Influence of Ambient Temperature on Resting Energy Expenditure of Healthy Adults

NCT05505240 | Completed

• 1 other identifier: TempRMR
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the influence of four different ambient temperatures (18, 22, 28, 38°C) on the resting energy expenditure of healthy adults by respiratory gas analysis. It is assumed that the resting energy expenditure is higher at 18°C and 38°C than at the temperatures in between.

Conditions

Resting Energy Expenditure

Keywords

Resting energy expenditure; Resting metabolic rate; Ambient temperature; Environmental temperature

Outcome Measures

Primary Outcomes (1)

• Resting Energy Expenditure

  Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min

  20 minutes

Secondary Outcomes (4)

• Body core temperature

  20 minutes

• Body surface temperature

  20 minutes

• Body composition

  5 minutes (after respiratory analysis)

• Blood pressure

  10 minutes (at beginning of study day)

Study Arms (4)

Cold temperature

EXPERIMENTAL

18°C

Other: Respiratory analysis at cold temperature

Room temperature

EXPERIMENTAL

22°C

Other: Respiratory analysis at room temperature

Thermoneutral temperature

EXPERIMENTAL

28°C

Other: Respiratory analysis at thermoneutral temperature

Hot temperature

EXPERIMENTAL

38°C

Other: Respiratory analysis at hot temperature

Interventions

Respiratory analysis at cold temperature OTHER

Respiratory analysis at an ambient temperature of 18°C

Cold temperature

Respiratory analysis at room temperature OTHER

Respiratory analysis at an ambient temperature of 22°C

Room temperature

Respiratory analysis at thermoneutral temperature OTHER

Respiratory analysis at an ambient temperature of 28°C

Thermoneutral temperature

Respiratory analysis at hot temperature OTHER

Respiratory analysis at an ambient temperature of 38°C

Hot temperature

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI: 18,5 - 24,9 kg/m2
• metabolically healthy

You may not qualify if:

• smoking
• low or high blood pressure
• dyslipidemia
• insulin resistance or diabetes mellitus type 1 or type 2
• gastrointestinal diseases (e.g. food intolerances or allergies)
• liver, kidney and/or thyroid diseases
• hepatitis B or C, HIV Infection
• chronic inflammatory diseases
• disordered eating
• psychological diseases
• alcohol and/or drug abuse
• use of medication
• pregnancy or lactating
• participation in another intervention study
• women: irregular menstrual cycle

Sponsors & Collaborators

• University of Bonn: lead
• DLR German Aerospace Center: collaborator

Study Sites (1)

University of Bonn

Bonn, 53115, Germany

Location

Related Publications (1)

• Henkel S, Frings-Meuthen P, Diekmann C, Coenen M, Stoffel-Wagner B, Nemeth R, Pesta D, Egert S. Influence of Ambient Temperature on Resting Energy Expenditure in Metabolically Healthy Males and Females. J Nutr. 2025 Mar;155(3):862-870. doi: 10.1016/j.tjnut.2025.01.013. Epub 2025 Jan 13.

  PMID: 39814140 DERIVED

Study Officials

• Sarah Egert, Prof. PhD

  University of Bonn

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. PhD

Study Record Dates

• First Submitted: August 15, 2022
• First Posted: August 17, 2022
• Study Start: November 21, 2022
• Primary Completion: April 6, 2023
• Study Completion: April 6, 2023
• Last Updated: April 12, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)