Meta-analysis of Low GI/GL Diets and Cardiometabolic Risk in Diabetes

NCT04045938 | Unknown

• 1 other identifier: DNSG-Low-GI/GL (trials)
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

Low glycemic index and low glycemic load diets have been shown to improve glycemic control and cardiometabolic risk factors in randomized controlled trials in people with diabetes and are associated with reduced incidence of diabetes and cardiovascular disease in prospective cohort studies inclusive of people with diabetes. These benefits have been recognized in the most recent updates of the clinical practice guidelines for the management of diabetes from the U.S., Canada, UK, and Australia. The European Association for the Study of Diabetes (EASD) also recommends low-GI/GL diets but has not updated their guidance in 15 years. To support the update of the EASD clinical practice guidelines for nutrition therapy, the investigators conducted a systematic review and meta-analysis of the totality of the available evidence from randomized controlled trials of the effect of low GI/GL dietary patterns on glycemic control and other established cardiometabolic risk factors in individuals with diabetes. The findings generated by this proposed knowledge synthesis will help improve the health of consumers through informing evidence-based guidelines and improving health outcomes by educating healthcare providers and patients, stimulating industry innovation, and guiding future research design.

Conditions

Diabetes

Keywords

glycemic index; glycemic load; glycaemic index; glycaemic load; cardiovascular disease; cardiometabolic risk; glycemic control

Outcome Measures

Primary Outcomes (1)

• HbA1c

  Mean Difference

  Up to 20-years

Secondary Outcomes (13)

• Glycemic control - Fasting blood glucose

  Up to 20-years

• Glycemic control - Fasting blood insulin

  Up to 20-years

• Blood lipids - LDL-cholesterol

  Up to 20-years

• Blood lipids - non-HDL-cholesterol

  Up to 20-years

• Blood lipids - apo B

  Up to 20-years

Interventions

Low Glycemic Index or Glycemic Load OTHER

Dietary pattern focused on low glycemic index foods or on a low glycemic load

Also known as: Low Glycaemic Index or Glycaemic Load

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Diabetes

You may qualify if:

• Dietary trials in humans
• Randomized treatment allocation
• ≥3 weeks
• Suitable control (i.e. isocaloric diet that is not low GI or low GL)
• Viable endpoint data

You may not qualify if:

• Non-human studies
• Non-randomized treatment allocation
• \<3 weeks
• Lack of a suitable control (i.e. non-isocaloric)
• No viable endpoint data

Sponsors & Collaborators

• University of Toronto: lead

Study Sites (1)

University of Toronto

Toronto, Ontario, M5C2T2, Canada

Location

Related Publications (1)

• Chiavaroli L, Lee D, Ahmed A, Cheung A, Khan TA, Blanco S, Mejia, Mirrahimi A, Jenkins DJA, Livesey G, Wolever TMS, Rahelic D, Kahleova H, Salas-Salvado J, Kendall CWC, Sievenpiper JL. Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials. BMJ. 2021 Aug 4;374:n1651. doi: 10.1136/bmj.n1651.

  PMID: 34348965 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus; Cardiovascular Diseases

Interventions

Glycemic Load

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Nutritive Value; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Food Quality; Food Technology; Food Industry; Industry; Technology, Industry, and Agriculture; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 2, 2019
• First Posted: August 6, 2019
• Study Start: August 1, 2019
• Primary Completion: May 31, 2021
• Study Completion: June 30, 2021
• Last Updated: May 17, 2021

Record last verified: 2021-05

Locations

CA (1)