Meta-analysis of Low-calorie Sweetened Beverages and Cardiometabolic Outcomes
Changing or Substituting Low-calorie Sweetened Beverages for Sugar-Sweetened Beverages or Water and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies
1 other identifier
observational
1
1 country
1
Brief Summary
We propose to conduct a systematic literature review and meta-analysis to assess the association of low-calorie sweetened beverages (LCSBs) on cardiometabolic outcomes in prospective cohort studies. We will be using methodological approaches (change in LCSBs intake, and/or substitution analysis) that attempt to overcome the issue of reverse causality associated with studies of LCSBs and cardiometabolic disease. Ten cardiometabolic outcomes will be assessed:
- 1.Global adiposity - body weight
- 2.Global adiposity - BMI
- 3.Global adiposity - body fat
- 4.Abdominal adiposity - waist circumference
- 5.Overweight/obesity incidence
- 6.Metabolic syndrome incidence
- 7.Type 2 diabetes incidence
- 8.Cardiovascular disease incidence
- 9.Cardiovascular disease mortality
- 10.Total mortality
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started May 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 16, 2019
CompletedFirst Submitted
Initial submission to the registry
January 23, 2020
CompletedFirst Posted
Study publicly available on registry
January 29, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2020
CompletedFebruary 25, 2020
February 1, 2020
10 months
January 23, 2020
February 21, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (10)
Global measures of adiposity with established clinical relevance - body weight
Change in body weight
More than 1 year
Global measures of adiposity with established clinical relevance - BMI
Change in body mass index (BMI)
More than 1 year
Global measures of adiposity with established clinical relevance - body fat
Change in body fat
More than 1 year
Abdominal measures of adiposity with established clinical relevance - waist circumference
Change in waist circumference
More than 1 year
Overweight/obesity incidence
Risk ratio of Overweight/obesity incidence
More than 1 year
Metabolic syndrome incidence
Risk ratio of metabolic syndrome incidence
More than 1 year
Type 2 diabetes incidence
Risk ratio of type 2 diabetes incidence
More than 1 year
Cardiovascular disease incidence
Risk ratio of cardiovascular disease incidence
More than 1 year
Cardiovascular disease mortality
Risk ratio of Cardiovascular disease mortality
More than 1 year
Total mortality
Risk ratio of total mortality
More than 1 year
Study Arms (1)
Low-calorie Sweetened Beverages (LCSBs)
Beverages exclusively using zero-energy (e.g., acesulfame-potassium, aspartame, cyclamate, saccharin, sucralose, advantame, neotame), and /or reduced-energy food additives (e.g., stevia, monk fruit).
Interventions
Effect of substituting LCSBs for SSBs or Water
Eligibility Criteria
Varies
You may qualify if:
- Prospective cohorts studies
- Duration: more than 1 year follow-up
- Exposure: LCSBs
- Change analysis or substitution analysis of exposure
You may not qualify if:
- Non-human studies
- Less than 1 year follow-up
- Analysis of baseline or prevalent intake of exposure only
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital
Toronto, Ontario, M5C 2T2, Canada
Related Publications (8)
Khan TA, Malik VS, Sievenpiper JL. Letter by Khan et al Regarding Article, "Artificially Sweetened Beverages and Stroke, Coronary Heart Disease, and All-Cause Mortality in the Women's Health Initiative". Stroke. 2019 Jun;50(6):e167-e168. doi: 10.1161/STROKEAHA.119.025571. Epub 2019 May 16. No abstract available.
PMID: 31092156BACKGROUNDMalik VS. Non-sugar sweeteners and health. BMJ. 2019 Jan 3;364:k5005. doi: 10.1136/bmj.k5005. No abstract available.
PMID: 30606710BACKGROUNDJohnson RK, Lichtenstein AH, Anderson CAM, Carson JA, Despres JP, Hu FB, Kris-Etherton PM, Otten JJ, Towfighi A, Wylie-Rosett J; American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Quality of Care and Outcomes Research; and Stroke Council. Low-Calorie Sweetened Beverages and Cardiometabolic Health: A Science Advisory From the American Heart Association. Circulation. 2018 Aug 28;138(9):e126-e140. doi: 10.1161/CIR.0000000000000569.
PMID: 30354445BACKGROUNDToews I, Lohner S, Kullenberg de Gaudry D, Sommer H, Meerpohl JJ. Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. BMJ. 2019 Jan 2;364:k4718. doi: 10.1136/bmj.k4718.
PMID: 30602577BACKGROUNDAzad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, Mann A, Jeyaraman MM, Reid AE, Fiander M, MacKay DS, McGavock J, Wicklow B, Zarychanski R. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ. 2017 Jul 17;189(28):E929-E939. doi: 10.1503/cmaj.161390.
PMID: 28716847BACKGROUNDImamura F, Fretts A, Marklund M, Ardisson Korat AV, Yang WS, Lankinen M, Qureshi W, Helmer C, Chen TA, Wong K, Bassett JK, Murphy R, Tintle N, Yu CI, Brouwer IA, Chien KL, Frazier-Wood AC, Del Gobbo LC, Djousse L, Geleijnse JM, Giles GG, de Goede J, Gudnason V, Harris WS, Hodge A, Hu F; InterAct Consortium; Koulman A, Laakso M, Lind L, Lin HJ, McKnight B, Rajaobelina K, Riserus U, Robinson JG, Samieri C, Siscovick DS, Soedamah-Muthu SS, Sotoodehnia N, Sun Q, Tsai MY, Uusitupa M, Wagenknecht LE, Wareham NJ, Wu JH, Micha R, Forouhi NG, Lemaitre RN, Mozaffarian D; Fatty Acids and Outcomes Research Consortium (FORCE). Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies. PLoS Med. 2018 Oct 10;15(10):e1002670. doi: 10.1371/journal.pmed.1002670. eCollection 2018 Oct.
PMID: 30303968BACKGROUNDRogers PJ, Hogenkamp PS, de Graaf C, Higgs S, Lluch A, Ness AR, Penfold C, Perry R, Putz P, Yeomans MR, Mela DJ. Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies. Int J Obes (Lond). 2016 Mar;40(3):381-94. doi: 10.1038/ijo.2015.177. Epub 2015 Sep 14.
PMID: 26365102BACKGROUNDLee JJ, Khan TA, McGlynn N, Malik VS, Hill JO, Leiter LA, Jeppesen PB, Rahelic D, Kahleova H, Salas-Salvado J, Kendall CWC, Sievenpiper JL. Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Diabetes Care. 2022 Aug 1;45(8):1917-1930. doi: 10.2337/dc21-2130.
PMID: 35901272DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
John L Sievenpiper, MD,PhD,FRCPC
University of Toronto
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
January 23, 2020
First Posted
January 29, 2020
Study Start
May 16, 2019
Primary Completion
March 1, 2020
Study Completion
May 1, 2020
Last Updated
February 25, 2020
Record last verified: 2020-02