Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
Lp(a)HORIZON
A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With Established Cardiovascular Disease
2 other identifiers
interventional
8,323
41 countries
866
Brief Summary
This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Dec 2019
Longer than P75 for phase_3
866 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 16, 2019
CompletedFirst Posted
Study publicly available on registry
July 17, 2019
CompletedStudy Start
First participant enrolled
December 12, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 30, 2026
May 6, 2026
May 1, 2026
6.6 years
July 16, 2019
May 4, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Time to first occurrence of clinical endpoint committee confirmed expanded major adverse cardiovascular events in patients with elevated Lp(a) ≥ 70 mg/dL
Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of expanded MACE (cardiovascular death, non-fatal MI, non-fatal stroke and urgent coronary re-vascularization requiring hospitalization) in the overall study population with established CVD and (Lp(a) ≥ 70 mg/dL)
approximately 4 years
Time to the first occurrence of clinical endpoint committee confirmed expanded major adverse cardiovascular events in a population of patients with elevated Lp(a) ≥ 90 mg/dL.
Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of expanded MACE (cardiovascular death, non-fatal MI, non-fatal stroke and urgent coronary re-vascularization requiring hospitalization) in the overall study population with established CVD and (Lp(a) ≥ 90 mg/dL)
approximately 4 years
Secondary Outcomes (4)
Time to the first occurrence of the clinical endpoint committee confirmed composite endpoint of major adverse cardiovascular events (CV death, non-fatal MI, and non-fatal stroke)
approximately 4 years
Time to the first occurrence of the clinical endpoint committee confirmed composite endpoint of coronary heart disease: coronary heart disease death, non-fatal MI, urgent coronary re-vascularization requiring hospitalization
approximately 4 years
Time to Clinical endpoint Committee confirmed all-cause death
approximately 4 years
Change in Lp(a) in the log scale from baseline
Baseline, year 1
Study Arms (2)
TQJ230
EXPERIMENTALTQJ230 80 mg injected monthly administered subcutaneously
Placebo
PLACEBO COMPARATORMonthly subcutaneous injections.
Interventions
Eligibility Criteria
You may qualify if:
- Lp(a) ≥ 70 mg/dL at the screening visit, measured at the Central laboratory
- Myocardial infarction: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
- Ischemic stroke: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
- Clinically significant symptomatic peripheral artery disease
You may not qualify if:
- Uncontrolled hypertension
- Heart failure New York Heart Association (NYHA) class IV
- History of malignancy of any organ system
- History of hemorrhagic stroke or other major bleeding
- Platelet count ≤LLN
- Active liver disease or hepatic dysfunction
- Significant kidney disease
- Pregnant or nursing women
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (904)
SEC Clinical Research LLC
Andalusia, Alabama, 36420, United States
Grandview Med Group Research LLC
Birmingham, Alabama, 35243, United States
Novartis Investigative Site
Birmingham, Alabama, 35243, United States
Heart Center Research Llc
Huntsville, Alabama, 35801, United States
Novartis Investigative Site
Huntsville, Alabama, 35801, United States
Mobile Heart Specialists
Mobile, Alabama, 36608, United States
Novartis Investigative Site
Mobile, Alabama, 36608, United States
Novartis Investigative Site
Cottonwood, Arizona, 86326, United States
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297, United States
Clinical Research Inst of Arizona
Sun City West, Arizona, 85375, United States
Novartis Investigative Site
Sun City West, Arizona, 85375, United States
Eclipse Clinical Research
Tucson, Arizona, 85745, United States
Novartis Investigative Site
Tucson, Arizona, 85745, United States
Cardiology and Medicine Clinic PA
Little Rock, Arkansas, 72204, United States
Novartis Investigative Site
Little Rock, Arkansas, 72204, United States
Cardiovascular Res Found
Beverly Hills, California, 90210, United States
National Heart Institute
Beverly Hills, California, 90211, United States
Novartis Investigative Site
Beverly Hills, California, 90211, United States
Flourish Clinical Resrch Covin
Covina, California, 91723, United States
Novartis Investigative Site
Covina, California, 91723, United States
Diabetes Lipid Management Center
Huntington Beach, California, 92648, United States
Novartis Investigative Site
Huntington Beach, California, 92648, United States
University of Calif Irvine Med Cntr
Irvine, California, 92660, United States
Novartis Investigative Site
La Jolla, California, 92037, United States
Memorial Care Health System
Long Beach, California, 90806, United States
Novartis Investigative Site
Long Beach, California, 90806, United States
Keck Medical Center USC
Los Angeles, California, 90033, United States
Novartis Investigative Site
Los Angeles, California, 90033, United States
Novartis Investigative Site
Los Angeles, California, 90073, United States
Novartis Investigative Site
Northridge, California, 91325, United States
Valley Clinical Trials
Northridge, California, 91325, United States
Novartis Investigative Site
Orange, California, 92868, United States
Stanford University Medical Center
Palo Alto, California, 94304, United States
University of California San Diego
San Diego, California, 92103, United States
UCSF
San Francisco, California, 94115, United States
Novartis Investigative Site
San Francisco, California, 94158, United States
Helping Hands Medical Associates INC
Santa Ana, California, 92704, United States
Novartis Investigative Site
Santa Ana, California, 92704, United States
Novartis Investigative Site
Stanford, California, 94305, United States
Manshadi Heart Institute
Stockton, California, 95204, United States
Novartis Investigative Site
Stockton, California, 95204, United States
Interv Cardiology Med Grp
West Hills, California, 91307, United States
Novartis Investigative Site
West Hills, California, 91307, United States
Novartis Investigative Site
Aurora, Colorado, 80045, United States
Univ Of Color Anschutz Med Center
Aurora, Colorado, 80045, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
Novartis Investigative Site
Bridgeport, Connecticut, 06610, United States
Novartis Investigative Site
Hartford, Connecticut, 06102-5037, United States
Hartford Hospital
Hartford, Connecticut, 06102, United States
Chase Medical Research LLC
Waterbury, Connecticut, 06708, United States
Novartis Investigative Site
Waterbury, Connecticut, 06708, United States
Excel Medical Clinical Trials LLC
Boca Raton, Florida, 33434, United States
Novartis Investigative Site
Boca Raton, Florida, 33434, United States
Cardiovascular and Vein Center of Florida
Bradenton, Florida, 34209, United States
Novartis Investigative Site
Bradenton, Florida, 34209, United States
Bay Area Cardiology Assoc
Brandon, Florida, 33511, United States
Novartis Investigative Site
Brandon, Florida, 33511, United States
Novartis Investigative Site
Fort Lauderdale, Florida, 33312, United States
CV Consultants of South Broward
Hollywood, Florida, 33021, United States
Novartis Investigative Site
Jacksonville, Florida, 32205, United States
Westside Center for Clinical Research
Jacksonville, Florida, 32205, United States
East Coast Institute for Research
Jacksonville, Florida, 32216, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Novartis Investigative Site
Jacksonville, Florida, 32216, United States
Infinite Clinical Research
Miami, Florida, 33133, United States
Novartis Investigative Site
Miami, Florida, 33133, United States
Advanced Research for Health Improvement LLC
Naples, Florida, 34102, United States
Novartis Investigative Site
Naples, Florida, 34102, United States
Southwest Florida Research
Naples, Florida, 34102, United States
Novartis Investigative Site
Port Charlotte, Florida, 33952, United States
Peace River Cardiovascular Center
Port Charlotte, Florida, 33952, United States
Novartis Investigative Site
Port Orange, Florida, 32127, United States
Progressive Medical Research
Port Orange, Florida, 32127, United States
East Coast Inst for Research LLC
Saint Augustine, Florida, 32086, United States
Novartis Investigative Site
Saint Augustine, Florida, 32086, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, 33449, United States
Novartis Investigative Site
Wellington, Florida, 33449, United States
Novartis Investigative Site
Atlanta, Georgia, 30084, United States
Grady Health System
Atlanta, Georgia, 30303, United States
Novartis Investigative Site
Atlanta, Georgia, 30309, United States
Piedmont Heart Institute
Atlanta, Georgia, 30309, United States
Emory University
Atlanta, Georgia, 30322, United States
Novartis Investigative Site
Atlanta, Georgia, 30324, United States
Novartis Investigative Site
Dunwoody, Georgia, 30338, United States
Alta Pharmaceutical Research Center
Peachtree Corners, Georgia, 30092, United States
Cardiovascular Consultants of S GA
Thomasville, Georgia, 31792, United States
Novartis Investigative Site
Thomasville, Georgia, 31792, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
Advocate Lutheran General Childrens Hospital
Park Ridge, Illinois, 60068, United States
Novartis Investigative Site
Park Ridge, Illinois, 60068, United States
Krannert Institute of Cardiology
Indianapolis, Indiana, 46202 4800, United States
Novartis Investigative Site
Indianapolis, Indiana, 46202 4800, United States
Novartis Investigative Site
Iowa City, Iowa, 52242, United States
Uni Of Iowa Hospitals And Clinics
Iowa City, Iowa, 52242, United States
Novartis Investigative Site
Kansas City, Kansas, 66160, United States
University of Kansas Hospital
Kansas City, Kansas, 66160, United States
Cotton O Neil Clinical Res Center
Topeka, Kansas, 66606, United States
Novartis Investigative Site
Topeka, Kansas, 66606, United States
Christus Health Central Louisiana
Alexandria, Louisiana, 71301, United States
Novartis Investigative Site
Alexandria, Louisiana, 71301, United States
Novartis Investigative Site
Baton Rouge, Louisiana, 70808, United States
Novartis Investigative Site
Bogalusa, Louisiana, 70427, United States
Novartis Investigative Site
Bossier City, Louisiana, 71111, United States
Cardiovascular Associates Research
Covington, Louisiana, 70433, United States
Louisiana Heart Center Research
Covington, Louisiana, 70433, United States
Novartis Investigative Site
Covington, Louisiana, 70433, United States
Novartis Investigative Site
Eunice, Louisiana, 70535, United States
Heart Clinic of Hammond
Hammond, Louisiana, 70403, United States
Novartis Investigative Site
Hammond, Louisiana, 70403, United States
CV Institute of the South
Houma, Louisiana, 70360, United States
Novartis Investigative Site
Houma, Louisiana, 70360, United States
Horizon Research Grp
Lafayette, Louisiana, 70501, United States
Novartis Investigative Site
Metairie, Louisiana, 70006, United States
Omega Clinical Research
Metairie, Louisiana, 70006, United States
Tulane Uni Health Sciences Center
New Orleans, Louisiana, 70112, United States
Crescent City Physicians Inc
New Orleans, Louisiana, 70115, United States
Novartis Investigative Site
New Orleans, Louisiana, 70115, United States
CV Ins of the South
Opelousas, Louisiana, 70570, United States
Novartis Investigative Site
Opelousas, Louisiana, 70570, United States
Grace Research Llc
Shreveport, Louisiana, 71105, United States
Novartis Investigative Site
Shreveport, Louisiana, 71105, United States
Louisiana Heart Center Research
Slidell, Louisiana, 70458, United States
Novartis Investigative Site
Slidell, Louisiana, 70458, United States
Novartis Investigative Site
Zachary, Louisiana, 70791, United States
Southern Clinical Research
Zachary, Louisiana, 70791, United States
Maine Health Cardiology
Scarborough, Maine, 04074, United States
Novartis Investigative Site
Scarborough, Maine, 04074, United States
Novartis Investigative Site
Baltimore, Maryland, 21201, United States
University of Maryland
Baltimore, Maryland, 21201, United States
Novartis Investigative Site
Baltimore, Maryland, 21209, United States
Sinai Ct for Throm Res and Drug Dev
Baltimore, Maryland, 21209, United States
Johns Hopkins Univ School of Med
Baltimore, Maryland, 21287, United States
Novartis Investigative Site
Baltimore, Maryland, 21287, United States
Johns Hopkins University
Columbia, Maryland, 21044, United States
Novartis Investigative Site
Columbia, Maryland, 21044, United States
Anderson Medical Research
Ft. Washington, Maryland, 20744, United States
Novartis Investigative Site
Ft. Washington, Maryland, 20744, United States
Adventist HealthCare Shady Grove Medical Center
Rockville, Maryland, 20850, United States
Novartis Investigative Site
Rockville, Maryland, 20850, United States
MGH
Boston, Massachusetts, 02114 2696, United States
Novartis Investigative Site
Boston, Massachusetts, 02114-2696, United States
Brigham and Womens Hosp Harvard Med School
Boston, Massachusetts, 02115, United States
Novartis Investigative Site
Boston, Massachusetts, 02115, United States
Novartis Investigative Site
Detroit, Michigan, 48201, United States
Wayne State University
Detroit, Michigan, 48201, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
Novartis Investigative Site
Detroit, Michigan, 48202, United States
AA Medical Research Center
Flint, Michigan, 48504, United States
Novartis Investigative Site
Flint, Michigan, 48504, United States
Genesys Regional Medical Center
Grand Blanc, Michigan, 48439, United States
Novartis Investigative Site
Grand Blanc, Michigan, 48439, United States
Novartis Investigative Site
Kalamazoo, Michigan, 49008, United States
Western Michigan University
Kalamazoo, Michigan, 49008, United States
McLaren Ctr Research Innovation
Petoskey, Michigan, 49770, United States
Novartis Investigative Site
Petoskey, Michigan, 49770, United States
Central Michigan University
Saginaw, Michigan, 48601, United States
Novartis Investigative Site
Saginaw, Michigan, 48601, United States
Metro Health Univ of MI Health
Wyoming, Michigan, 49519, United States
Novartis Investigative Site
Wyoming, Michigan, 49519, United States
Saint Johns Hospital
Maplewood, Minnesota, 55109, United States
Minneapolis Heart Institute
Minneapolis, Minnesota, 55407, United States
Novartis Investigative Site
Minneapolis, Minnesota, 55407, United States
Novartis Investigative Site
Minneapolis, Minnesota, 55455, United States
University Of Minnesota
Minneapolis, Minnesota, 55455, United States
Belzoni Clinical Research
Belzoni, Mississippi, 39038, United States
Novartis Investigative Site
Belzoni, Mississippi, 39038, United States
Novartis Investigative Site
Southaven, Mississippi, 38671, United States
Stern Cardiovascular Foundation Inc
Southaven, Mississippi, 38671, United States
Novartis Investigative Site
Yazoo City, Mississippi, 39194, United States
Novartis Investigative Site
City of Saint Peters, Missouri, 63303, United States
StudyMetrix Research
City of Saint Peters, Missouri, 63303, United States
Novartis Investigative Site
St Louis, Missouri, 63110, United States
Washington Univ School Of Medicine
St Louis, Missouri, 63110, United States
Mercy South
St Louis, Missouri, 63128, United States
Mercy Hospital St Louis
St Louis, Missouri, 63141, United States
Novartis Investigative Site
Lincoln, Nebraska, 68526, United States
Novartis Investigative Site
Omaha, Nebraska, 68114, United States
Quality Clinical Research
Omaha, Nebraska, 68114, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
Novartis Investigative Site
Lebanon, New Hampshire, 03756, United States
Novartis Investigative Site
Ridgewood, New Jersey, 07450, United States
The Valley Hospital
Ridgewood, New Jersey, 07450, United States
Novartis Investigative Site
Summit, New Jersey, 07901, United States
Overlook Medical Center
Summit, New Jersey, 07901, United States
Albany Medical College
Albany, New York, 12206, United States
Northwell Health
Manhasset, New York, 11030, United States
Novartis Investigative Site
Manhasset, New York, 11030, United States
New York Uni Med Ctr
New York, New York, 10016, United States
Novartis Investigative Site
New York, New York, 10016, United States
Novartis Investigative Site
New York, New York, 10021, United States
Weill Cornell Medical Center
New York, New York, 10021, United States
Icahn School of Med at Mt Sinai
New York, New York, 10029, United States
Novartis Investigative Site
New York, New York, 10029, United States
Novartis Investigative Site
New York, New York, 10075, United States
Lenox Hill Hospital
New York, New York, 43210, United States
Northwell Health Physician Peconic
Riverhead, New York, 11901, United States
Rochester Regional Health
Rochester, New York, 14621, United States
Strong Memorial Hospital
Rochester, New York, 14642, United States
Novartis Investigative Site
Southampton, New York, 11968, United States
Novant Health Heart Vas Inst
Charlotte, North Carolina, 28204, United States
Novartis Investigative Site
Charlotte, North Carolina, 28204, United States
Medication Management LLC
Greensboro, North Carolina, 27405, United States
Novartis Investigative Site
Greensboro, North Carolina, 27405, United States
Novartis Investigative Site
High Point, North Carolina, 27262, United States
Accellacare US Inc
Raleigh, North Carolina, 27609, United States
Novartis Investigative Site
Sanford, North Carolina, 27330, United States
Jones Family Practice PA
Shelby, North Carolina, 28150, United States
Novartis Investigative Site
Shelby, North Carolina, 28150, United States
Novartis Investigative Site
Winston-Salem, North Carolina, 27157, United States
Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina, 27157, United States
Novartis Investigative Site
Akron, Ohio, 44304, United States
Akron Hospital Summa Health System
Akron, Ohio, 44309, United States
Aultman Hospital
Canton, Ohio, 44710, United States
Novartis Investigative Site
Canton, Ohio, 44710, United States
Lindner Ctr At The Christ Hosp
Cincinnati, Ohio, 45219, United States
Novartis Investigative Site
Cincinnati, Ohio, 45219, United States
Novartis Investigative Site
Cincinnati, Ohio, 45246, United States
Velocity Clin Research Springdale
Cincinnati, Ohio, 45246, United States
Novartis Investigative Site
Cincinnati, Ohio, 45267, United States
University Of Cincinnati
Cincinnati, Ohio, 45267, United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
Novartis Investigative Site
Cleveland, Ohio, 44195, United States
Novartis Investigative Site
Columbus, Ohio, 43210, United States
Ohio State University
Columbus, Ohio, 43210, United States
Novartis Investigative Site
Marion, Ohio, 43302, United States
Rama Research LLC
Marion, Ohio, 43302, United States
Novartis Investigative Site
Portland, Oregon, 97239, United States
Oregon Health Sciences University
Portland, Oregon, 97239, United States
Lancaster General Health
Lancaster, Pennsylvania, 17603, United States
Novartis Investigative Site
Lancaster, Pennsylvania, 17603, United States
Novartis Investigative Site
Philadelphia, Pennsylvania, 19104, United States
Perelman School of Medicine
Philadelphia, Pennsylvania, 19104, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
Cardiology Consultants of Philadelphia
Yardley, Pennsylvania, 19067, United States
Novartis Investigative Site
Yardley, Pennsylvania, 19067, United States
Miriam Hospital
Providence, Rhode Island, 02906, United States
Novartis Investigative Site
Providence, Rhode Island, 02906, United States
Novartis Investigative Site
Fort Mill, South Carolina, 29707, United States
Piedmont Research Partners LLC
Fort Mill, South Carolina, 29707, United States
Novartis Investigative Site
Summerville, South Carolina, 29485, United States
Palmetto Clinical Research
Summerville, South Carolina, 29485, United States
Monument Health Clinical Research
Rapid City, South Dakota, 57701, United States
Novartis Investigative Site
Rapid City, South Dakota, 57701, United States
Novartis Investigative Site
Germantown, Tennessee, 38138, United States
The Stern Cardiovascular Foundation
Germantown, Tennessee, 38138, United States
Apex Cardiology Research Associates of Jackson
Jackson, Tennessee, 38301, United States
Novartis Investigative Site
Jackson, Tennessee, 38301, United States
Novartis Investigative Site
Nashville, Tennessee, 37232, United States
Vanderbilt Univ Medi Cen
Nashville, Tennessee, 37232, United States
Cardiovascular Res of Knoxville LLC
Powell, Tennessee, 37849, United States
Novartis Investigative Site
Powell, Tennessee, 37849, United States
Novartis Investigative Site
Dallas, Texas, 75226, United States
Soltero Cardiovascular Research Center
Dallas, Texas, 75226, United States
North Texas Endocrine Center
Dallas, Texas, 75231, United States
Novartis Investigative Site
Dallas, Texas, 75231, United States
Novartis Investigative Site
Dallas, Texas, 75235, United States
SW Family Medicine Associates
Dallas, Texas, 75235, United States
UT Southwestern Medical Center
Dallas, Texas, 75390, United States
Baylor College Of Medicine
Houston, Texas, 77030, United States
Novartis Investigative Site
Houston, Texas, 77030, United States
Novartis Investigative Site
Livingston, Texas, 77351, United States
Grace Research
Marshall, Texas, 75670, United States
Novartis Investigative Site
Temple, Texas, 76508, United States
Northwest Houston Clinical Research PLLC
Tomball, Texas, 77375, United States
Novartis Investigative Site
Tomball, Texas, 77375, United States
Novartis Investigative Site
Bountiful, Utah, 84010, United States
Progressive Clinical Research
Bountiful, Utah, 84010, United States
Intermountain Medical Center
Murray, Utah, 84107, United States
Novartis Investigative Site
Murray, Utah, 84107, United States
The University of Utah
Salt Lake City, Utah, 84132-0001, United States
Novartis Investigative Site
Danville, Virginia, 24541, United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042, United States
Novartis Investigative Site
Falls Church, Virginia, 22042, United States
Virginia Heart
Falls Church, Virginia, 22042, United States
Carient Heart and Vascular
Manassas, Virginia, 20109, United States
Novartis Investigative Site
Manassas, Virginia, 20109, United States
York Clinical Research
Norfolk, Virginia, 23504, United States
Novartis Investigative Site
Norfolk, Virginia, 23510, United States
Dominion Medical Associates
Richmond, Virginia, 23219, United States
Novartis Investigative Site
Richmond, Virginia, 23219, United States
Harborview Medical Center
Seattle, Washington, 98104, United States
Novartis Investigative Site
Seattle, Washington, 98104, United States
Novartis Investigative Site
Seattle, Washington, 98122, United States
Swedish Medical Center-Cardiovascular Research
Seattle, Washington, 98122, United States
Novartis Investigative Site
Seattle, Washington, 98195, United States
Univ of Washington Medical Center
Seattle, Washington, 98195, United States
West Virginia University Hospital
Morgantown, West Virginia, 26506, United States
Novartis Investigative Site
Milwaukee, Wisconsin, 53215, United States
St Luke s Medical Center Aurora
Milwaukee, Wisconsin, 53215, United States
Novartis Investigative Site
CABA, Buenos Aires, 1280, Argentina
Novartis Investigative Site
CABA, Buenos Aires, 1407, Argentina
Novartis Investigative Site
CABA, Buenos Aires, 1426, Argentina
Novartis Investigative Site
CABA, Buenos Aires, C1056ABI, Argentina
Novartis Investigative Site
Mar del Plata, Buenos Aires, 7600, Argentina
Novartis Investigative Site
Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Novartis Investigative Site
Córdoba, Córdoba Province, 5000, Argentina
Novartis Investigative Site
San Miguel de Tucumán, San Miguel de Tucuman, T4000ICL, Argentina
Novartis Investigative Site
Rosario, Santa Fe Province, 2000, Argentina
Novartis Investigative Site
Rosario, Santa Fe Province, S200CVD, Argentina
Novartis Investigative Site
Santa Fe, Santa Fe Province, S3000FWO, Argentina
Novartis Investigative Site
San Miguel Tucuman, Tucumán Province, T4000IFL, Argentina
Novartis Investigative Site
Caba, C1426, Argentina
Novartis Investigative Site
Capital Federal, C1023AAB, Argentina
Novartis Investigative Site
Corrientes, W3400CDS, Argentina
Novartis Investigative Site
Córdoba, X5002, Argentina
Novartis Investigative Site
San Luis, D5702JRS, Argentina
Novartis Investigative Site
Camperdown, New South Wales, 2050, Australia
Novartis Investigative Site
Chemside, Queensland, 4032, Australia
Novartis Investigative Site
Southport, Queensland, 4215, Australia
Novartis Investigative Site
Woolloongabba, Queensland, 4102, Australia
Novartis Investigative Site
Clayton, Victoria, 3168, Australia
Novartis Investigative Site
Perth, Western Australia, 6000, Australia
Novartis Investigative Site
Liverpool, 2170, Australia
Novartis Investigative Site
Graz, 8036, Austria
Novartis Investigative Site
Innsbruck, 6020, Austria
Novartis Investigative Site
Linz, 4021, Austria
Novartis Investigative Site
Salzburg, 5020, Austria
Novartis Investigative Site
Vienna, 1090, Austria
Novartis Investigative Site
Vienna, 1210, Austria
Novartis Investigative Site
Brussels, Brussels Capital, 1070, Belgium
Novartis Investigative Site
Genk, Limburg, 3600, Belgium
Novartis Investigative Site
Aalst, Oost Vlaanderen, 9300, Belgium
Novartis Investigative Site
Kortrijk, West-Vlaanderen, 8500, Belgium
Novartis Investigative Site
Bruges, 8000, Belgium
Novartis Investigative Site
Dendermonde, 9200, Belgium
Novartis Investigative Site
Huy, 4500, Belgium
Novartis Investigative Site
Mechelen, 2800, Belgium
Novartis Investigative Site
Maceió, Alagoas, 57051-160, Brazil
Novartis Investigative Site
Vitória, Espírito Santo, 29055-450, Brazil
Novartis Investigative Site
Salvador, Estado de Bahia, 40170-130, Brazil
Novartis Investigative Site
Brasília, Federal District, 70390-700, Brazil
Novartis Investigative Site
Goiânia, Goiás, 74605-020, Brazil
Novartis Investigative Site
Belo Horizonte, Minas Gerais, 30150-270, Brazil
Novartis Investigative Site
Belo Horizonte, Minas Gerais, 30220-330, Brazil
Novartis Investigative Site
Juiz de Fora, Minas Gerais, 36033-318, Brazil
Novartis Investigative Site
Uberlândia, Minas Gerais, 38400 500, Brazil
Novartis Investigative Site
Curitiba, Paraná, 80230-130, Brazil
Novartis Investigative Site
Curitiba, Paraná, 80730-150, Brazil
Novartis Investigative Site
Canoas, Rio Grande do Sul, 92425 900, Brazil
Novartis Investigative Site
Porto Alegre, Rio Grande do Sul, 90160-093, Brazil
Novartis Investigative Site
Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
Novartis Investigative Site
Blumenau, Santa Catarina, 89020-430, Brazil
Novartis Investigative Site
Aracaju, Sergipe, 49055-530, Brazil
Novartis Investigative Site
Campinas, São Paulo, 13060 080, Brazil
Novartis Investigative Site
Campinas, São Paulo, 13092133, Brazil
Novartis Investigative Site
Ribeirão Preto, São Paulo, 14026-020, Brazil
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Santo André, São Paulo, 09060-870, Brazil
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Santo André, São Paulo, 09090-790, Brazil
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Sao Jose Rio Preto, São Paulo, 15015-750, Brazil
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Sao Jose Rio Preto, São Paulo, 15090 000, Brazil
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São Paulo, São Paulo, 01323 000, Brazil
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São Paulo, São Paulo, 04005-003, Brazil
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São Paulo, São Paulo, 04023-900, Brazil
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São Paulo, São Paulo, 04266 010, Brazil
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São Paulo, São Paulo, 05403 000, Brazil
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São Paulo, São Paulo, 05403-900, Brazil
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Rio de Janeiro, 20241-180, Brazil
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Blagoevgrad, Bulgaria, 2700, Bulgaria
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Burgas, 8001, Bulgaria
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Pernik, 2300, Bulgaria
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Pleven, 5800, Bulgaria
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Plovdiv, 4000, Bulgaria
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Rousse, 7002, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1750, Bulgaria
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Vancouver, British Columbia, V5Z 1M9, Canada
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Vancouver, British Columbia, V6Z 1Y6, Canada
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Victoria, British Columbia, V8R4R2, Canada
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Victoria, British Columbia, V8T 5G4, Canada
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Oakville, Ontario, L6K 3W7, Canada
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Toronto, Ontario, M9V 4B4, Canada
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Lévis, Quebec, G6V 4Z5, Canada
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Montreal, Quebec, H1T 1C8, Canada
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Montreal, Quebec, H2X 1R9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1R 2J6, Canada
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Québec, Quebec, G1V 4G2, Canada
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Québec, Quebec, G1V 4G5, Canada
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Québec, Quebec, G1V 4W2, Canada
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Terrebonne, Quebec, J6V 2H2, Canada
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Santiago, RM, 7500588, Chile
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Santiago, Santiago Metropolitan, 7500710, Chile
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Santiago, Santiago Metropolitan, 8331143, Chile
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Santiago, Santiago Metropolitan, 8380465, Chile
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Santiago, 7500710, Chile
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Santiago, 8380456, Chile
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Beijing, Beijing Municipality, 100013, China
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Lanzhou, Gansu, 730030, China
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Foshan, Guangdong, 528000, China
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Guangzhou, Guangdong, 510030, China
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Guangzhou, Guangdong, 510080, China
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Harbin, Heilongjiang, 150000, China
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Changsha, Hunan, 410003, China
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Changsha, Hunan, 410008, China
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Changsha, Hunan, 410011, China
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Baotou, Inner Mongolia, 014040, China
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Nanjing, Jiangsu, 210009, China
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Nanjing, Jiangsu, 210029, China
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Nanjing, Jiangsu, 211166, China
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Suzhou, Jiangsu, 215004, China
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Xuzhou, Jiangsu, 221003, China
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Changchun, Jilin, 130021, China
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Dalian, Liaoning, 116011, China
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Shenyang, Liaoning, 110004, China
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Shenyang, Liaoning, 110016, China
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Jinan, Shandong, 250013, China
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Xian, Shanxi, 710061, China
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Chengdu, Sichuan, 610041, China
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Ürümqi, Xinjiang, 830054, China
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Hangzhou, Zhejiang, 310014, China
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Hangzhou, Zhejiang, 310016, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 100050, China
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Beijing, 100191, China
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Beijing, 100730, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Shanghai, 200065, China
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Shanghai, 200120, China
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Tianjin, 030045, China
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Tianjin, 300052, China
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Tianjin, 300121, China
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Xiamen, 361004, China
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Medellín, Antioquia, 050001, Colombia
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Barranquilla, Colombia, 080020, Colombia
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Bucaramanga, Santander Department, 681017, Colombia
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Cali, Valle del Cauca Department, 760001, Colombia
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Cali, Valle del Cauca Department, 760032, Colombia
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Bogotá, 111211, Colombia
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Medellín, 050037, Colombia
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San Gil, 684031, Colombia
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Chlumec nad Cidlinou, Chlumec Nad Cidlinou, 503 51, Czechia
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Kroměříž, Czech Republic, 767 55, Czechia
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Louny, Czech Republic, 440 01, Czechia
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Ostrava, Czech Republic, 725 27, Czechia
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Ústí nad Labem, Czech Republic, 400 01, Czechia
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Ostrava, Zabreh, 700 30, Czechia
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Brandýs nad Labem, 250 01, Czechia
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Brno, 602 00, Czechia
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Brno, 625 00, Czechia
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Broumov, 550 01, Czechia
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CZE, 110 00, Czechia
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Český Krumlov, 381 01, Czechia
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Hlučín, 748 01, Czechia
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Hodonín, 695 01, Czechia
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Jihlava, 586 01, Czechia
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Kolín, 280 20, Czechia
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Liberec, 460 01, Czechia
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Liberec, 460 05, Czechia
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Mariánské Lázně, 353 01, Czechia
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Mělník, 276 01, Czechia
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Most, 434 01, Czechia
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Olomouc, 779 00, Czechia
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Ostrava, 700 30, Czechia
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Ostrava, 710 00, Czechia
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Pardubice, 532 03, Czechia
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Polička, 57201, Czechia
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Prague, 101 00, Czechia
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Prague, 110 00, Czechia
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Prague, 128 08, Czechia
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Prague, 158 00, Czechia
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Přerov, 751 52, Czechia
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Slaný, 274 01, Czechia
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Svitavy, 568 25, Czechia
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Trutnov, 460 63, Czechia
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Třebíč, 674 01, Czechia
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Uherské Hradiště, 686 01, Czechia
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Valašské Meziříčí, 75742, Czechia
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Zlín, 760 01, Czechia
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Aarhus N, 8200, Denmark
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Copenhagen, DK-2100, Denmark
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Esbjerg, 6700, Denmark
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Gistrup, 9260, Denmark
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Herlev, DK-2730, Denmark
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Roskilde, 4000, Denmark
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Viborg, 8800, Denmark
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Bron, 69677, France
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Chambray-lès-Tours, 37170, France
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Compiègne, 60321, France
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Grenoble, 38043, France
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Le Coudray, 28630, France
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Lille, 59000, France
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Nantes, 44093, France
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Paris, 75012, France
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Paris, 75015, France
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Paris, 75018, France
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Toulouse, 31054, France
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Tourcoing, 59208, France
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Valenciennes, 59300, France
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Mannheim, Baden-Wurttemberg, 68305, Germany
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Künzing, Bavaria, 94550, Germany
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Muehldorf Am Inn, Bavaria, 84453, Germany
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Munich, Bavaria, 81377, Germany
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Weiden in Der Oberpfalz, Bavaria, 92637, Germany
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Frankfurt am Main, Hesse, 60590, Germany
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Frankfurt am Main, Hesse, 60594, Germany
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Hanover, Lower Saxony, 30159, Germany
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Cologne, North Rhine-Westphalia, 50733, Germany
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Cologne, North Rhine-Westphalia, 50937, Germany
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Essen, North Rhine-Westphalia, 45355, Germany
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Löhne, North Rhine-Westphalia, 32584, Germany
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Saint Ingbert, Saarland, 66386, Germany
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Chemnitz, Saxony, 09113, Germany
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Dresden, Saxony, 01099, Germany
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Dresden, Saxony, 01307, Germany
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Leipzig, Saxony, 04103, Germany
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Leipzig, Saxony, 04107, Germany
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Wittenberg, Saxony-Anhalt, 06886, Germany
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Jena, Thuringia, 07740, Germany
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Aachen, 52074, Germany
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Bad Homburg, 61348, Germany
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Bad Krozingen, 79189, Germany
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Bad Oeynhausen, 32545, Germany
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Bamberg, 96049, Germany
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Berlin, 10367, Germany
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Berlin, 10559, Germany
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Berlin, 10787, Germany
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Berlin, 10789, Germany
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Berlin, 13347, Germany
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Berlin, 13353, Germany
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Bielefeld, 33604, Germany
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Chemnitz, 09122, Germany
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Dessau, 06846, Germany
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Dortmund, 44137, Germany
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Dresden, 01069, Germany
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Dresden, 01277, Germany
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Dresden, 01307, Germany
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Essen, 45277, Germany
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Essen, 45355, Germany
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Essen, 45359, Germany
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Gelnhausen, 63571, Germany
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Hamburg, 22041, Germany
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Hamburg, 22607, Germany
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Kassel, 34121, Germany
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Lüneburg, 21339, Germany
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Magdeburg, 39120, Germany
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Mannheim, 68165, Germany
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Meissen, 01662, Germany
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München, 80636, Germany
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Münster, 48149, Germany
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Potsdam, 14471, Germany
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Rüdersdorf, 15562, Germany
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Ulm, 89077, Germany
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Warendorf, 48231, Germany
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Athens, 115 21, Greece
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Athens, 115 27, Greece
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Athens, 142 33, Greece
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Chalcis, 341 00, Greece
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Ioannina, 455 00, Greece
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Larissa, 411 10, Greece
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Thessaloniki, 54636, Greece
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Guatemala City, Departamento de Guatemala, 01001, Guatemala
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Guatemala City, 01010, Guatemala
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Guatemala City, 01011, Guatemala
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Hong Kong, 999077, Hong Kong
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Shatin, 999077, Hong Kong
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Pécs, Baranya, 7623, Hungary
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Baja, 6500, Hungary
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Budapest, 1204, Hungary
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Budapest, H-1083, Hungary
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Budapest, H-1097, Hungary
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Budapest, H-1145, Hungary
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Kistarcsa, 2143, Hungary
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Makó, 6900, Hungary
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Miskolc, 3526, Hungary
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Nyíregyháza, 4400, Hungary
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Szeged, 6725, Hungary
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Székesfehérvár, H-8000, Hungary
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Kopavogur, 201, Iceland
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Reykjavik, 101, Iceland
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Guntur, Andhra Pradesh, 522001, India
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Hyderabad, Andhra Pradesh, 500033, India
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Ahmedabad, Gujarat, 380054, India
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Ahmedabad, Gujarat, 380060, India
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Vadodara, Gujarat, 390022, India
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Belagavi, Karnataka, 590010, India
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Mangalore, Karnataka, 575018, India
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Manipal, Karnataka, 576104, India
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Mysore, Karnataka, 570015, India
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Kochi, Kerala, 682018, India
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Kochi, Kerala, 682027, India
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Kochi, Kerala, 682041, India
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Kozhikode, Kerala, 673008, India
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Mumbai, Maharashtra, 401107, India
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Nagpur, Maharashtra, 440008, India
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Nagpur, Maharashtra, 440009, India
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Nagpur, Maharashtra, 440012, India
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Nagpur, Maharashtra, 440033, India
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Nashik, Maharashtra, 422005, India
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Pune, Maharashtra, 411001, India
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Pune, Maharashtra, 411004, India
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Pune, Maharashtra, 411045, India
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New Delhi, National Capital Territory of Delhi, 110060, India
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New Delhi, National Capital Territory of Delhi, 110075, India
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Bikaner, Rajasthan, 334003, India
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Chennai, Tamil Nadu, 600006, India
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Coimbatore, Tamil Nadu, 641009, India
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Coimbatore, Tamil Nadu, 641037, India
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Hyderabad, Telangana, 500034, India
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Hyderabad, Telangana, 500082, India
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Secunderabad, Telangana, 500003, India
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Ghaziabad, Uttar Pradesh, 201012, India
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Lucknow, Uttar Pradesh, 226003, India
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Varanasi, Uttar Pradesh, 221010, India
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Dehradun, Uttarakhand, 248001, India
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New Delhi, 110025, India
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Beersheba, 8457108, Israel
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Haifa, 3104802, Israel
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Haifa, 3436212, Israel
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Holon, 5822012, Israel
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Jerusalem, 9112001, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 5265601, Israel
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Ancona, AN, 60128, Italy
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Bergamo, BG, 24127, Italy
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Bologna, BO, 40138, Italy
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Brescia, BS, 25123, Italy
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Cona, FE, 44124, Italy
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Florence, FI, 50134, Italy
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Pozzilli, IS, 86077, Italy
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Milan, MI, 20132, Italy
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Milan, MI, 20138, Italy
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Milan, MI, 20149, Italy
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Milan, MI, 20162, Italy
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Rozzano, MI, 20089, Italy
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Palermo, PA, 90127, Italy
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Perugia, PG, 06129, Italy
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Pisa, PI, 56124, Italy
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Pisa, PI, 56126, Italy
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Roma, RM, 00161, Italy
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Roma, RM, 00189, Italy
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Salerno, SA, 84131, Italy
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Varese, VA, 21100, Italy
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Naples, 80131, Italy
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Nagoya, Aichi-ken, 453-8511, Japan
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Seto, Aichi-ken, 4898642, Japan
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Hirosaki, Aomori, 0368563, Japan
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Asahi, Chiba, 289-2511, Japan
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Funabashi, Chiba, 273-8588, Japan
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Matsudo, Chiba, 270-2251, Japan
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Fukuoka, Fukuoka, 8140180, Japan
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Kitakyushu, Fukuoka, 8028555, Japan
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Ōgaki, Gifu, 503-8502, Japan
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Kure, Hiroshima, 737-0023, Japan
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Tsuchiura, Ibaraki, 300-0028, Japan
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Kahoku-gun, Ishikawa-ken, 920-0293, Japan
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Komatsu, Ishikawa-ken, 923-0961, Japan
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Takamatsu, Kagawa-ken, 7608557, Japan
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Kawasaki, Kanagawa, 2120021, Japan
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Sagamihara, Kanagawa, 252-0375, Japan
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Yokohama, Kanagawa, 232-0024, Japan
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Yokohama, Kanagawa, 2360037, Japan
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Sendai, Miyagi, 981-0914, Japan
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Miyhazaki, Miyazaki, 8802102, Japan
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Nagaoka, Niigata, 940-8621, Japan
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Osaka, Osaka, 5300001, Japan
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Osaka, Osaka, 543-8922, Japan
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Kawaguchi, Saitama, 3330842, Japan
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Sayama, Saitama, 350-1305, Japan
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Ōmihachiman, Shiga, 523-0082, Japan
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Bunkyo Ku, Tokyo, 1138431, Japan
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Chuo Ku, Tokyo, 104-8560, Japan
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Chuo-ku, Tokyo, 1030027, Japan
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Hachiōji, Tokyo, 192-0918, Japan
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Itabashi-ku, Tokyo, 1738610, Japan
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Ōta-ku, Tokyo, 1438541, Japan
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Shinagawa-ku, Tokyo, 1428666, Japan
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Toshima-ku, Tokyo, 171-0014, Japan
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Ishikawa, 9208641, Japan
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Aguascalientes, Aguascalientes, 20230, Mexico
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Cuernavaca, Morelos, 62250, Mexico
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San Luis Potosí City, San Luis Potosí, 78200, Mexico
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Culiacan Sinaloa, 80230, Mexico
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Distrito Federal, 14080, Mexico
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Apeldoorn, Gelderland, 7334 DZ, Netherlands
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Arnhem, Gelderland, 6815 AD, Netherlands
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Nijmegen, Gelderland, 6500HB, Netherlands
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Tiel, Gelderland, 4002 WP, Netherlands
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Nijmegen, Gerlderland, 6532 SZ, Netherlands
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Heerlen, Limburg, 6419 PC, Netherlands
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Tilburg, North Brabant, 5042 AD, Netherlands
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Alkmaar, North Holland, 1815 JD, Netherlands
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Amsterdam, North Holland, 1090 HM, Netherlands
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Amsterdam, North Holland, 1105 AZ, Netherlands
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Heemstede, North Holland, 2035 RC, Netherlands
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Deventer, Overijssel, 7416 SE, Netherlands
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Zwolle, Overijssel, 8025 AB, Netherlands
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Sneek, Provincie Friesland, 8601 ZK, Netherlands
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Groningen, Provincie Groningen, 9728 NZ, Netherlands
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Delft, South Holland, 2625 AD, Netherlands
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Leiden, South Holland, 2333 ZA, Netherlands
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Leiderdorp, South Holland, 2353 GA, Netherlands
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The Hague, South Holland, 2545 AA, Netherlands
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Amersfoort, 3813 TZ, Netherlands
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Enschede, 7512KZ, Netherlands
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Gouda, 2803 HH, Netherlands
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Hardenberg, 7770 SE, Netherlands
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Utrecht, 3584 CX, Netherlands
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Venlo, 5912 BL, Netherlands
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Oslo, 0514, Norway
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Skedsmokorset, 2020, Norway
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San Miguel, Lima region, 32, Peru
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Bielsko-Biala, 43-316, Poland
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Chrzanów, 32-500, Poland
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Gdansk, 80-214, Poland
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Gdynia, 81-157, Poland
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Kędzierzyn-Koźle, 47 220, Poland
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Krakow, 30-082, Poland
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Krakow, 31-216, Poland
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Lodz, 91-347, Poland
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Lodz, 93-338, Poland
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Poznan, 60-589, Poland
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Sochaczew, 96-500, Poland
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Tarnów, 33-100, Poland
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Coimbra, 3004-561, Portugal
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Guimarães, 4835-044, Portugal
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Setúbal, 2910-549, Portugal
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Ponce, 00717-1322, Puerto Rico
Research and Cardiovascular Corp
Ponce, 00717-1322, Puerto Rico
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Buzău, Buzău, 120133, Romania
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Craiova, Dolj, 200513, Romania
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Iași, Jud Iasi, 700732, Romania
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Baia Mare, Maramureş, 430123, Romania
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Baia Mare, Maramureş, 430222, Romania
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Timișoara, Timiș County, 300362, Romania
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Brasov, 500283, Romania
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Bucharest, 010192, Romania
Novartis Investigative Site
Bucharest, 050098, Romania
Novartis Investigative Site
Iași, 700503, Romania
Novartis Investigative Site
Saint Petersburg, Russia, 195197, Russia
Novartis Investigative Site
Saint Petersburg, Russia, 198328, Russia
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Chelyabinsk, 454047, Russia
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Ivanovo, 153012, Russia
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Izhevsk, 426061, Russia
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Kemerovo, 650002, Russia
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Kirov, 610035, Russia
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Krasnodar, 350086, Russia
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Moscow, 101990, Russia
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Moscow, 117198, Russia
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Moscow, 117997, Russia
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Moscow, 121552, Russia
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Moscow, 127473, Russia
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Moscow, 141060, Russia
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Moscow, 143420, Russia
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Novosibirsk, 630090, Russia
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Perm, 614097, Russia
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Petrozavodsk, 185019, Russia
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Rostov-on-Don, 344022, Russia
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Ryazan, 390039, Russia
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Saint Petersburg, 191015, Russia
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Saint Petersburg, 192007, Russia
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Saint Petersburg, 194354, Russia
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Saint Petersburg, 195197, Russia
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Saint Petersburg, 196143, Russia
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Saint Petersburg, 197110, Russia
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Saint Petersburg, 197136, Russia
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Saint Petersburg, 197341, Russia
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Samara, 443070, Russia
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Saratov, 410012, Russia
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Saratov, 410028, Russia
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Sochy, 354002, Russia
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Tomsk, 634009, Russia
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Ulyanovsk, 432063, Russia
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Vsevolozhsk, 188643, Russia
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Yaroslavl, 150062, Russia
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Yekaterinburg, 620028, Russia
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Yekaterinburg, 620137, Russia
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Yekaterinburg, 620144, Russia
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Brezno, Slovakia, 977 01, Slovakia
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Košice, Slovakia, 040 01, Slovakia
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Trnava, Slovakia, 917 02, Slovakia
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Banská Bystrica, 974 05, Slovakia
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Bratislava, 821 07, Slovakia
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Bratislava, 833 05, Slovakia
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Bratislava, 833 48, Slovakia
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Bratislava, 841 08, Slovakia
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Bratislava, 851 01, Slovakia
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Bratislava, 851 07, Slovakia
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Dolný Kubín, 026 01, Slovakia
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Handlová, 972 51, Slovakia
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Kláštor pod Znievom, 038 43, Slovakia
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Komárno, 945 01, Slovakia
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Komárno, 945 05, Slovakia
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Košice, 040 01, Slovakia
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Košice, 040 22, Slovakia
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Lučenec, 984 01, Slovakia
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Nitra, 949 01, Slovakia
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Nitra, 949 11, Slovakia
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Nitra, 950 01, Slovakia
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Nové Zámky, 940 01, Slovakia
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Piešťany, 921 01, Slovakia
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Považská Bystrica, 017 01, Slovakia
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Prešov, 080 01, Slovakia
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Rimavská Sobota, 979 01, Slovakia
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Rožňava, 048 01, Slovakia
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Svidník, 089 01, Slovakia
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Žilina, 010 01, Slovakia
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Ljubljana, 1000, Slovenia
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Soweto, Gauteng, 2013, South Africa
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Cape Town, Western Cape, 7500, South Africa
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Cape Town, Western Cape, 7925, South Africa
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George, Western Cape, 6529, South Africa
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Cape Town, 6665, South Africa
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Daegu, Dalseo gu, 42602, South Korea
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Wŏnju, Gangwon-do, 26426, South Korea
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Bundang Gu, Gyeonggi-do, 13620, South Korea
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Suwon, Gyeonggi-do, 16499, South Korea
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Incheon, Korea, 405 760, South Korea
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Seoul, Korea, 02841, South Korea
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Seoul, Korea, 08308, South Korea
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Seoul, Seoul, 03080, South Korea
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Busan, 49201, South Korea
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Gwangju, 61469, South Korea
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Seoul, 03181, South Korea
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Seoul, 06591, South Korea
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Santiago Compostela, A Coruna, 15706, Spain
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Seville, Andalusia, 41014, Spain
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Badalona, Barcelona, 08916, Spain
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Santander, Cantabria, 39008, Spain
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Cáceres, Extremadura, 10003, Spain
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Reus, Tarragona, 43201, Spain
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A Coruña, 15001, Spain
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Barcelona, 08025, Spain
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Córdoba, 14004, Spain
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Huelva, 21080, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Seville, 41009, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Zaragoza, 50009, Spain
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Gothenburg, 413 46, Sweden
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Lund, 222 21, Sweden
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Stockholm, 14186, Sweden
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Bern, 3010, Switzerland
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Liestal, 4410, Switzerland
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Zurich, 8091, Switzerland
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Taichung, Taiwan ROC, 40201, Taiwan
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Hsinchu, 30069, Taiwan
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 83301, Taiwan
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Keelung, 20401, Taiwan
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Tainan, 71004, Taiwan
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Izmir, Balcova, 35340, Turkey (Türkiye)
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Istanbul, Fatih, 34098, Turkey (Türkiye)
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Samsun, Ilkadim, 55090, Turkey (Türkiye)
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Istanbul, Kadikoy, 34668, Turkey (Türkiye)
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Mersin, Yenisehir, 33110, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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London, GBR, EC1M 6BQ, United Kingdom
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London, Greater London, EN3 4GS, United Kingdom
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Taunton, Somerset, TA1 5DA, United Kingdom
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Hardwick, Stockton on Tees, TS19 8PE, United Kingdom
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Chertsey, Surrey, KT16 0PZ, United Kingdom
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Chichester, West Sussex, PO19 6SE, United Kingdom
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Bristol, BS2 8HW, United Kingdom
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Cardiff, CF64 2XX, United Kingdom
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Chesterfield, S40 4AA, United Kingdom
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Newport, NP20 2UB, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Rhyl, LL18 5UJ, United Kingdom
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Tyne and Wear, NE29 8NH, United Kingdom
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Related Publications (8)
Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2025 Dec 2. doi: 10.2215/CJN.0000000968. Online ahead of print.
PMID: 41329869DERIVEDCho L, Nicholls SJ, Nordestgaard BG, Landmesser U, Tsimikas S, Blaha MJ, Leitersdorf E, Lincoff AM, Lesogor A, Manning B, Kozlovski P, Cao H, Wang J, Nissen SE. Design and Rationale of Lp(a)HORIZON Trial: Assessing the Effect of Lipoprotein(a) Lowering With Pelacarsen on Major Cardiovascular Events in Patients With CVD and Elevated Lp(a). Am Heart J. 2025 Sep;287:1-9. doi: 10.1016/j.ahj.2025.03.019. Epub 2025 Apr 2.
PMID: 40185318DERIVEDNicholls SJ, Nelson AJ, Michael LF. Oral agents for lowering lipoprotein(a). Curr Opin Lipidol. 2024 Dec 1;35(6):275-280. doi: 10.1097/MOL.0000000000000953. Epub 2024 Sep 25.
PMID: 39329200DERIVEDBurvill A, Watts GF, Norman R, Ademi Z. Early health technology assessment of gene silencing therapies for lowering lipoprotein(a) in the secondary prevention of coronary heart disease. J Clin Lipidol. 2024 Nov-Dec;18(6):e946-e956. doi: 10.1016/j.jacl.2024.08.012. Epub 2024 Aug 31.
PMID: 39322524DERIVEDDimitriadis K, Theofilis P, Iliakis P, Pyrpyris N, Dri E, Sakalidis A, Soulaidopoulos S, Tsioufis P, Fragkoulis C, Chrysohoou C, Tsiachris D, Tsioufis K. Management of dyslipidemia in coronary artery disease: the present and the future. Coron Artery Dis. 2024 Sep 1;35(6):516-524. doi: 10.1097/MCA.0000000000001375. Epub 2024 Apr 29.
PMID: 38682459DERIVEDKarp A, Jacobs M, Barris B, Labkowsky A, Frishman WH. Lipoprotein(a): A Review of Risk Factors, Measurements, and Novel Treatment Modalities. Cardiol Rev. 2025 Jul-Aug 01;33(4):352-358. doi: 10.1097/CRD.0000000000000667. Epub 2024 Feb 28.
PMID: 38415744DERIVEDTsimikas S, Reeves RR, Patel MP. Always Present, But Now Rediscovered: Lp(a) as a Predictor of Long-Term Outcomes in PCI. JACC Cardiovasc Interv. 2021 Sep 27;14(18):2069-2072. doi: 10.1016/j.jcin.2021.08.032. No abstract available.
PMID: 34556281DERIVEDPlakogiannis R, Sorbera M, Fischetti B, Chen M. The Role of Antisense Therapies Targeting Lipoprotein(a). J Cardiovasc Pharmacol. 2021 Jul 1;78(1):e5-e11. doi: 10.1097/FJC.0000000000001045.
PMID: 34232223DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Novartis Pharmaceuticals
Novartis Pharmaceuticals
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
- Expanded Access
- Yes
Study Record Dates
First Submitted
July 16, 2019
First Posted
July 17, 2019
Study Start
December 12, 2019
Primary Completion (Estimated)
June 30, 2026
Study Completion (Estimated)
June 30, 2026
Last Updated
May 6, 2026
Record last verified: 2026-05
Data Sharing
- IPD Sharing
- Will share
Novartis is committed to sharing with qualified external researchers, access to patient -level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with the applicable laws and regulations. This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com.