Peking University Birth Cohort in Weifang (PKUBC-WF)

NCT06234332 | Recruiting

• 1 other identifier: PKUBC-WF
• Study Type: observational
• Target: 2,800
• Locations: 1 country
• Sites: 1

Brief Summary

The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.

Conditions

Health Problems in Pregnancy; Pregnancy Outcomes; Gestational Diabetes; Gestational Hypertension; Preterm Birth; Obesity; Mother-Infant Interaction; Child Development; Anemia

Outcome Measures

Primary Outcomes (2)

• Numbers and morbidity of participants with pregnancy complications

  Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy

  At delivery

• Numbers and morbidity of participants with adverse pregnancy outcomes

  Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects.

  At delivery

Secondary Outcomes (10)

• Weight in kilogram changes during childhood

  At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years

• Height in centimeter changes during childhood

  At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years

• Early Child development

  Age at 6 weeks, 6 months and 12 months

• Incidence of diabetes mellitus in women

  6 weeks after delivery and 3 years after delivery

• Incidence of hypertension in women

  6 weeks after delivery and 3 years after delivery

Study Arms (2)

Exposure group

Group with environmental, nutritional or lifestyle exposures

Other: No Interventions

Non-exposed group

Group without any environmental, nutritional and lifestyle exposures

Interventions

No Interventions OTHER

No intervention This is an observational study without any intervention

Exposure group

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women and their children in Weifang, China

You may qualify if:

• Pregnant woman
• Pregnant women, 6-13\^+6 gestational weeks
• Resided in Weifang in the past half years and have no plan to move out after delivery
• Pregnant women who plan to have antenatal care and delivery in Weifang maternal\&Child Hospital.
• Pregnant women who is willing to participate in this study with informed consent
• Pregnant woman's husband
• His wife was eligible for enrollment
• He is the biological father of the child (his wife's current pregnancy)
• Pregnant women's husband who is willing to participate in this study with informed consent
• \. Before the age of 8 years, his/her mother provided written informed consent. 6. After 8 years old, he/she agreed to continue this study and signed the informed consent.

You may not qualify if:

• Participants who cannot communicate normally.

Sponsors & Collaborators

• Peking University: lead
• National Natural Science Foundation of China: collaborator

Study Sites (1)

Peking University

Beijing, Beijing Municipality, 100191, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Pregnancy: During pregnancy and 42 days after delivery: the remaining peripheral blood sample (about 2ml) and urine sample (about 8ml); additional anticoagulant peripheral blood (5ml) and urine (10ml) of women and their husband (only when pregnant women were enrolled) . Pre-delivery: feces (5g). After delivery: samples of umbilical cord blood (about 10ml), placenta (8 to 10 pieces of tissue with a diameter of 1.0cm), umbilical cord (4 pieces of tissue with a length of 1cm), meconium (5g), and heel blood (about 0.5ml) Childhood: 6 months of age: extra fingertip blood (about 0.5ml). At the age of 1 and 2: urine sample (about 10ml) . At the age of 3 and 6: the remaining peripheral blood sample (about 2ml) and urine sample (about 8ml) . At the age of 9, 12, 15 and 17: the remaining peripheral blood sample examined by blood biochemistry (about 2ml) , the remaining peripheral blood sample examined by blood routine (about 2ml) and urine routine residual urine sample (about 8ml).

MeSH Terms

Conditions

Diabetes, Gestational; Hypertension, Pregnancy-Induced; Premature Birth; Obesity; Anemia

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Obstetric Labor, Premature; Obstetric Labor Complications; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Haijun Wang, Ph.D

  Peking University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Haijun Wang, Ph.D

CONTACT

86-010-82805583; whjun1@bjmu.edu.cn

Jue Liu, Ph.D

CONTACT

86-13426455743; jueliu@bjmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: January 23, 2024
• First Posted: January 31, 2024
• Study Start: February 1, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2043
• Last Updated: November 24, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)