The Relationship Between the Change of Resting Energy Expenditure and Nutritional Status .

NCT03511950 | Unknown

• 1 other identifier: REE and peritonitis
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Peritonitis is a common and devastating complication in patients on peritoneal dialysis (PD). It is a known fact that persistent inflammatory state and nutritional deterioration are closely associated with increased mortality in PD patients.And resting energy expenditure(REE) is significantly increased in acute and chronic inflammation in patients with chronic kidney disease (including dialysis patients).However,it is limited to the changing trend and duration of REE in peritonitis.Investigators hypothesize that the increase in total energy consumption resulting from the increase of REE which may accompany with decreased energy intake will lead to negative energy balance and nutritional deterioration, which may affect the prognosis of patients.Therefore,a prospective cohort study will be designed to dynamically research the change of REE accompanied with the nutrition status in peritonitis and provide the basis for peritonitis management in the future.

Conditions

Peritonitis; Resting Energy Expenditure; Nutrition

Outcome Measures

Primary Outcomes (1)

• The relationship between the change of REE and the change of albumin

  Method: REE, indirect calorimetry

  90 days

Secondary Outcomes (4)

• The relationship between the change of REE and the change of BMI

  90 days

• The relationship between the change of REE and the change of handgrip strength

  90 days

• The relationship between the change of REE and the change of Fat mass

  90 days

• The relationship between the change of REE and the change of lean body mass

  90 days

Other Outcomes (1)

• The relationship between the change of REE and the outcome of patients

  90 days or 180days

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

PD patients with confirm diagnosis of peritonitis

You may qualify if:

• Receiving PD for\>3 months
• Age between 18 and 80 years
• Confirm diagnosis of peritonitis

You may not qualify if:

• Disability
• Other acute complications: including systemic infections except for peritonitis, acute cardia-cerebrovascular disease in one month
• Active hepatitis and musculoskeletal diseases in the past
• Cancer and is treated with chemoradiotherapy within 1 year
• Severe edema of the whole body or a large amount of body cavity effusion
• Thyroid dysfunction
• History of hormonal drugs use
• During pregnancy or lactation
• Mental disorder

Sponsors & Collaborators

• Peking University First Hospital: lead

Study Sites (1)

Peking University First Hospital

Beijing, China

RECRUITING

MeSH Terms

Conditions

Peritonitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Peritoneal Diseases; Digestive System Diseases

Central Study Contacts

Jie Dong

CONTACT

13911841538; jie.dong@bjmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor in Renal Division, Department of Medicine

Study Record Dates

• First Submitted: April 1, 2018
• First Posted: April 30, 2018
• Study Start: April 1, 2021
• Primary Completion: August 30, 2023
• Study Completion: October 30, 2023
• Last Updated: September 29, 2022

Record last verified: 2022-09

Locations

CN (1)