Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes

NCT04094194 | Unknown

• 1 other identifier: DNSG-Nordic diet
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe. Studies have shown a protective effect of the Nordic Diet on cardiometabolic risk factors, however only select clinical practice guidelines for the management of diabetes (i.e. Diabetes Canada) recommend this dietary pattern. To support the update of the EASD clinical practice guidelines for nutrition therapy, the investigators propose to conduct a systematic review and meta-analysis of prospective cohort studies and clinical trials to investigate the association between the Nordic Diet, cardiometabolic outcomes and cardiovascular disease incidence and mortality. The findings generated by this proposed knowledge synthesis will help improve the health of consumers through informing evidence-based guidelines and improving health outcomes by educating healthcare providers and patients, stimulating industry innovation, and guiding future research design.

Conditions

Body Weight; Obesity; Overweight and Obesity; Obesity, Abdominal; Hypertension; Hyperlipidemias; Cardiovascular Diseases; Coronary Heart Disease; Stroke; Mortality; Dyslipidemias; Diabetes; PreDiabetes; Insulin Tolerance; Dysglycemia; Metabolic Syndrome

Keywords

Nordic diet; Cardiometabolic risk factors; Mortality; Cardiovascular diseases; Type 2 diabetes; Hypertension; Systematic review and meta-analysis; Randomized controlled trials; Prospective cohort studies

Outcome Measures

Primary Outcomes (2)

• Incident Cardiovascular Disease (Prospective Cohort Studies)

  Relative Risks

  Time Frame: At least 1 year

• LDL-cholesterol (randomized and non-randomized controlled trials)

  Mean difference

  Time Frame: Up to 20 years

Secondary Outcomes (15)

• Glycemic control - Fasting blood glucose (randomized and non-randomized controlled trials)

  Time Frame: Up to 20 years

• Glycemic control - HbA1c (randomized and non-randomized controlled trials)

  Time Frame: Up to 20-years

• Glycemic control - Fasting insulin (randomized and non-randomized controlled trials)

  Time Frame: Up to 20-years

• Blood lipids - non-HDL-cholesterol (randomized and non-randomized controlled trials)

  Time Frame: Up to 20-years

• Blood lipids - HDL-cholesterol (randomized and non-randomized controlled trials)

  Time Frame: Up to 20-years

Interventions

Nordic diet OTHER

Healthy dietary pattern that is consumed in Nordic countries

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All individuals, both children, and adults, regardless of health status.

You may qualify if:

• dietary trials in humans
• Nordic diets intervention
• Presence of an adequate comparator (ad libitum control)
• Diet duration \>=3 weeks
• Viable outcome data
• Prospective cohort studies
• Duration \>= 1 year
• Assessment of the exposure of a Nordic Diet
• Ascertainment of viable data by level of exposure

You may not qualify if:

• Non-human trials
• Observational studies
• Lack of suitable comparator diet (i.e. non-isocaloric)
• Diet duration \<3-weeks
• No viable outcome data
• Ecological, cross-sectional, retrospective observational studies, clinical trials, and non-human studies
• Duration \< 1 year
• non assessment of exposure of a Nordic diet
• No ascertainment viable clinical outcome data by level of exposure

Sponsors & Collaborators

• University of Toronto: lead
• Canadian Institutes of Health Research (CIHR): collaborator
• Canada Research Chairs Endowment of the Federal Government of Canada: collaborator
• The Physicians' Services Incorporated Foundation: collaborator
• Canadian Diabetes Association: collaborator

Study Sites (1)

The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, M5C 2T2, Canada

Location

Related Publications (8)

• Salas-Salvado J, Bullo M, Babio N, Martinez-Gonzalez MA, Ibarrola-Jurado N, Basora J, Estruch R, Covas MI, Corella D, Aros F, Ruiz-Gutierrez V, Ros E; PREDIMED Study Investigators. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care. 2011 Jan;34(1):14-9. doi: 10.2337/dc10-1288. Epub 2010 Oct 7.

  PMID: 20929998 BACKGROUND

• Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation. 2009 Mar 3;119(8):1093-100. doi: 10.1161/CIRCULATIONAHA.108.816736. Epub 2009 Feb 16.

  PMID: 19221219 BACKGROUND

• Papadaki A, Scott JA. The impact on eating habits of temporary translocation from a Mediterranean to a Northern European environment. Eur J Clin Nutr. 2002 May;56(5):455-61. doi: 10.1038/sj.ejcn.1601337.

  PMID: 12001018 BACKGROUND

• Adamsson V, Reumark A, Cederholm T, Vessby B, Riserus U, Johansson G. What is a healthy Nordic diet? Foods and nutrients in the NORDIET study. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.18189. Epub 2012 Jun 27.

  PMID: 22761599 BACKGROUND

• Adamsson V, Reumark A, Fredriksson IB, Hammarstrom E, Vessby B, Johansson G, Riserus U. Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET). J Intern Med. 2011 Feb;269(2):150-9. doi: 10.1111/j.1365-2796.2010.02290.x. Epub 2010 Oct 22.

  PMID: 20964740 BACKGROUND

• Roswall N, Sandin S, Scragg R, Lof M, Skeie G, Olsen A, Adami HO, Weiderpass E. No association between adherence to the healthy Nordic food index and cardiovascular disease amongst Swedish women: a cohort study. J Intern Med. 2015 Nov;278(5):531-41. doi: 10.1111/joim.12378. Epub 2015 May 19.

  PMID: 25991078 BACKGROUND

• Kanerva N, Kaartinen NE, Rissanen H, Knekt P, Eriksson JG, Saaksjarvi K, Sundvall J, Mannisto S. Associations of the Baltic Sea diet with cardiometabolic risk factors--a meta-analysis of three Finnish studies. Br J Nutr. 2014 Aug 28;112(4):616-26. doi: 10.1017/S0007114514001159. Epub 2014 May 27.

  PMID: 24867656 BACKGROUND

• Massara P, Zurbau A, Glenn AJ, Chiavaroli L, Khan TA, Viguiliouk E, Mejia SB, Comelli EM, Chen V, Schwab U, Riserus U, Uusitupa M, Aas AM, Hermansen K, Thorsdottir I, Rahelic D, Kahleova H, Salas-Salvado J, Kendall CWC, Sievenpiper JL. Nordic dietary patterns and cardiometabolic outcomes: a systematic review and meta-analysis of prospective cohort studies and randomised controlled trials. Diabetologia. 2022 Dec;65(12):2011-2031. doi: 10.1007/s00125-022-05760-z. Epub 2022 Aug 26.

  PMID: 36008559 DERIVED

MeSH Terms

Conditions

Body Weight; Obesity; Overweight; Obesity, Abdominal; Hypertension; Hyperlipidemias; Cardiovascular Diseases; Coronary Disease; Stroke; Dyslipidemias; Diabetes Mellitus; Prediabetic State; Metabolic Syndrome; Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Vascular Diseases; Lipid Metabolism Disorders; Metabolic Diseases; Myocardial Ischemia; Heart Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Glucose Metabolism Disorders; Endocrine System Diseases; Insulin Resistance; Hyperinsulinism

Study Officials

• John Sievenpiper, MD,PhD,FRCPC

  University of Toronto

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, FRCPC

Study Record Dates

• First Submitted: September 16, 2019
• First Posted: September 18, 2019
• Study Start: December 1, 2017
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2019
• Last Updated: September 18, 2019

Record last verified: 2019-09

Locations

CA (1)