Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

8.4%

41 terminated/withdrawn out of 490 trials

Success Rate

87.5%

+1.0% vs industry average

Late-Stage Pipeline

28%

135 trials in Phase 3/4

Results Transparency

57%

164 of 288 completed trials have results

Key Signals

90 recruiting164 with results35 terminated6 withdrawn

Enrollment Performance

Analytics

Phase 1
151(35.7%)
Phase 2
117(27.7%)
Phase 3
93(22.0%)
Phase 4
42(9.9%)
N/A
16(3.8%)
Early Phase 1
4(0.9%)
423Total
Phase 1(151)
Phase 2(117)
Phase 3(93)
Phase 4(42)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (490)

Showing 20 of 490 trials
NCT06596694Phase 1Active Not Recruiting

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

Role: collaborator

NCT06780111Phase 1Recruiting

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

Role: collaborator

NCT07743164Phase 3Not Yet Recruiting

A Clinical Trial of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab in Participants With Ovarian Cancer Who Have Progressed During Treatment With PARP-inhibitors Treatment on First Line Maintenance (MK-5909-008/ENGOT-ov107/GOG-3142 / REJOICE-Ovarian05)

Role: collaborator

NCT05898165Active Not Recruiting

Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): Pilot Study

Role: collaborator

NCT07205822Phase 3Recruiting

A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer

Role: collaborator

NCT06780098Phase 2Recruiting

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

Role: collaborator

NCT07405151Phase 1Recruiting

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

Role: collaborator

NCT07286149Phase 1Recruiting

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

Role: collaborator

NCT06172478Phase 2Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Role: lead

NCT07227597Phase 1Recruiting

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

Role: collaborator

NCT06780085Phase 2Recruiting

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

Role: collaborator

NCT06362252Phase 1Recruiting

A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

Role: lead

NCT07701941Phase 1Recruiting

A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deruxtecan (T-DXd) in Participants With HR-Positive, HER2-Low or HER2-Ultralow Unresectable or Metastatic Breast Cancer

Role: lead

NCT07357597Phase 4Recruiting

An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

Role: collaborator

NCT05875168Phase 1Recruiting

First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors

Role: lead

NCT07474649Phase 3Not Yet Recruiting

A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without Cardiovascular Events

Role: lead

NCT07060807Phase 3Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Role: collaborator

NCT03734029Phase 3Completed

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Role: lead

NCT06103864Phase 3Recruiting

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

Role: collaborator

NCT07630974Phase 1Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

Role: collaborator