NCT03699228

Brief Summary

In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. The aim of this study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30,000

participants targeted

Target at P75+ for all trials

Timeline
8mo left

Started Dec 2017

Longer than P75 for all trials

Geographic Reach
1 country

6 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress93%
Dec 2017Dec 2026

Study Start

First participant enrolled

December 1, 2017

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

October 5, 2018

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 9, 2018

Completed
7.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2026

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

August 17, 2025

Status Verified

February 1, 2025

Enrollment Period

8.6 years

First QC Date

October 5, 2018

Last Update Submit

August 13, 2025

Conditions

OsteoporosisObesityLiver Steatoses

Keywords

Bone mineral density, quantitative computed tomography, Osteoporosis, obesity, liver steatosis

Outcome Measures

Primary Outcomes (1)

  • The spinal volumetric bone mineral density (vBMD)

    The volumetric bone mineral density of L1-2 measured by QCT

    2 year

Secondary Outcomes (2)

  • The visceral adipose tissue (VAT)

    2 year

  • Liver fat

    2 years

Eligibility Criteria

Age30 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

General health check population

You may qualify if:

  • health check subjects 30-90 years old low dose chest CT scan

You may not qualify if:

  • pregnant women metal implant in the CT scan area

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (6)

Wu Hu Yijishan Hospital

Wuhu, Anhui, 100035, China

RECRUITING

Beijing Jishuitan hospital

Beijing, Beijing Municipality, 100035, China

RECRUITING

The first affiliated hospital of Guiyang Medical University

Guiyang, Guizhou, China

RECRUITING

The first affiliated hospital of Zhengzhou University

Zhengzhou, Henan, China

RECRUITING

Hua Shan hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Shanghai Ruijin hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Related Publications (3)

  • Sun Y, Qi X, Wang X, Lin X, Zhou Y, Du Y, Liu A, Lv X, Zhou J, Li Z, Wu X, Zou Z, Zhang M, Zhu J, Shang F, Li Y, Li H. Association between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study. Lipids Health Dis. 2024 Jan 24;23(1):27. doi: 10.1186/s12944-024-02023-1.

    PMID: 38267987DERIVED

  • Sun Y, Qi X, Lin X, Zhou Y, Lv X, Zhou J, Li Z, Wu X, Zou Z, Li Y, Li H. Association between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023. Lipids Health Dis. 2023 Oct 21;22(1):180. doi: 10.1186/s12944-023-01946-5.

    PMID: 37865752DERIVED

  • Cheng X, Zhao K, Zha X, Du X, Li Y, Chen S, Wu Y, Li S, Lu Y, Zhang Y, Xiao X, Li Y, Ma X, Gong X, Chen W, Yang Y, Jiao J, Chen B, Lv Y, Gao J, Hong G, Pan Y, Yan Y, Qi H, Ran L, Zhai J, Wang L, Li K, Fu H, Wu J, Liu S, Blake GM, Pickhardt PJ, Ma Y, Fu X, Dong S, Zeng Q, Guo Z, Hind K, Engelke K, Tian W; China Health Big Data (China Biobank) project investigators. Opportunistic Screening Using Low-Dose CT and the Prevalence of Osteoporosis in China: A Nationwide, Multicenter Study. J Bone Miner Res. 2021 Mar;36(3):427-435. doi: 10.1002/jbmr.4187. Epub 2020 Nov 4.

    PMID: 33145809DERIVED

MeSH Terms

Conditions

OsteoporosisObesityFatty Liver

Condition Hierarchy (Ancestors)

Bone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesOverweightOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsLiver DiseasesDigestive System Diseases

Study Officials

  • xiaoguang cheng, MD

    Beijing Jishuitan Hospital

    PRINCIPAL INVESTIGATOR

  • qiang zeng

    General PLA hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

xiaoguang cheng, md

CONTACT

0086-010-58516947xiao65@263.net

xiaoxia fu, md

CONTACT

0086-13683132746

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
professor of radiology, chairman of department

Study Record Dates

First Submitted

October 5, 2018

First Posted

October 9, 2018

Study Start

December 1, 2017

Primary Completion (Estimated)

June 30, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

August 17, 2025

Record last verified: 2025-02

Locations

CN(6)