Acute and Chronic Metabolic Flexibility in Individuals Living With Obesity: The i-FLEX Study

NCT03527446 | Completed

• 1 other identifier: UNewBrunswick
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Regular exercise is a cornerstone in the prevention and the management of cardio-metabolic risk factors. Some of the beneficial effect of exercise training occurs through metabolic flexibility' enhancement. Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand, and previous literature has shown that individuals living with obesity have an impaired metabolic flexibility compared to lean individuals. However, there is a lack of empirical evidence on the impact of sprint interval training on metabolic flexibility and whether this translates into clinically meaningful outcomes. This study will evaluate the impact of 4-week sprint interval training in normal weight individuals as well as individuals living with obesity on acute and chronic metabolic flexibility, irisin secretion and insulin sensitivity.

Conditions

Obesity; Obesity; Endocrine; Insulin Sensitivity; Exercise

Keywords

Metabolic flexibility; Insulin sensitivity; Sprint interval training; Obesity; Exercise intensity

Outcome Measures

Primary Outcomes (2)

• Change in Metabolic Flexibility

  Chronic and acute metabolic flexibility will be quantified from the respiratory quotient (RQ) at rest and from the respiratory exchange ratio (RER) during a 4-6 minutes steady rate exercise bout.

  Baseline and post-intervention (4 weeks)

• Change in Insulin Sensitivity

  Insulin sensitivity will be measure with the Matsuda Index

  Baseline and post-intervention (4 weeks)

Secondary Outcomes (1)

• Change in Irisin

  Baseline and post-intervention (4 weeks)

Study Arms (2)

Normal Weight

EXPERIMENTAL

BMI ≥ 18.5 \< 25.0 km/m2 Sprint Interval Training

Behavioral: Sprint Interval Training

Individuals living with Obesity

EXPERIMENTAL

BMI ≥ 30.0 km/m2 Sprint Interval Training

Behavioral: Sprint Interval Training

Interventions

Sprint Interval Training BEHAVIORAL

The 4-week sprint interval intervention will consist of a work-rest ratio of four 30-s intervals of exercise at maximal capacity and 4-min of passive recovery at 50% of maximal capacity between intervals. There will be three sessions per week.

Individuals living with Obesity; Normal Weight

Eligibility Criteria

• Age: 19 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Adults (Ages 19-60)
• Physically inactive for individuals living with obesity (not meeting Canadian Physical Activity Guidelines)
• Normal Weight (BMI ≥ 18.5 \< 25.0 km/m2)
• Obesity (BMI ≥ 30.0 km/m2)

You may not qualify if:

• Individuals with Type 2 Diabetes.
• Individuals with impaired glucose tolerance.
• Individuals living with obesity that partake in regular exercise training / meet the Canadian Physical Activity Guidelines.
• Individuals with a condition or injury that may impact the ability to perform exercise or may be worsened by exercise.
• Individuals currently being treated with corticosteroids or atypical antipsychotics, as these agents significantly influence carbohydrate metabolism.
• have experienced \>10% weight loss or enrolled in weight loss program within six months of enrolment.
• require use of medication(s) known to affect insulin sensitivity or secretion within the last 30 days.
• Medication(s) known to cause weight gain.
• weight loss medication(s).

Sponsors & Collaborators

• University of New Brunswick: lead

Study Sites (1)

University of New Brunswick - Kinesiology

Fredericton, New Brunswick, E3B 5A3, Canada

Location

Related Publications (1)

• Muoio DM. Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell. 2014 Dec 4;159(6):1253-62. doi: 10.1016/j.cell.2014.11.034.

  PMID: 25480291 BACKGROUND

MeSH Terms

Conditions

Obesity; Insulin Resistance; Motor Activity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Martin Senechal, PhD

  University of New Brunswick

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Individuals living with obesity (BMI ≥ 30 km/m2; n=15) as well as normal weight (BMI ≥ 18.5 \< 25.0 km/m2; n=15) adults (aged between 19 to 60 years) will be recruited to participate in the study. All participants will be asked to come in for a total of two visits and participate in a 4-week intervention.

Study Record Dates

• First Submitted: May 3, 2018
• First Posted: May 17, 2018
• Study Start: July 3, 2018
• Primary Completion: February 28, 2020
• Study Completion: February 28, 2020
• Last Updated: March 25, 2020

Record last verified: 2020-03

Locations

CA (1)