Cortical Activation and Cognitive-Motor Learning

NCT04666181 | Completed DMC

• 1 other identifier: 20-001938
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to assess the effects of dual-task training using a dynamic balance task and an auditory reaction time task on dual-task performance in healthy young adults and to assess the cortical activity within the prefrontal and sensorimotor cortices in response to dual-task training using functional near infrared spectroscopy (fNIRS).

Conditions

Dual-task; Healthy Adults

Keywords

Cognition; Motor; Dual-task; Prefrontal cortex; Sensorimotor cortex

Outcome Measures

Primary Outcomes (4)

• Change in auditory reaction time task performance

  Average amount of time in seconds for a button press in response to an auditory tone

  Baseline to 10 days, and upto 3 weeks. Shorter reaction time indicates better performance.

• Change in balance task performance

  The average amount of time in seconds that a participant maintains the stability platform within 3 degrees of horizontal position during 6 trials of 30 sec each. The total score will range between 0-30 s. Higher balance score indicates better balance performance.

  Baseline to 10 days, and upto 3 weeks

• Change in dual-task performance

  Dual-task performance will assess performance on the combined auditory reaction time task and the balance task, i.e. performance under influence of dual-task situation.

  Baseline to 10 days, and upto 3 weeks

• Change in Cortical Activation

  The amount of change in cortical activity (change in oxyhemoglobin concentration in umol) within the prefrontal and sensorimotor cortices in response to dual-task training.

  Baseline to 10 days, and upto 3 weeks

Secondary Outcomes (2)

• Errors in auditory reaction time task performance

  Baseline to 10 days, and upto 3 weeks

• Balance variability

  Baseline to 10 days, and upto 3 weeks

Study Arms (1)

Dual-task training

EXPERIMENTAL

Dual-task training will consist of balancing on the dynamic stability platform and responding to auditory stimuli. Participants will perform 18 trials total in 3 blocks of 6 trials. Each trial will be 30 seconds (s) in duration followed by 30 s of rest (i.e. quiet standing on the platform while holding onto the rails.) Between each training block, the participant will step off the platform and rest for 2 minutes. Dual-task training will occur on consecutive visits 2-6.

Behavioral: Dual-task training

Interventions

Dual-task training BEHAVIORAL

See descriptions under arm description. The dual-task training will occur across a total of 5 consecutive workday visits.

Dual-task training

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy young adults
• Right-handed

You may not qualify if:

• Individuals with cognitive deficits or communication problems
• Individuals with impaired vision
• Individuals with balance disorders such as vestibular disorders, etc.
• Individuals with known cardiorespiratory dysfunctions
• Individuals with presence of lower extremity condition, injury, or surgery within last 3 months which could compromise training
• Individuals with history of concussion

Sponsors & Collaborators

• East Carolina University: lead

Study Sites (1)

East Carolina University

Greenville, North Carolina, 27834, United States

Location

Related Publications (6)

• Beauchet O, Dubost V, Herrmann FR, Kressig RW. Stride-to-stride variability while backward counting among healthy young adults. J Neuroeng Rehabil. 2005 Aug 11;2:26. doi: 10.1186/1743-0003-2-26.

  PMID: 16095533 BACKGROUND

• Fraser SA, Li KZ, Berryman N, Desjardins-Crepeau L, Lussier M, Vadaga K, Lehr L, Minh Vu TT, Bosquet L, Bherer L. Does Combined Physical and Cognitive Training Improve Dual-Task Balance and Gait Outcomes in Sedentary Older Adults? Front Hum Neurosci. 2017 Jan 18;10:688. doi: 10.3389/fnhum.2016.00688. eCollection 2016.

  PMID: 28149274 BACKGROUND

• Ghai S, Ghai I, Effenberg AO. Effects of dual tasks and dual-task training on postural stability: a systematic review and meta-analysis. Clin Interv Aging. 2017 Mar 23;12:557-577. doi: 10.2147/CIA.S125201. eCollection 2017.

  PMID: 28356727 BACKGROUND

• Kiss R, Brueckner D, Muehlbauer T. Effects of Single Compared to Dual Task Practice on Learning a Dynamic Balance Task in Young Adults. Front Psychol. 2018 Mar 12;9:311. doi: 10.3389/fpsyg.2018.00311. eCollection 2018.

  PMID: 29593614 BACKGROUND

• Pinti P, Tachtsidis I, Hamilton A, Hirsch J, Aichelburg C, Gilbert S, Burgess PW. The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience. Ann N Y Acad Sci. 2020 Mar;1464(1):5-29. doi: 10.1111/nyas.13948. Epub 2018 Aug 7.

  PMID: 30085354 BACKGROUND

• Techayusukcharoen R, Iida S, Aoki C. Observing brain function via functional near-infrared spectroscopy during cognitive program training (dual task) in young people. J Phys Ther Sci. 2019 Jul;31(7):550-555. doi: 10.1589/jpts.31.550. Epub 2019 Jul 9.

  PMID: 31417220 BACKGROUND

Study Officials

• Swati M Surkar, PhD

  East Carolina University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 23, 2020
• First Posted: December 14, 2020
• Study Start: January 15, 2021
• Primary Completion: August 30, 2021
• Study Completion: November 30, 2021
• Last Updated: January 19, 2022

Record last verified: 2022-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: Data will be available immediately after completion of the study.

Locations

US (1)