Effects of Mixed Nut Consumption on Satiety and Weight Management

NCT03375866 | Recruiting

• 1 other identifier: 2515098
• Study Type: interventional
• Target: 56
• Locations: 1 country
• Sites: 1

Brief Summary

The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine the mechanisms by which mixed nut consumption regulates of food intake and body weight.

Conditions

Satiety

Outcome Measures

Primary Outcomes (5)

• Change of Satiety

  Hunger feeling (appetite) will be examined using visual analog scale (0-10): 0 least and 10 greatest

  0, 20, 40, 60, 90 and 120 minutes post snack consumption

• Change of glucose level

  Glucose level will be examined using glucose analysis

  Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption

• Change of insulin level

  Insulin level will be examined using an ELISA biochemical method

  Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption

• Change of cholesterol levels

  Cholesterol levels will be examined using a biochemical method

  8 weeks and 16 weeks post daily consumption

• Change of Lp(a)

  Lp(a) levels will be examined using an ELISA biochemical method

  8 weeks and 16 weeks post daily consumption

Secondary Outcomes (1)

• Change of microbiome

  8 weeks and 16 weeks post daily consumption

Study Arms (2)

Pretzels

ACTIVE COMPARATOR

Other: Pretzels

Mixed nuts

EXPERIMENTAL

Other: Mixed nuts

Interventions

Pretzels OTHER

Subjects consume 240 kcal of pretzels daily for 16 weeks.

Pretzels

Mixed nuts OTHER

Subjects consume 240 kcal of mixed nuts daily for 16 weeks.

Mixed nuts

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years old
• BMI 27-40

You may not qualify if:

• Smoker
• Pregnant woman
• Required dietary supplement use
• Required medication of metabolic disorders
• Allergy to nuts or gluten

Sponsors & Collaborators

• San Diego State University: lead

Study Sites (1)

School of Exercise and Nutritional Sciences, SDSU

San Diego, California, 92182-7251, United States

RECRUITING

Related Publications (2)

• Nora CL, Zhang L, Castro RJ, Marx A, Carman HB, Lum T, Tsimikas S, Hong MY. Effects of mixed nut consumption on LDL cholesterol, lipoprotein(a), and other cardiometabolic risk factors in overweight and obese adults. Nutr Metab Cardiovasc Dis. 2023 Aug;33(8):1529-1538. doi: 10.1016/j.numecd.2023.05.013. Epub 2023 May 15.

  PMID: 37263914 DERIVED

• Rosas M Jr, Liu C, Hong MY. Effects of Mixed Nut Consumption on Blood Glucose, Insulin, Satiety, and the Microbiome in a Healthy Population: A Pilot Study. J Med Food. 2023 May;26(5):342-351. doi: 10.1089/jmf.2022.0121. Epub 2023 Apr 20.

  PMID: 37083461 DERIVED

Central Study Contacts

Mee Young Hong

CONTACT

619-594-2392; mhong2@mail.sdsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 11, 2017
• First Posted: December 18, 2017
• Study Start: December 1, 2016
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: January 21, 2026

Record last verified: 2026-01

Locations

US (1)