Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

8.4%

41 terminated/withdrawn out of 486 trials

Success Rate

87.5%

+1.0% vs industry average

Late-Stage Pipeline

27%

132 trials in Phase 3/4

Results Transparency

57%

164 of 287 completed trials have results

Key Signals

87 recruiting164 with results35 terminated6 withdrawn

Enrollment Performance

Analytics

Phase 1
149(35.6%)
Phase 2
118(28.2%)
Phase 3
90(21.5%)
Phase 4
42(10.0%)
N/A
16(3.8%)
Early Phase 1
4(1.0%)
419Total
Phase 1(149)
Phase 2(118)
Phase 3(90)
Phase 4(42)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (486)

Showing 20 of 486 trials
NCT06863272Phase 1Recruiting

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

Role: collaborator

NCT04656652Phase 3Active Not Recruiting

Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)

Role: lead

NCT07206472Recruiting

A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in Patients With Primary Hypercholesterolaemia or Mixed Dyslipidaemia

Role: lead

NCT07739966Phase 1Not Yet Recruiting

A Study of DS-3939a in Participants With Solid Tumors

Role: lead

NCT04165070Phase 1Recruiting

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Role: collaborator

NCT04165798Recruiting

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

Role: collaborator

NCT04784715Phase 3Active Not Recruiting

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Role: collaborator

NCT07405151Phase 1Recruiting

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

Role: collaborator

NCT07060807Phase 3Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Role: collaborator

NCT06596694Phase 1Recruiting

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

Role: collaborator

NCT03030066Phase 1Completed

Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas

Role: lead

NCT06644768Phase 1Active Not Recruiting

A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations

Role: lead

NCT07227597Phase 1Recruiting

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

Role: collaborator

NCT05765851Phase 1Recruiting

A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors

Role: lead

NCT07022483Phase 3Recruiting

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

Role: lead

NCT06161025Phase 2Recruiting

A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Role: lead

NCT07129993Phase 2Recruiting

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Role: lead

NCT04612751Phase 1Active Not Recruiting

Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer

Role: collaborator

NCT07205822Phase 3Recruiting

A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer

Role: collaborator

NCT06843447Phase 1Recruiting

A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

Role: collaborator