Myocardial Blood Volume Measurement by Real-Time Myocardial Perfusion Echocardiography Correlates to Myocardial Compressibility by Cardiac Magnetic Resonance Imaging in Healthy Subjects

NCT04724304 | Completed

• 1 other identifier: 20-000936
• Study Type: interventional
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

This study is being done to find out the normal amount of blood within the heart muscle and the variations in this blood flow between a cardiac MRI and TTE.

Conditions

Healthy Adults

Outcome Measures

Primary Outcomes (1)

• Myocardial blood volume

  Ratio in systole and diastole (MBVs/MBVd) by real-time myocardial perfusion echocardiography (RTMPE)

  Baseline

Study Arms (1)

Healthy adults

EXPERIMENTAL

Healthy adults will have blood flow to the heart evaluated using s Real-Time Myocardial Echocardiography (RTMPE) and magnetic resonance image (MRI) to the heart.

Diagnostic Test: Real-Time Myocardial Echocardiography (RTMPE); Diagnostic Test: Magnetic resonance image (MRI)

Interventions

Real-Time Myocardial Echocardiography (RTMPE) DIAGNOSTIC_TEST

Uses sound waves (ultrasound) to produce an images of the heart. During RTMPE a microbubble contrast agent is administered through an intravenous line (IV) to make the images of your heart clearer.

Healthy adults

Magnetic resonance image (MRI) DIAGNOSTIC_TEST

Imaging that focuses on the heart or blood vessels to assess size and function of the heart's chambers, thickness and movement of the walls of the heart, and blood flow in the blood vessels.

Healthy adults

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years.
• Available for testing performed in Rochester, MN.
• Willing to undergo both an echocardiogram with RTMPE and CMR.
• Study subject providing consent.

You may not qualify if:

• Adults \< 18 years.
• BMI \<30 kg/m\^2.
• Hypertension.
• Diabetes Mellitus.
• Stroke.
• Cardiomyopathy or structural heart disease.
• Known coronary artery disease or history of myocardial infarction.
• Contraindication to echo enhancement agent or gadolinium administration such as an allergy.
• Renal GFR \< 50 mL/mL.
• Females who are pregnant.
• Subject unwilling to consent.

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo clinic Rochester

Rochester, Minnesota, 55905, United States

Location

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Courtney Bennett, D.O.

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 22, 2021
• First Posted: January 26, 2021
• Study Start: February 9, 2021
• Primary Completion: November 11, 2021
• Study Completion: November 11, 2021
• Last Updated: April 7, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)