REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
REDEFINE 3
The Cardiovascular Safety and Efficacy of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) Once-weekly in Participants With Established Cardiovascular Disease
4 other identifiers
interventional
7,101
25 countries
628
Brief Summary
This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participants will get will be decided by chance. Participant's chance of getting CagriSema or placebo is the same. Participants will inject the study medicine once a week. The study medicine will be injected briefly with a thin needle, typically in the stomach, thighs or upper arms. The study will last for up to 4.5 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 2023
Longer than P75 for phase_3
628 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 20, 2022
CompletedFirst Posted
Study publicly available on registry
January 3, 2023
CompletedStudy Start
First participant enrolled
March 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 13, 2027
March 12, 2026
March 1, 2026
4.5 years
December 20, 2022
March 10, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Time to first occurrence of 3-point major adverse cardiovascular event (MACE), a composite endpoint consisting of: cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke
Measured in days.
From baseline (week 0) to end of study (up to 242 weeks or more)
Secondary Outcomes (18)
Time to first occurrence of a composite endpoint: Onset of persistent ≥40% reduction in eGFRcr (CKD-EPI), eGFRcr (CKD-EPI) <15 mL/min/1.73 m^2, Initiation of chronic kidney replacement therapy, Kidney death and CV death
From baseline (week 0) to end of study (up to 242 weeks or more)
Time to first occurrence of composite endpoint consisting of: Onset of persistent macro albuminuria, ≥40% reduction in eGFRcr (CKD-EPI), eGFRcr (CKD-EPI) <15 mL/min/1.73 m^2, Initiation of chronic kidney replacement therapy and kidney death
From baseline (week 0) to end of study (up to 242 weeks or more)
Time to first occurrence of an expanded 5-point MACE composite endpoint consisting of: CV death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularisation and unstable angina requiring hospitalisation
From baseline (week 0) to end of study (up to 242 weeks or more)
Time to first occurrence of a composite endpoint consisting of: all-cause death, non-fatal myocardial infarction and non-fatal stroke
From baseline (week 0) to end of study (up to 242 weeks or more)
Time to first occurrence of myocardial infarction (fatal and non-fatal)
From baseline (week 0) to end of study (up to 242 weeks or more)
- +13 more secondary outcomes
Study Arms (2)
CagriSema
EXPERIMENTALParticipants will receive cagrilintide and semaglutide subcutaneously (s.c.) once-weekly after a dose escalation period of 16 weeks during the maintenance period of 219 weeks.
Placebo
PLACEBO COMPARATORParticipants will receive placebo matched to cagrilintide and placebo matched to semaglutide s.c. once weekly for 235 weeks.
Interventions
Participants will receive cagrilintide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.
Participants will receive semaglutide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.
Participants will receive placebo matched to cagrilintide and placebo matched to semaglutide subcutaneously.
Eligibility Criteria
You may qualify if:
- Male or female
- Age above or equal to 55 years at the time of signing informed consent
- Body mass index (BMI) greater than or equal to (\>=) 25.0 kilograms per meter square (kg/m\^2)
- Established CVD as evidenced by at least one of the following:
- Prior myocardial infarction
- Prior stroke (ischemic or haemorrhagic stroke)
- Symptomatic peripheral arterial disease (PAD) defined as at least one of the following:
- Intermittent claudication with an ankle-brachial index (ABI) less than (\<) 0.85 at rest
- Intermittent claudication with a \>= 50% stenosis in a lower extremity peripheral artery documented by X-ray angiography, magnetic resonance (MR) angiography, computed tomography (CT) angiography or Doppler ultrasound
- Prior revascularization procedure of a lower extremity peripheral artery
- Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g., trauma or osteomyelitis)
- Diagnosed with type 2 diabetes mellitus (T2D) \>= 180 days before screening
- HbA1c 6.5%-10% (47-86 millimoles per mole \[mmol/mol\]) (both inclusive), as measured by central laboratory at screening
- Treatment with either:
- Lifestyle intervention alone
- +2 more criteria
You may not qualify if:
- Myocardial infarction, stroke, hospitalization for unstable angina pectoris or transient ischaemic attack within 60 days before screening
- Planned coronary, carotid or peripheral artery revascularisation known on the day of screening
- Heart failure classified as being in New York Heart Association (NYHA) Class IV at screening
- Treatment with any glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or a medication with GLP-1 activity within 90 days before screening
- End stage renal disease defined as estimated glomerular filtration rate (eGFR) \< 15 millileters per minutes per 1.73\^2 (mL/min/1.73 m\^2), as measured by the central laboratory at screening
- Chronic or intermittent haemodialysis or peritoneal dialysis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Novo Nordisk A/Slead
Study Sites (628)
Univ of Alabama Birmingham
Birmingham, Alabama, 32533, United States
Chambliss Clinical Trials LLC
Montgomery, Alabama, 36106, United States
Honor Health
Scottsdale, Arizona, 85258, United States
National Heart Institute Cal
Beverly Hills, California, 90211, United States
Valley Clinical Trials
Covina, California, 91723, United States
Scripps Wht Diab Inst La Jolla
La Jolla, California, 92037, United States
First Valley Medical Group
Lancaster, California, 93534, United States
Clinical Trials Research_Sacramento
Lincoln, California, 95648, United States
Torrance Clin Res Inst, Inc.
Lomita, California, 90717, United States
Pacific Clinical Studies
Los Alamitos, California, 90720, United States
Monterey Endocrine & Diabetes Institute, Inc
Monterey, California, 93940, United States
Valley Clinical Trials, Inc.
Northridge, California, 91325, United States
Desert Oasis Hlthcr Med Group
Palm Springs, California, 92262, United States
Western University of Health Sciences
Pomona, California, 91766, United States
Linda Vista Health Care Ctr
San Diego, California, 92111, United States
N America Res Inst - San Dimas
San Dimas, California, 91773, United States
Encompass Clinical Research_Spring Valley
Spring Valley, California, 91978, United States
Lundquist Inst.-Biom Inno-UCLA
Torrance, California, 90502, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
Innovative Research of W FL
Clearwater, Florida, 33756, United States
Florida Premier Cardiology
Delray Beach, Florida, 33445, United States
Fleming Island Center for Clinical Research
Fleming Island, Florida, 32003, United States
Life Spring Research Foundation LLC
Miami, Florida, 33130, United States
Clinical Trial Services Corp
Miami, Florida, 33144, United States
Oceane 7 Medical & Research Center, Inc.
Miami, Florida, 33144, United States
Reyes Clinical Research, Inc
Miami, Florida, 33174, United States
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, 33014, United States
Floridian Clinical Research, LLC
Miami Lakes, Florida, 33016, United States
Adult Medicine of Lake County, Inc.
Mt. Dora, Florida, 32757, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
Hanson Clinical Research Center
Port Charlotte, Florida, 33952, United States
Northeast Research Institute
Saint Augustine, Florida, 32080, United States
Cardio Partners Clin Res Inst
Wellington, Florida, 33449, United States
Endo Res Solutions Inc
Roswell, Georgia, 30076, United States
Atlanta Heart Specialists, LLC
Tucker, Georgia, 30084, United States
Rocky Mountain Diab&Osteo Ctr
Idaho Falls, Idaho, 83404-7596, United States
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, 60005, United States
Macoupin Research Group
Gillespie, Illinois, 62033, United States
Clinical Invest Special_Gurnee
Gurnee, Illinois, 60031, United States
Endeavor Health
Skokie, Illinois, 60077, United States
American Hlth Ntwk of IN LLC
Franklin, Indiana, 46131, United States
West Broadway Clinic
Council Bluffs, Iowa, 51501, United States
Iowa Diab & Endo Res Center
West Des Moines, Iowa, 50266, United States
Midwest Heart & Vasc Spec
Overland Park, Kansas, 66211, United States
The Research Group of Lexington LLC
Lexington, Kentucky, 40503, United States
L-MARC Research Center
Louisville, Kentucky, 40213, United States
Louisiana Heart Center
Covington, Louisiana, 70433, United States
Louisiana Heart Center
Hammond, Louisiana, 70403, United States
Tulane University Health Sciences Center
New Orleans, Louisiana, 70112, United States
Clinical Trials Of America
West Monroe, Louisiana, 71291, United States
Ascension Saint Agnes Heart Ca
Baltimore, Maryland, 21229, United States
Elite Research Center
Flint, Michigan, 48532, United States
Arcturus HC PLC Troy Med Res
Troy, Michigan, 48098, United States
NDORI
Diamondhead, Mississippi, 39525, United States
StudyMetrix Research LLC
City of Saint Peters, Missouri, 63303, United States
Clinical Research Consultants, LLC
Kansas City, Missouri, 64111, United States
Clinvest Research
Springfield, Missouri, 65807, United States
Amicis Centers of Clinical Research
St Louis, Missouri, 63128, United States
St Louis Heart & Vascular, P.C.
St Louis, Missouri, 63136, United States
VA Neb West Iowa Hlth System
Omaha, Nebraska, 68105, United States
Methodist Physicians Clin
Omaha, Nebraska, 68114, United States
Univ of NE Med Center_Omaha
Omaha, Nebraska, 68198-6828, United States
Southern New Hampshire Diabetes and Endocrinology
Nashua, New Hampshire, 03063, United States
Renal Medicine Associates
Albuquerque, New Mexico, 87109, United States
Albany Medical College
Albany, New York, 12203, United States
Mid Hudson Med Res-New Windsor
New Windsor, New York, 12553, United States
IMA Clinical Research- NY
New York, New York, 10036, United States
Saratoga Clinical Research
Saratoga Springs, New York, 12866, United States
Prime Global Research Inc.
The Bronx, New York, 10456, United States
Southgate Medical Group, LLP
West Seneca, New York, 14224, United States
Great Lakes Medical Research
Westfield, New York, 14787, United States
UNC- Chapel Hill
Chapel Hill, North Carolina, 27599, United States
Duke University
Durham, North Carolina, 27710, United States
Carteret Medical Group
Morehead City, North Carolina, 28557, United States
Eastern Nephrology Associates, PLLC
New Bern, North Carolina, 28562, United States
Piedmont Healthcare/Research
Statesville, North Carolina, 28625, United States
Brookview Hills Research Associates, LLC
Winston-Salem, North Carolina, 27103, United States
Lillestol Research LLC
Fargo, North Dakota, 58104, United States
Cleveland Clinic - Main Campus
Cleveland, Ohio, 44195, United States
Providence Health Partners Ctr
Dayton, Ohio, 45439, United States
Ohio- Advanced Medical Research
Maumee, Ohio, 43537, United States
Heritage Valley Medical Group
Beaver, Pennsylvania, 15009, United States
Capital Area Research LLC
Newport, Pennsylvania, 17074, United States
Aria Endocrine Metabolic Assoc
Philadelphia, Pennsylvania, 19114, United States
Carolina Health Specialists
Myrtle Beach, South Carolina, 29572, United States
Univ Diab & Endo Consultants
Chattanooga, Tennessee, 37411, United States
PharmaTex Research
Amarillo, Texas, 79106, United States
Arlington Family Res. Ctr Inc
Arlington, Texas, 76012-4637, United States
South Texas Clinical Research
Corpus Christi, Texas, 78404, United States
Baylor Scott & White Res Inst
Dallas, Texas, 75226, United States
Velocity Clinical Res-Dallas
Dallas, Texas, 75230, United States
Dallas Heart and Vascular
Duncanville, Texas, 75137, United States
Academy of Diabetes, T&E
El Paso, Texas, 79935, United States
Diabetes and Thyroid Ctr of FW
Fort Worth, Texas, 76132, United States
Forefront Med Res Inst PLLC
Harlingen, Texas, 78550, United States
PrimeCare Medical Group
Houston, Texas, 77024, United States
Synergy Groups Medical
Houston, Texas, 77061, United States
Southwest Houston Research Ltd
Houston, Texas, 77099, United States
Prem Internal Med Asso Houston
Katy, Texas, 77493, United States
Radiance Clinical Research
Lampasas, Texas, 76550, United States
DCOL Ctr for Clin Res
Longview, Texas, 75605, United States
Texas Inst, Kdny & Endo Disor
Lufkin, Texas, 75904, United States
Texas Institute of Cardiology PA
McKinney, Texas, 75071, United States
Texas Diabetes & Endocrinology_Round Rock
Round Rock, Texas, 78681, United States
Univ Of Texas Hlth Science Cntr
San Antonio, Texas, 78207, United States
Clinical Advancement Center
San Antonio, Texas, 78212, United States
San Antonio Prem Int Med
San Antonio, Texas, 78220, United States
Audie L. Murphy VA Hospital
San Antonio, Texas, 78229, United States
Northeast Clinical Research of San Antonio
San Antonio, Texas, 78233, United States
Simcare Medical Research, LLC
Sugar Land, Texas, 77478, United States
Crossroads Clinical Res- Texas
Victoria, Texas, 77901, United States
Hillcrest Family Health Center
Waco, Texas, 76708, United States
Valley Diab. & Endo Comp Ctr
Weslaco, Texas, 78596, United States
York Clinical Research LLC
Norfolk, Virginia, 23540, United States
Dominion Medical Associates
Richmond, Virginia, 23219, United States
VA Medical Center_Salem
Salem, Virginia, 24153-6404, United States
Selma Medical Associates
Winchester, Virginia, 22601-3834, United States
Confluence Health Hospital
Wenatchee, Washington, 98801, United States
Aspirus Research Institute
Wausau, Wisconsin, 54401, United States
Mautalen Salud e investigación
CABA, Buenos Aires, C1128 AAF, Argentina
CEMEDIC
CABA, Buenos Aires, C1440CFD, Argentina
Hospital Italiano de la Plata
La Plata, Buenos Aires, B 1900AXI, Argentina
Instituto Medico Catamarca
Rosario, Santa Fe Province, S2000, Argentina
CIPREC Pueyrredon
Buenos Aires, C1119ACN, Argentina
Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
Buenos Aires, C1425AGC, Argentina
CEDIC Centro de Investigación Clínica
CABA, C1060ABA, Argentina
Centro de Investigación y Prevención Cardiovascular
CABA, C1061AAS., Argentina
CENUDIAB Centro Médico de Nutrición v Diabetes
CABA, C1440AAD, Argentina
Medical Center of Diabetes and Nutrition
CABA, C1440AAD, Argentina
Centro de Investigaciones Metabólicas
Capital Federal, C1056ABI, Argentina
Instituto Médico DAMIC
Córdoba, X5003DCE, Argentina
Centro Médico Privado San Vicente Diabetes
Córdoba, X5006IKK, Argentina
Instituto de Investigaciones Clinicas Mar Del Plata
Mar del Plata, B7600FZN, Argentina
Consultorio Integral de Atención al Diabético
Morón, B1708IFF, Argentina
Instituto de Investigaciones Clinicas San Nicolás
San Nicolás, B2900, Argentina
Sanatorio Norte
Santiago del Estero, G4200, Argentina
Gosford Renal Research
Gosford, New South Wales, 2250, Australia
Paratus Clinical
Kanwal, New South Wales, 2259, Australia
Southern Neurology
Kogarah, New South Wales, 2217, Australia
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
Macquarie University - Clinical Trials Unit
Macquarie Park, New South Wales, 2109, Australia
Advara HeartCare Auchenflower
Auchenflower, Queensland, 4066, Australia
Logan Hospital
Meadowbrook, Queensland, 4131, Australia
Nightingale Research
Adelaide, South Australia, 5000, Australia
Royal Adelaide Hospital - Cardiology Department
Adelaide, South Australia, 5000, Australia
Advara HeartCare Leabrook
Leabrook, South Australia, 5068, Australia
Royal Hobart Hospital
Hobart, Tasmania, 7000, Australia
Baker Heart and Diabetes Institute
Melbourne, Victoria, 3004, Australia
Advara HeartCare Joondalup
Joondalup, Western Australia, 6027, Australia
One Clinical Research
Nedlands, Western Australia, 6009, Australia
Clinitrials
Perth, Western Australia, 6000, Australia
CPHosp Manaus Medicina, Ensino e Pesquisa LTDA
Manaus, Amazonas, 69057-088, Brazil
Centro de Pesquisa em Diabetes Doenças Endócrino-Metabólicas
Fortaleza, Ceará, 60430-350, Brazil
Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo
Vitória, Espírito Santo, 29055-450, Brazil
Núcleo de Pesquisa Clínica S/S
Curitiba, Paraná, 80730-150, Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda.
Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Instituto de Pesquisa Clínica de Campinas
Campinas, São Paulo, 13060-080, Brazil
PUCCAMP - Hospital e Maternidade Celso Pierro
Campinas, São Paulo, 13060-803, Brazil
i9 Pesquisas Clínicas
Campinas, São Paulo, 13092-133, Brazil
CIP Centro Integrado de Pesquisas do Hospital de Base
São José do Rio Preto, São Paulo, 15090-000, Brazil
Instituto São José dos Campos em Pesquisas Médicas
São José dos Campos, São Paulo, 12243-280, Brazil
Instituto de Pesquisa Clinica (IPEC)
São Paulo, São Paulo, 01223-001, Brazil
CPQuali Pesquisa Clínica Ltda
São Paulo, São Paulo, 01228-000, Brazil
CPCLIN - Centro de Pesquisas Clínicas
São Paulo, São Paulo, 01228-200, Brazil
Hospital São Lucas Copacabana
Rio de Janeiro, 22061-080, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
São Paulo, 04266-010, Brazil
Medical centre Asclepius OOD
Dupnitsa, Kyustendil, 2600, Bulgaria
SRH - Zdrave EAD
Bankya, 1320, Bulgaria
DCC - Burgas EOOD
Burgas, 8000, Bulgaria
IPSOMC - Dr. Georgi Marinov
Burgas, 8000, Bulgaria
MC Diamedical - 2013 OOD, Dimitrovgrad
Dimitrovgrad, 6400, Bulgaria
AIPSMC - DiMed EOOD
Haskovo, 6300, Bulgaria
Medical centre Zdrave 1 OOD
Kozloduy, 3320, Bulgaria
MHAT - UniHospital OOD
Panagyurishte, 4500, Bulgaria
"MHAT - Pazardzhik"
Pazardzhik, 4401, Bulgaria
MHAT - Pazardzhik AD
Pazardzhik, 4401, Bulgaria
Medical center Medconsult Pleven OOD
Pleven, 5800, Bulgaria
OCSOMCE - Dr. Albena Dinkova EOOD
Pleven, 5800, Bulgaria
DCC Pulmed EOOD
Plovdiv, 4000, Bulgaria
MHAT Med Line Clinic
Plovdiv, 4000, Bulgaria
UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic
Plovdiv, 4001, Bulgaria
UMHAT - Plovdiv AD
Plovdiv, 4002, Bulgaria
UMHAT Pulmed OOD - Plovdiv, Department of Endocrinology
Plovdiv, 4002, Bulgaria
MHAT Sveta Karidad EAD
Plovdiv, 4004, Bulgaria
UMHAT Medica - Ruse OOD
Rousse, 7013, Bulgaria
AIPSOMCIDEMD - Dr. Lilyana Bodurova-Troharova EOOD
Samokov, 2000, Bulgaria
MHAT Dr. Ivan Seliminski - Sliven AD
Sliven, 8800, Bulgaria
Nader Yabrudi - ASMPVBE Individual practice
Smolyan, 4700, Bulgaria
MHAT Knyaginya Klementina - Sofia EAD
Sofia, 1233, Bulgaria
MHAT Sveta Sofia EOOD
Sofia, 1404, Bulgaria
Acibadem City Clinic UMHAT Tokuda EAD, Endocrinology
Sofia, 1407, Bulgaria
UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases
Sofia, 1431, Bulgaria
UMHAT Sveti Ivan Rilski EAD, Nephrology
Sofia, 1431, Bulgaria
MC Orthopaedic Center Kinov EOOD
Sofia, 1527, Bulgaria
Medical Institute of Ministry of interior
Sofia, 1606, Bulgaria
MC Diamedical - 2013 OOD, Sofia
Sofia, 1618, Bulgaria
Medical centre Vitclinic EOOD
Sofia, 1680, Bulgaria
MBAL Trakia EOOD
Stara Zagora, 6000, Bulgaria
Medical center Zara-Med EOOD
Stara Zagora, 6000, Bulgaria
Prevencia - 2000 - MCOC OOD
Stara Zagora, 6000, Bulgaria
Medical Center Nov Rehabilitatsionen center EOOD
Stara Zagora, 6001, Bulgaria
UMHAT Prof. Dr. Stoyan Kirkovich AD
Stara Zagora, 6003, Bulgaria
UMHAT Sveta Marina EAD, Clinic of Internal Diseases
Varna, 9010, Bulgaria
UMHAT Sveta Marina EAD
Varna, 9010, Bulgaria
DCC 1 Velingrad EOOD
Velingrad, 4600, Bulgaria
Medical centre Runkovi OOD
Yambol, 8600, Bulgaria
MHAT Sveti Panteleimon - Yambol AD
Yambol, 8600, Bulgaria
Centricity Research Calgary Endocrinology
Calgary, Alberta, T2H 2G4, Canada
Centricity Research Calgary
Calgary, Alberta, T2H 2G4, Canada
C-endo Diab Endo Clin Calgery
Calgary, Alberta, T2V 4J2, Canada
C-Health Partners
Calgary, Alberta, T2V 4J2, Canada
G.A. Research Associates Ltd.
Moncton, New Brunswick, E1G 1A7, Canada
Nova Scotia Health Authority
Halifax, Nova Scotia, B3H 1V7, Canada
Centricity Res. Barrie Endo
Barrie, Ontario, L4N 7L3, Canada
Centricity Research Brampton Endocrinology
Brampton, Ontario, L6S 0C6, Canada
Cambridge Cardiac Care Centre
Cambridge, Ontario, N1R 6V6, Canada
Wharton Med Clin Trials
Hamilton, Ontario, L8L 5G8, Canada
Premier Clinical Trial Research Network (PCTRN)
Hamilton, Ontario, L8M 1K7, Canada
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2, Canada
Clinical Research Solutions Inc.
Waterloo, Ontario, N2T 0C1, Canada
Ctr de recherche Clinique de Laval
Laval, Quebec, H7T 2P5, Canada
Manna Research Mirabel
Mirabel, Quebec, J7J 2K8, Canada
Applied Medical Informatics Research
Montreal, Quebec, H4A 3T2, Canada
Clin des Mal Lipid de Quebec
Québec, Quebec, G1V 4W2, Canada
Viacar Recherche Clinique Inc.
Saint-Lambert, Quebec, J4P-1S9, Canada
CHU-Sherbrooke
Sherbrooke, Quebec, J1H 5H3, Canada
Ctr de méd métab de Lanaudière
Terrebonne, Quebec, J6X 4P7, Canada
Recherche Clinique Sigma Inc.
Québec, G1G 5X1, Canada
Institut universitaire de cardiologie
Québec, G1V 4G5, Canada
Diex Recherche Quebec
Québec, G1V 4T3, Canada
Servicios de Salud Ips Suramericana S.A.S.
Medellín, Antioquia, 05001, Colombia
Clinica de la Costa
Barranquilla, Atlántico, 80020, Colombia
Fundación Hospital Universidad del Norte
Soledad, Barranquilla, 83001, Colombia
Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia
Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander Department, 681012, Colombia
FOSCAL
Floridablanca, Santander Department, 681004, Colombia
Fundacion del Caribe para la Investigacion Biomedica-BIOS
Barranquilla, 080020, Colombia
CentrodeInvestigaciónenReumatologíayEspecialidadesMédicas
Bogotá, 110221, Colombia
Somer Sociedad Medica Rionegro S.A. Somer S.A.
Rionegro, 054040, Colombia
Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1
Herlev, Capital Region, 2730, Denmark
Aarhus Universitetshospital, Hjertesygdomme
Aarhus N, Central Jutland, 8200, Denmark
Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4
Holbæk, Region Sjælland, 4300, Denmark
Svendborg Sygehus - Kardiologisk
Svendborg, Region South, 5700, Denmark
Aarhus Universitetshospital, Steno Diabetes Center Aarhus
Aarhus N, 8200, Denmark
Regionshospitalet Gødstrup, Hjertesygdomme
Herning, 7400, Denmark
Hillerød Endokrinologisk amb. H0652
Hillerød, 3400, Denmark
Kolding Sygehus Karkirurgi
Kolding, 6000, Denmark
Slagelse Sygehus Ambulatorium for hjertesygdomme
Slagelse, 4200, Denmark
Viborg Sygehus
Viborg, 8800, Denmark
Centre Hospitalier d'Annonay
Annonay, 07100, France
Centre Hospitalier Ardeche Nord
Annonay, 07103, France
Ap-Hp-Hopital Avicenne
Bobigny, 93000, France
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-2
Grenoble, 38043, France
CH Louis Pasteur
Le Coudray, 28630, France
Les Hopitaux de Chartres-Hopital Louis Pasteur
Le Coudray, 28630, France
Groupe Hospitalier Du Havre
Le Havre, 76600, France
Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez
Lille, 59000, France
Centre Hospitalier Universitaire de Montpellier-Hopital Lapeyronie
Montpellier, 34090, France
Aphp-Hopital La Pitie Salpetriere-2
Paris, 75013, France
Hopital Novo
Pontoise, 95300, France
Centre Hospitalier Bretagne Atlantique
Vannes, 56000, France
Centre de Recherche Clinique Portes Du Sud
Vénissieux, 69200, France
RESEAU DE SANTE MUTUALISTE-Médipôle Hôpital Mutualiste
Villeurbanne, 69100, France
Diabeteszentrum-Do Dres. K U. Ch. Busch GbR
Dortmund, 44137, Germany
Uniklinik TU Dresden - Med. Klinik III
Dresden, 01307, Germany
Zentrum fuer klinische Studien Suedbrandenburg GmbH
Elsterwerda, 04910, Germany
InnoDiab Forschung GmbH
Essen, 45136, Germany
MVZ CCB Frankfurt und Main-Taunus GbR
Frankfurt, 60389, Germany
Diabetes-Zentrum Wilhelmsburg
Hamburg, 21109, Germany
Diabetes-Zentrum-Wilhelmsburg GbR
Hamburg, 21109, Germany
Wendisch - Dahl Hamburg - DZHW
Hamburg, 22607, Germany
Uniklinik Heidelberg - Innere Medizin I
Heidelberg, 69120, Germany
Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie
Leipzig, 04103, Germany
AmBeNet GmbH
Leipzig, 04107, Germany
Diabeteszentrum Ludwigsburg
Ludwigsburg, 71634, Germany
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
Münster, 48145, Germany
Uniklinik Münster, Klinik für Kardiologie I
Münster, 48149, Germany
Universitätsklinikum Münster - Klinik für Kardiologie I
Münster, 48149, Germany
RED-Institut für medizinische Forschung und Fortbildung GmbH
Oldenburg in Holstein, 23758, Germany
Zentrum für klinische Studien Alexander Segner
Saint Ingbert-Oberwürzbach, 66386, Germany
Al-Zoebi
Wermsdorf, 04779, Germany
Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
Witten, 58455, Germany
Endolife Specialty Hospitals
Guntur, Andhra Pradesh, 522001, India
Lalitha PVS Institute of Medical Sciences
Guntur, Andhra Pradesh, 522001, India
Lalitha Super Specialities Hospital
Guntur, Andhra Pradesh, 522001, India
Ramdev Rao Hospital
Hyderabad, Andhra Pradesh, 500072, India
Sunrise Hospital
Vijayawada, Andhra Pradesh, 520002, India
Excelcare Hospital
Guwahati, Assam, 781033, India
SMC Heart Institute and IVF Research Centre
Raipur, Chhattisgarh, 390001, India
SMC Heart Institute and IVF Research Centre
Raipur, Chhattisgarh, 492007, India
CIMS- Care Institute of Medical Sciences
Ahmedabad, Gujarat, 380060, India
Unicare heart institute and research centre
Surat, Gujarat, 395001, India
Nirmal Hospital Pvt. Ltd.
Surat, Gujarat, 395002, India
SSG Hospital, Baroda
Vadodara, Gujarat, 390001, India
Bankers Heart Institute
Vadodara, Gujarat, 390015, India
Rhythm Heart Institute
Vadodara, Gujarat, 390022, India
Ramaiah Memorial Hospital
Bangalore, Karnataka, 560054, India
Lifecare Hospital and Research Centre
Bangalore, Karnataka, 560092, India
Narayana Hrudayalya Institute of Cardiac Sciences
Bangalore, Karnataka, 560099, India
Omega Hospital (P) Limited
Mangalore, Karnataka, 575002, India
Mysore Medical College and Research Institute
Mysore, Karnataka, 570001, India
Government Medical College, Kozhikode
Kozhikode, Kerala, 673008, India
Mohak Bariatrics and Robotics
Indore, Madhya Pradesh, 452007, India
Kamalnayan Bajaj Hospital
Aurangabad, Maharashtra, 431005, India
Kamalnayan Bajaj Hospital
Aurangabad, Maharashtra, 431010, India
Krishna Institute of medical sciences
Karad, Maharashtra, 415539, India
Excel Endocrine Centre
Kolhāpur, Maharashtra, 416008, India
Sir H. N. Reliance Foundation Hospital and Research Centre
Mumbai, Maharashtra, 400004, India
Wockhardt Hospital, Mumbai Central
Mumbai, Maharashtra, 400011, India
Seth GS Medical College & KEM Hospital
Mumbai, Maharashtra, 400012, India
Hrudaya Cardiac and Vascular Care Centre
Nagpur, Maharashtra, 440019, India
Sengupta Hospital and Research Institute
Nagpur, Maharashtra, 440033, India
All India Institute of Medical Sciences (AIIMS), Nagpur
Nagpur, Maharashtra, 441108, India
Shalini Tai Meghe Hospital and Research Center
Nagpur, Maharashtra, 441110, India
Magnum Heart Institute
Nashik, Maharashtra, 422005, India
Grant Medical Foundation Ruby Hall Clinic
Pune, Maharashtra, 411001, India
Chellaram Diabetes Institute
Pune, Maharashtra, 411021, India
Ashirwad Hospital and Research Centre
Thane, Maharashtra, 421004, India
G B Pant Institute of Postgraduate Medical Education and Research
New Delhi, National Capital Territory of Delhi, 110002, India
All India Institute of Medical Sciences_Delhi
Ansārinagar, New Delhi, 110029, India
Apollo Hospital
Delhi, New Delhi, 110076, India
AMRI Hospital
Bhubaneswar, Odisha, 751030, India
All India Institute of Medical Sciences_Khurda
Khurda, Odisha, 751019, India
Christian Medical College and Hospital
Ludhiana, Punjab, 141008, India
Fortis Heart Institute and Multispeciality Hospital
Mohali, Punjab, 160062, India
Jawahar Lal Nehru Govt. Medical College
Ajmer, Rajasthan, 305001, India
SP Medical College
Bikaner, Rajasthan, 334003, India
SMS Medical College & Attached Hospitals
Jaipur, Rajasthan, 302004, India
Diabetes, Thyroid and Endocrine Centre
Jaipur, Rajasthan, 302006, India
All India Institute of Medical Sciences (AIIMS)
Jodhpur, Rajasthan, 342005, India
Madras Diabetes Research Foundation
Chennai, Tamil Nadu, 600086, India
Kg Hospital and Post Graduate Medical Institute
Coimbatore, Tamil Nadu, 641018, India
Christian Medical College Hospital, Vellore
Vellore, Tamil Nadu, 632004, India
Guru Nanak CARE Hospitals
Hyderabad, Telangana, 500020, India
AIG Hospitals,Hyderabad
Hyderabad, Telangana, 500032, India
Diabetes Research Center, Hyderabad
Hyderabad, Telangana, 500082, India
Yashoda Hospital
Hyderabad, Telangana, 500084, India
J N Medical College
Aligarh, Uttar Pradesh, 202002, India
King George's Medical University (KGMU)
Lucknow, Uttar Pradesh, 226003, India
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, 226014, India
Sanjay Gandhi Postgraduate Institute of Medical Science
Lucknow, Uttar Pradesh, 226014, India
Shri Mahant Indiresh Hospital
Dehradun, Uttarakhand, 248001, India
IPGME&R and SSKM Hospital
Kolkata, West Bengal, 700020, India
Apollo Multispeciality Hospital, Kolkata
Kolkata, West Bengal, 700054, India
J N Medical College
Aligarh, 202002, India
Narayana Hrudayalya Institute of Cardiac Sciences
Bangalore, 560 099, India
Himachal Heart Institute
Gutkar, 175021, India
All India Institute of Medical Sciences (AIIMS)
Jodhpur, 342005, India
Krishna Institute of medical sciences
Karad, 415539, India
Diabetes Care N' Research Centre Pvt. Ltd.
Nagpur, 440010, India
Hrudaya Cardiac and Vascular Care Centre
Nagpur, 440019, India
Magnum Heart Institute
Nashik, 422005, India
G.B Pant Institute of Post Graduate medical education and research
New Delhi, 110002, India
BL Kapur Super Specialty Hospital
New Delhi, 110005, India
Dr. BL Kapur Memorial Hospital
New Delhi, 110005, India
Sir Ganga Ram Hospital
New Delhi, 110060, India
B J Medical College & Sassoon Hospital
Pune, 411001, India
WMF's Villoo Poonawalla Memorial Hospital
Pune, 411028., India
Citi neuro centre
Telangana, 500034, India
CRF - Galway
Galway, Connaght, H91 YR71, Ireland
CRF HRB - Galway
Galway, Connaght, H91 YR71, Ireland
Clinical Research Centre, St. Vincent's University Hospital,
Dublin, Leinster, D04 T6F4, Ireland
Mater Miscericordiae Hospital
Dublin, Leinster, D07 XAO9, Ireland
St James's CRF
Dublin, Leinster, D08 A978, Ireland
Connolly Hospital_Blanchardstown_Diabetes Day Centre
Dublin, Leinster, D15 X40D, Ireland
Mater Miscericordiae Hospital
Dublin, Leinster, DUBLIN 7, Ireland
Università degli studi G. D'Annunzio Chieti Pescara - CAST
Chieti, Abruzzo, 66100, Italy
A.O.U. Consorziale Policlinico di Bari
Bari, BA, 70124, Italy
Azienda Ospedaliero Universitaria di Modena
Modena, Emilia-Romagna, 41126, Italy
Azienda Ospedaliera-Universitaria Parma
Parma, Emilia-Romagna, 43126, Italy
Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia
Rome, Lazio, 00128, Italy
Policlinico San Donato S.p.A.
San Donato Milanese (MI), Lombardy, 20097, Italy
Ospedale Santa Maria Goretti - UOD Diabetologia
Latina, LT, 04100, Italy
Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab
San Donato Milanese (MI), Mi, 20097, Italy
ICS Maugeri
Pavia, Pv, 27100, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCS
Rome, RM, 00168, Italy
AOUP Giaccone Palermo
Palermo, Sicily, 90127, Italy
Azienda Ospedaliera Universitaria Senese
Siena, Si, 53100, Italy
AOU Careggi Firenze
Florence, Tuscany, 50134, Italy
Azienda Ulss 3 Serenissima
Mirano, VE, 30035, Italy
Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC
Acquaviva delle Fonti, 70021, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona
Ancona, 60126, Italy
A.O.U. Bologna_ Policlinico S.Orsola Malpighi
Bologna, 40138, Italy
A.O.U. Policlinico S.Orsola Malpighi
Bologna, 40138, Italy
A.O.U policlinico "G. Rodolico-San Marco"
Catania, 95123, Italy
Azienda Ospedaliera Luigi Sacco
Milan, 20157, Italy
Azienda Ospedaliero Universitaria di Modena Ospedale Civile di Baggiovara
Modena, 41126, Italy
Azienda Ospedaliera Universitaria Federico II di Napoli
Naples, 80131, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, 56126, Italy
Pol. Uni. Campus Biomedico UOC Endocrinologia e Diabetologia
Roma, 00128, Italy
Azienda Ospedaliero - Universitaria Sant'Andrea
Roma, 00189, Italy
IRCCS Multimedica
Sesto San Giovanni (MI), 20099, Italy
Seino Internal Medicine Clinic_Internal medicine
Koriyama-shi, Fukushima, Fukushima, Japan, 963-8851, Japan
Seino Internal Medicine Clinic
Koriyama-shi, Fukushima, Japan, 963-8851, Japan
Jinnouchi Hospital_Internal Medicine
Kumamoto, Kumamoto, Japan, 862-0976, Japan
Akaicho Clinic
Chiba-shi, Chiba, 260-0804, Japan
Mikannohana Clinic, Diabetes, Endocrinology and Metabolism_Diabetes Internal Medicine
Ehime, 790-0034, Japan
Naka Kinen Clinic_Internal medicine
Ibaraki, 311-0113, Japan
Tokyo Saiseikai Central Hospital
Minato-ku, Tokyo, 108-0073, Japan
Minami Akatsuka Clinic
Mito-shi, Ibaraki, 311-4153, Japan
Nanbu Tokushukai Hospital_Internal medicine
Okinawa, 901-0493, Japan
Osaka NISHI-UMEDA Clinic_Internal Medicine
Osaka, 530-0001, Japan
Nozaki Tokushukai Hospital_Internal medicine
Osaka, 574-0074, Japan
Yao Tokushukai General Hospital_Cardiovascular division
Osaka, 581-0011, Japan
Yao Tokushukai General Hospital
Osaka, 581-0011, Japan
Sakurabashi Watanabe Advanced Healthcare Hospital
Osaka-city, Osaka, 530-0005, Japan
Saga University Hospital, Department of Cardiology
Saga, 849-8501, Japan
Kagawa Prefectural Central Hospital_Cardiovascular Medicine
Takamatsu-shi, Kagawa, 760-8557, Japan
Takasaki General Medical Center_Department of Endocrinology / Metabolism Internal Medicine
Takasaki-shi, Gunma, 370-0829, Japan
Tokyo-Eki Center-building Clinic_Internal Medicine
Tokyo, 103-0027, Japan
Tokyo-Eki Center-building Clinic
Tokyo, 103-0027, Japan
Fukuwa Clinic_Internal Medicine
Tokyo, 104-0031, Japan
Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology
Wakayama, 640-8558, Japan
National Hospital Organization Saitama Hospital_Cardiology
Wako-shi, Saitama, 351-0102, Japan
University Malaya Medical Centre
Lembah Pantai, Kuala Lumpur, 59100, Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, Pahang, 25100, Malaysia
Hospital Sultan Haji Ahmad Shah
Temerluh, Pahang, 28000, Malaysia
Hospital Seri Manjung
Seri Manjung, Perak, 32040, Malaysia
Hospital Pulau Pinang
George Town, Pulau Pinang, 10450, Malaysia
Sarawak General Hospital
Kuching, Sarawak, 93586, Malaysia
Hospital Miri
Miri, Sarawak, 98000, Malaysia
Hospital Sibu
Sibu, Sarawak, 96000, Malaysia
Hospital Ampang
Ampang, Selangor, 68000, Malaysia
Hospital Serdang
Kajang, Selangor, 43000, Malaysia
Hospital Melaka
Malacca, 75400, Malaysia
Hospital Putrajaya
Putrajaya, 62250, Malaysia
Hospital Miri
Sarawak, 98000, Malaysia
Hospital Ampang
Selangor Darul Ehsan, 68000, Malaysia
Hospital Shah Alam
Shah Alam, 40000, Malaysia
Hospital Putrajaya
Wilayah Persekutuan Putrajaya, 62250, Malaysia
Centro de Investigacion Clinica Endocrinologica de Jalisco
Guadalajara, Jalisco, 44670, Mexico
Virgen Cardiovascular Research SC
Guadalajara, Jalisco, 44670, Mexico
Instituto de Diabetes Obesidad y Nutricion S.C.
Cuernavaca, Morelos, 62250, Mexico
Internal Medicine Clin Trials
Monterrey, Nuevo León, 64020, Mexico
Cardiolink Clin Trials S.C.
Monterrey, Nuevo León, 64060, Mexico
Unidad Biomedica Avanzada Monterrey
Monterrey, Nuevo León, 64460, Mexico
Clínica García Flores
Monterrey, Nuevo León, 64610, Mexico
Centro de atención e investigación cardiovascular del Potosí
San Luis Potosí City, San Luis Potosí, 78200, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.
Culiacán, Sinaloa, 80230, Mexico
Centro para el Desarrollo de la Medicina y la Asistencia
Culiacán, Sinaloa, 80230, Mexico
Centro de Estudios de Investigación Metabólicos y Cardio
Ciudad Madero, Tamaulipas, 89440, Mexico
Consultorio 1020 Hospital Angeles Xalapa
Xalapa, Veracruz, 91193, Mexico
Promotora Medica Aguascalientes SA de CV
Aguascalientes, 20230, Mexico
Gelre Zkh Apeldoorn Cardiologie
Apeldoorn, 7334 DZ, Netherlands
Maxima MC Eindhoven - Cardiologie
Eindhoven, 5631 BM, Netherlands
Groene Hart Zkh Gouda - Cardiologie
Gouda, 2803HH, Netherlands
UMC Groningen - Cardiologie
Groningen, 9713 GZ, Netherlands
Frisius MC Leeuwarden
Leeuwarden, 8934 AD, Netherlands
Radboudumc
Nijmegen, 6525 GA, Netherlands
Franciscus Gasthuis en Vlietland
Rotterdam, 3045 PM, Netherlands
D & A Research B.V.
Sneek, 8601 ZR, Netherlands
Zkh Rivierenland Tiel - Cardiologie
Tiel, 4002 WP, Netherlands
NSZOZ Unica CR
Dąbrówka, Greater Poland Voivodeship, 62-069, Poland
Gierach-Med
Bygdoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
Malopolskie Centrum Sercowo-Naczyniowe
Chrzanów, Lesser Poland Voivodeship, 32-500, Poland
Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
Krakow, Lesser Poland Voivodeship, 31-261, Poland
Regionalna Poradnia Diabetologiczna-Zytkiewicz-Jaruga, Stasinska Spolka Partnerska Lekarzy
Wroclaw, Lower Silesian Province, 50-127, Poland
4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
Wroclaw, Lower Silesian Voivodeship, 50-981, Poland
4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
Wroclaw, Lower Silesian Voivodeship, 53-114, Poland
Velocity Nova Sp. z o.o.
Lublin, Lublin Voivodeship, 20-362, Poland
ETG Poniatowa
Poniatowa, Lublin Voivodeship, 24-320, Poland
Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
Gorzów Wielkopolski, Lubusz Voivodeship, 66-400, Poland
Provita Poliklinika Sp. z o.o
Warsaw, Masovian Province, 02-647, Poland
MEDI CLINICAL Badania Kliniczne
Warsaw, Masovian Province, 02-786, Poland
Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego Centrum Medycznego Ksztalcenia Podyplomowego
Warsaw, Masovian Voivodeship, 00-416, Poland
Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orłowskiego Centrum Medycznego Kształcenia Podyplomowego
Warsaw, Masovian Voivodeship, 00-416, Poland
ETG Warszawa Sp. z o.o.
Warsaw, Masovian Voivodeship, 02-677, Poland
Prywatna Praktyka Lekarska Anna Chudoba
Żyrardów, Masovian Voivodeship, 96-300, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio
Bialystok, Podlaskie Voivodeship, 15-276, Poland
Gabinet Leczenia Otylosci i Chorob Dietozaleznych
Bialystok, Podlaskie Voivodeship, 15-281, Poland
Kresmed Sp. z o. o.
Bialystok, Podlaskie Voivodeship, 15-481, Poland
Centrum Medyczne Pratia Gdynia
Gdynia, Pomeranian Voivodeship, 81-338, Poland
M2M Med. Badania Sp. z o.o.
Chorzów, Silesian Voivodeship, 41-500, Poland
Kardio Klinika Brynow
Katowice, Silesian Voivodeship, 40-555, Poland
Pro Familia Altera Sp. z o.o.
Katowice, Silesian Voivodeship, 40-648, Poland
Slaskie Centrum Chorob Serca W Zabrzu
Zabrze, Silesian Voivodeship, 41-800, Poland
Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu
Zabrze, Silesian Voivodeship, 41-800, Poland
Centrum Zdrowia Metabolicznego
Poznan, Wielkopolskie Voivodeship, 60-589, Poland
Osteo-Medic s.c. A. Racewicz, J. Supronik
Bialystok, 15-351, Poland
Renew Clinic Sp. z o.o.
Bialystok, 15-797, Poland
American Heart of Poland S.A.
Bielsko-Biala, 43-316, Poland
Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.
Bydgoszcz, 85-231, Poland
Pratia S.A.
Chojnice, 89-600, Poland
NSZOZ Unica CR
Dąbrówka, 62-069, Poland
Centrum Kliniczno Badawcze
Elblag, 82-300, Poland
UCK Klinika Nadcisnienia Tetniczego i Diabetologii
Gdansk, 80-214, Poland
Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
Gorzów Wielkopolski, 66-400, Poland
Care Clinic Sp. z o. o.
Katowice, 40-568, Poland
Uniwersyteckie Centrum Kliniczne SUM w Katowicach
Katowice, 40-752, Poland
Grazyna Pulka Specjalistyczny Osrodek "All-Med"
Krakow, 30-033, Poland
Gabinet Lekarski Malgorzata Saryusz-Wolska
Lodz, 90-132, Poland
Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi
Lodz, 92-213, Poland
Zanamed Medical Clinic Sp. z o.o.
Lublin, 20-601, Poland
Provita Centrum Medyczne Sp. z o.o.
Piotrkow Trybunalski, 97-300, Poland
Gaja Poradnie Lekarskie
Poznan, 61-251, Poland
Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Specjalistyczna A Wittek H Rudzki Sp. j.
Ruda Śląska, 41-709, Poland
Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach
Tychy, 43-100, Poland
Szpital Czerniakowski Sp. z o.o.
Warsaw, 00-739, Poland
BodyClinic
Warsaw, 03-712, Poland
NASMED
Warsaw, 03-984, Poland
Pracownia Badan Klinicznych SALUS
Wroclaw, 53-034, Poland
Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu
Zabrze, 41-800, Poland
Velocity Nova Sp. z o.o. Velocity Zamosc
Zamość, 22-400, Poland
Szpitale Powiatowe Sp. z o.o.
Łask, 98-100, Poland
American Heart of Poland S.A.
Bełchatów, Łódź Voivodeship, 97-400, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika
Lodz, Łódź Voivodeship, 93-513, Poland
Velocity Nova Sp. z o.o.
Staszów, Świętokrzyskie Voivodeship, 28-200, Poland
Isis Clinical Res. Ctr P.S.C.
Guaynabo, 00968, Puerto Rico
University Clinical Centre Nis
Niš, RS, 18 000, Serbia
Clinical Centre Nis, Endocrinology, Diabetes and Metabolism
Niš, RS, 18000, Serbia
Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
Novi Sad, Vojvodina, 21000, Serbia
CHC Zvezdara, Clinical department for endocrinology
Belgrade, 11000, Serbia
Endocrinology, Diabetes and Metabolism Diseases Clinic
Belgrade, 11000, Serbia
Military Medical Academy
Belgrade, 11000, Serbia
Clinical Hospital Center Bezanijska Kosa
Belgrade, 11080, Serbia
Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department
Kragujevac, 34000, Serbia
Policlinic for diabetes
Zaječar, 19000, Serbia
Phoenix Pharma
Port Elizabeth, Eastern Cape, 6001, South Africa
Soweto Clinical Trial Centre
Johannesburg, Gauteng, 1818, South Africa
Hemant Makan
Johannesburg, Gauteng, 1827, South Africa
Wits Bara Clinical Trial Site
Johannesburg, Gauteng, 2013, South Africa
Ezintsha Research Centre
Johannesburg, Gauteng, 2193, South Africa
Prinshof Medical Campus
Pretoria, Gauteng, 0002, South Africa
Dr Seeber
Pretoria, Gauteng, 0083, South Africa
Raslouw Private Hospital
Pretoria, Gauteng, 0157, South Africa
Prof P. Joshi
Pretoria, Gauteng, 0181, South Africa
Jongaie Research
Pretoria, Gauteng, 0183, South Africa
Clinical Trial Systems (CTC)
Pretoria, Gauteng, 0186, South Africa
Dr A Amod
Durban, KwaZulu-Natal, 4092, South Africa
Netcare Umhlanga Medical Centre
Durban, KwaZulu-Natal, 4320, South Africa
Dr Pillay's Rooms
Durban, KwaZulu-Natal, 4450, South Africa
Lenmed Shifa Private Hospital
Durban, KwaZulu-Natal, 4901, South Africa
Tread Research (Pty)Ltd
Cape Town, Western Cape, 7500, South Africa
Prof Rayner_Division of Nephrology
Cape Town, Western Cape, 7925, South Africa
Cardiac Clinical Research Unit, University of Cape Town
Cape Town, Western Cape, 7935, South Africa
Dr Hendrik Snyman's Practice
Mossel Bay, Western Cape, 6500, South Africa
Clinical Projects Research
Worcester, Western Cape, 6850, South Africa
Hospital Universitario de Fuenlabrada
Fuenlabrada, Madrid, 28942, Spain
H.de La Ribera_Endocrinología
Alzira, Valencia, 46600, Spain
Hosp. Comarcal de Antequera_Medicina Interna
Antequera, 29200, Spain
Hospital Vall d'Hebron
Barcelona, 08035, Spain
Hospital Vithas Sevilla
Castilleja de la Cuesta, 41950, Spain
Hospital Reina Sofia
Córdoba, 14004, Spain
Hospital Univ. de Gran Canaria Doctor Negrín
Las Palmas de Gran Canaria, 35010, Spain
Hospital Gregorio Marañón
Madrid, 28009, Spain
H. Clinico Univ. Virgen de la Victoria
Málaga, 29010, Spain
Hospital Clínico Virgen de la Victoria
Málaga, 29010, Spain
Hospital Son Espases
Palma de Mallorca, 07120, Spain
H.U. Quirónsalud Madrid
Pozuelo de Alarcón, 28223, Spain
Hospital Quirón
Pozuelo de Alarcón, 28223, Spain
H Virgen del Camino_Sanlúcar_Medicina Interna
Sanlúcar de Barrameda, 11540, Spain
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
Seville, 41003, Spain
Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
Hospital General Universitario de Toledo
Toledo, 45007, Spain
Hospital General de Valencia
Valencia, 46014, Spain
Siriraj Hospital
Bangkok, Bangkok Noi, 10700, Thailand
Songklanagarind Hospital
Songkhla, Had-Yai, 90110, Thailand
Vajira Hospital - Cardio
Bangkok, 10300, Thailand
King Chulalongkorn Memorial Hospital
Bangkok, 10330, Thailand
Phramongkutklao Hospital_Neurology
Bangkok, 10400, Thailand
Phramongkutklao Hospital
Bangkok, 10400, Thailand
Rajavithi Hospital_Diabetes and Endocrinology
Bangkok, 10400, Thailand
Ramathibodi Hospital
Bangkok, 10400, Thailand
Siriraj Hospital
Bangkok, 10700, Thailand
Maharaj Nakorn Chiang Mai
Chiang Mai, 50200, Thailand
RIHES-CMU_Research Institute for Health Sciences
Chiang Mai, 50200, Thailand
Chiang Rai Prachanukroh Hospital
Chiang Rai, 57000, Thailand
Srinagarind Hospital
Khon Kaen, 40002, Thailand
Maharat Nakhon Ratchasima Hospital
Nakhon Ratchasima, 30000, Thailand
Thammasat Hospital_Cardiology
Pathum Thani, 12120, Thailand
Baskent University Ankara Hospital
Ankara, Bahcelievler, 06490, Turkey (Türkiye)
Başkent Üniversitesi Ankara Hastanesi-Endokrinoloji
Ankara, Bahcelievler, 06490, Turkey (Türkiye)
Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi
Istanbul, Kartal, 34844, Turkey (Türkiye)
Eskisehir Osmangazi University Sağlık Uygulama ve Arastirma
Eskişehir, Odunpazari, 26040, Turkey (Türkiye)
Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
Eskişehir, Odunpazari, 26040, Turkey (Türkiye)
Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji
Bursa, Yildirim, 16110, Turkey (Türkiye)
T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan
Adana, 01000, Turkey (Türkiye)
Baskent Universitesi Adana
Adana, 01250, Turkey (Türkiye)
Başkent Üniversitesi Adana Dr. Turgut Noyan Uygulama ve Araştırma Merkezi
Adana, 01250, Turkey (Türkiye)
Afyonkarahisar Health Sciences University
Afyonkarahisar, 03200, Turkey (Türkiye)
Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
Afyonkarahisar, 03200, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-Dahiliye
Ankara, 06800, Turkey (Türkiye)
Ankara Sehir Hastanesi Dahiliye Klinigi
Ankara, 06800, Turkey (Türkiye)
Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
Edirne, 22030, Turkey (Türkiye)
Eskişehir Şehir Hastanesi- Kardiyoloji
Eskişehir, 26080, Turkey (Türkiye)
İstanbul Üniversitesi-Cerrahpaşa Tıp Fakültesi Kardiyoloji Enstitüsü
Istanbul, 34098, Turkey (Türkiye)
Kanuni Sultan Suleyman Egitim ve Arastirma Hastanesi
Istanbul, 34303, Turkey (Türkiye)
Seyrantepe Hamidiye Etfal Egitim ve Arastirma Hastanesi
Istanbul, 34371, Turkey (Türkiye)
Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi- Seyrantepe Yerleşkesi- Endokrinoloji
Istanbul, 34371, Turkey (Türkiye)
Basaksehir Cam ve Sakura Sehir Hastanesi
Istanbul, 34480, Turkey (Türkiye)
Başakşehir Çam ve Sakura Şehir Hastanesi
Istanbul, 34480, Turkey (Türkiye)
Göztepe Prof. Dr.Süleyman Yalçın Şehir Hastanesi- Dahiliye
Istanbul, 34722, Turkey (Türkiye)
Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Endokrinoloji
Izmir, 35340, Turkey (Türkiye)
Kahramanmaras Sutcu Imam University
Kahramanmaraş, 46040, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi
Kayseri, 38039, Turkey (Türkiye)
Erciyes Üniversitesi Hastanesi- Endokrinoloji
Kayseri, 38039, Turkey (Türkiye)
Erciyes Üniversitesi Hastanesi- Kardiyoloji
Kayseri, 38039, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi Hastanesi
Kocaeli, 41380, Turkey (Türkiye)
Kocaeli Üniversitesi Hastanesi- Kardiyoloji
Kocaeli, 41380, Turkey (Türkiye)
Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi EAH- Kardiyoloji
Kütahya, 43040, Turkey (Türkiye)
Mersin Üniversitesi Tip Fakültesi Hastanesi- Endokrinoloji
Mersin, 33070, Turkey (Türkiye)
Mersin University Cardiology
Mersin, 33343, Turkey (Türkiye)
Mersin Üniversitesi Hastanesi- Kardiyoloji
Mersin, 33343, Turkey (Türkiye)
Marmara Üniversitesi Pendik EAH- Endokrinoloji
Pendik/istanbul, 34899, Turkey (Türkiye)
Ondokuz Mayıs Üniversitesi Hastanesi- Kardiyoloji
Samsun, 55200, Turkey (Türkiye)
Adana Şehir Eğitim ve Araştırma Hastanesi-Endokrinoloji
Yüreğir/Adana, 1370, Turkey (Türkiye)
Blackpool Victoria Hospital
Blackpool, Lancashire, FY3 8NR, United Kingdom
Heartlands Hospital - Diabetes
Birmingham, West Midlands, B9 5SS, United Kingdom
St. Richard's Hospital_Cardiology
Chichester, West Sussex, PO19 6SE, United Kingdom
Bradford Royal Infirmary
Bradford, BD9 6RJ, United Kingdom
The Health Centre
Bradford-on-Avon, BA15 1DQ, United Kingdom
Southmead Hospital
Bristol, BS10 5NB, United Kingdom
Countess of Chester Hospital - Diabetes
Chester, CH2 1UL, United Kingdom
University Hospital Coventry - WISDEM Centre
Coventry, CV2 2DX, United Kingdom
Ninewells Hospital
Dundee, DD1 9SY, United Kingdom
Western General Hospital
Edinburgh, EH4 2XU, United Kingdom
Royal Devon and Exeter Hospital
Exeter, EX2 5DW, United Kingdom
Intelligent Clinical
Glasgow, G20 0XA, United Kingdom
Hull Royal Infirmary - Diabetes
Hull, HU3 2JZ, United Kingdom
Ipswich Hospital - Diabetes
Ipswich, IP4 5PD, United Kingdom
St James's University Hospital - Diabetes
Leeds, LS9 7TF, United Kingdom
Leicester General Hospital
Leicester, LE5 4PW, United Kingdom
The Good Practice
London, SW10 0LR, United Kingdom
NIHR Commercial Research Delivery Centre Newcastle
Newcastle upon Tyne, NE1 4LP, United Kingdom
Derriford Hospital
Plymouth, PL6 5FP, United Kingdom
East Surrey Hospital
Redhill, RH1 5RH, United Kingdom
Clifton Medical Centre
Rotherham, S65 1DA, United Kingdom
Staploe Medical Centre
Soham, CB7 5JD, United Kingdom
Royal Cornwall Hospital (Treliske)
Truro, TR1 3LJ, United Kingdom
MeSH Terms
Conditions
Interventions
Study Officials
- STUDY DIRECTOR
Clinical Transparency dept. 2834
Novo Nordisk A/S
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 20, 2022
First Posted
January 3, 2023
Study Start
March 1, 2023
Primary Completion (Estimated)
September 1, 2027
Study Completion (Estimated)
October 13, 2027
Last Updated
March 12, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will share
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com