Role of Advanced Magnetic Resonance Imaging in Assessment of Pediatric Cerebral Stroke

NCT03617159 | Unknown

• 1 other identifier: MRI in Pediatric Brain stroke
• Study Type: observational
• Target: 68
• Locations: 0 countries
• Sites: N/A

Brief Summary

Stroke can be ischemic, hemorrhagic, or both. Early recognition and treatment of pediatric stroke are critical in optimizing long-term functional outcomes, reducing morbidity and mortality, and preventing recurrent stroke. Neuroimaging plays a vital role in achieving this goal. Neuroimaging is usually the first step in diagnosis, helping discriminate between ischemic/hemorrhagic strokes and also in the identification of underlying potential causes. Multiparametric magnetic resonance imaging (MRI) plays a crucial role in assessing pediatric cerebral stroke including diffusion-weighted imaging (DWI), susceptibility weighted imaging (SWI) and magnetic resonance angiography (MRA).

Conditions

Pediatric Cerebral Stroke; Brain Infarction/Diagnosis

Keywords

magnetic resonance imaging; diffusion weighted imaging

Outcome Measures

Primary Outcomes (1)

• To compare the diagnostic accuracy of advanced MRI sequences versus the conventional sequences in early pediatric cerebral stroke.

  To compare the diagnostic accuracy of advanced MRI sequences including diffusion-weighted imaging (DWI and susceptibility weighted imaging (SWI) with the conventional MRI sequences including T1 weighted imaging, T2 weighted imaging and fluid attenuating inversion recovery (FLAIR) in assessing pediatric cerebral stroke in assessing early infarction by DWI and presence of blood signal by SWI and comparing these findings with the MR conventional sequences.

  Wiithin the first day of stroke

Interventions

Magnetic Resonance Imaging DEVICE

Diagnostic Modality

Eligibility Criteria

• Age: 5 Years - 15 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the pediatric neurological intensive care unit with cerebral stroke

You may qualify if:

• Patients with acute pathological changes in the central nervous system CNS within 7 days admitted from outpatient, emergency room, or inpatient department
• Confirmed diagnosis of acute stroke by clinical testings performed by a neurologist
• Signed informed consent from the patient

You may not qualify if:

• Any person with a pacemaker, metal implant, claustrophobia, or any other contraindication for MR examination
• Any person with epilepsy, brain tumor.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Husson B, Rodesch G, Lasjaunias P, Tardieu M, Sebire G. Magnetic resonance angiography in childhood arterial brain infarcts: a comparative study with contrast angiography. Stroke. 2002 May;33(5):1280-5. doi: 10.1161/01.str.0000014504.18199.0d.

  PMID: 11988604 BACKGROUND

• Husson B, Lasjaunias P. Radiological approach to disorders of arterial brain vessels associated with childhood arterial stroke-a comparison between MRA and contrast angiography. Pediatr Radiol. 2004 Jan;34(1):10-5. doi: 10.1007/s00247-003-1109-0. Epub 2003 Dec 10.

  PMID: 14669061 BACKGROUND

MeSH Terms

Conditions

Brain Infarction; Disease

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Vascular Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Mohammad Farghali, MD

CONTACT

+201090122141; radiologydr2017@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: July 25, 2018
• First Posted: August 6, 2018
• Study Start: October 1, 2018
• Primary Completion: September 1, 2021
• Study Completion: November 1, 2021
• Last Updated: August 7, 2018

Record last verified: 2018-08