Twins Born in Guangzhou
2-BIG
1 other identifier
observational
1,000
1 country
1
Brief Summary
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2012
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2012
CompletedFirst Submitted
Initial submission to the registry
October 20, 2017
CompletedFirst Posted
Study publicly available on registry
November 6, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2038
ExpectedFebruary 26, 2024
February 1, 2024
13.9 years
October 20, 2017
February 22, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Neurodevelopment at early childhood
Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules.
At age of 1 year old
Intelligence quotient
Assessed using the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition including 5 verbal and 3 performance subtests. Intelligence quotient ranges 40-160, in which under 70 is defined as mental retardation. The total score was calculated by an online system.
At age of 6 years old
Change of gene expression during childhood
DNA methylation, histone acetylation etc. assessed by analyses of blood samples
Age at 1 year , 6 years, 12years and 18years
Secondary Outcomes (4)
Change of intestinal flora during early childhood
Age at 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years
Changes of body composition and bone density during early childhood
At birth, age of 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years
Height in kilometer changes during childhood
At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year
Weight in kilogram changes during childhood
At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year
Study Arms (2)
Identical Twins
Twins develop from one zygote with no intervention
Dizygotic Twins
Twins develop from two different zygote with no intervention
Interventions
Eligibility Criteria
Twins delivered in Guangzhou, China and their parents
You may qualify if:
- Live twins delivered in Guangzhou Women and Children's Medical Center
- Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years
- Baseline information during pregnancy available
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, 510623, China
Related Publications (1)
Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20.
PMID: 28321694RESULT
Related Links
Biospecimen
During pregnancy: maternal blood, urine and stool At delivery: cord, cord blood and placenta During Infancy：dry blood spot, stool and blood During childhood: blood, buccal swab and stool
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xiu Qiu, PhD
Born in Guangzhou Cohort Study in Guangzhou Women and Children's Medical Center
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of the Born in Guangzhou Cohort Study
Study Record Dates
First Submitted
October 20, 2017
First Posted
November 6, 2017
Study Start
February 1, 2012
Primary Completion
December 31, 2025
Study Completion (Estimated)
December 31, 2038
Last Updated
February 26, 2024
Record last verified: 2024-02