Assessment of Cerebrospinal Fluid Flow Related Disorders Using a Phase-contrast Magnetic Resonance Imaging Technique.

NCT03656016 | Unknown

• 1 other identifier: CSFFPCMRI
• Study Type: observational
• Target: 87
• Locations: 1 country
• Sites: 1

Brief Summary

Cerebrospinal fluid is a clear, colorless fluid that circulates in the cranial and spinal subarachnoid spaces, located between the pia and arachnoid matters. It is mainly produced by the choroid plexus, while lesser amount produced by the ependymal cells lining the ventricles. Its function includes cushioning and lubrication of the central nervous system, circulation of nutrients and waste collection providing basic mechanical and immunological protection to the brain.

Conditions

Cerebrospinal Fluid

Outcome Measures

Primary Outcomes (1)

• To calculate different cerebrospinal fluid flow parameters at different levels of flow quantification.

  measure Systolic stroke volume and Peak systolic velocity at different levels of flow quantification

  base line

Secondary Outcomes (1)

• To correlate these parameters to the normal values of age matched control group

  baseline

Study Arms (2)

study group

patients with congenital and acquired disorders that can alter the CSF dynamics will undergo phase-contrast magnetic resonance imaging

Device: Magnetic Resonance Imaging

control group

age matched healthy individuals will undergo phase-contrast magnetic resonance imaging

Device: Magnetic Resonance Imaging

Interventions

Magnetic Resonance Imaging DEVICE

Phase contrast magnetic resonance imaging technique

control group; study group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with different age groups and both sex with clinical and routine conventional magnetic resonance imaging findings suggestive of cerebrospinal fluid flow disorders

You may qualify if:

• Patients with different age groups and both sex with clinical and routine conventional magnetic resonance imaging findings suggestive of cerebrospinal fluid flow disorders.

You may not qualify if:

• Patients with contraindications for MRI, e.g. an implanted magnetic device, pacemakers or claustrophobia.
• Patients with VP shunts
• Patients with ventriculomegally due to brain SOLs.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Faculty of medicine

Asyut, 71111, Egypt

RECRUITING

Related Publications (5)

• Sakka L, Coll G, Chazal J. Anatomy and physiology of cerebrospinal fluid. Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Dec;128(6):309-16. doi: 10.1016/j.anorl.2011.03.002. Epub 2011 Nov 18.

  PMID: 22100360 BACKGROUND

• Yildiz H, Yazici Z, Hakyemez B, Erdogan C, Parlak M. Evaluation of CSF flow patterns of posterior fossa cystic malformations using CSF flow MR imaging. Neuroradiology. 2006 Sep;48(9):595-605. doi: 10.1007/s00234-006-0098-8. Epub 2006 Jun 3.

  PMID: 16752134 BACKGROUND

• Yamada S, Tsuchiya K, Bradley WG, Law M, Winkler ML, Borzage MT, Miyazaki M, Kelly EJ, McComb JG. Current and emerging MR imaging techniques for the diagnosis and management of CSF flow disorders: a review of phase-contrast and time-spatial labeling inversion pulse. AJNR Am J Neuroradiol. 2015 Apr;36(4):623-30. doi: 10.3174/ajnr.A4030. Epub 2014 Jul 10.

  PMID: 25012672 BACKGROUND

• Parkkola RK, Komu ME, Aarimaa TM, Alanen MS, Thomsen C. Cerebrospinal fluid flow in children with normal and dilated ventricles studied by MR imaging. Acta Radiol. 2001 Jan;42(1):33-8. doi: 10.1080/028418501127346431.

  PMID: 11167329 BACKGROUND

• Ng SE, Low AM, Tang KK, Lim WE, Kwok RK. Idiopathic normal pressure hydrocephalus: correlating magnetic resonance imaging biomarkers with clinical response. Ann Acad Med Singap. 2009 Sep;38(9):803-8.

  PMID: 19816640 BACKGROUND

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Shimaa Bakr, MSc

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mostafa Hussein

CONTACT

01122999878; thabet.mostafa@yahoo.com

Hazem Youseif

CONTACT

01005075888; bozaidhazz@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal Investigator

Study Record Dates

• First Submitted: August 29, 2018
• First Posted: September 4, 2018
• Study Start: March 25, 2019
• Primary Completion: May 1, 2025
• Study Completion: July 1, 2025
• Last Updated: November 20, 2024

Record last verified: 2024-01

Locations

EG (1)