Effect of Music on Reading Comprehension in Patients With Aphasia

NCT03600987 | Completed

• 1 other identifier: IRB #2408
• Study Type: interventional
• Target: 4
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this investigation is to examine the evidence on emotion, language, and music, and propose a first step, in the form of a single-subject research design, to determine the most effective and efficient method for application to the rehabilitation of patients with aphasia. A single-subject adapted alternating treatment design will be used to compare two music conditions, using music with sung lyrics simultaneously with reading of the lyrics, and priming with music and sung lyrics followed by a reading of the lyrics, with a control condition using reading lyrics without music. Results are expected to provide evidence of independent versus shared processing of music and language at the phrase level applied to the behavior of human subjects with aphasia.

Conditions

Aphasia

Keywords

left middle cerebral artery; cerebrovascular accident (CVA); stroke

Outcome Measures

Primary Outcomes (3)

• Percent correct responses per day on phrase completion task.

  Differential response to the interventions (counted as the percent correct responses per day).

  through study completion, an average of 1 year.

• Number of sessions required to achieve mastery.

  Count number of sessions.

  through study completion, an average of 1 year.

• Retention of the reading material.

  Number of items recalled.

  3 weeks post-intervention.

Secondary Outcomes (2)

• International Classification of Functioning, Disability, and Health (ICF) body Functions/Structures, Activities, and Participation.

  through study completion, an average of 1 year.

• Boston Diagnostic Aphasia Examination-Third Edition (BDAE-3) (Goodglass, Harold, & Barresi, Austin: PRO-Ed.).

  through study completion, an average of 1 year.

Study Arms (1)

Music and reading lyrics

EXPERIMENTAL

A single-subject adapted alternating treatment design will be used to compare two music conditions, using music with sung lyrics simultaneously with silent reading of the lyrics, and priming with music and sung lyrics followed by reading of the lyrics, with a control condition using reading materials without music.

Behavioral: Simultaneous music and reading lyrics; Behavioral: Priming with music; Behavioral: Control

Interventions

Simultaneous music and reading lyrics BEHAVIORAL

listening to music with singing of the lyrics simultaneously with reading the written lyrics.

Music and reading lyrics

Priming with music BEHAVIORAL

priming by listening to music and singing of the lyrics followed by reading the written lyrics.

Music and reading lyrics

Control BEHAVIORAL

control condition using reading materials without music.

Music and reading lyrics

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Post-hospitalization;
• premorbid reading at the 8th grade level or higher based on the participant's/family's stated years of formal education;
• post-stroke aphasia/left middle cerebral artery (MCA) cerebral vascular accident (CVA) based on electronic medical record (EMR) and computed tomography (CT) and/or magnetic resonance imaging (MRI) imaging reports, or consult with the neurologist;
• intact left amygdala and left extrastriate cortex based on EMR and CT/MRI imaging reports, or consult with the neurologist;
• reliability in answering yes-no questions as determined by an 80% score on therapy tasks during regular speech therapy;
• capacity to provide informed consent concerning a study involving an intervention with music therapy determined by the physician who refers the patient.

You may not qualify if:

• Co-morbidities diagnosed and reported in the EMR or shown on CT scan or MRI including past history of stroke in other brain regions with residual symptoms, dementia, Parkinson disease, head injury, etc.;
• hemianopsia or other visual field defects affecting vision for reading, and in particular right homonymous hemi- or inferior quadrantanopsia;
• previous history of learning disabilities in reading/writing;
• significant psychiatric diagnosis;
• English as a Second Language or non-English language.

Sponsors & Collaborators

• Carilion Clinic: lead

Study Sites (1)

Carilion Franklin Memorial Hospital, Carilion Community Memorial Hospital Inpatient Rehab, Carilion Day Rehab

Rocky Mount, Virginia, 24151, United States

Location

MeSH Terms

Conditions

Aphasia; Stroke

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Jacqueline A. Treichler

  Carilion Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ClinScD, CCC-SLP; Speech-Language Pathologist

Model Details: Single-subject adapted alternating treatment design.

Study Record Dates

• First Submitted: July 17, 2018
• First Posted: July 26, 2018
• Study Start: October 18, 2017
• Primary Completion: October 17, 2019
• Study Completion: October 17, 2019
• Last Updated: January 6, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)