NCT04096586

Brief Summary

The objective of the proposed research is to determine the effects of watermelon (fruit and rind blenderized) on satiety, metabolic markers, bowel habits, microbiome and weight management in children and adults

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
33mo left

Started Aug 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress72%
Aug 2019Dec 2028

Study Start

First participant enrolled

August 1, 2019

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

September 18, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 20, 2019

Completed
9.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2028

Last Updated

January 21, 2026

Status Verified

January 1, 2026

Enrollment Period

9.4 years

First QC Date

September 18, 2019

Last Update Submit

January 16, 2026

Conditions

Satiety

Outcome Measures

Primary Outcomes (4)

  • Change of satiety

    Change of hunger feeling (appetite) will be examined using visual analog scale (0-10), 0 least and 10 greatest

    0 and 20, 40, 60, 90 and 120 minutes post juice consumption

  • Change of glucose level

    Change of blood glucose level will be determined to examine effects of watermelon juice consumption vs red juice

    0 and 20, 40, 60, 90 and 120 minutes post juice consumption

  • Change of insulin level

    Change of blood insulin level will be determined to examine effects of watermelon juice consumption vs red juice

    0 and 20, 40, 60, 90 and 120 minutes post juice consumption

  • Change of triglyceride level

    Change of triglyceride level with watermelon juice consumption vs red juice consumption

    Baseline and week 8

Secondary Outcomes (1)

  • Change of alpha diversity in microbiome

    Baseline and week 8

Study Arms (2)

Red juice

ACTIVE COMPARATOR

Subjects consume 8 fl oz of red juice daily for 8 weeks

Other: Red juice

Watermelon juice

EXPERIMENTAL

Subjects consume 8 fl oz of watermelon juice daily for 8 weeks

Other: Watermelon juice

Interventions

Red juiceOTHER

To determine the effects of red juice on satiety and gut health

Red juice
Watermelon juiceOTHER

To determine the effects of watermelon juice on satiety and gut health

Watermelon juice

Eligibility Criteria

Age10 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Generally healthy subjects

You may not qualify if:

  • Smoker
  • Pregnant woman
  • Required dietary supplement use
  • Required medication of metabolic disorders
  • Allergy to watermelon

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Exercise and Nutritional Sciences, SDSU

San Diego, California, 92182-7251, United States

RECRUITING

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 18, 2019

First Posted

September 20, 2019

Study Start

August 1, 2019

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2028

Last Updated

January 21, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

US(1)