NCT04656652

Brief Summary

This study will evaluate the efficacy, safety, and pharmacokinetics of DS-1062a versus docetaxel in participants with previously treated advanced or metastatic non-small cell lung cancer (NSCLC) with or without actionable genomic alterations.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
605

participants targeted

Target at P75+ for phase_3 nonsmall-cell-lung-cancer

Timeline
10mo left

Started Dec 2020

Typical duration for phase_3 nonsmall-cell-lung-cancer

Geographic Reach
26 countries

209 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress87%
Dec 2020Feb 2027

First Submitted

Initial submission to the registry

November 19, 2020

Completed
18 days until next milestone

First Posted

Study publicly available on registry

December 7, 2020

Completed
14 days until next milestone

Study Start

First participant enrolled

December 21, 2020

Completed
3.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 10, 2024

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

July 23, 2025

Completed
1.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 15, 2027

Expected
Last Updated

March 24, 2026

Status Verified

March 1, 2026

Enrollment Period

3.4 years

First QC Date

November 19, 2020

Results QC Date

May 7, 2025

Last Update Submit

March 3, 2026

Conditions

Keywords

Metastatic Non-small Cell Lung CancerAdvanced Non-small Cell Lung CancerNon-small Cell Lung CancerDS-1062DocetaxelDatopotamab Deruxtecan (Dato-DXd)

Outcome Measures

Primary Outcomes (2)

  • Progression-free Survival (PFS) As Assessed by Blinded Independent Central Review (BICR) Per RECIST v1.1 Following DS-1062a Versus Docetaxel

    PFS is defined as the time from randomization to the earlier of the dates of the first documentation of radiographic progressive disease or death due to any cause.

    From randomization until disease progression or death (whichever occurs first), up to approximately 27 months

  • Overall Survival (OS) Following DS-1062a Versus Docetaxel

    OS is defined as the time from randomization to the date of death due to any cause.

    From randomization until date of death due to any cause, up to to approximately 38 months

Secondary Outcomes (3)

  • Progression-free Survival (PFS) As Assessed by Investigator Per RECIST v1.1 Following DS-1062a Versus Docetaxel

    From randomization until disease progression or death (whichever occurs first), up to approximately 43 months

  • Objective Response Rate (ORR) As Assessed by Blinded Independent Central Review (BICR) and Investigator As Per RECIST v1.1 Following DS-1062a Versus Docetaxel

    From randomization until disease progression or death (whichever occurs first), up to approximately 43 months

  • Duration of Response (DOR) As Assessed by Blinded Independent Central Review (BICR) and Investigator As Per RECIST v1.1 Following DS-1062a Versus Docetaxel

    From date of first objective response (CR or PR) to date of first radiographic disease progression or death due to any cause (whichever occurs first), up to approximately 43 months

Study Arms (2)

DS-1062a 6.0 mg/kg

EXPERIMENTAL

Participants will be randomized to receive 6.0 mg/kg of DS-1062a.

Drug: DS-1062a

Docetaxel 75 mg/m^2

ACTIVE COMPARATOR

Participants will be randomized to receive 75 mg/m\^2 docetaxel.

Drug: Docetaxel

Interventions

DS-1062a will be administered as an intravenous (IV) infusion on Day 1 of each 3-week cycle

Also known as: Datopotamab deruxtecan (Dato-DXd)
DS-1062a 6.0 mg/kg

Docetaxel will be administered as an IV infusion on Day 1 of each 3-week cycle.

Docetaxel 75 mg/m^2

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Sign and date the inform consent form (ICF) prior to the start of any study specific qualification procedures.
  • Adults ≥18 years (if the legal age of consent is \>18 years old, then follow local regulatory requirements)
  • Life expectancy ≥3 months
  • Has pathologically documented Stage IIIB, IIIC, or stage IV NSCLC disease with or without actionable genomic alterations (AGA) at the time of randomization (based on the American Joint Committee on Cancer, Eighth Edition) and meets following criteria for NSCLC:
  • Participants without AGA:
  • Must have documented negative test results for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK).
  • Must have no known genomic alterations in ROS proto-oncogene 1 (ROS1), neurotrophic tyrosine receptor kinase (NTRK), proto oncogene B-raf (BRAF), mesenchymal-epithelial transition (MET) exon 14 skipping, or rearranged during transfection (RET).
  • Participants with AGA must have one or more documented actionable genomic alteration(s): EGFR, ALK, ROS1, NTRK, BRAF, MET exon 14 skipping, or RET.
  • Has documentation of radiographic disease progression while on or after receiving the most recent treatment regimen for advanced or metastatic NSCLC.
  • Participant without AGA must meet 1 of the following prior therapy requirements for advanced or metastatic NSCLC:
  • Received platinum-based chemotherapy in combination with α-PD-1/α-PD-L1 monoclonal antibody as the only prior line of therapy.
  • Includes participants who received prior platinum-based/chemotherapy with or without radiotherapy with maintenance α-PD-1/α-PD-L1 monoclonal antibody for Stage III disease and relapsed/progressed within 6 months from the last dose of platinum-based chemotherapy.
  • Includes participants who received prior platinum-based/chemotherapy with or without radiotherapy (with or without maintenance α-PD-1/α-PD-L1 monoclonal antibody) for Stage III disease and subsequently received α-PD-1/α-PD-L1 monoclonal antibody therapy (with or without platinum-based chemotherapy) for recurrent disease.
  • Received platinum-based chemotherapy and α-PD-1/α-PD-L1 monoclonal antibody (in either order) sequentially as the only 2 prior lines of therapy.
  • Participants with AGA must meet the following for advanced or metastatic NSCLC:
  • +19 more criteria

You may not qualify if:

  • Mixed small-cell lung cancer (SCLC) and NSCLC histology
  • Has spinal cord compression or clinically active central nervous system metastases, defined as untreated and symptomatic, or requiring therapy with corticosteroids or anticonvulsants to control associated symptoms. Participants with clinically inactive brain metastases may be included in the study. Participants with treated brain metastases who are no longer symptomatic and who require no treatment with corticosteroids or anticonvulsants may be included in the study if they have recovered from the acute toxic effect of radiotherapy.
  • Has leptomeningeal carcinomatosis or metastasis
  • Had prior treatment with:
  • Any agent including antibody drug conjugate (ADC) containing a chemotherapeutic agent targeting topoisomerase I
  • TROP2-targeted therapy
  • Docetaxel
  • Had prior treatment with platinum-based chemotherapy and prior immunotherapy for Stage II NSCLC disease (eg, in the neo-adjuvant or adjuvant setting) without subsequently meeting the prior therapy requirements for Stage III or metastatic NSCLC disease
  • Has NSCLC disease that is eligible for definitive local therapy alone
  • Has uncontrolled or significant cardiac disease, including:
  • Mean QT interval corrected for heart rate using Fridericia's formula \>470 msec (based on the average of Screening triplicate 12-lead electrocardiogram \[ECG\] determinations).
  • Myocardial infarction or uncontrolled/unstable angina within 6 months before randomization
  • Congestive heart failure (CHF) (New York Heart Association Class II to IV) at Screening. Participants with a history of Class II to IV CHF prior to Screening, must have returned to Class I CHF and have LVEF ≥50% (by either an ECHO or MUGA scan within 28 days before randomization) in order to be eligible.
  • Uncontrolled or significant cardiac arrhythmia
  • LVEF \<50% by ECHO or MUGA scan within 28 days before randomization
  • +13 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (209)

Ironwood Cancer and Research Center

Chandler, Arizona, 85224, United States

Location

St. Joseph Heritage Healthcare

Anaheim, California, 92835, United States

Location

The Oncology Institute of Hope and Innovation

Glendale, California, 91204, United States

Location

University of California San Diego

La Jolla, California, 92093, United States

Location

UCLA

Los Angeles, California, 90095, United States

Location

PIH Health

Whittier, California, 90602, United States

Location

Memorial Healthcare System- Memorial Cancer Institute

Hollywood, Florida, 33021, United States

Location

Orlando Health

Orlando, Florida, 32806, United States

Location

Florida Cancer Specialists

Tallahassee, Florida, 32308, United States

Location

Northwestern University

Chicago, Illinois, 60611, United States

Location

University of Chicago

Chicago, Illinois, 60637, United States

Location

Ft. Wayne Medical Oncology and Hematology

Fort Wayne, Indiana, 46804, United States

Location

Baptist Health Louisville

Louisville, Kentucky, 40207, United States

Location

Baton Rouge General

Baton Rouge, Louisiana, 70809, United States

Location

American Oncology Partners of Maryland

Bethesda, Maryland, 20817, United States

Location

Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States

Location

Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

Location

OptumCare Cancer Care

Las Vegas, Nevada, 89106, United States

Location

Meridian Hematology and Oncology

Manahawkin, New Jersey, 08050, United States

Location

Astera Cancer Care

Somerset, New Jersey, 08873, United States

Location

Montefiore Medical Center

The Bronx, New York, 10461, United States

Location

Messino Cancer Centers

Asheville, North Carolina, 28806, United States

Location

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States

Location

Roger Williams Medical Center

Providence, Rhode Island, 02908, United States

Location

Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States

Location

Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States

Location

The Center for Cancer and Blood Disorders

Fort Worth, Texas, 76104, United States

Location

Utah Cancer Specialists

Salt Lake City, Utah, 84106, United States

Location

University of Virginia Health System

Charlottesville, Virginia, 22903, United States

Location

Virginia Cancer Specialist

Fairfax, Virginia, 22031, United States

Location

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States

Location

Northwest Medical Specialties

Tacoma, Washington, 98405, United States

Location

CER San Juan

Buenos Aires, 01878, Argentina

Location

Centro de Investigacion Pergamino S.A.

Pergamino, B2700CPM, Argentina

Location

Instituto de OncologÃÂ-a de Rosario

Rosario, S2000KZE, Argentina

Location

Gaston Martinengo

Rosario, S2000, Argentina

Location

Flinders Medical Centre

Bedford Park, 05042, Australia

Location

Blacktown Hosital

Blacktown, 02148, Australia

Location

Austin Hospital

Heidelberg, 03084, Australia

Location

Macquarie Hospital

North Ryde, 02109, Australia

Location

Crown Princess Mary Cancer Centre Westmead Hospital

Sydney, 2145, Australia

Location

Southern Medical Day Care Centre

Wollongong, 02500, Australia

Location

Centre Hospitalier Jolimont-Lobbes

Haine-Saint-Paul, 07100, Belgium

Location

CHA Centre Hospitalier de l Ardenne

Libramont, B-6800, Belgium

Location

CHR site de la Citadelle

Liège, 04000, Belgium

Location

CHU UCL Namur

Yvoir, 05530, Belgium

Location

Instituto do Cancer do Ceara - ICC

Fortaleza, 60430-230, Brazil

Location

Hospital Sao Lucas da Pucrs

Porto Alegre, 90610-000, Brazil

Location

Hospital Nossa Senhora da Conceição

Porto Alegre, 91350-200, Brazil

Location

Instituto Nacional de Cancer-INCA

Rio de Janeiro, 20231-050, Brazil

Location

Hospital de Base de Sao Jose do Rio Preto

São José do Rio Preto, 15090-000, Brazil

Location

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

Location

University Health Network - Princess Margaret Hospital

Toronto, Ontario, M5G0A3, Canada

Location

Sunnbrook Health Sciences Centre

Toronto, Ontario, ON M4N 3M5, Canada

Location

MUHC-Glen Site and MUHC Research Institute

Montreal, Quebec, H4A 3J1, Canada

Location

Beijing Cancer Hospital

Beijing, 100142, China

Location

Hunan Cancer Hospital

Changsha, China

Location

Xiangya Hospital central south university

Changsha, China

Location

Linyi Cancer Hospital

Hangzhou, 310003, China

Location

The First Affiliated Hospital of Zhejiang University

Hangzou, 310022, China

Location

Harbin Medical University Cancer Hospital

Heilongjiang, 150081, China

Location

Jiamusi Cancer Tuberculosis Hospital

Heilongjiang, 154007, China

Location

Fudan University Shanghai Cancer Center

Henan, 450008, China

Location

Hubei Cancer Hospital

Hubei, 430079, China

Location

Jiangsu Province Hospital

Nanjing, China

Location

The First Affiliated Hospital of Xi'an Jiaotong University

Shandong, 276000, China

Location

Shanghai Chest Hospital

Shanghai, China

Location

Henan Cancer Hospital

Shanghai Sheng, 200032, China

Location

Zhejiang Cancer Hospital

Shanxi, 710061, China

Location

West China Hospital, Sichuan University

Sichuan Province, China

Location

Tianjin Medical University Cancer Institute and Hospital

Tianjin, 300060, China

Location

Affiliated Cancer Hospital of Xinjiang Medical University

Ürümqi, China

Location

Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, 43002, China

Location

Sir Run Run Shaw Hospital Zhejiang University School of Medicine

Zhejiang, 310016, China

Location

Vseobecna Fakultni Nemocnice VFN

Prague, 12800, Czechia

Location

Hopital Jean Minjoz

Besançon, 25030, France

Location

Centre Hospitalier Universitaire de Grenoble

Grenoble, 38043, France

Location

Centre Leon Berard

Lyon, 69008, France

Location

CHU Louis Pradel

Lyon, France

Location

APHM - Hopital Nord

Marseille, 13915, France

Location

University Hospital of Nantes - Thoracic Oncology

Nantes, 44000, France

Location

Institut Curie

Paris, 75248, France

Location

CHU de Poitier Pole regional de Cancerologie

Poitiers, 86000, France

Location

Hopital Pontchaillou

Rennes, 35000, France

Location

Hopitaux Universitaire de Strasbourg

Strasbourg, 67098, France

Location

Hopital Foch

Sureesnes, 92150, France

Location

CHU Toulouse Hopital Larrey

Toulouse, 31059, France

Location

Gustav Roussy Cancer Campus Grand Paris

Villejuif, 94805, France

Location

Charite - Universitaetsmedizin Berlin

Berlin, 10117, Germany

Location

Evangelische Lungenklinik Berlin

Berlin, 13125, Germany

Location

Universitaet zu Koeln - Uniklinik Koeln

Cologne, 50937, Germany

Location

IKF Krankenhaus Nordwest

Frankfurt am Main, 60488, Germany

Location

Universitaetsklinikum Freiburg

Freiburg im Breisgau, 79106, Germany

Location

Asklepios Fachklinik Muenchen-Gauting

Gauting, 82131, Germany

Location

Thoraxklinik Heidelberg gGmbH

Heidelberg, 69126, Germany

Location

Lungenklinik Hemer

Hemer, 58675, Germany

Location

Klinikverbund Allgäu

Kempten, 87439, Germany

Location

Medizinische Klinik V

Standort Gießen, Germany

Location

Klinikum Traunstein

Traunstein, Germany

Location

Queen Mary Hospital

Hong Kong, 999077, Hong Kong

Location

Prince of Wales Hospital / The Chinese University of Hong Kong

Hong Kong, 99999, Hong Kong

Location

Orszagos Koranyi TBC es Pulmonologiai Intezet

Budapest, 01121, Hungary

Location

Uzsoki Utcai Korhaz

Budapest, 1145, Hungary

Location

Szent Borbala Korhaz

Tatabánya, 02800, Hungary

Location

Tolna Megyei Balassa Janos Korhaz

Tolna, Hungary

Location

Tudogyogyintezet Torokbalint

Törökbálint, H-2045, Hungary

Location

Azienda Ospedaliero- Universitaria Policlinico S. Orsola-Malpighi

Bologna, 40138, Italy

Location

Azienda Ospedaliera Universitaria Policlinico G Rodolico San Marco

Catania, 95030, Italy

Location

ASL 3 Genovese Oncologia Medica Villa Scassi

Genova, 16149, Italy

Location

Fondazione IRCCS Istituto Nazionale Tumori

Milan, 20133, Italy

Location

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy

Location

IRCCS Istituto Europeo di Oncologia

Milan, 20141, Italy

Location

Azienda Ospedaliero-Universitaria San Luigi Gonzaga

Orbassano, 10043, Italy

Location

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, 00168, Italy

Location

Instituicao de Fisioterapeutas Ocupacionais

Roma, RM00144, Italy

Location

Hyogo Cancer Center

Akashi, 673-8558, Japan

Location

Niigata Cancer Center Hospital

Chūōku, 951-8566, Japan

Location

Kyushu University Hospital

Fukuoka, 812-8582, Japan

Location

Saitama Medical University International Medical Center

Hidaka, 350-1298, Japan

Location

Kansai Medical University Hospital

Hirakata, 573-1191, Japan

Location

Kanazawa University Hospital

Kanazawa, 920-8641, Japan

Location

National Cancer Center Hospital East

Kashiwa, 277-8577, Japan

Location

The Cancer Institute Hospital of JFCR

Kōtoku, 135-8550, Japan

Location

Kyoto University Hospital

Kyoto, 606-8507, Japan

Location

NHO Shikoku Cancer Center

Matsuyama, 791-0280, Japan

Location

Shizuoka Cancer Center

Nagaizumi-chō, 411-8777, Japan

Location

Okayama University Hospital

Okayama, 36927, Japan

Location

Osaka City General Hospital

Osaka, 534-0021, Japan

Location

Osaka International Cancer Institute

Osaka, 541-8567, Japan

Location

Kindai University Hospital

Ōsaka-sayama, 589-8511, Japan

Location

Saitama Cancer Center

Saitama, 362-0806, Japan

Location

Sendai Kousei Hospital

Sendai, 980-0873, Japan

Location

NHO Hokkaido Cancer Center

Shiroishi, 003-0804, Japan

Location

Tokushima University Hospital

Tokushima, 770-8503, Japan

Location

National Cancer Center Hospital

Tokyo, 104-0045, Japan

Location

Fujita Health University Hospital

Toyoake, 470-1192, Japan

Location

San Peregrino Cancer Center

Aguascalientes, 20230, Mexico

Location

Hospital Civil de Guadalajara Fray Antonio Alcalde

Guadalajara, 44280, Mexico

Location

Hospital Medica Sur Tlalpan

Mexico City, 14050, Mexico

Location

Hospital Universitario Jose Eleuterio Gonzalez

Monterrey, 64460, Mexico

Location

Erasmus MC

Amsterdam, 3000 CA, Netherlands

Location

Amphia Ziekenhuis

Breda, 4818 CK, Netherlands

Location

Isala Klinieken

Harderwijk, 3844 DG, Netherlands

Location

St. Jansdal Ziekenhuis

Rotterdam, 3015 CD, Netherlands

Location

II Klinika Chorob Pluc i Gruzlicy

Bialystok, 15-276, Poland

Location

Szpitale Pomorskie Sp.zo.o

Gdynia, 81-519, Poland

Location

Ms Pneumed

Lublin, 20-090, Poland

Location

SP Zespol Gruzlicy i Chorob Pluc

Olsztyn, 10-357, Poland

Location

Med Polonia Sp. z o.o.

Poznan, 60-693, Poland

Location

Szpital Specjalistyczny w Prabutach Sp. z o.o.

Prabuty, 82-550, Poland

Location

Oddział Onkologii Wojewódzki Szpital Specjalistyczny Słupsk

Słupsk, 76-200, Poland

Location

Magodent Sp. z.o.o Szpital Elblaska

Warsaw, 01-748, Poland

Location

Maria Sklodowska-Curie National Research Institute of Oncology

Warsaw, 02-781, Poland

Location

FDI Clinical Research

San Juan, 00927, Puerto Rico

Location

SC Oncopremium Team SRL

Baia Mare, 430291, Romania

Location

Institutul Oncologic Profesor Doctor Alexandru Trestioreanu

Bucharest, 022328, Romania

Location

Centrul Medical Sanador

Bucharest, 20125, Romania

Location

Clinical Emergency Hospital

Constanța, 900591, Romania

Location

Onco Clinic Consult SA

Craiova, 200103, Romania

Location

Sf Nectarie Oncology Center

Craiova, 200347, Romania

Location

Oncolab SRL

Craiova, 200385, Romania

Location

SC Oncomed SRL

Timișoara, 300425, Romania

Location

Kursk Regional Clinical Oncology Dispensary

Kursk, 305524, Russia

Location

Federal State Budgetary Institution - N.N. Blokhin National Medical Research Center of Oncology

Moscow, 115478, Russia

Location

University Headache Clinic LLC

Moscow, 121467, Russia

Location

VitaMed LLC

Moscow, 129515, Russia

Location

Institute of Oncology Hadassah Moscow

Moscow, Russia

Location

LLC MSCH "Klinitsist"

Novosibirsk, 630099, Russia

Location

N.N. Petrov Research Institute of Oncology

Saint Petersburg, 197758, Russia

Location

National Cancer Centre Singapore

Singapore, 169610, Singapore

Location

ICON Cancer Centre Farrer Park Hospital

Singapore, 217562, Singapore

Location

OncoCare Cancer Centre - Gleneagles Medical Centre Location

Singapore, 258499, Singapore

Location

Chungbuk National University Hospital

Cheongju-si, 28644, South Korea

Location

Kyungpook National University Chilgok Hospital

Daegu, 41404, South Korea

Location

St. Vincents Hospital The Catholic University of Korea

Gyeonggi-do, 16247, South Korea

Location

Seoul National University Bundang Hospital

Seongnam-si, 13620, South Korea

Location

Kangbuk Samsung Hospital

Seoul, 03181, South Korea

Location

Yonsei University Health System - Severance Hospital

Seoul, 03722, South Korea

Location

Asan Medical Center

Seoul, 05505, South Korea

Location

Samsung Medical Center

Seoul, 06351, South Korea

Location

The Catholic University of Korea, Seoul St. Marys Hospital

Seoul, 06591, South Korea

Location

Seoul National University Boramae Medical Center

Seoul, 07061, South Korea

Location

Hospital de la Santa Creu i Sant Pau

Barcelona, 08025, Spain

Location

Hospital Clinic i Provincial de Barcelona

Barcelona, 08036, Spain

Location

Hospital Universitario Vall d'Hebron

Barcelona, 80350, Spain

Location

Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain

Location

Hospital Universitario 12 de Octubre

Madrid, 28041, Spain

Location

Hospital Puerte de Hierro de Majadahonda

Madrid, 28222, Spain

Location

Hospital Regional Universitario Málaga

Málaga, 29010, Spain

Location

CHUO

Ourense, 32005, Spain

Location

Hospital Virgen Macarena

Seville, 41007, Spain

Location

Hospital Universitario de Valme

Seville, 41014, Spain

Location

Hospital General Universitario de Valencia

Valencia, 46014, Spain

Location

Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain

Location

Hospital Clinico Universitario Lozano Bleza

Zaragoza, 50009, Spain

Location

Inselspital Universitätsspital Bern

Bern, 3010, Switzerland

Location

Kantonsspital St. Gallen

Sankt Gallen, 9007, Switzerland

Location

Stadtspital Waid ; Triemli, Site Triemli - clinic for Medical oncology &amp; hematology

Zurich, 8063, Switzerland

Location

E-Da Hospital

Kaohsiung City, 00824, Taiwan

Location

Chang Gung Memorial Hospital CGMH - Kaohsiung Branch

Niaosong, 00833, Taiwan

Location

Chung Shan Medical University Hospital

Taichung, 00420, Taiwan

Location

Taichung Veterans General Hospital

Taichung, 40705, Taiwan

Location

National Cheng Kung University Hospital NCKUH

Tainan, 00704, Taiwan

Location

Chi Mei Medical Center CMMC - Liouying Branch

Tainan, 00736, Taiwan

Location

National Taiwan University Hospital NTUH

Taipei, 00100, Taiwan

Location

LinKou Chang Gung Memorial Hospital

Taoyuan District, 333, Taiwan

Location

University College Hospital

London, NW1 2BU, United Kingdom

Location

The Christie Hospital

Manchester, M20 4BX, United Kingdom

Location

The James Cook University Hospital

Middlesbrough, TS4 3BW, United Kingdom

Location

Related Publications (2)

  • Sands J, Ahn MJ. Datopotamab deruxtecan versus docetaxel for non-small cell lung cancer: a plain language summary of the TROPION-Lung01 study. Future Oncol. 2026 Feb;22(3):271-284. doi: 10.1080/14796694.2025.2586004. Epub 2025 Nov 21.

  • Ahn MJ, Tanaka K, Paz-Ares L, Cornelissen R, Girard N, Pons-Tostivint E, Vicente Baz D, Sugawara S, Cobo M, Perol M, Mascaux C, Poddubskaya E, Kitazono S, Hayashi H, Hong MH, Felip E, Hall R, Juan-Vidal O, Brungs D, Lu S, Garassino M, Chargualaf M, Zhang Y, Howarth P, Uema D, Lisberg A, Sands J; TROPION-Lung01 Trial Investigators. Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study. J Clin Oncol. 2025 Jan 20;43(3):260-272. doi: 10.1200/JCO-24-01544. Epub 2024 Sep 9.

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

Docetaxel

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsLung NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

TaxoidsCyclodecanesCycloparaffinsHydrocarbons, AlicyclicHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsDiterpenesTerpenes

Results Point of Contact

Title
Contact for Clinical Trial Information
Organization
Daiichi Sankyo

Study Officials

  • Global Clinical Leader

    Daiichi Sankyo

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 19, 2020

First Posted

December 7, 2020

Study Start

December 21, 2020

Primary Completion

May 10, 2024

Study Completion (Estimated)

February 15, 2027

Last Updated

March 24, 2026

Results First Posted

July 23, 2025

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

De-identified individual participant data (IPD) and applicable supporting clinical trial documents may be available upon request at https://vivli.org/. In cases where clinical trial data and supporting documents are provided pursuant to our company policies and procedures, Daiichi Sankyo will continue to protect the privacy of our clinical trial participants. Details on data sharing criteria and the procedure for requesting access can be found at this web address: https://vivli.org/ourmember/daiichi-sankyo/

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
Studies for which the medicine and indication have received European Union (EU) and United States (US), and/or Japan (JP) marketing approval on or after 01 January 2014 or by the US or EU or JP Health Authorities when regulatory submissions in all regions are not planned and after the primary study results have been accepted for publication.
Access Criteria
Formal request from qualified scientific and medical researchers on IPD and clinical study documents from clinical trials supporting products submitted and licensed in the United States, the European Union and/or Japan from 01 January 2014 and beyond for the purpose of conducting legitimate research. This must be consistent with the principle of safeguarding study participants' privacy and consistent with provision of informed consent.
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