Effect of Music on Reading Comprehension for Patients With Aphasia

NCT02875938 | Completed

• 1 other identifier: CarilionClinic
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

This investigation uses a single-subject, adapted alternating research design to compare two different experimental conditions using music with lyrics combined with visual stimulation of the written lyrics, to extend the emotional word effect to phrases, in order to stimulate reading comprehension of the trained material for patients with aphasia. The two music conditions include 1) music with sung lyrics simultaneously with silent reading of the written lyrics; and 2) music with sung lyrics, followed by silent reading of the written lyrics (i.e. priming with the music). A control set without music will be used additionally within every third session to detect potential history and maturation effects. All conditions will be followed by a silent reading phrase-completion task composed of written words from the total combined sets of stimuli.

Conditions

Aphasia

Keywords

left middle cerebral artery; cerebrovascular accident (CVA); stroke

Outcome Measures

Primary Outcomes (3)

• Percent correct responses per day on phrase completion task.

  Differential response to the interventions (counted as the percent correct responses per day.

  through study completion, an average of 1 year

• Number of sessions required to achieve mastery.

  count number of sessions.

  through study completion, an average of 1 year

• Retention of the reading material

  Number of items recalled.

  3 weeks post-intervention.

Secondary Outcomes (2)

• International Classification of Functioning, Disability, and Health (ICF) Body Functions/Structures, Activities, and Participation

  through study completion, an average of 1 year

• Boston Diagnostic Aphasia Examination-Third Edition (BDAE-3)

  through study completion, an average of 1 year

Study Arms (1)

Music and reading lyrics

EXPERIMENTAL

A single-subject adapted alternating treatment design will be used to compare two music conditions, using music with sung lyrics simultaneously with silent reading of the lyrics, and priming with music and sung lyrics followed by reading of the lyrics, with a control condition using reading materials without music.

Behavioral: Simultaneous music and reading lyrics; Behavioral: Priming with music; Behavioral: Control

Interventions

Simultaneous music and reading lyrics BEHAVIORAL

music with sung lyrics simultaneously with silent reading of the lyrics.

Music and reading lyrics

Priming with music BEHAVIORAL

priming with music and sung lyrics followed by reading of the lyrics.

Music and reading lyrics

Control BEHAVIORAL

control condition using reading materials without music.

Music and reading lyrics

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Post-hospitalization;
• premorbid reading at the 8th grade level or higher based on the participant's/family's stated years of formal education;
• post-stroke aphasia/left middle cerebral artery (MCA) CVA based on electronic medical record (EMR) and computed tomography (CT)/magnetic resonance imaging (MRI) imaging reports, or consult with the neurologist;
• intact left amygdala and left extrastriate cortex based on EMR and CT/MRI imaging reports, or consult with the neurologist;
• reliability in answering yes/no questions as determined by a 90% score on yes/no comprehension therapy tasks during regular speech therapy.
• Capacity to provide informed consent concerning a study involving an intervention with music therapy: determined by the physician who refers the patient.

You may not qualify if:

• Co-morbidities diagnosed and reported in the EMR or shown on CT scan or MRI including past history of stroke with residual symptoms, dementia, Parkinson's disease, head injury, etc.;
• hemianopsia or other visual field defects affecting vision for reading, and in particular right homonymous hemi- or inferior quadrantanopsia;
• previous history of learning disabilities in reading/writing;
• significant psychiatric diagnosis;
• English as a Second Language or non-English language.

Sponsors & Collaborators

• Carilion Clinic: lead

Study Sites (1)

Carilion Franklin Memorial Hospital

Rocky Mount, Virginia, 24151, United States

Location

MeSH Terms

Conditions

Aphasia; Stroke

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Jacqueline A. Treichler, MS, CCC-SLP

  Carilion Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 10, 2016
• First Posted: August 23, 2016
• Study Start: July 1, 2016
• Primary Completion: July 1, 2017
• Study Completion: August 1, 2017
• Last Updated: September 20, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)