Preterm Birth Cohort Study in Guangzhou
PBCSG
1 other identifier
observational
5,000
1 country
1
Brief Summary
The Preterm Birth Cohort Study in Guangzhou (PBCSG) aims to explore the impact of genetic and environmental factors including life styles on preterm birth, to examine the interaction effect between these factors, and to follow up the short-term and long-term outcomes of preterm childrens.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2012
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2012
CompletedFirst Submitted
Initial submission to the registry
September 7, 2018
CompletedFirst Posted
Study publicly available on registry
September 12, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2038
ExpectedFebruary 26, 2024
February 1, 2024
13.9 years
September 7, 2018
February 22, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Neurodevelopment at early childhood
Assessed by using the Gesell Developmental Schedules, which include adaptive, gross motor, fine motor, language, and social function domains. Higher score in each domain is considered a better outcome, while no more than 85 is defined as suspected development retardation
At age of 1 year
Secondary Outcomes (6)
Intelligence quotient of offspring
At age of 6 years old
Height changes during childhood and adolescence
At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year
Weight changes during childhood and adolescence
At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year
Change of intestinal flora during early childhood
At age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 years old
Changes of body fat percentage during early childhood
At age of 3 years, 6 years, 12 years and 18 years old
- +1 more secondary outcomes
Eligibility Criteria
The study population are childrens born before 37 weeks of gestation and their mothers in Guangzhou.
You may qualify if:
- Born before 37 weeks of gestation
- Born in Guangzhou Women and Children's Medical Center
- Intended to remain in Guangzhou for more than 3 years
You may not qualify if:
- Multiple birth
- Stillbirth
- With major congenital abnormalities
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Guangzhou Women and Children's Medical Center, China
Guangzhou, China
Related Publications (1)
Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20.
PMID: 28321694BACKGROUND
Biospecimen
At delivery: maternal blood, cord, cord blood and placenta. During infancy: dry blood spot, stool and blood. During childhood: blood, buccal swab and stool.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xiu Qiu, MD,PhD
Guangzhou Women and Children's Medical Center, China
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of the Born in Guangzhou Cohort Study
Study Record Dates
First Submitted
September 7, 2018
First Posted
September 12, 2018
Study Start
February 1, 2012
Primary Completion
December 31, 2025
Study Completion (Estimated)
December 31, 2038
Last Updated
February 26, 2024
Record last verified: 2024-02