Pairing Word Retrieval and Physical Endurance Tasks to Treat Anomia in People With Aphasia

NCT03326687 | Withdrawn

• 1 other identifier: 17337
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Many individuals have difficulty with word retrieval, also called anomia, following cerebrovascular accident (CVA). These difficulties impede effective communication in everyday conversations and can negatively impact the resumption of pre-injury activities. Even after rehabilitation specifically targeting these areas, many individuals report persistent difficulties with anomia. Additionally, most individuals report that these difficulties worsen when distracted, fatigued, or when attempting to divide attention between tasks. Given that everyday activities frequently require efficient communication when attention is divided (e.g., walking and talking), it is important to investigate viable interventions to improve these skills. Recovery from CVA and resumption of pre-injury activities is best supported by rehabilitation interventions that are functional and directly related to the tasks individuals aim to resume. For example, a therapy task requiring an individual to generate a grocery list and then go to a grocery store to acquire the items on the list has a greater impact on recovery for the underlying language and cognitive skills than a series of generic language and cognition tasks completed in a therapy room. In addition to this, interventions that incorporate dual-task practices tend to have better outcomes than more traditional single-task practices. The aim of this study is to compare the effectiveness of pairing word retrieval tasks with physical endurance tasks versus presenting them in isolation. Additionally, this study will investigate whether improvements in word retrieval and physical endurance generalize to the functional, everyday task of holding a conversation while walking. The researchers hypothesize that participants will perform better on word retrieval tasks after participating in dual language and physical tasks than after participating in language tasks presented in isolation.

Conditions

Aphasia

Keywords

Language; Anomia; Therapy

Outcome Measures

Primary Outcomes (1)

• Number of words named in a category

  The researcher will provide a participant with a category label. The participants will name as many words as he/she can in that category within a one-minute time period. The researcher will tally the total number of unique and category-appropriate words named.

  One or two times daily until discharge from the facility (up to 24 weeks).

Secondary Outcomes (3)

• Distance traveled (in feet) while using an exercise machine

  One or two times daily until discharge from the facility (up to 24 weeks).

• Number of words generated during discourse

  Two times per week until discharge from the facility (up to 24 weeks).

• Distance traveled (in feet) while walking

  Two times per week until discharge from the facility (up to 24 weeks).

Study Arms (2)

Treatment ABAB

EXPERIMENTAL

Participants will receive anomia treatment in isolation and will perform a physical endurance task in isolation during A phases. They will receive anomia treatment in combination with performing a physical endurance task during B phases.

Behavioral: Treatment ABAB

Treatment BABA

EXPERIMENTAL

Participants will receive anomia treatment in isolation and will perform a physical endurance task in isolation during A phases. They will receive anomia treatment in combination with performing a physical endurance task during B phases.

Behavioral: Treatment BABA

Interventions

Treatment ABAB BEHAVIORAL

Participants will perform the phases in the ABAB order.

Treatment ABAB

Treatment BABA BEHAVIORAL

Participants will perform the phases in the BABA order.

Treatment BABA

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Have acquired brain injury due to left cerebrovascular accident (CVA)
• Be older than 19 years of age
• Speak English as a native language
• Be less than 3 months post-left CVA at the time of participation initiation
• Use natural speech as a primary means of communicating
• Have hearing adequate for conversational speech
• Have mild to moderate deficits in word retrieval and physical endurance as a result of left CVA
• Be currently receiving treatment services at Quality Living for CVA-related deficits

Sponsors & Collaborators

• University of Nebraska Lincoln: lead
• Quality Living, Inc.: collaborator

Study Sites (1)

Quality Living

Omaha, Nebraska, 68104, United States

Location

MeSH Terms

Conditions

Aphasia; Language; Anomia

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Communication; Behavior

Study Officials

• Karen A Hux, PhD

  University of Nebraska Lincoln

  PRINCIPAL INVESTIGATOR

• Carly R Dinnes, MA

  University of Nebraska Lincoln

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All participants will receive both the isolated and combined treatments in an ABAB or BABA order of phases.

Study Record Dates

• First Submitted: October 20, 2017
• First Posted: October 31, 2017
• Study Start: May 1, 2018
• Primary Completion: June 8, 2018
• Study Completion: June 8, 2018
• Last Updated: June 13, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)