5 mACathodal-tDCS 2 mASham tDCS

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Male and female healthy adults
  • Age range between 18 - 60 years old
  • Right-handed dominant identified by the Edinburg Handedness Inventory
  • No recent muscle injuries of both limbs for a past 6-months

You may not qualify if:

  • Consumed caffeine within 24 hours prior the experiment
  • History of neurological symptoms i.e. seizures, weakness, loss of sensation or unclear history of pass illness
  • Presence of metal implantation, intracranial shunt, cochlear implantation or cardiac pacemakers
  • Presence of opened wound or infectious wound around scalp
  • Presence of pain in evaluating muscle groups
  • History of surgery in evaluating limbs

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Physical Therapy, Mahidol University

Salaya, Changwat Nakhon Pathom, 73170, Thailand

Location

Related Publications (1)

  • Vimolratana O, Lackmy-Vallee A, Aneksan B, Hiengkaew V, Klomjai W. Non-linear dose response effect of cathodal transcranial direct current stimulation on muscle strength in young healthy adults: a randomized controlled study. BMC Sports Sci Med Rehabil. 2023 Jan 30;15(1):10. doi: 10.1186/s13102-023-00621-7.

    PMID: 36717894DERIVED

MeSH Terms

Interventions

Transcranial Direct Current Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation TherapyTherapeuticsConvulsive TherapyPsychiatric Somatic TherapiesBehavioral Disciplines and ActivitiesElectroshockPsychological Techniques

Study Officials

  • Wanalee Klomjai, PhD

    MU

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 9, 2020

First Posted

December 17, 2020

Study Start

November 16, 2020

Primary Completion

March 31, 2022

Study Completion

March 31, 2022

Last Updated

June 22, 2022

Record last verified: 2022-06

Data Sharing

IPD Sharing
Will not share

Locations

TH(1)