Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

8.5%

41 terminated/withdrawn out of 481 trials

Success Rate

87.5%

+1.0% vs industry average

Late-Stage Pipeline

27%

130 trials in Phase 3/4

Results Transparency

57%

164 of 286 completed trials have results

Key Signals

88 recruiting164 with results35 terminated6 withdrawn

Enrollment Performance

Analytics

Phase 1
146(35.3%)
Phase 2
118(28.5%)
Phase 3
88(21.3%)
Phase 4
42(10.1%)
N/A
16(3.9%)
Early Phase 1
4(1.0%)
414Total
Phase 1(146)
Phase 2(118)
Phase 3(88)
Phase 4(42)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (481)

Showing 20 of 481 trials
NCT06843447Phase 1Recruiting

A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

Role: collaborator

NCT07405151Phase 1Recruiting

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

Role: collaborator

NCT06780111Phase 1Recruiting

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

Role: collaborator

NCT05215340Phase 3Active Not Recruiting

Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations

Role: lead

NCT07227597Phase 1Recruiting

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

Role: collaborator

NCT05573893Recruiting

PROVIDENCE - Prospective Non-interventional Study (NIS) to Examine Patient-reported Outcomes and Real-world Clinical Data in Patients With HER2-positive, HER2-low or HER2-ultralow Unresectable or Metastatic Breast Cancer Treated With Trastuzumab Deruxtecan

Role: collaborator

NCT05950945Phase 3Recruiting

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

Role: lead

NCT07286149Phase 1Recruiting

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

Role: collaborator

NCT05765851Phase 1Recruiting

A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors

Role: lead

NCT04379596Phase 2Recruiting

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

Role: collaborator

NCT05113251Phase 3Active Not Recruiting

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

Role: collaborator

NCT07535359Unknown

Medical Access Program for Ifinatamab Deruxtecan in 3L+ Pretreated Extensive-stage Small Cell Lung Cancer

Role: lead

NCT04619004Phase 2Active Not Recruiting

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

Role: lead

NCT07129993Phase 2Recruiting

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Role: lead

NCT07060807Phase 3Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Role: collaborator

NCT06807632Phase 1Recruiting

A Study of Valemetostat in Combination With Atezolizumab in People With Lung Cancer

Role: collaborator

NCT07630974Phase 1Not Yet Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

Role: collaborator

NCT06203210Phase 3Recruiting

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

Role: lead

NCT04938817Phase 1Active Not Recruiting

Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

Role: collaborator

NCT06596694Phase 1Recruiting

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

Role: collaborator