Effect of Dual-task Training on the Number of EEG Band in Stroke Patients

NCT06286436 | Completed

• 1 other identifier: IR.SBMU.RETECH.REC.1401.842
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Stroke is a prevalent global health concern, causing widespread disability as it disrupts blood supply to the brain, leading to functional impairments. Upper limb dysfunction affects over 80% of stroke survivors acutely and becomes permanent in approximately 60%, hindering daily activities and autonomy. Dual-task training (DTT), involving simultaneous cognitive and motor tasks resembling daily activities, is proposed as an effective intervention. The study suggests using electroencephalogram (EEG) analysis, particularly the Fast Fourier Transform (FFT), to assess changes in brain signals pre- and post-DTT intervention. EEG provides real-time insights into brain function, and FFT analyzes signal frequencies. The intervention involves three tasks performed concurrently with mental calculations, such as sorting blocks and manipulating objects. This 12-session, four-week intervention aims to improve upper limb function. The study explores EEG's role in evaluating DTT effects on stroke patients, particularly using FFT to analyze brain signal frequencies.

Conditions

Stroke; Electroencephalography

Keywords

Electroencephalography; rehabilitation; physiotherapy; stroke

Outcome Measures

Primary Outcomes (1)

• EEG Data

  EEG data will be collected both before and after intervention, under the supervision of a neurologist, with the participant in a resting state and eyes closed. EEG recording will be carried out during 3 minutes with 10-20 system, 19 electrodes (Fp1, Fp2, F7, F3, Fz, F4, F8, T7, C3, Cz, C4, T8, T10, P3, Pz, P4, P8, T9, P7) and a sampling rate of 256 Hz. Frequencies below 1Hz and above 40Hz will be filtered. One of the three minutes of EEG collection will be randomly selected, and analysis will be carried out for that minute only. Before data analysis, abnormal waves such as blinking and electromyographic signals will be removed. All these operations will be carried out in MATLAB and by EEGLab toolbox.

  Before and after intervention (4 weeks)

Secondary Outcomes (4)

• Upper limb function

  Before and after intervention (4 weeks)

• Elbow flexor muscle tone

  Before and after intervention (4 weeks)

• Wrist extension range of motion

  Before and after intervention (4 weeks)

• ADLs

  Before and after intervention (4 weeks)

Study Arms (1)

Dual-task training

EXPERIMENTAL

Other: Dual-task training

Interventions

Dual-task training OTHER

The intervention will consist of three different tasks that participants have to carry out while performing mental calculations (counting backwards from 100 by ones, twos, and threes). The three tasks will be as follows: grouping blocks of different colours into groups according to colour; picking up beans with a spoon and carrying them to a specific place; opening and closing a bottle cap with the affected hand. The total duration of the intervention will be 12 sessions, divided into three days per week for four weeks.

Dual-task training

Eligibility Criteria

• Age: 35 Years - 75 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Unilateral stroke proven by imaging evidence
• Women between 35 and 75 years old
• At least six months have passed since the onset of the stroke

You may not qualify if:

• Suffering from another neurological or orthopedic disease
• Score greater than 3 on the modified modified Ashworth scale in the upper limb
• Having received a botulinum toxin injection before or during the course of the study
• History of brain surgery
• Be using medication that may alter cortical activity or brain plasticity or aimed at reducing the level of spasticity.

Sponsors & Collaborators

• Universidad de Zaragoza: lead
• Mahia Physiotherapy Clinic (Qom, Iran): collaborator

Study Sites (1)

Shahid Beheshti University of Medical Sciences

Tehran, Velenjak, Iran

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of iHealthy Research Group

Study Record Dates

• First Submitted: February 22, 2024
• First Posted: February 29, 2024
• Study Start: February 15, 2024
• Primary Completion: April 29, 2024
• Study Completion: April 29, 2024
• Last Updated: May 16, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: Once research has been published

Locations

IR (1)