Effects of Dual-Task Training on Upper Extremity Function in Parkinson's Disease

NCT07536542 | Not Yet Recruiting

• 1 other identifier: f57111e3114a4f65
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to investigate the effects of dual-task training on upper extremity function and muscle thickness in individuals with Parkinson's disease. The main questions it aims to answer are: Does dual-task training improve upper extremity function in individuals with Parkinson's disease? Does dual-task training lead to changes in upper extremity muscle thickness measured by ultrasonography? Researchers will compare a dual-task training group with a control group receiving routine care to determine whether 8 weeks of dual-task training results in greater improvements in upper extremity outco Participants will: complete baseline and post-intervention assessments of upper extremity function, muscle thickness, grip strength, and pinch strength be assigned to either a control group or a dual-task training group receive dual-task training 3 days per week for 8 weeks if assigned to the intervention group

Conditions

Parkinson Disease (PD)

Keywords

Parkinson Disease; Dual-Task Training; Upper Extremity Function; Muscle Thickness; Ultrasonography

Outcome Measures

Primary Outcomes (4)

• Upper Extremity Function

  Upper extremity function will be assessed using the Purdue Pegboard Test. Performance will be recorded as the number of pins placed within the specified time for dominant hand, nondominant hand, and both hands; higher scores indicate better fine motor performance and manual dexterity.

  Baseline and 8 weeks

• Upper Extremity Muscle Thickness

  Muscle thickness of the deltoid, biceps brachii, triceps brachii, and forearm flexor muscles will be measured using ultrasonography. The mean of three repeated measurements for each site will be recorded in millimeters.

  Baseline and 8 weeks

• Hand Grip Strength

  Hand grip strength will be measured using a Jamar hydraulic hand dynamometer according to the ASHT protocol. The mean of three trials will be recorded.

  Baseline and 8 weeks

• Pinch Strength

  Lateral pinch, three-jaw chuck pinch, and two-point pinch strength will be assessed using a pinch meter. The mean of three trials will be recorded in kilograms or Newtons.

  Baseline and 8 weeks

Study Arms (2)

Dual-Task Training Group

EXPERIMENTAL

Participants will receive dual-task training in addition to their routine daily activities. The training program will be performed 3 times per week for 8 weeks, with each session lasting 60 minutes and consisting of combined motor and cognitive tasks.

Behavioral: Dual-Task Training

Control Group

NO INTERVENTION

Participants will continue their routine daily activities without receiving any additional exercise, training, or rehabilitation intervention during the study period.

Interventions

Dual-Task Training BEHAVIORAL

Dual-task training will be applied 3 times per week for 8 weeks, with each session lasting 60 minutes. The program combines motor tasks (such as peg placement, object manipulation, bilateral coordination, and mobility tasks) with simultaneous cognitive tasks (such as backward counting, category-based word generation, and memory tasks).

Dual-Task Training Group

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of idiopathic Parkinson's disease confirmed by a neurologist
• Modified Hoehn and Yahr stage 2 to 3
• No medication or dosage change within the last 6 months
• Cognitive capacity sufficient to understand and follow instructions, defined as Montreal Cognitive Assessment score ≥21
• Voluntary participation with written informed consent

You may not qualify if:

• Atypical or secondary parkinsonism
• Advanced orthopedic condition affecting the upper extremity
• Surgery, trauma, or immobilization involving the upper extremity within the last 6 months
• Wound or dermatological condition preventing upper extremity ultrasonographic evaluation
• Severe visual or hearing loss
• Severe depression, psychosis, or communication difficulty
• Any additional health problem preventing regular participation in the study

Sponsors & Collaborators

• Ankara University: lead
• Hacettepe University: collaborator

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Büşra Seçkinoğulları Korkusuz

  Ankara University

  PRINCIPAL INVESTIGATOR

• Süleyman Korkusuz

  Atılım University

  STUDY CHAIR

• Ayşenur Özcan

  Çankırı Karatekin University

  STUDY CHAIR

• Ayla Fil

  Hacettepe University

  STUDY CHAIR

• Gül Yalçın Çakmaklı

  Hacettepe University

  STUDY CHAIR

Central Study Contacts

Büşra Seçkinoğulları Korkusuz, PhD

CONTACT

+905442436914; bskorkusuz@ankara.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assist. Prof. Dr

Model Details: Participants will be randomly assigned to either a dual-task training group or a control group using block randomization. The dual-task training group will receive a structured exercise program consisting of combined motor and cognitive tasks, performed 3 times per week for 8 weeks, in addition to their usual daily activities. The control group will continue their routine daily life without receiving any additional intervention. Outcome assessments will be conducted at baseline and after 8 weeks by a blinded evaluator.

Study Record Dates

• First Submitted: April 11, 2026
• First Posted: April 17, 2026
• Study Start: April 24, 2026
• Primary Completion (Estimated): July 24, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: April 17, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)