The Irisin and Metabolic Exercise Training Study

NCT03514238 | Completed

• 1 other identifier: University of New Brunswick
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

It has been established that greater amounts of vigorous intensity physical activity lead to improved health outcomes. Interestingly, the response of biologically active substances, called myokines, differs according to exercise intensity. As such, the current study aims to compare the difference in the response to irisin according to different exercise intensities in both normal weight subjects and individuals living with obesity. This study will compare continuous moderate intensity physical activity to high intensity physical activity against a control condition. Furthermore, this study will determine whether differences in exercise intensity are associated with better insulin sensitivity.

Conditions

Obesity

Keywords

Exercise; Physical Activity; Cardio-metabolic Health; Myokines; Cardiorespiratory Fitness; Obesity; Type 2 Diabetes

Outcome Measures

Primary Outcomes (1)

• Insulin Sensitivity

  Insulin sensitivity using the Matsuda Index.

  Baseline

Study Arms (2)

Adults (BMI: ≥30 kg/m2)

EXPERIMENTAL

Obese individuals will participate to three conditions: Control Sitting Condition (C), Sitting for 35 minutes Acute Bout of Continuous Moderate Aerobic Exercise (MOD) 50-55% of heart rate reserve Acute Bout of High Intensity Interval Aerobic Exercise (HIIT) 85-90% heart rate reserve

Behavioral: High Intensity Interval Aerobic Exercise (HIIT); Behavioral: Continuous Moderate Aerobic Exercise (MOD); Behavioral: Control Sitting Condition (C)

Adults (BMI: 18.5-24.9 kg/m2)

EXPERIMENTAL

Normal weight individuals will participate to three conditions: Control Sitting Condition (C), Sitting for 35 minutes Acute Bout of Continuous Moderate Aerobic Exercise (MOD) 50-55% of heart rate reserve Acute Bout of High Intensity Interval Aerobic Exercise (HIIT) 85-90% heart rate reserve

Behavioral: High Intensity Interval Aerobic Exercise (HIIT); Behavioral: Continuous Moderate Aerobic Exercise (MOD); Behavioral: Control Sitting Condition (C)

Interventions

High Intensity Interval Aerobic Exercise (HIIT) BEHAVIORAL

Cycling at 50-55% heart rate reserve for 5 minutes followed by 2 minutes of cycling at 85-90% heart rate reserve consecutively for a total of 35 minutes. Blood draws will occur at 6 different time points during exercise (0min, 7min, 14min, 21min, 28min, 35min).

Adults (BMI: 18.5-24.9 kg/m2); Adults (BMI: ≥30 kg/m2)

Continuous Moderate Aerobic Exercise (MOD) BEHAVIORAL

35 minutes of cycling at 50-55% heart rate reserve. Blood draws will occur at 6 different time points during exercise (0min, 7min, 14min, 21min, 28min, 35min).

Adults (BMI: 18.5-24.9 kg/m2); Adults (BMI: ≥30 kg/m2)

Control Sitting Condition (C) BEHAVIORAL

Blood draws matched for exercise time will be taken while participant remains seated for 35 minutes (0min, 7min, 14min, 21min, 28min, 35min).

Adults (BMI: 18.5-24.9 kg/m2); Adults (BMI: ≥30 kg/m2)

Eligibility Criteria

• Age: 19 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Obesity (≥30 kg/m2);
• Physical inactivity (must not reach Canadian Physical Activity Guidelines);
• At risk for Type 2 diabetes;
• Adult (aged 19-50).

You may not qualify if:

• Individuals with Type 2 diabetes;
• Chronic conditions or injuries that would impact exercise;
• Regular exercise training.

Sponsors & Collaborators

• University of New Brunswick: lead
• New Brunswick Health Research Foundation: collaborator

Study Sites (1)

University of New Brunswick - Kinesiology

Fredericton, New Brunswick, E3B 5A3, Canada

Location

Related Publications (3)

• Fox J, Rioux BV, Goulet EDB, Johanssen NM, Swift DL, Bouchard DR, Loewen H, Senechal M. Effect of an acute exercise bout on immediate post-exercise irisin concentration in adults: A meta-analysis. Scand J Med Sci Sports. 2018 Jan;28(1):16-28. doi: 10.1111/sms.12904. Epub 2017 May 24.

  PMID: 28453881 BACKGROUND

• Blizzard LeBlanc DR, Rioux BV, Pelech C, Moffatt TL, Kimber DE, Duhamel TA, Dolinsky VW, McGavock JM, Senechal M. Exercise-induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial. Physiol Rep. 2017 Dec;5(23):e13539. doi: 10.14814/phy2.13539.

  PMID: 29208692 BACKGROUND

• Rioux B, Paudel Y, Thomson A, Peskett L, Senechal M. An examination of exercise intensity and its impact on the acute release of irisin across obesity status: a randomized controlled crossover trial. Appl Physiol Nutr Metab. 2024 Dec 1;49(12):1712-1728. doi: 10.1139/apnm-2024-0091. Epub 2024 Sep 3.

  PMID: 39226615 DERIVED

MeSH Terms

Conditions

Obesity; Motor Activity; Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases

Study Officials

• Martin Sénéchal, PhD

  University of New Brunswick

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 18, 2018
• First Posted: May 2, 2018
• Study Start: September 1, 2017
• Primary Completion: November 1, 2019
• Study Completion: November 1, 2019
• Last Updated: November 3, 2020

Record last verified: 2020-11

Locations

CA (1)