Meta-analysis of Fruit and Vegetable Sources and Cardiovascular Outcomes

NCT03394339 | Unknown

• 1 other identifier: CIHR-FRU VEG & CVD 2017
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

Fruit and vegetables are a cornerstone of healthy dietary patterns and dietary guidelines worldwide. The supporting evidence, however, is largely derived from observational studies of protective associations with cardiovascular disease (CVD) in health-conscious populations or from randomized trials of the effect of specific fruit or vegetable derived nutrients on CVD risk factors. A growing body of literature has influenced a shift away from a focus on single nutrients to a focus on whole foods and dietary patterns. To what extent fruit and vegetables should contribute to dietary patterns for cardiovascular health and whether specific types of fruit or vegetables should be recommended is unclear. Although previous systematic reviews and meta-analyses have elucidated the association between the intake of total and some specific fruit and vegetables with cardiovascular outcomes, a comprehensive synthesis comparing the certainty of the evidence for the different types of fruit and vegetables in relation to a range of cardiovascular outcomes has yet to be completed. We propose to conduct a systematic review and meta-analysis of the available prospective cohort studies using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the association between different types of fruit and vegetables and different cardiovascular outcomes that include CVD, coronary heart disease \[CHD\], and stroke incidence and mortality.

Conditions

CHD - Coronary Heart Disease; CVD - Cerebrovascular Disease; Stroke

Keywords

Systematic review and meta-anaylsis; Evidence-based nutrition (EBN); Dietary guidelines; Fruit; Vegetables

Outcome Measures

Primary Outcomes (3)

• Cardiovascular disease (CVD)

  Risk ratios for CVD incidence and mortality

  1 year follow-up

• Coronary heat disease (CHD)

  Risk ratios for CHD incidence and mortality

  1 year follow-up

• Stroke

  Rsk ratios for stroke incidence and mortality

  1 year follow-up

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Varied

You may qualify if:

• Prospective cohort studies or case-cohort studies
• Duration \>= 1 year
• Assessment of the exposure of fruit and/or vegetables
• Ascertainment of viable data by level of exposure

You may not qualify if:

• Ecological, cross-sectional, and retrospective observational studies, clinical trials, and non-human studies
• Duration \< 1 year
• No assessment of exposures of fruit or vegetables
• No ascertainment viable clinical outcome data by level of exposure

Sponsors & Collaborators

• University of Toronto: lead

Study Sites (1)

The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, M5C 2T2, Canada

Location

Related Publications (1)

• Zurbau A, Au-Yeung F, Blanco Mejia S, Khan TA, Vuksan V, Jovanovski E, Leiter LA, Kendall CWC, Jenkins DJA, Sievenpiper JL. Relation of Different Fruit and Vegetable Sources With Incident Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. J Am Heart Assoc. 2020 Oct 20;9(19):e017728. doi: 10.1161/JAHA.120.017728. Epub 2020 Oct 1.

  PMID: 33000670 DERIVED

MeSH Terms

Conditions

Coronary Artery Disease; Cerebrovascular Disorders; Stroke

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• John Sievenpiper, MD, PhD, FRCPC

  Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre and Toronto 3D Knowledge Institute and Clinical Trials Unit, St. Michael's Hospital

  PRINCIPAL INVESTIGATOR

• Sonia Blanco Mejia, MD

  Clinical Nutrition and Risk Factor Modifcation Centre and Toronto 3D Knowledge Institute and Clinical Trials Unit, St. Michael's Hosptial

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: January 3, 2018
• First Posted: January 9, 2018
• Study Start: April 1, 2017
• Primary Completion: November 1, 2018
• Study Completion: December 1, 2018
• Last Updated: October 11, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)