A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice
IMreal
A Non-Interventional, Multicenter, Multiple Cohort Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice
1 other identifier
observational
2,756
29 countries
230
Brief Summary
This is a non-interventional, multi-country, multi-centre, multiple cohort prospective study, with retrospective collection of prior medical/treatment history data from medical records, designed to assess the real-world outcomes and safety of atezolizumab for indications in the existing label in the real world setting of routine clinical practice.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2019
Longer than P75 for all trials
230 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 28, 2018
CompletedFirst Posted
Study publicly available on registry
December 20, 2018
CompletedStudy Start
First participant enrolled
February 7, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 31, 2026
January 8, 2026
January 1, 2026
7.5 years
November 28, 2018
January 7, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
Overall Survival (OS)
Time from index date until date of death from any cause. Index date is the date of administration of the first ever dose of atezolizumab for each patient.
Index date up to approximately 6 years
OS at 2 Years
Percentage of participants alive 2 years after initiation of atezolizumab treatment.
After index date up to 2 years
Secondary Outcomes (15)
Time to Loss of Clinical Benefit (TTLCB)
Index date up to approximately 6 years
Progression Free Survival (PFS)
Index date up to approximately 6 years
Objective Response Rate (ORR)
After index date up to approximately 6 years
Time to Response
Index date up to approximately 6 years
Duration of Response (DoR)
Index date up to approximately 6 years
- +10 more secondary outcomes
Study Arms (6)
Cohort 1 (UC LOT2+later lines[LOT2+] & platinum eligible LOT1)
Participants diagnosed with locally advanced or metastatic Urothelial Cancer previously treated with platinum-containing chemotherapy. Enrollment is closed.
Cohort 2 (NSCLC LOT2 plus later lines [LOT2+])
Participants diagnosed with Locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) after prior chemotherapy. Participants with epidermal growth factor receptor (EGFR) activating mutations or anaplastic lymphoma kinase (ALK)-positive tumor mutations should also have received targeted therapy. Enrollment closed.
Cohort 3 (NSCLC LOT1 plus EGFR+/ALK+ LOT2+)
EMA: Participants diagnosed with locally advanced/metastatic non-squamous NSCLC not previously treated. Participants with EGFR-activating mutations or ALK-positive tumor mutations should have received at least one line of targeted therapy. FDA: for the treatment of adult participants with metastatic NSCLC who have disease progression during or following platinum-containing chemotherapy. Participants with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for NSCLC harboring these aberrations prior to receiving TECENTRIQ. Enrollment is closed.
Cohort 4 (ES-SCLC LOT1)
Participants diagnosed with extensive stage (ES) small cell lung cancer (SCLC) not previously treated. Enrollment is closed.
Cohort 5 (NSCLC LOT1)
Participants diagnosed with metastatic Non-Small Cell Lung cancer with high PD-L1 expression, previously untreated.
Cohort 6 (HCC LOT1)
Participants diagnosed with unresectable locally advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy.
Interventions
Atezolizumab will be administered at the discretion of the treating physician per local guidelines and independently of participation in this study.
Eligibility Criteria
Participants diagnosed with locally advanced /mUC previously treated with platinum-containing chemotherapy, participants diagnosed with locally advanced/metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy, participants diagnosed with extensive-stage small cell lung cancer (ES-SCLC), participants diagnosed with metastatic NSCLC previously untreated,and participants diagnosed with locally unresectable locally advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy.
You may qualify if:
- Patient must have one of the following confirmed diagnoses for which atezolizumab is locally approved in the SmPC: (1) As monotherapy for the treatment of adult patients with locally advanced/metastatic UC after prior platinum-containing chemotherapy (Cohort 1 LOT2+mUC) or (2) As monotherapy for the treatment of adult patients with locally advanced/metastatic NSCLC after prior chemotherapy. Patients with EGFR activating mutations or ALK-positive tumour mutations should also have received targeted therapy before receiving atezolizumab (Cohort 2 LOT2+NSCLC) or (3) In combination with bevacizumab, paclitaxel and carboplatin for the first line treatment of adult patients with metastatic non-squamous NSCLC. Patients with EGFR activating mutations or ALK- positive tumour mutations should also have received targeted therapy (Cohort 3 LOT1 NSCLC) or (4) In combination with carboplatin and etoposide, is indicated for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) (Cohort 4 LOT1 ES-SCLC) or (5) As a monotherapy, for the treatment of metastatic NSCLC with high PD-L1 expression, previously untreated (Cohort 5 LOT1 NSCLC) or (6) In combination with bevacizumab for unresectable locally advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy (Cohort 6 LOT1 HCC) .
- Patient is administered atezolizumab therapy for the first time.
You may not qualify if:
- Patients not receiving treatment for a disease with atezolizumab according to standard of care and in line with the current summary of product characteristics (SPC) or local labelling. Cisplatin ineligible patients receiving atezolizumab LOT1 for the treatment of locally advanced/metastatic UC patients will be excluded
- Concomitant anti-cancer therapy at the time of starting atezolizumab on the index date not part of locally approved combination therapy with atezolizumab.
- Treatment with atezolizumab as part of a clinical trial or for compassionate use as part of a pre-approval or compassionate use program.
- Patients not receiving atezolizumab, but a biosimilar or non-original biologic.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (258)
Hospital Universitario Austral
Buenos Aires, 16290, Argentina
Lucen S.A.
Buenos Aires, C1405CUB, Argentina
Consultorio Privado Korbenfeld
CABA, C1426AGE, Argentina
Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, C1199ABB, Argentina
Sanatorio Allende
Córdoba, X5000JHQ, Argentina
Sanatorio de la Mujer
Rosario, S2000ORE, Argentina
Fundacion Koriza
Santa Rosa, 6300, Argentina
Klinikum Klagenfurt
Klagenfurt, 9020, Austria
Landesklinikum Krems
Krems, 3500, Austria
Salzkammergut-Klinikum Voecklabruck
Vöcklabruck, 4840, Austria
Klinikum Wels-Grieskirchen
Wels, 4600, Austria
AZ KLINA
Brasschaat, 2930, Belgium
AZ St Maarten Campus Leopoldstr
Mechelen, 2800, Belgium
CHU UCL Mont-Godinne
Mont-godinne, 5530, Belgium
AZ Oostende
Ostend, 8400, Belgium
AZ Delta (Campus Rumbeke)
Roeselare, 8800, Belgium
Sint Trudo Ziekenhuis
Sint-Truiden, 3800, Belgium
Beneficencia Portuguesa de Sao Paulo
São Paulo, São Paulo, 01323-900, Brazil
Complex Oncology Center Burgas
Burgas, DUMMY_VALUE, Bulgaria
Multiprofile Hospital for Active Treatment Uni Hospital
Panagyurishte, 4500, Bulgaria
Umhat Dr Georgi Stranski
Pleven, 5800, Bulgaria
University Hospital Palmed
Plovdiv, 4001, Bulgaria
Complex Oncological Center - Plovdiv, EOOD
Plovdiv, 4004, Bulgaria
Complex Oncology Center - Plovdiv First Internal Chemotherapy Department
Plovdiv, 4004, Bulgaria
DDODIU-Plovdiv, EOOD
Plovdiv, 4004, Bulgaria
Complex Oncological Center-Ruse EOOD
Rousse, 7000, Bulgaria
Tokuda Hospital
Sofia, 1407, Bulgaria
UMHAT "Sv. Ivan Rilski", EAD
Sofia, 1431, Bulgaria
MBAL Serdika EOOD
Sofia, 1632, Bulgaria
MHAT SofiaMed
Sofia, DUMMY_VALUE, Bulgaria
Specialized Hospital for Active Cancer Treatment, Dr. Mark Antonov Markov - Varna Ltd
Varna, 9010, Bulgaria
Centro de Estudios Clínicos SAGA
Santiago, DUMMY_VALUE, Chile
Angiografia del Occidente
Cali, 760045, Colombia
Fundacion Clinica Valle del Lili
Cali, DUMMY_VALUE, Colombia
Hospital Pablo Tobon Uribe
Medellín, 050034, Colombia
Clinica ASTORGA
Medellín, 50010, Colombia
Clinical Hospital Centre Osijek
Osijek, 31000, Croatia
Klinicki Bolnicki Centar Split
Split, 21000, Croatia
Clinical Hospital Center Sestre Milosrdnice
Zagreb, 10000, Croatia
Clinical Hospital Centre Zagreb
Zagreb, 10000, Croatia
SUN Oncology center- Alexandria
Alexandria, DUMMY_VALUE, Egypt
Yasser Abdel Kader Private Clinic
Cairo, 11391, Egypt
Air Force Specialized Hospital
Cairo, DUMMY_VALUE, Egypt
Barsoum Oncology Center
Cairo, DUMMY_VALUE, Egypt
Cairo Oncology Center
Cairo, DUMMY_VALUE, Egypt
International Medical Center
Cairo, DUMMY_VALUE, Egypt
North Estonia Medical Centre Foundation
Tallinn, 13419, Estonia
Tartu Uni Hospital
Tartu, 51014, Estonia
Clinique Du Docteur Calabet
Agen, 47000, France
Ch Du Pays D Aix
Aix-en-Provence, 13616, France
Clinique de l'Europe
Amiens, 80090, France
Centre Hospitalier Uni Ire
Angers, 49933, France
Hopital Prive D Antony
Antony, 92166, France
CHG Henri Dufaut médecine interne-onco-hematologie
Avignon, 84902, France
CH de Beauvais
Beauvais, 60000, France
Hopital Jean Minjoz
Besançon, 25030, France
Ch De Beziers
Béziers, 34525, France
Clinique Tivoli
Bordeaux, 33030, France
Polyclinique Bordeaux Nord Aquitaine
Bordeaux, 33077, France
Hopital Cote De Nacre
Caen, 14033, France
Ch De Chambery
Chambéry, 73011, France
Oncologie 37
Chambray-lès-Tours, 37170, France
Hopital Gabriel Montpied
Clermont-Ferrand, 63003, France
Ch De Compiegne
Compiègne, 60321, France
Ch Laennec
Creil, 60109, France
Centre Georges Francois Leclerc
Dijon, 21079, France
Hopital Simone Veil Eaubonne
Eaubonne, 95602, France
Chi Alpes Du Sud Site De Gap
Gap, 05007, France
Hopital Nord Ouest
Gleizé, 69400, France
Ch Saint Louis
La Rochelle, 17019, France
Hopital La Source
La Source, 45100, France
Hopital Louis Pasteur
Le Coudray, 28630, France
Centre Hospitalier Du Mans
Le Mans, 72037, France
Hôpital Privé La Louviere
Lille, 59042, France
Hopital Dupuytren
Limoges, 87042, France
Ch Bretagne Sud Site Scorff
Lorient, 56100, France
Hopital Privé Jean Mermoz
Lyon, 69008, France
Hopital Europeen
Marseille, 13003, France
Clinique Clementville
Montpellier, 34070, France
Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque
Montpellier, 34298, France
Hopital Emile Muller
Mulhouse, 68070, France
Hopital Caremeau
Nîmes, 30029, France
Polyclinique Kenval
Nîmes, 30900, France
Institut Curie
Paris, 75005, France
Hopital Cochin
Paris, 75014, France
Hopital Europeen Georges Pompidou
Paris, 75908, France
Centre Hospitalier
Pau, 64046, France
Centre Catalan D' Oncologie
Perpignan, 66000, France
Ch Annecy - Genevois
Pringy, 74374, France
Hopital De La Maison Blanche
Reims, 51092, France
Clinique Mutualiste L Estuaire
Saint-Nazaire, 44606, France
Hopital Nord
Saint-Priest-en-Jarez, 42770, France
Ch De Saint Quentin
Saint-Quentin, 02321, France
Hopital Robert Pax
Sarreguemines, DUMMY_VALUE, France
Hopital Sainte Musse
Toulon, 83056, France
Hopital Larrey
Toulouse, 31059, France
Centre Hospitalier de Valence
Valence, 26000, France
Service de pneumologie Clinique médico-chirurgicale Tessier
Valenciennes, 59326, France
Ch Bretagne Atlantique
Vannes, 56017, France
Hopital Robert Schuman
Vantoux, 57070, France
Orszagos Koranyi TBC es Pulmonologiai Intezet
Budapest, 1121, Hungary
Semmelweis Egyetem, AOK, Pulmonologiai Klinika
Budapest, 1125, Hungary
Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika
Debrecen, 4032, Hungary
University of Pecs
Pécs, 7623, Hungary
Református Pulmonológiai Centrum
Törökbálint, 2045, Hungary
HCG Cancer Center
Ahmedabad, Gujarat, 380060, India
Sunshine Global Hospital (A unit of Baroda Medicare Pvt Ltd)
Surat, Gujarat, 395007, India
Manipal Hospital
Bangalore, Karnataka, 560017, India
Aster Medcity
Kochi, Kerala, 682027, India
MVR Cancer Centre and Research Institute
Kozhikode, Kerala, 673601, India
MOC Cancer Care & Research Centre
Mumbai, Maharashtra, 400056, India
AIG Hospitals
Gachibowli, Telangana, 500032, India
Ospedale San Salvatore, UOC Oncologia
L’Aquila, Abruzzo, 67100, Italy
Grande Ospedale Metropolitano
Reggio Calabria, Calabria, 89133, Italy
Az. Osp. Monaldi
Naples, Campania, 80131, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
Naples, Campania, 80131, Italy
A.O. Universitaria Policlinico Di Modena
Modena, Emilia-Romagna, 41100, Italy
Azienda Ospedaliera San Camillo Forlanini
Rome, Lazio, 00152, Italy
Ospedale S.S. Trinità Nuovo
Sora, Lazio, 03039, Italy
IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST)
Genoa, Liguria, 16132, Italy
Ospedale Maggiore Policlinico
Milan, Lombardy, 20122, Italy
Asst Santi Paolo E Carlo
Milan, Lombardy, 20142, Italy
Asst Grande Ospedale Metropolitano Niguarda
Milan, Lombardy, 20162, Italy
Ospedale Di Circolo E Fondazione Macchi
Varese, Lombardy, 21100, Italy
Ospedale Civile SS. Antonio E Biagio DI Alessandria
Alessandria, Piedmont, 15100, Italy
Ospedale Oncologico A.Businco
Cagliari, Sardinia, 09121, Italy
Azienda Ospedaliero Universitaria Di Sassari
Sassari, Sardinia, 07100, Italy
Az Ospedaliera Nuovo Garibaldi Quartiere Nesima
Catania, Sicily, 95122, Italy
Az. Osp. Uni. Ria Policlinico G. Martino
Messina, Sicily, 98124, Italy
Ospedale Di Macerata
Macerata, The Marches, 62100, Italy
Azienda Ospedaliero Universitaria Careggi
Florence, Tuscany, 50134, Italy
Azienda Ospedaliero-Universitaria Careggi
Florence, Tuscany, 50134, Italy
Ospedale Nuovo Della Versilia
Lido di Camaiore, Tuscany, 55043, Italy
A.O.U. Integrata Verona - Policlinico G.B. Rossi
Verona, Veneto, 37134, Italy
Azienda ULSS 8 Berica
Vicenza, Veneto, 36100, Italy
Kuwait Cancer control center
Kuwait City, DUMMY_VALUE, Kuwait
Kuwait Cancer control center
Shuwakh Industrial, 70653, Kuwait
Saint George Hospital
Beirut, 166378, Lebanon
Middle East Institute of Health Hospital
Bsalim, Mount Lebanon-Metn, 2624 0000, Lebanon
Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution
Kaunas, 50009, Lithuania
National Cancer Institute
Vilnius, LT-08660, Lithuania
Medica sur Hospital
Mexico City, Mexico CITY (federal District), 14050, Mexico
Clinica Opcion Oncologia S.A. de C.V.
Monterrey, Nuevo León, 64000, Mexico
Oncare
San Pedro Garza García, Nuevo León, 66220, Mexico
Onze Lieve Vrouwe Gasthuis, locatie Oost
Amsterdam, 1091 AC, Netherlands
Catharina ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Medisch Centrum Leeuwarden
Leeuwarden, 8934 AD, Netherlands
Zaans Medisch Centrum
Zaandam, 1502 DV, Netherlands
Royal Hospital
Muscat, 111, Oman
Sultan Qaboos Comprehensive Cancer Care & Research Center
Muscat, DUMMY_VALUE, Oman
Shaukat Khanum Memorial Cancer Hospital
Lahore, Punjab Province, 54000, Pakistan
Aga Khan University
Karachi, Sindh, 74800, Pakistan
WZZOZ Centrum Leczenia Chorob Pluc i Rehabilitacji
?ód?, 91-520, Poland
Wojewódzki Szpital Specjalistyczny im. M. Kopernika w ?odzi
?ód?, 93-513, Poland
Beskidzkie Centrum Onkologii - Szpital Miejski im. Jana Pawla II
Bielsko-Bia?a, 43-300, Poland
Centrum Onkologii im. Prof. Franciszka ?ukaszczyka
Bydgoszcz, 85-796, Poland
Centrum Pulmonologii i Torakochirurgii
Bystra, 43-360, Poland
Wojewodzki Szpital Zespolony
Elblag, 82-300, Poland
Regionalny Szpital Specjalistyczny im. W. Bieganskiego
Grudzi?dz, 86-300, Poland
Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
Lublin, 20-954, Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
Olsztyn, 10-357, Poland
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy
Otwock, 05-400, Poland
Szpital Kliniczny im. Heliodora ?wi?cickiego UM w Poznaniu
Późna, 60-569, Poland
Instytut Gruzlicy i Chorob P?uc
Warsaw, 01-138, Poland
Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego
Warsaw, 02-091, Poland
Dolno?L?Skie Centrum Onkologii, Pulmonologii I Hematologii
Wroc?aw, 53-439, Poland
Hospital Geral
Coimbra, 3041-801, Portugal
Centro Clinico Champalimaud
Lisbon, 1400-038, Portugal
Hospital Pulido Valente
Lisbon, 1796-001, Portugal
Hospital Pedro Hispano
Matosinhos Municipality, 4454-509, Portugal
Centro Hospitalar do Porto ? Hospital de Santo António
Porto, 4099-001, Portugal
Hospital CUF Porto
Porto, 4100-180, Portugal
CHVNG/E_Unidade 1
Vila Nova de Gaia, 4434-502, Portugal
Institutul Clinic Fundeni Bucuresti
Bucharest, 022328, Romania
Institutul Regional de Gastroenterologie si Hepatologie Prof. Dr. Octavian Fodor
Cluj-Napoca, 400162, Romania
Altai Regional Oncological Center
Barnaul, Altayskiy Kray, 656049, Russia
Arkhangelsk Regional Clinical Oncology Dispensary
Arkhangelsk, Arhangelsk, 163045, Russia
Bashkirian Republican Clinical Oncology Dispensary
Ufa, Bashkortostan Republic, 450054, Russia
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky
Krasnoyarsk, Krasnodarskiy Kray, 660133, Russia
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF
Moscow, Moscow Oblast, 115478, Russia
Medical Clinic "AB Medical group"
Saint Petersburg, Sankt-Peterburg, 196006, Russia
EuroCityClinic
Saint Petersburg, Sankt-Peterburg, 197022, Russia
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
Saint Petersburg, Sankt-Peterburg, 197758, Russia
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic
Kazan', Tatarstan Republic, 420029, Russia
SBIH Kaluga Region Clinical Oncology Dispensary
Kaluga, 248007, Russia
Tver Regional Oncology Clinical Dispensary
Tver', 170008, Russia
Tan Tock Seng Hospital
Singapore, 308433, Singapore
Institute of Oncology Ljubljana
Ljubljana, 1000, Slovenia
University Medical Center Ljubljana
Ljubljana, 1000, Slovenia
Univerzitetni klini?ni center Maribor
Maribor, 2000, Slovenia
Complejo Hospitalario Torrecardenas
Almería, Almeria, 04009, Spain
Hospital Universitario Son Espases
Palma de Mallorca, Balearic Islands, 07014, Spain
Hospital General de Mataro
Mataró, Barcelona, 08304, Spain
Corporacio Sanitaria Parc Tauli
Sabadell, Barcelona, 08208, Spain
Complejo Hospitalario Universitario de Santiago (CHUS)
Santiago de Compostela, LA Coruna, 15706, Spain
Hospital Infanta Sofia
San Sebastián de los Reyes, Madrid, 28702, Spain
Clinica Universitaria de Navarra
Pamplona, Navarre, 31008, Spain
Complejo Hospitalario de Navarra
Pamplona, Navarre, 31008, Spain
Hospital Universitario de Canarias
San Cristóbal de La Laguna, Tenerife, 38320, Spain
Complejo Hospitalario Nuestra Señora de la Candelaria
Santa Cruz de Tenerife, Tenerife, 38010, Spain
Hospital Universitario Infanta Cristina
Badajoz, 06080, Spain
Hospital Universitari Dexeus - Grupo Quironsalud
Barcelona, 08028, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 08041, Spain
Complejo Asistencial Universitario De Burgos
Burgos, 09006, Spain
Hospital San Pedro De Alcantara
Cáceres, 10003, Spain
Hospital Clinico de Granada
Granada, 18006, Spain
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico
Jaén, 23007, Spain
Complejo Asistencial Universitario de Leon
León, 24071, Spain
Hospital Lucus Augusti
Lugo, 27003, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
Hospital de Madrid Norte Sanchinarro- Centro Integral Oncologico Clara Campal
Madrid, 28050, Spain
Hospital Universitario Puerta de Hierro
Madrid, 28222, Spain
Hospital Quiron de Madrid
Madrid, 28223, Spain
Complejo Hospitalario de Orense
Ourense, 32005, Spain
Hospital General de Segovia
Segovia, 40002, Spain
Hospital Univ. Nuestra Señora de Valme
Seville, 41014, Spain
Hospital Clinico Universitario de Valladolid
Valladolid, 47005, Spain
Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
Tawam Hospital
Al Ain City, 15258, United Arab Emirates
Barnet Hospital
Barnet, EN5 3DJ, United Kingdom
Royal United Hospital
Bath, BA1 3NG, United Kingdom
Clatterbridge Cancer Centre
Bebington, CH63 4JY, United Kingdom
Queen Elizabeth Hospital
Birmingham, B15 2TH, United Kingdom
Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
East Lancashire Hospitals NHS Trust
Burnley, BB10 2PQ, United Kingdom
Addenbrookes Hospital
Cambridge, CB2 0QQ, United Kingdom
Velindre Cancer Centre
Cardiff, CF14 2TL, United Kingdom
Castle Hill Hospital
Cottingham, HU16 5JG, United Kingdom
Royal Surrey County Hospital
Guildford, GU2 7XX, United Kingdom
Northwick Park Hospital
Harrow, HA1 3UJ, United Kingdom
Huddersfield Royal Infirmary
Huddersfield, HD3 3EA, United Kingdom
Airedale General Hospital
Keighley, BD20 6TD, United Kingdom
Royal Marsden Hospital
Kingston upon Thames, KT2 7QB, United Kingdom
St James Hospital
Leeds, LS9 7TF, United Kingdom
St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
Royal Free Hospital
London, NW3 2QG, United Kingdom
Guys and St Thomas Hospital
London, SE1 9RT, United Kingdom
Queen Elizabeth Hospital
London, SE18 4QH, United Kingdom
St George's Hospital
London, SW17 0QT, United Kingdom
Royal Marsden Hospital - Fulham
London, SW3 6JJ, United Kingdom
Hammersmith Hospital
London, W12 OHS, United Kingdom
Charing Cross Hospital
London, W6 8RF, United Kingdom
Maidstone Hospital
Maidstone, ME16 0FS, United Kingdom
The Christie
Manchester, M20 4BX, United Kingdom
James Cook Hospital
Middlesbrough, TS4 3BW, United Kingdom
Freeman Hospital
Newcastle upon Tyne, NE7 7DN, United Kingdom
Nottingham City Hospital
Nottingham, NG5 1PB, United Kingdom
Churchill Hospital
Oxford, OX3 7LJ, United Kingdom
Royal Preston Hospital
Preston, PR2 9HT, United Kingdom
Weston Park Hospital
Sheffield, S10 2SJ, United Kingdom
Royal Stoke University Hospital
Stoke-on-Trent, ST4 6QG, United Kingdom
Royal Marsden Hospital (Sutton)
Sutton, SM2 5PT, United Kingdom
Torbay Hospital
Torquay, TQ27AA, United Kingdom
Royal Cornwall Hospital
Truro, TR1 3LQ, United Kingdom
Pinderfields General Hospital
Wakefield, WF1 4DG, United Kingdom
Great Western Hospitals NHS Foundation Trust.
Wiltshire, SN3 6BB, United Kingdom
New Cross Hospital
Wolverhampton, WV10 0QP, United Kingdom
The York Hospital
York, YO31 8HE, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Clinical Trials
Hoffmann-La Roche
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 28, 2018
First Posted
December 20, 2018
Study Start
February 7, 2019
Primary Completion (Estimated)
July 31, 2026
Study Completion (Estimated)
July 31, 2026
Last Updated
January 8, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will not share