Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

8.6%

41 terminated/withdrawn out of 479 trials

Success Rate

87.4%

+0.9% vs industry average

Late-Stage Pipeline

27%

130 trials in Phase 3/4

Results Transparency

56%

160 of 285 completed trials have results

Key Signals

90 recruiting160 with results35 terminated6 withdrawn

Enrollment Performance

Analytics

Phase 1
145(35.1%)
Phase 2
118(28.6%)
Phase 3
88(21.3%)
Phase 4
42(10.2%)
N/A
16(3.9%)
Early Phase 1
4(1.0%)
413Total
Phase 1(145)
Phase 2(118)
Phase 3(88)
Phase 4(42)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (479)

Showing 20 of 479 trials
NCT07060807Phase 3Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Role: collaborator

NCT06941272Phase 1Recruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

Role: collaborator

NCT07227597Phase 1Recruiting

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

Role: collaborator

NCT06925737Phase 3Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

Role: collaborator

NCT04686305Phase 1Recruiting

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

Role: collaborator

NCT06863272Phase 1Recruiting

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

Role: collaborator

NCT04938817Phase 1Recruiting

Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

Role: collaborator

NCT07405151Phase 1Recruiting

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

Role: collaborator

NCT06780137Phase 1Recruiting

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

Role: collaborator

NCT06610825Phase 2Recruiting

Castrate Resistant Prostate Cancer Enhertu Therapy

Role: collaborator

NCT07286149Phase 1Recruiting

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

Role: collaborator

NCT05950945Phase 3Recruiting

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

Role: lead

NCT06973161Completed

ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors

Role: collaborator

NCT06112379Phase 3Active Not Recruiting

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

Role: collaborator

NCT04165798Recruiting

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

Role: collaborator

NCT06445972Phase 1Recruiting

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

Role: collaborator

NCT06807632Phase 1Recruiting

A Study of Valemetostat in Combination With Atezolizumab in People With Lung Cancer

Role: collaborator

NCT06780098Phase 2Recruiting

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

Role: collaborator

NCT03793478Phase 1Active Not Recruiting

Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood

Role: lead

NCT06740799Phase 1Recruiting

Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment

Role: lead