The Function and Proteome Alteration of HDL Subclass After Aerobic Exercise

NCT04294238 | Completed

• 1 other identifier: SYSEC-KY-KS-2019-011
• Study Type: interventional
• Target: 6
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is one of the most important risk factors for cardiovascular disease (CVD). HDL protein composition can be altered without a change in cholesterol content. Alteration of the HDL proteome can result in dysfunctional HDL particles with reduced ability to protect against CVD. The aim of this study was to evaluate the influence of moderate aerobic exercise on HDL protein composition and its related function. This was a self-control study including 6 inactive male youths with abdominal obesity. HDL functions and its associations with proteome alteration would be analysized.

Conditions

Obesity

Keywords

Obesity, Aerobic exercise, HDL subclass, Proteome, function

Outcome Measures

Primary Outcomes (2)

• The percentage change of HDL cholesterol efflux capacity

  The primary outcome was the mearsurement of HDL function for removing excess cholesterol from peripheral cells

  12 week

• Proteome alteration of HDL subclass

  HDL proteome was analyzed by mass spectrometry using label-free protein quantification.

  12 week

Study Arms (1)

Post-exercise

EXPERIMENTAL

The aerobic exercise intervention consisted of 12 weeks of aerobic exercise training of moderate intensity (about 75 percentage of peak heart rate) of 40-60 min per time, 3-5 times per week, at least 150 min per week.

Behavioral: Aerobic exercise

Interventions

Aerobic exercise BEHAVIORAL

The aerobic exercise intervention consisted of 12 weeks of aerobic exercise training of moderate intensity (about 75 percentage peak heart rate) of 40-60 min per time, 3-5 times per week, at least 150 min per week.

Post-exercise

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Inactive youth males with abdominal obesity: BMI\>28 (weight in kilograms divided by height in meters squared) and weight stable for 6 months, waist to height ratio was ≥0.5 and/or waist circumference was ≥102 centimetres between the ages of 18 and 30 years.

You may not qualify if:

• Participants with cardiovascular disease, diabetes or other chronic diseases, treatment with any medications, and had surgical procedures within the last 6 months.

Sponsors & Collaborators

• Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University: lead

Study Sites (1)

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

Location

MeSH Terms

Conditions

Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Jingfeng Wang

  Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Self-control study

Study Record Dates

• First Submitted: February 25, 2020
• First Posted: March 4, 2020
• Study Start: January 30, 2018
• Primary Completion: January 20, 2020
• Study Completion: February 20, 2020
• Last Updated: March 4, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: The data will become available at 01/01/2021 and for 1 year.

Locations

CN (1)